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Protein Page:
Nogo (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Nogo Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex. Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; Cell development/differentiation; Membrane protein, integral; Inhibitor protein; Motility/polarity/chemotaxis; Endoplasmic reticulum
Chromosomal Location of Human Ortholog: 2p16.3
Cellular Component: cell projection; cell soma; endoplasmic reticulum; plasma membrane; integral to endoplasmic reticulum membrane; nuclear envelope; intracellular
Molecular Function: protein binding
Biological Process: regulation of apoptosis; nerve growth factor receptor signaling pathway; apoptosis; cerebral cortex radial glia guided migration; axonal fasciculation; negative regulation of axonogenesis; negative regulation of cell growth; angiogenesis; negative regulation of axon extension; regulation of axonogenesis; regulation of cell migration
Reference #:  Q9NQC3 (UniProtKB)
Alt. Names/Synonyms: ASY; Foocen; Human NogoA; KIAA0886; My043 protein; Nbla00271; Nbla10545; neurite growth inhibitor 220; Neurite outgrowth inhibitor; Neuroendocrine-specific protein; Neuroendocrine-specific protein C homolog; NI220/250; NOGO; Nogo protein; NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; reticulon 4; reticulon 5; Reticulon-4; Reticulon-5; RTN-x; RTN4; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C
Gene Symbols: RTN4
Molecular weight: 129,931 Da
Basal Isoelectric point: 4.43  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Nogo

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 10 S7-p _MEDLDQsPLVsssD
0 3 S11-p LDQsPLVsssDsPPR
0 6 S12-p DQsPLVsssDsPPRP
0 3 S13-p QsPLVsssDsPPRPQ
1 28 S15-p PLVsssDsPPRPQPA
0 1 Y25-p RPQPAFKyQFVREPE
0 2 R29 AFKyQFVREPEDEEE
0 1 K58-ub ELEVLERkPAAGLSA
0 1 D84-ca PLMDFGNdFVPPAPR
0 39 V100 PLPAAPPVAPERQPs
1 345 S107-p VAPERQPsWDPsPVs
0 46 S111-p RQPsWDPsPVsstVP
0 2 S114-p sWDPsPVsstVPAPs
0 4 S115-p WDPsPVsstVPAPsP
0 1 T116-p DPsPVsstVPAPsPL
