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PARP1 (mouse)

Overview PARP1 Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP- ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Component of a base excision repair (BER) complex, containing at least XRCC1, PARP2, POLB and LRIG3. Homo- and heterodimer with PARP2. Interacts with PARP3, APTX and SRY. The SWAP complex consists of NPM1, NCL, PARP1 and SWAP70. Interacts with TIAM2 and ZNF423. Interacts (when poly-ADP- ribosylated) with CHD1L. Interacts with the DNA polymerase alpha catalytic subunit POLA1; this interaction functions as part of the control of replication fork progression. Interacts with EEF1A1, RNF4 and TXK. Note: This description may include information from UniProtKB. Protein type: Transferase; Nuclear receptor co-regulator; DNA repair; Nuclear envelope; EC 2.4.2.30 Cellular Component: nucleoplasm; transcription factor complex; protein complex; nucleolus; nuclear envelope; nucleus Molecular Function: protein binding; protein N-terminus binding; transcription factor binding; NAD binding; NAD+ ADP-ribosyltransferase activity Biological Process: protein autoprocessing; protein amino acid ADP-ribosylation; cellular response to insulin stimulus; base-excision repair; DNA damage response, detection of DNA damage; regulation of growth rate; DNA repair; DNA metabolic process; telomere maintenance Reference #:  P11103 (UniProtKB) Alt. Names/Synonyms: 5830444G22Rik; ADP-ribosyltransferase (NAD+; ADP-ribosyltransferase (NAD+, poly (ADP-ribose) polymerase) 1; Adprp; Adprt; ADPRT 1; Adprt1; AI893648; C80510; msPARP; NAD(+) ADP-ribosyltransferase 1; PARP; PARP-1; Parp1; poly (ADP-ribose) polymerase family, member 1; poly (ADP-ribose) polymerase) 1; Poly [ADP-ribose] polymerase 1; Poly[ADP-ribose] synthase 1; poly[ADP-ribose] synthetase 1; PPOL; sPARP-1 Gene Symbols: Parp1 Molecular weight: 113,100 Da Basal Isoelectric point: 9.05  Predict pI for various phosphorylation states CST Pathways:  Death Receptor Signaling  |  NF-kB Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PARP1 1UK0 - A/B=662-1011 (human) 1UK1 - A/B=662-1011 (human) 1WOK - A/B/C/D=662-1011 (human) 2COK - A=385-486 (human) 2CR9 - A=518-643 (human) 2CS2 - A=103-224 (human) 2DMJ - A=1-93 (human) 2JVN - A=233-358 (human) 2L30 - A=1-108 (human) 2L31 - A=103-214 (human) 2RCW - A=662-1011 (human) 2RD6 - A=662-1011 (human) 2RIQ - A=216-366 (human) 3GJW - A=662-1011 (human) 3GN7 - A=662-1011 (human) 3L3L - A=662-1011 (human) 3L3M - A=662-1011 (human) 3OD8 - F/A/E/B/H/C/D/G=2-96 (human) 3ODA - F/A/E/B/H/C/D/G=2-96 (human) 3ODC - A/B=105-206 (human) 3ODE - A/B=105-206 (human) 4AV1 - A/D/C/B=5-202 (human) 4DQY - A/D=1-96 E/B=216-366 F/C=518-1014 (human) 4HHY - A/D/C/B=660-1011 (human) 4HHZ - A/D/C/B=660-1011 (human) 2LE0 - A=389-487 (rat)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			mouse ► Hide Isoforms
0	1		S5	___MAEASERLYRVQ
0	1		S25	RASCKKCSESIPKDS
0	1		S27	SCKKCSESIPKDSLR
0	1		S32	SESIPKDSLRMAIMV
0	2		S41	RMAIMVQSPMFDGKV
0	1		K87	DDQQKVKKtAEAGGV
0	1		T88-p	DQQKVKKtAEAGGVA
0	3		K97	EAGGVAGKGQDGSGG
0	1		K97	EAGGVAGKGQDGSGG
0	3		K105-a	GQDGSGGkAEKTLGD
0	1		K108	GSGGkAEKTLGDFAA
0	8		K119	DFAAEYAKSNRSMCK
0	1		K131	MCKGCLEKIEKGQMR
0	2		K165	YHPTCFVKKRDELGF
1	1		S177	LGFRPEYSASQLKGF
0	3		S179	FRPEYSASQLKGFSL
1	0		K203	KKQLPAIKNEGKRKG
0	1		K209	IKNEGKRKGDEVDGT
0	1		K221	DGTDEVAKKKSRKET
0	1		S224	DEVAKKKSRKETDKY
0	1		K239	SKLEKALKAQNELIW
0	3		K249	NELIWNIKDELKKAC
0	1		K249	NELIWNIKDELKKAC
0	7		K253	WNIKDELKKACSTND
0	1		K254	NIKDELKKACSTNDL
0	1		K254	NIKDELKKACSTNDL
0	3		K262	ACSTNDLKELLIFNQ
0	36		Q269	KELLIFNQQQVPSGE
0	1		S274	FNQQQVPSGESAILD
0	1		K296-u	FGALLPCkECSGQLV
0	1		K320	GDVTAWTKCMVKTQN
0	1		K331	KTQNPSRKEWVTPKE
0	1		K337	RKEWVTPKEFREISY
0	2		H368	SSAPITVHWPLSVTS
1	2		S372	ITVHWPLSVTSAPTA
1	1		V373	TVHWPLSVTSAPTAV
0	1		S375	HWPLSVTSAPTAVNS
0	1		K394	DKPLSNMKILTLGKL
0	2		K400	MKILTLGKLSQNKDE
0	6		K400	MKILTLGKLSQNKDE
0	2		K414	EAKAVIEKLGGKLTG
0	2		K425	KLTGSANKASLCISI
0	3		K433	ASLCISIKKEVEKMN
0	1		K434	SLCISIKKEVEKMNK
0	7		K447	NKKMEEVKEANIRVV
0	3		K467	QDVSASTKSLQDLLS
0	1		K486	SPWGAEVKAEPGEVV
3	1		K486	SPWGAEVKAEPGEVV
1	0		K498	EVVAPRGKSAAPSKK
0	1		S499	VVAPRGKSAAPSKKS
1	0		K504	GKSAAPSKKSKGCFK
1	0		K507	AAPSKKSKGCFKEEG
0	6		K507	AAPSKKSKGCFKEEG
0	3		K517	FKEEGVNKSEKRMKL
1	26		K520	EGVNKSEKRMKLTLK
1	0		K523	NKSEKRMKLTLKGGA
0	2		K527	KRMKLTLKGGAAVDP
0	1		K547-a	HSAHVLEkGGKVFSA
0	13		K547-u	HSAHVLEkGGKVFSA
0	1		K550	HVLEkGGKVFSATLG
