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Protein Page:
PSMD4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PSMD4 Binds and presumably selects ubiquitin-conjugates for destruction. Displays selectivity for longer polyubiquitin chains. Modulates intestinal fluid secretion. The 26S proteasome is composed of a core protease, known as the 20S proteasome, capped at one or both ends by the 19S regulatory complex (RC). The RC is composed of at least 18 different subunits in two subcomplexes, the base and the lid, which form the portions proximal and distal to the 20S proteolytic core, respectively. Directly interacts with NUB1. Interacts with SQSTM1. Interacts with UBQLN4. Belongs to the proteasome subunit S5A family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Proteasome complex; Protease
Cellular Component: nucleoplasm; proteasome complex; cytoplasm; nucleolus; nucleus; cytosol
Molecular Function: identical protein binding; protein binding
Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; viral reproduction; apoptosis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; mRNA metabolic process; regulation of apoptosis; antigen processing and presentation of peptide antigen via MHC class I; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; RNA metabolic process; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression; mitotic cell cycle; regulation of amino acid metabolic process; negative regulation of apoptosis; G1/S transition of mitotic cell cycle
Reference #:  P55036 (UniProtKB)
Alt. Names/Synonyms: 26S protease subunit S5a; 26S proteasome non-ATPase regulatory subunit 4; 26S proteasome regulatory subunit S5A; AF; AF-1; angiocidin; Antisecretory factor 1; ASF; MCB1; multiubiquitin chain binding protein; Multiubiquitin chain-binding protein; proteasome (prosome, macropain) 26S subunit, non-ATPase, 4; proteasome 26S non-ATPase subunit 4; PSMD4; pUB-R5; Rpn10; RPN10 homolog; S5A; S5a/antisecretory factor protein
Gene Symbols: PSMD4
Molecular weight: 40,737 Da
Basal Isoelectric point: 4.68  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PSMD4

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 125 K40-ub VNIVCHSkTRSNPEN
0 124 K74-ub DTGRILSkLHTVQPk
0 39 K81-ub kLHTVQPkGkITFCT
0 38 K83-ub HTVQPkGkITFCTGI
0 5 K98-ub RVAHLALkHRQGKNH
0 1 S115-p RIIAFVGsPVEDNEk
0 1 K122-ac sPVEDNEkDLVkLAk
0 51 K122-ub sPVEDNEkDLVkLAk
0 51 K126-ub DNEkDLVkLAkRLKk
0 12 K129-ub kDLVkLAkRLKkEkV
0 1 K133-ub kLAkRLKkEkVNVDI
0 48 K135-ub AkRLKkEkVNVDIIN
0 25 K152-ub EEEVNTEkLTAFVNT
0 1 S242 ARRAAAASAAEAGIA
0 11 T250-p AAEAGIAtTGtEDsD
0 6 T253-p AGIAtTGtEDsDDAL
0 5 S256-p AtTGtEDsDDALLkM
0 64 K262-ub DsDDALLkMTIsQQE
0 40 S266-p ALLkMTIsQQEFGRT
0 4 Y326-p PAKEEDDyDVMQDPE
0 7 S358-p AIRNAMGsLAsQATk
0 5 S361-p NAMGsLAsQATkDGK
0 1 K365-ac sLAsQATkDGKkDKK
0 9 K365-ub sLAsQATkDGKkDKK
0 1 K369-ub QATkDGKkDKKEEDK
  PSMD4 iso4  
K40 VNIVCHSKTRSNPEN
K74 DTGRILSKLHTVQPK
K81 KLHTVQPKGKITFCT
K83 HTVQPKGKITFCTGI
K98 RVAHLALKHRQGKNH
S115 RIIAFVGSPVEDNEK
K122 SPVEDNEKDLVKLAK
K122 SPVEDNEKDLVKLAK
K126 DNEKDLVKLAKRLKK
K129 KDLVKLAKRLKKEKV
K133 KLAKRLKKEKVNVDI
K135 AKRLKKEKVNVDIIN
K152 EEEVNTEKLTAFVNT
S242 ARRAAAASAAEAGIA
T250 AAEAGIATTGTEGER
T253 AGIATTGTEGERDSD
S259 GTEGERDSDDALLkM
K265-ub DSDDALLkMTISQQE
S269 ALLkMTISQQEFGRT
Y329 PAKEEDDYDVMQDPE
S361 AIRNAMGSLASQATK
S364 NAMGSLASQATKDGK
K368 SLASQATKDGKKDKK
K368 SLASQATKDGKKDKK
K372 QATKDGKKDKKEEDK
  mouse