0 9 S121-p sstVPAPsPLSAAAV
0 4 S129-p PLSAAAVsPSKLPED
0 1 S131 SAAAVsPSKLPEDDE
0 11 S152-p PPPPASVsPQAEPVW
0 1 T160-p PQAEPVWtPPAPAPA
1 4 T172 APAAPPSTPAAPKRR
0 29 S181-p AAPKRRGssGsVDEt
0 13 S182-p APKRRGssGsVDEtL
0 19 S184-p KRRGssGsVDEtLFA
0 18 T188-p ssGsVDEtLFALPAA
0 1 S202 ASEPVIRSSAENMDL
0 2 S203 SEPVIRSSAENMDLK
0 1 T282-p EVSEKAKtLLIDRDL
0 2 S307-p MGSSFSVsPKAESAV
0 1 K328 EEIIVKNKDEEEKLV
0 1 N342 VSNNILHNQQELPTA
0 1 L346 ILHNQQELPTALTKL
0 7 S361 VKEDEVVSSEKAKDS
0 4 A365 EVVSSEKAKDSFNEK
0 19 Y384-p EAPMREEyADFKPFE
0 1 K388 REEyADFKPFERVWE
0 1 K388 REEyADFKPFERVWE
0 1 K397 FERVWEVKDSKEDSD
0 1 S418-p KIESNLEsKVDKKCF
0 2 K423 LEsKVDKKCFADSLE
0 1 S428 DKKCFADSLEQTNHE
0 2 S446 ESSNDDTSFPStPEG
0 1 S449 NDDTSFPStPEGIKD
0 2 T450-p DDTSFPStPEGIKDR
0 1 K455 PStPEGIKDRSGAYI
0 1 T506 EKKAQIVTEKNTSTK
0 10 T510 QIVTEKNTSTKTsNP
0 16 S511 IVTEKNTSTKTsNPF
0 1 S515-p KNTSTKTsNPFLVAA
0 2 S525-p FLVAAQDsETDyVTT
0 1 Y529-p AQDsETDyVTTDNLT
0 1 Y646-p LEASSVNyESIKHEP
0 5 Y659-p EPENPPPyEEAMSVS
0 2 K674 LKKVSGIKEEIKEPE
0 3 K678 SGIKEEIKEPENINA
0 1 N682 EEIKEPENINAALQE
1 0 Y694-p LQETEAPyISIACDL
0 1 T705 ACDLIKETKLSAEPA
0 6 K706 CDLIKETKLSAEPAP
0 1 S708 LIKETKLSAEPAPDF
0 1 A709 IKETKLSAEPAPDFS
0 5 A712 TKLSAEPAPDFSDyS
0 9 Y718-p PAPDFSDySEMAKVE
0 1 K723 SDySEMAKVEQPVPD
0 1 S739-p SELVEDSsPDsEPVD
0 1 S742-p VEDSsPDsEPVDLFs
0 1 S749-p sEPVDLFsDDsIPDV
0 1 S752-p VDLFsDDsIPDVPQK
0 1 T763-p VPQKQDEtVMLVKES
0 1 S778-p LTETSFEsMIEyENK
0 1 Y782-p SFEsMIEyENKEKLS
0 1 K785 sMIEyENKEKLSALP
0 3 S789 yENKEKLSALPPEGG
0 4 L791 NKEKLSALPPEGGKP
0 1 K797 ALPPEGGKPYLESFK
0 1 K824 DEVSTLSKKEKIPLQ
0 2 Y840-p EELSTAVySNDDLFI
0 1 T858 AQIRETETFsDssPI
0 4 S860-p IRETETFsDssPIEI
0 4 S862-p ETETFsDssPIEIID
0 9 S863-p TETFsDssPIEIIDE
0 1 S876-p DEFPTLIsSKTDsFS
0 14 S881-p LIsSKTDsFSKLARE
0 6 Y889-p FSKLAREyTDLEVSH
0 1 T890 SKLAREyTDLEVSHK
0 1 D905-ca SEIANAPdGAGSLPC
0 3 S920-p TELPHDLsLKNIQPK
0 3 S943-p DDFSKNGsAtsKVLL
0 2 T945-p FSKNGsAtsKVLLLP
0 2 S946-p SKNGsAtsKVLLLPP
0 1 K947 KNGsAtsKVLLLPPD
0 1 K969 AEIESIVKPKVLVKE
0 4 S983-p EAEKKLPsDTEKEDR
0 2 T985 EKKLPsDTEKEDRsP