0	5		K563-u	LGLVDIVkGTNSYYK
0	2		K578-u	LQLLEDDkESRYWIF
0	1		K599	GTVIGSNKLEQMPSK
0	1		K599	GTVIGSNKLEQMPSK
0	1		S605	NKLEQMPSKEEAVEQ
0	1		Y617-p	VEQFMKLyEEKTGNA
0	2		K620	FMKLyEEKTGNAWHS
0	1		K636	NFTKYPKKFYPLEID
0	1		T660	KLTVKPGTKSKLPKP
0	1		K661	LTVKPGTKSKLPKPV
0	1		K663	VKPGTKSKLPKPVQE
0	1		K666	GTKSKLPKPVQELVG
0	1		G673	KPVQELVGMIFDVDS
0	1		S680	GMIFDVDSMKKALVE
0	1		K694	EYEIDLQKMPLGKLS
0	5		K747	PHDFGMKKPPLLNNA
0	1		Y774	LLDIEVAYSLLRGGs
1	12		S781-p	YSLLRGGsDDSSKDP
1	0		S784	LRGGsDDSSKDPIDV
1	0		S785	RGGsDDSSKDPIDVN
0	3		K786	GGsDDSSKDPIDVNY
0	5		K795	PIDVNYEKLKTDIKV
0	1		K797	DVNYEKLKTDIKVVD
0	1		S807	IKVVDRDSEEAEVIR
0	1		T823	YVKNTHATTHNAYDL
0	1		K837	LEVIDIFKIEREGES
0	3		R851	SQRYKPFRQLHNRRL
0	6		K939	KHASHISKLPKGKHS
0	7		K948	PKGKHSVKGLGKTTP
0	2		K1009	LKLKFNFKTSLW___

	PARP1 iso3
S5	___MAEASERLYRVE
S25	RASCKKCSESIPKDS
S27	SCKKCSESIPKDSLR
S32	SESIPKDSLRMTIMV
S41	RMTIMVQSPMFDGKV
K87	DDQQKVKKTAEAGGV
T88	DQQKVKKTAEAGGVA
K97	EAGGVAGKGQDGSGG
K97	EAGGVAGKGQDGSGG
K105	GQDGSGGKAEKTLGD
K108	GSGGKAEKTLGDFLA
K119-u	DFLAEYAkSNRSMCK
K131	MCKGCLEKIEKGQMR
K165	YHPTCFVKKRDELGF
S177	LGFRPEYSASQLKGF
S179	FRPEYSASQLKGFSL
K203	KKQLPAIKNEGKRKG
K209	IKNEGKRKGDEVDGT
K221	DGTDEVAKKKSKKGK
S224	DEVAKKKSKKGKDKD
K240	SKLEKALKAQNELIW
K250	NELIWNIKDELKKAC
K250	NELIWNIKDELKKAC
K254	WNIKDELKKACSTND
K255	NIKDELKKACSTNDL
K255	NIKDELKKACSTNDL
K263	ACSTNDLKELLIFNQ
Q270	KELLIFNQQQVPSGE
S275	FNQQQVPSGESAILD
K297	FGALLPCKECSGQLV
K321	GDVTAWTKCMVKTQN
K332	KTQNPSRKEWVTPKG
K338	RKEWVTPKGFREISY
A369	SSAPAPLALPLSVTS
S373	APLALPLSVTSAPTA
V374	PLALPLSVTSAPTAV
S376	ALPLSVTSAPTAVNS
K395	DKPLSNMKILTLGKL
K401	MKILTLGKLSQNKDE
K401	MKILTLGKLSQNKDE
K415	EAKAVIEKLGGKLTG
K426	KLTGSANKASLCIST
K434	ASLCISTKKEVEKMS
K435	SLCISTKKEVEKMSK
K448	SKKMEEVKAANVRVV
K468-u	QDVSASTkSLQELLS
K487	SSWGAEVKAEPGEVV
K487	SSWGAEVKAEPGEVV
K499	EVVAPKGKSAAPSKK
S500	VVAPKGKSAAPSKKS
K505	GKSAAPSKKSKGAVK
K508	AAPSKKSKGAVKEEG
K508	AAPSKKSKGAVKEEG
K518	VKEEGVNKSEkRMKL
K521-a	EGVNKSEkRMKLTLK
K524	NKSEkRMKLTLKGGA
K528	kRMKLTLKGGAAVDP
K548	HSAHVLEKGGKVFSA
K548	HSAHVLEKGGKVFSA
K551	HVLEKGGKVFSATLG
R564	LGLVDIVRGTNSYYK
K579	LQLLEDDKESRYWIF
K600	GTVIGSNKLEQMPSK
K600	GTVIGSNKLEQMPSK
S606	NKLEQMPSKEDAVEH
Y618	VEHFMKLYEEKTGNA
K621	FMKLYEEKTGNAWHS
K637	NFTKYPKKFYPLEID