► Hide Isoforms
 
K40-ub VNIVCHSkTRSNPEN
K74-ub DTGRILSkLHTVQPK
K81 kLHTVQPKGKITFCT
K83 HTVQPKGKITFCTGI
K98 RVAHLALKHRQGKNH
S115 RIIAFVGSPVEDNEk
K122-ac SPVEDNEkDLVkLAK
K122-ub SPVEDNEkDLVkLAK
K126-ub DNEkDLVkLAKRLKK
K129 kDLVkLAKRLKKEkV
K133 kLAKRLKKEkVNVDI
K135-ub AKRLKKEkVNVDIIN
K152 EEEVNTEKLTAFVNT
S242-p ARRAAAAsAAEAGIA
T250-p AAEAGIAtPGtEDsD
T253-p AGIAtPGtEDsDDAL
S256-p AtPGtEDsDDALLkM
K262-ub DsDDALLkMTINQQE
N266 ALLkMTINQQEFGRP
Y325 PVKEEDDYDVMQDPE
A357 AIRSVMGALASQATk
S360 SVMGALASQATkDGK
K364 ALASQATKDGKNDKK
K364-ub ALASQATkDGKNDKK
N368 QATkDGKNDKKEEEK
  PSMD4 iso2  
K40 VNIVCHSKTRSNPEN
K74 DTGRILSKLHTVQPK
K81 KLHTVQPKGKITFCT
K83 HTVQPKGKITFCTGI
K98 RVAHLALKHRQGKNH
S115 RIIAFVGSPVEDNEK
K122 SPVEDNEKDLVKLAK
K122 SPVEDNEKDLVKLAK
K126 DNEKDLVKLAKRLKK
K129 KDLVKLAKRLKKEKV
K133 KLAKRLKKEKVNVDI
K135 AKRLKKEKVNVDIIN
K152 EEEVNTEKLTAFVNT
S242 ARRAAAASAAEAGIA
T250-p AAEAGIAtPGtEGER
T253-p AGIAtPGtEGERDsD
S259-p GtEGERDsDDALLKM
K265 DsDDALLKMTINQQE
N269 ALLKMTINQQEFGRP
Y328 PVKEEDDYDVMQDPE
A360 AIRSVMGALASQATK
S363 SVMGALASQATKDGK
K367 ALASQATKDGKNDKK
K367 ALASQATKDGKNDKK
N371 QATKDGKNDKKEEEK
  rat

► Hide Isoforms
 
K40 VNIVCHSKTRSNPEN
K74 DTGRILSKLHTVQPK
K81 KLHTVQPKGKITFCT
K83 HTVQPKGKITFCTGI
K98 RVAHLALKHRQGKNH
S115 RIIAFVGSPVEDNEK
K122 SPVEDNEKDLVKLAK
K122 SPVEDNEKDLVKLAK
K126 DNEKDLVKLAKRLKK
K129 KDLVKLAKRLKKEKV
K133 KLAKRLKKEKVNVDI
K135 AKRLKKEKVNVDIIN
K152 EEEVNTEKLTAFVNT
S242 ARRAAAASAAEAGIA
T250 AAEAGIATPGTEDSD
T253 AGIATPGTEDSDDAL
S256 ATPGTEDSDDALLKM
K262 DSDDALLKMTISQQE
S266 ALLKMTISQQEFGRA
Y326 PVKEEDDYDVMQDPE
S358 AIRNAMGSLASQATK
S361 NAMGSLASQATKDGK
K365 SLASQATKDGKKDKK
K365 SLASQATKDGKKDKK
K369 QATKDGKKDKKEEEK
  PSMD4 iso2  
K40 VNIVCHSKTRSNPEN
K74 DTGRILSKLHTVQPK
K81 KLHTVQPKGKITFCT
K83 HTVQPKGKITFCTGI
K98 RVAHLALKHRQGKNH
S115 RIIAFVGSPVEDNEK
K122 SPVEDNEKDLVKLAK
K122 SPVEDNEKDLVKLAK
K126 DNEKDLVKLAKRLKK
K129 KDLVKLAKRLKKEKV
K133 KLAKRLKKEKVNVDI
K135 AKRLKKEKVNVDIIN
K152 EEEVNTEKLTAFVNT
S242 ARRAAAASAAEAGIA
T250 AAEAGIATPGTEGER
T253 AGIATPGTEGERDSD
S259 GTEGERDSDDALLKM
K265 DSDDALLKMTISQQE
S269 ALLKMTISQQEFGRA
Y329 PVKEEDDYDVMQDPE
S361 AIRNAMGSLASQATK
S364 NAMGSLASQATKDGK
K368 SLASQATKDGKKDKK
K368 SLASQATKDGKKDKK
K372 QATKDGKKDKKEEEK
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