0 4 S991-p DTEKEDRsPsAIFSA
0 1 S993-p EKEDRsPsAIFSAEL
0 1 S997 RsPsAIFSAELSKTS
0 1 K1066-ub GVIQAIQkSDEGHPF
0 8 K1090-ub ISEELVQkYSNSALG
0 1 K1104-ac GHVNCTIkELRRLFL
0 6 K1104-ub GHVNCTIkELRRLFL
0 4 K1171-ub HYLGLANkNVkDAMA
0 6 K1174-ub GLANkNVkDAMAkIQ
0 1 K1174-sc GLANkNVkDAMAkIQ
0 1 K1179-ub NVkDAMAkIQAkIPG
0 1 K1183-ub AMAkIQAkIPGLKRK
  Nogo iso2  
S7 _MEDLDQSPLVSSSD
S11 LDQSPLVSSSDSPPR
S12 DQSPLVSSSDSPPRP
S13 QSPLVSSSDSPPRPQ
S15 PLVSSSDSPPRPQPA
Y25 RPQPAFKYQFVREPE
R29 AFKYQFVREPEDEEE
K58 ELEVLERKPAAGLSA
D84 PLMDFGNDFVPPAPR
V100 PLPAAPPVAPERQPs
S107-p VAPERQPsWDPSPVS
S111 RQPsWDPSPVSSTVP
S114 sWDPSPVSSTVPAPS
S115 WDPSPVSSTVPAPSP
T116 DPSPVSSTVPAPSPL
S121 SSTVPAPSPLSAAAV
S129 PLSAAAVSPSKLPED
S131 SAAAVSPSKLPEDDE
S152 PPPPASVSPQAEPVW
T160 PQAEPVWTPPAPAPA
T172 APAAPPSTPAAPKRR
S181-p AAPKRRGssGsVVVD
S182-p APKRRGssGsVVVDL
S184-p KRRGssGsVVVDLLY
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K247 GVIQAIQKSDEGHPF
K271 ISEELVQKYSNSALG
K285 GHVNCTIKELRRLFL
K285 GHVNCTIKELRRLFL
K352 HYLGLANKNVKDAMA
K355 GLANKNVKDAMAKIQ
K355 GLANKNVKDAMAKIQ
K360 NVKDAMAKIQAKIPG
K364 AMAKIQAKIPGLKRK
  Nogo iso3  
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K73 GVIQAIQKSDEGHPF
K97 ISEELVQKYSNSALG
K111 GHVNCTIKELRRLFL
K111 GHVNCTIKELRRLFL
K178 HYLGLANKNVKDAMA
K181 GLANKNVKDAMAKIQ
K181 GLANKNVKDAMAKIQ
K186 NVKDAMAKIQAKIPG
K190 AMAKIQAKIPGLKRK
  mouse

► Hide Isoforms
 
S7 _MEDIDQSSLVSSsA
S11 IDQSSLVSSsADsPP
S12 DQSSLVSSsADsPPR
S13-p QSSLVSSsADsPPRP
S16-p LVSSsADsPPRPPPA
Y26 RPPPAFKYQFVtEPE
T30-p AFKYQFVtEPEDEED
K59 ELEVLERKPAAGLSA
D82 PLLDFSSDSVPPAPR
T98-p PLPAAPPtAPERQPs
S105-p tAPERQPsWERsPAA
S109-p RQPsWERsPAAsAPs
A112 sWERsPAAsAPsLPP
S113-p WERsPAAsAPsLPPA
A114 ERsPAAsAPsLPPAA
S116-p sPAAsAPsLPPAAAV
L124 LPPAAAVLPsKLPED
S126-p PAAAVLPsKLPEDDE
S145-p PPAPAGAsPLAEPAA
- gap
T156-p EPAAPPStPAAPKRR
S165-p AAPKRRGsGsVDEtL
- gap
S167-p PKRRGsGsVDEtLFA
T171-p GsGsVDEtLFALPAA
S185-p ASEPVIPssAEKIMD
S186-p SEPVIPssAEKIMDL
N266 ELPERATNPFVNRES
S291-p MGSSFNGsPKGESAM
K312-ub EEVIVRSkDKEDLVC
N325 VCSAALHNPQEsPAT