T661	KLTVKPGTKSKLPKP
K662	LTVKPGTKSKLPKPV
K664	VKPGTKSKLPKPVQE
K667	GTKSKLPKPVQELVG
G674	KPVQELVGMIFDVES
S681	GMIFDVESMKKALVE
K695	EYEIDLQKMPLGKLS
K748	PHDFGMKKPPLLNNA
Y775	LLDIEVAYSLLRGGS
S782	YSLLRGGSDDSSKDP
S785	LRGGSDDSSKDPIDV
S786	RGGSDDSSKDPIDVN
K787	GGSDDSSKDPIDVNY
K796	PIDVNYEKLKTDIKV
K798	DVNYEKLKTDIKVVD
S808	IKVVDRDSEEAEVIR
T824	YVKNTHATTHNAYDL
K838	LEVIDIFKIEREGES
R852	SQRYKPFRQLHNRRL
K940	KHASHISKLPKGKHS
K949	PKGKHSVKGLGKTTP
K1010	LKLKFNFKTSLW___

	human
S5-p	___MAESsDKLYRVE
S25-p	RASCKKCsEsIPKDs
S27-p	SCKKCsEsIPKDsLR
S32-p	sEsIPKDsLRMAIMV
S41-p	RMAIMVQsPMFDGKV
K87-u	DDQQKVKkTAEAGGV
T88	DQQKVKkTAEAGGVT
K97-a	EAGGVTGkGQDGIGS
K97-u	EAGGVTGkGQDGIGS
K105-a	GQDGIGSkAEkTLGD
K108-u	GIGSkAEkTLGDFAA
K119-u	DFAAEYAkSNRSTCK
K131-a	TCKGCMEkIEKGQVR
K165-u	YHPGCFVkNREELGF
S177-p	LGFRPEYsAsQLKGF
S179-p	FRPEYsAsQLKGFSL
K203-s	KKQLPGVkSEGKRkG
K209-u	VkSEGKRkGDEVDGV
K221-u	DGVDEVAkKKsKKEK
S224-p	DEVAkKKsKKEKDKD
K239-u	SKLEKALkAQNDLIW
K249-a	NDLIWNIkDELkkVC
K249-u	NDLIWNIkDELkkVC
K253-a	WNIkDELkkVCSTND
K254-a	NIkDELkkVCSTNDL
K254-u	NIkDELkkVCSTNDL
K262-u	VCSTNDLkELLIFNk
K269-u	kELLIFNkQQVPsGE
S274-p	FNkQQVPsGESAILD
E296	FGALLPCEECSGQLV
K320-u	GDVTAWTkCMVKTQT
K331-u	KTQTPNRkEWVTPkE
K337-u	RkEWVTPkEFREISY
T368-p	TSASVAAtPPPstAs
S372-p	VAAtPPPstAsAPAA
T373-p	AAtPPPstAsAPAAV
S375-p	tPPPstAsAPAAVNS
K394-u	DKPLSNMkILTLGkL
K400-a	MkILTLGkLSRNKDE
K400-u	MkILTLGkLSRNKDE
K414-u	EVKAMIEkLGGKLTG
K425-u	KLTGTANkASLCIST
K433-a	ASLCISTkkEVEKMN
K434-u	SLCISTkkEVEKMNK
K447-u	NKKMEEVkEANIRVV
K467	QDVSASTKSLQELFL
K486-u	SPWGAEVkAEPVEVV
K486-s	SPWGAEVkAEPVEVV
K498-a	EVVAPRGksGAALSk
S499-p	VVAPRGksGAALSkK
K505-a	ksGAALSkKSkGQVK
K508-a	AALSkKSkGQVKEEG
K508-m1	AALSkKSkGQVKEEG
K518-a	VKEEGINkSEkRMkL
K521-a	EGINkSEkRMkLTLk
K524-a	NkSEkRMkLTLkGGA
K528-u	kRMkLTLkGGAAVDP
K548	HSAHVLEKGGkVFSA
K548-u	HSAHVLEkGGkVFSA
K551-u	HVLEkGGkVFSATLG
K564-u	LGLVDIVkGTNSYYK
K579-u	LQLLEDDkENRYWIF
K600-a	GTVIGSNkLEQMPsK
K600-u	GTVIGSNkLEQMPsK
S606-p	NkLEQMPsKEDAIEH
Y618	IEHFMKLYEEkTGNA
K621-a	FMKLYEEkTGNAWHS
K637-u	NFTKYPKkFYPLEID
T661-p	KLTVNPGtkSkLPkP
K662-u	LTVNPGtkSkLPkPV
K664-u	VNPGtkSkLPkPVQD
K667-u	GtkSkLPkPVQDLIk
K674-m2	kPVQDLIkMIFDVEs
S681-p	kMIFDVEsMKKAMVE
K695-u	EYEIDLQkMPLGKLS
K748-u	PHDFGMKkPPLLNNA
Y775-p	LLDIEVAySLLRGGs
S782-p	ySLLRGGsDDsskDP
