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Protein Page:
RanBP1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
RanBP1 a Ran-binding protein that functions in nuclear trafficking, mitosis, chromosomal segregation, and ciliogenesis. Controls both nuclear import and export. Contains a Ran binding domain and a C-terminal nuclear export signal. Following export from the nucleus, forms a complex with RanGTP and XPO1/cargo, leading to dissociation of cargo from XPO1. Stimulates RanGAP1 association with RanGTP, facilitating RanGTP hydrolysis to RanGDP. Stabilizes and regulates the formation of a RanGDP-importin/NLS receptor-RanBP1 complex during nuclear import. Controls RanGTP distribution along mitotic microtubules, which localizes critical factors, such as cyclin B1 and DLG7, to mitotic microtubles and regulates chromosome segregation. Knock down or overexpression experiments affect cellular ciliogenesis by regulating the local RanGTP concentation at the base of cilia.Belongs to the RANBP1 family. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Microtubule binding protein; G protein regulator, misc.
Chromosomal Location of Human Ortholog: 22q11.21
Cellular Component: centrosome; cytoplasm; nuclear envelope; nucleus
Molecular Function: GDP-dissociation inhibitor activity; Ran GTPase binding; GTPase activator activity
Biological Process: intracellular transport; positive regulation of mitotic centrosome separation; viral reproduction; regulation of catalytic activity; signal transduction; spindle organization and biogenesis; positive regulation of GTPase activity
Reference #:  P43487 (UniProtKB)
Alt. Names/Synonyms: HTF9A; MGC88701; RAN binding protein 1; Ran-binding protein 1; Ran-specific GTPase-activating protein; RANBP1; RANG
Gene Symbols: RANBP1
Molecular weight: 23,310 Da
Basal Isoelectric point: 5.19  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

RanBP1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K5-ac ___MAAAkDtHEDHD
0 2 T7-p _MAAAkDtHEDHDts
0 7 T13-p DtHEDHDtstENtDE
0 10 S14-p tHEDHDtstENtDEs
0 5 T15-p HEDHDtstENtDEsN
0 11 T18-p HDtstENtDEsNHDP
0 6 S21-p stENtDEsNHDPQFE
0 1 S32-p PQFEPIVsLPEQEIK
0 8 K50-ub EDEEELFkMRAkLFR
0 1 K54-ac ELFkMRAkLFRFAsE
0 201 S60-p AkLFRFAsENDLPEW
0 1 K68-ac ENDLPEWkERGTGDV
0 15 K68-ub ENDLPEWkERGTGDV
0 1 K68-sc ENDLPEWkERGTGDV
0 7 K76-ub ERGTGDVkLLkHKEK
0 1 K79-ac TGDVkLLkHKEKGAI
0 86 Y103-p LKICANHyItPMMEL
0 18 T105-p ICANHyItPMMELkP
0 1 K111-ac ItPMMELkPNAGSDR
0 2 K111-ub ItPMMELkPNAGSDR
0 7 K134-ac DFADECPkPELLAIR
0 2 K134-ub DFADECPkPELLAIR
0 22 K150-ac LNAENAQkFkTkFEE
0 23 K150-ub LNAENAQkFkTkFEE
0 3 K152-ac AENAQkFkTkFEECR
0 8 K154-ac NAQkFkTkFEECRkE
0 1 K154-ub NAQkFkTkFEECRkE
0 3 K160-ac TkFEECRkEIEEREK
0 13 K183-ac HAEKVAEkLEALsVk
0 4 K183-ub HAEKVAEkLEALsVk
0 4 S188-p AEkLEALsVkEETkE
0 8 K190-ac kLEALsVkEETkEDA
0 1 K194-ac LsVkEETkEDAEEkQ
0 1 K200-ac TkEDAEEkQ______
  mouse

 
K5 ___MAAAKDsHEDHD
S7-p _MAAAKDsHEDHDts
T13-p DsHEDHDtstENADE
S14-p sHEDHDtstENADEs
T15-p HEDHDtstENADEsN
A18 HDtstENADEsNHDP
S21-p stENADEsNHDPQFE
S32 PQFEPIVSLPEQEIK
K50-ub EDEEELFkMRAKLFR
K54 ELFkMRAKLFRFAsE
S60-p AKLFRFAsENDLPEW
K68 ENDLPEWKERGTGDV
K68-ub ENDLPEWkERGTGDV
K68 ENDLPEWKERGTGDV
K76 ERGTGDVKLLKHKEK
K79 TGDVKLLKHKEKGTI
Y103-p LKICANHyITPMMEL
T105 ICANHyITPMMELKP
K111 ITPMMELKPNAGSDR
K111 ITPMMELKPNAGSDR
K134 DFADECPKPELLAIR
K134 DFADECPKPELLAIR
K150-ac LNAENAQkFKTKFEE
K150-ub LNAENAQkFKTKFEE
K152 AENAQkFKTKFEECR
K154 NAQkFKTKFEECRKE
K154 NAQkFKTKFEECRKE
K160 TKFEECRKEIEEREK
K182 NAEKVAEKLEALSVR
K182 NAEKVAEKLEALSVR
S187 AEKLEALSVREAREE
R189 KLEALSVREAREEAE
E196 REAREEAEEKSEEKQ
K202 AEEKSEEKQ______
  rat

 
K5-ac ___MAAAkDSHEDHD
S7 _MAAAkDSHEDHDTS
T13 DSHEDHDTSTENAEE
S14 SHEDHDTSTENAEES
T15 HEDHDTSTENAEESN
A18 HDTSTENAEESNHDP
S21 STENAEESNHDPQFE
S32 PQFEPIVSLPEQEIK
K50 EDEEELFKMRAKLFR
K54 ELFKMRAKLFRFAsE
S60-p AKLFRFAsENDLPEW
K68 ENDLPEWKERGTGDV
K68 ENDLPEWKERGTGDV
K68 ENDLPEWKERGTGDV
K76 ERGTGDVKLLKHKEK
K79 TGDVKLLKHKEKGTI
Y103 LKICANHYITPMMEL
T105 ICANHYITPMMELKP
K111 ITPMMELKPNAGSDR
K111 ITPMMELKPNAGSDR
K134 DFADECPKPELLAIR
K134 DFADECPKPELLAIR
K150-ac LNAENAQkFKTKFEE
K150 LNAENAQKFKTKFEE
K152 AENAQkFKTKFEECR
K154 NAQkFKTKFEECRKE
K154 NAQkFKTKFEECRKE
K160 TKFEECRKEIEEREK
K182-ac NAEKVAEkLEALsVR
K182 NAEKVAEKLEALsVR
S187-p AEkLEALsVREARDE
R189 kLEALsVREARDEAE
E196 REARDEAEEKSEEKQ
K202 AEEKSEEKQ______
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