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UBE2N
The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Heterodimer with UBE2V2. Interacts (UBE2V2-UBE2N heterodimer) with the E3 ligase STUB1 (via the U-box domain); the complex has a specific 'Lys-63'-linked polyubiquitination activity. Interacts with RNF8 and RNF168. Interacts with RNF11. Interacts with the E3 ligases, HLTF and SHPRH; the interactions promote the 'Lys-63'-linked polyubiquitination of PCNA upon genotoxic stress and lead to DNA repair. Interacts with ARIH2 (via RING-type 2). Belongs to the ubiquitin-conjugating enzyme family. Note: This description may include information from UniProtKB.
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| Protein type: DNA repair; EC 6.3.2.19; Ubiquitin ligase; Ubiquitin conjugating system; Ligase |
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Cellular Component: cytoplasm; cytosol; nucleus; ubiquitin ligase complex; UBC13-MMS2 complex
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Molecular Function: protein binding; ubiquitin binding; ubiquitin-protein ligase activity; ATP binding
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Biological Process: regulation of histone ubiquitination; positive regulation of DNA repair; positive regulation of I-kappaB kinase/NF-kappaB cascade; postreplication repair; positive regulation of histone modification; cytokine and chemokine mediated signaling pathway; DNA double-strand break processing; protein modification process; protein ubiquitination; proteolysis; T cell receptor signaling pathway; Toll signaling pathway; double-strand break repair via homologous recombination; activation of NF-kappaB transcription factor; toll-like receptor 2 signaling pathway; toll-like receptor 1 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; regulation of DNA repair; positive regulation of ubiquitin-protein ligase activity; histone ubiquitination; toll-like receptor signaling pathway; innate immune response; toll-like receptor 4 signaling pathway
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Reference #:
P61088 (UniProtKB)
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| Alt. Names/Synonyms: bendless-like ubiquitin conjugating enzyme; Bendless-like ubiquitin-conjugating enzyme; BLU; MGC131857; MGC8489; Ubc13; UbcH-ben; UBE2N; Ubiquitin carrier protein N; Ubiquitin-conjugating enzyme E2 N; ubiquitin-conjugating enzyme E2N (homologous to yeast UBC13); ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast); Ubiquitin-protein ligase N; yeast UBC13 homolog |
| Gene Symbols: UBE2N |
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Molecular weight: 17,138 Da
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Basal Isoelectric point: 6.13
Predict pI for various phosphorylation states
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CST Pathways:
NF-kB Signaling
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Toll-like Receptors Pathway
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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