S785-p	LRGGsDDsskDPIDV
S786-p	RGGsDDsskDPIDVN
K787-u	GGsDDsskDPIDVNY
K796-u	PIDVNYEkLkTDIKV
K798-u	DVNYEkLkTDIKVVD
S808-p	IKVVDRDsEEAEIIR
T824-p	YVKNTHAtTHNAYDL
K838-u	LEVIDIFkIEREGEC
K852-u	CQRYKPFkQLHNRRL
K940-u	KHASHISkLPKGKHS
K949-u	PKGKHSVkGLGKTTP
K1010-u	LKLKFNFkTSLW___

	rat
T5	___MAEATERLYRVE
S25	RASCKKCSESIPKDS
S27	SCKKCSESIPKDSLR
S32	SESIPKDSLRMAIMV
S41	RMAIMVQSPMFDGKV
K87	DDQQKVKKTAEAGGV
T88	DQQKVKKTAEAGGVA
K97	EAGGVAGKGQHGGGG
K97	EAGGVAGKGQHGGGG
K105	GQHGGGGKAEKTLGD
K108	GGGGKAEKTLGDFAA
K119	DFAAEYAKSNRSTCK
K131	TCKGCMEKIEKGQMR
K165	YHPTCFVKNRDELGF
S177	LGFRPEYSASQLKGF
S179	FRPEYSASQLKGFSL
K203	KKQLPAVKSEGKRKC
K209	VKSEGKRKCDEVDGI
K221	DGIDEVAKKKSKKGK
S224	DEVAKKKSKKGKDKE
K240	SKLEKALKAQNELVW
K250	NELVWNIKDELKKAC
K250	NELVWNIKDELKKAC
K254	WNIKDELKKACSTND
K255	NIKDELKKACSTNDL
K255	NIKDELKKACSTNDL
K263	ACSTNDLKELLIFNQ
Q270	KELLIFNQQQVPSGE
S275	FNQQQVPSGESAILD
K297	FGALLPCKECSGQLV
K321	GDVTAWTKCMVKTQN
K332	KTQNPSRKEWVTPKE
K338	RKEWVTPKEFREISY
A369	SSAPAPPAPPVSITS
S373	APPAPPVSITSAPTA
I374	PPAPPVSITSAPTAV
S376	APPVSITSAPTAVNS
K395	DKPLSNMKILTLGKL
K401	MKILTLGKLSQNKDE
K401	MKILTLGKLSQNKDE
K415	EAKAMIEKLGGKLTG
K426	KLTGSANKASLCIST
K434	ASLCISTKKEVEKMS
K435	SLCISTKKEVEKMSK
K448	SKKMEEVKAANVRVV
K468	QDVSASAKSLQELLS
K487	SSWGAEVKVEPGEVV
K487	SSWGAEVKVEPGEVV
K499	EVVVPKGKSAAPSKK
S500	VVVPKGKSAAPSKKS
K505	GKSAAPSKKSKGAVK
K508	AAPSKKSKGAVKEEG
K508	AAPSKKSKGAVKEEG
K518	VKEEGVNKSEKRMKL
K521	EGVNKSEKRMKLTLK
K524	NKSEKRMKLTLKGGA
K528	KRMKLTLKGGAAVDP
K548	HSAHVLEKGGKVFSA
K548	HSAHVLEKGGKVFSA
K551	HVLEKGGKVFSATLG
K564	LGLVDIVKGTNSYYK
K579	LQLLESDKESRYWIF
K600	GTVIGSNKLEQMPSK
K600	GTVIGSNKLEQMPSK
S606	NKLEQMPSKEDAVEH
Y618	VEHFMKLYEEKTGNA
K621	FMKLYEEKTGNAWHS
K637	NFTKYPKKFYPLEID
T661	KLAVKPGTKSKLPKP
K662	LAVKPGTKSKLPKPV
K664	VKPGTKSKLPKPVQE
K667	GTKSKLPKPVQELVG
G674	KPVQELVGMIFDVES
S681	GMIFDVESMKKALVE
K695	EYEIDLQKMPLGKLS
K748	PHDFGMKKPPLLNNT
Y775	LLDIEVAYSLLRGGS
S782	YSLLRGGSDDSSKDP
S785	LRGGSDDSSKDPIDV
S786	RGGSDDSSKDPIDVN
K787	GGSDDSSKDPIDVNY
K796	PIDVNYEKLKTDIKV
K798	DVNYEKLKTDIKVVD
S808	IKVVDRDSEEAEVIR
T824	YVKNTHATTHNAYDL
K838	LEVIDIFKIEREGES
R852	SQRYKPFRQLHNRRL
K940	KHASHISKLPKGKHS
K949	PKGKHSVKGLGKTAP
K1010	LKLKFNFKTSLW___

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