S329-p ALHNPQEsPATLTKV
S344-p VKEDGVMsPEKtMDI
T348-p GVMsPEKtMDIFNEM
Y367 VAPVREEYADFkPFE
K371-ub REEYADFkPFEQAWE
K371-ac REEYADFkPFEQAWE
K380-ub FEQAWEVkDTYEGSR
S398 AARANMESKVDKkCF
K403-ub MESKVDKkCFEDsLE
S408-p DKkCFEDsLEQKGHG
S426-p ESRNENAsFPRTPEL
R429 NENAsFPRTPELVkD
T430 ENAsFPRTPELVkDG
K435-ub PRTPELVkDGSRAYI
T485-p ERKAQIItEKtsPKT
T488-p AQIItEKtsPKTSNP
S489-p QIItEKtsPKTSNPF
S493 EKtsPKTSNPFLVAI
S503-p FLVAIHDsEADYVTT
Y507 IHDsEADYVTTDNLS
Y625 EVPSPVSYDGIKLEP
Y638 EPENPPPYEEAMSVA
K652-ub ALKTSDSkEEIkEPE
K656-ub SDSkEEIkEPEsFNA
S660-p EEIkEPEsFNAAAQE
Y672 AQEAEAPYISIACDL
T683-p ACDLIKEtkLstEPs
K684-ub CDLIKEtkLstEPsP
S686-p LIKEtkLstEPsPEF
T687-p IKEtkLstEPsPEFS
S690-p tkLstEPsPEFSNYS
Y696 PsPEFSNYSEIAkFE
K701-ub SNYSEIAkFEKSVPD
S717-p CELVDDSsPEsEPVD
S720-p VDDSsPEsEPVDLFs
S727-p sEPVDLFsDDsIPEV
S730-p VDLFsDDsIPEVPQT
A741 VPQTQEEAVMLMKES
T755 SLTEVSETVTQHKHk
H759 VSETVTQHKHkERLs
K762-ub TVTQHKHkERLsAsP
S766-p HKHkERLsAsPQEVG
S768-p HkERLsAsPQEVGkP
K774-ub AsPQEVGkPYLESFQ
K800-ub NEIPTLTkKETISLQ
Y816 EEFNTAIYSNDDLLS
T834-p DKMKESEtFsDssPI
S836-p MKESEtFsDssPIEI
S838-p ESEtFsDssPIEIID
S839-p SEtFsDssPIEIIDE
S852 DEFPTFVSAKDDsPK
S857-p FVSAKDDsPKEytDL
Y861-p KDDsPKEytDLEVSN
T862-p DDsPKEytDLEVSNK
S877 SEIANVQSGANSLPC
S892-p SELPCDLsFKNTYPK
S913 DEFSKSRSSVSkVPL
V915 FSKSRSSVSkVPLLL
S916 SKSRSSVSkVPLLLP
K917-ub KSRSSVSkVPLLLPN
K939-ub IEMGNIVkPKVLTKE
S953-p EAEEKLPsDtEKEDR
T955-p EEKLPsDtEKEDRsL
S961-p DtEKEDRsLTAVLsA
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S967-p RsLTAVLsAELNKTS
K1036 GVIQAIQKSDEGHPF
K1060-ub ISEELVQkYSNSALG
K1074 GHVNSTIKELRRLFL
K1074-ub GHVNSTIkELRRLFL
K1141-ub HYLGLANkSVKDAMA
K1144 GLANkSVKDAMAKIQ
K1144 GLANkSVKDAMAKIQ
K1149 SVKDAMAKIQAKIPG
K1153 AMAKIQAKIPGLKRK
  Nogo iso4  
S7 _MEDIDQSSLVSSSA
S11 IDQSSLVSSSADSPP
S12 DQSSLVSSSADSPPR
S13 QSSLVSSSADSPPRP
S16 LVSSSADSPPRPPPA
Y26 RPPPAFKYQFVTEPE
T30 AFKYQFVTEPEDEED
K59 ELEVLERKPAAGLSA
D82 PLLDFSSDSVPPAPR
T98 PLPAAPPTAPERQPS
S105 TAPERQPSWERSPAA
S109 RQPSWERSPAASAPS
A112 SWERSPAASAPSLPP
S113 WERSPAASAPSLPPA
A114 ERSPAASAPSLPPAA
