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RanBP1 (human)

Overview RanBP1 Inhibits GTP exchange on Ran. Forms a Ran-GTP-RANBP1 trimeric complex. Increase GTP hydrolysis induced by the Ran GTPase activating protein RANGAP1. May act in an intracellular signaling pathway which may control the progression through the cell cycle by regulating the transport of protein and nucleic acids across the nuclear membrane. Belongs to the RANBP1 family. Note: This description may include information from UniProtKB. Protein type: G protein regulator, misc. Cellular Component: centrosome; cytoplasm; nuclear envelope; nucleus Molecular Function: GDP-dissociation inhibitor activity; Ran GTPase binding; GTPase activator activity Biological Process: positive regulation of mitotic centrosome separation; intracellular transport; viral reproduction; signal transduction; spindle organization and biogenesis Reference #:  P43487 (UniProtKB) Alt. Names/Synonyms: HTF9A; MGC88701; RAN binding protein 1; Ran-binding protein 1; Ran-specific GTPase-activating protein; RANBP1; RANG Gene Symbols: RANBP1 Molecular weight: 23,310 Da Basal Isoelectric point: 5.19  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below RanBP1 1K5D - B/E/H/K=1-201 (human) 1K5G - B/E/H/K=1-201 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1K5D 1K5G  |  Phospho3D  |  DISEASE  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T7-p	_MAAAKDtHEDHDts
0	5		T13-p	DtHEDHDtstENtDE
0	9		S14-p	tHEDHDtstENtDEs
0	4		T15-p	HEDHDtstENtDEsN
0	7		T18-p	HDtstENtDEsNHDP
0	4		S21-p	stENtDEsNHDPQFE
0	8		K50-u	EDEEELFkMRAkLFR
0	1		K54-a	ELFkMRAkLFRFAsE
0	171		S60-p	AkLFRFAsENDLPEW
0	1		K68-a	ENDLPEWkERGTGDV
0	15		K68-u	ENDLPEWkERGTGDV
0	7		K76-u	ERGTGDVkLLkHKEK
0	1		K79-a	TGDVkLLkHKEKGAI
0	85		Y103-p	LKICANHyItPMMEL
0	15		T105-p	ICANHyItPMMELkP
0	1		K111-a	ItPMMELkPNAGSDR
0	2		K111-u	ItPMMELkPNAGSDR
0	6		K134-a	DFADECPkPELLAIR
0	2		K134-u	DFADECPkPELLAIR
0	21		K150-a	LNAENAQkFkTkFEE
0	23		K150-u	LNAENAQkFkTkFEE
0	3		K152-a	AENAQkFkTkFEECR
0	8		K154-a	NAQkFkTkFEECRkE
0	1		K154-u	NAQkFkTkFEECRkE
0	3		K160-a	TkFEECRkEIEEREK
0	12		K183-a	HAEKVAEkLEALSVk
0	4		K183-u	HAEKVAEkLEALSVk
0	7		K190-a	kLEALSVkEETkEDA
0	1		K194-a	LSVkEETkEDAEEkQ
0	1		K200-a	TkEDAEEkQ______

	mouse
S7-p	_MAAAKDsHEDHDts
T13-p	DsHEDHDtstENADE
S14-p	sHEDHDtstENADEs
T15-p	HEDHDtstENADEsN
A18	HDtstENADEsNHDP
S21-p	stENADEsNHDPQFE
K50-u	EDEEELFkMRAKLFR
K54	ELFkMRAKLFRFAsE
S60-p	AKLFRFAsENDLPEW
K68	ENDLPEWKERGTGDV
K68-u	ENDLPEWkERGTGDV
K76	ERGTGDVKLLKHKEK
K79	TGDVKLLKHKEKGTI
Y103-p	LKICANHyITPMMEL
T105	ICANHyITPMMELKP
K111	ITPMMELKPNAGSDR
K111	ITPMMELKPNAGSDR
K134	DFADECPKPELLAIR
K134	DFADECPKPELLAIR
K150-a	LNAENAQkFKTKFEE
K150-u	LNAENAQkFKTKFEE
K152	AENAQkFKTKFEECR
K154	NAQkFKTKFEECRKE
K154	NAQkFKTKFEECRKE
K160	TKFEECRKEIEEREK
K182	NAEKVAEKLEALSVR
K182	NAEKVAEKLEALSVR
R189	KLEALSVREAREEAE
E196	REAREEAEEKSEEKQ
K202	AEEKSEEKQ______

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