S116 SPAASAPSLPPAAAV
L124 LPPAAAVLPSKLPED
S126 PAAAVLPSKLPEDDE
S145 PPAPAGASPLAEPAA
- gap
T156 EPAAPPSTPAAPKRR
S165-p AAPKRRGsGSVDETL
- gap
S167 PKRRGsGSVDETLFA
T171 GsGSVDETLFALPAA
S185 ASEPVIPSSAEKIMD
S186 SEPVIPSSAEKIMDL
N266 ELPERATNPFVNRES
S291 MGSSFNGSPKGESAM
K312 EEVIVRSKDKEDLVC
N325 VCSAALHNPQESPAT
S329 ALHNPQESPATLTKV
S344 VKEDGVMSPEKTMDI
T348 GVMSPEKTMDIFNEM
Y367 VAPVREEYADFKPFE
K371 REEYADFKPFEQAWE
K371 REEYADFKPFEQAWE
K380 FEQAWEVKDTYEGSR
S398 AARANMESKVDKKCF
K403 MESKVDKKCFEDSLE
S408 DKKCFEDSLEQKSHG
S426 ESRNENASFPSTPEL
S429 NENASFPSTPELVKD
T430 ENASFPSTPELVKDG
K435 PSTPELVKDGSRAYI
T485 ERKAQIITEKTSPKT
T488 AQIITEKTSPKTSNP
S489 QIITEKTSPKTSNPF
S493 EKTSPKTSNPFLVAI
S503 FLVAIHDSEADYVTT
Y507 IHDSEADYVTTDNLS
Y625 EVPSPVSYDGIKLEP
Y638 EPENPPPYEEAMSVA
K652 ALKTSDAKEEIKEPE
K656 SDAKEEIKEPESFNA
S660 EEIKEPESFNAAAQE
Y672 AQEAEAPYISIACDL
T683 ACDLIKETKLSTEPS
K684 CDLIKETKLSTEPSP
S686 LIKETKLSTEPSPGF
T687 IKETKLSTEPSPGFS
S690 TKLSTEPSPGFSNYS
Y696 PSPGFSNYSEIAKFE
K701 SNYSEIAKFEKSVPD
S717 CELVDDSSPESEPVD
S720 VDDSSPESEPVDLFS
S727 SEPVDLFSDDSIPEV
S730 VDLFSDDSIPEVPQT
A741 VPQTQEEAVMLMKES
T755 SLTEVSETVTQHKHK
H759 VSETVTQHKHKERLS
K762 TVTQHKHKERLSASP
S766 HKHKERLSASPQEVG
S768 HKERLSASPQEVGKP
K774 ASPQEVGKPYLESFQ
K800 NEIPTLTKKETISLQ
Y816 EEFNTAIYSNDDLLS
T834 DKMKESETFSDSSPI
S836 MKESETFSDSSPIEI
S838 ESETFSDSSPIEIID
S839 SETFSDSSPIEIIDE
S852 DEFPTFVSAKDDSPK
S857 FVSAKDDSPKEYTDL
Y861 KDDSPKEYTDLEVSN
T862 DDSPKEYTDLEVSNK
S877 SEIANVQSGANSLPC
S892 SELPCDLSFKNTYPK
S913 DEFSKSRSSVSKVPL
V915 FSKSRSSVSKVPLLL
S916 SKSRSSVSKVPLLLP
K917 KSRSSVSKVPLLLPN
K939 IEMGNIVKPKVLTKE
S953 EAEEKLPSDTEKEDR
T955 EEKLPSDTEKEDRSL
S961 DTEKEDRSLTAVLSA
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S967 RSLTAVLSAELNKTS
K1037 GVIQAIQKSDEGHPF
K1061 ISEELVQKYSNSALG
K1075 GHVNSTIKELRRLFL
K1075 GHVNSTIKELRRLFL
K1142 HYLGLANKSVKDAMA
K1145 GLANKSVKDAMAKIQ
K1145 GLANKSVKDAMAKIQ
K1150 SVKDAMAKIQAKIPG
K1154 AMAKIQAKIPGLKRK
  Nogo iso5  
S7 _MEDIDQSSLVSSSA
S11 IDQSSLVSSSADSPP
S12 DQSSLVSSSADSPPR
S13 QSSLVSSSADSPPRP
S16 LVSSSADSPPRPPPA
Y26 RPPPAFKYQFVTEPE
T30 AFKYQFVTEPEDEED
K59 ELEVLERKPAAGLSA
D82 PLLDFSSDSVPPAPR
T98 PLPAAPPTAPERQPS
S105 TAPERQPSWERSPAA
S109 RQPSWERSPAASAPS
A112 SWERSPAASAPSLPP
S113 WERSPAASAPSLPPA
A114 ERSPAASAPSLPPAA
S116 SPAASAPSLPPAAAV
L124 LPPAAAVLPSKLPED
S126 PAAAVLPSKLPEDDE
S145 PPAPAGASPLAEPAA
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T156 EPAAPPSTPAAPKRR
S165-p AAPKRRGsGsVVVDL
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S167-p PKRRGsGsVVVDLLY
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K230 GVIQAIQKSDEGHPF
K254 ISEELVQKYSNSALG
K268 GHVNSTIKELRRLFL
K268 GHVNSTIKELRRLFL
K335 HYLGLANKSVKDAMA
K338 GLANKSVKDAMAKIQ
K338 GLANKSVKDAMAKIQ
K343 SVKDAMAKIQAKIPG
K347 AMAKIQAKIPGLKRK
  Nogo iso6  
S7 _MEDIDQSSLVSSSA
S11 IDQSSLVSSSADSPP
S12 DQSSLVSSSADSPPR
S13 QSSLVSSSADSPPRP
S16 LVSSSADSPPRPPPA
Y26 RPPPAFKYQFVTEPE
T30 AFKYQFVTEPEDEED
K59 ELEVLERKPAAGLSA
D82 PLLDFSSDSVPPAPR
T98 PLPAAPPTAPERQPS
S105 TAPERQPSWERSPAA
S109 RQPSWERSPAASAPS
A112 SWERSPAASAPSLPP
S113 WERSPAASAPSLPPA
A114 ERSPAASAPSLPPAA
S116 SPAASAPSLPPAAAV
L124 LPPAAAVLPSKLPED
S126 PAAAVLPSKLPEDDE
S145 PPAPAGASPLAEPAA
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T156 EPAAPPSTPAAPKRR
S165-p AAPKRRGsGsVDETL
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S167-p PKRRGsGsVDETLFA
T171 GsGsVDETLFALPAA
S185 ASEPVIPSSAVVDLL
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- gap
- gap
- gap
- gap
K249 GVIQAIQKSDEGHPF
K273 ISEELVQKYSNSALG
K287 GHVNSTIKELRRLFL
K287 GHVNSTIKELRRLFL
K354 HYLGLANKSVKDAMA
K357 GLANKSVKDAMAKIQ
K357 GLANKSVKDAMAKIQ
K362 SVKDAMAKIQAKIPG
K366 AMAKIQAKIPGLKRK
  rat

► Hide Isoforms
 
S7 _MEDIDQSSLVSSST
S11 IDQSSLVSSSTDsPP
S12 DQSSLVSSSTDsPPR
S13 QSSLVSSSTDsPPRP
S16-p LVSSSTDsPPRPPPA
Y26 RPPPAFKYQFVTEPE
T30 AFKYQFVTEPEDEED
K60 ELEVLERKPAAGLSA
D84 PLLDFSSDSVPPAPR
A100 PLPAAPPAAPERQPs
S107-p AAPERQPsWERSPAA
S111 RQPsWERSPAAPAPS
A114 sWERSPAAPAPSLPP
P115 WERSPAAPAPSLPPA
A116 ERSPAAPAPSLPPAA
S118 SPAAPAPSLPPAAAV
L126 LPPAAAVLPSKLPED
S128 PAAAVLPSKLPEDDE
S149-p PPPPAGAsPLAEPAA
- gap
T160 EPAAPPSTPAAPKRR
S169-p AAPKRRGsGSVDEtL
- gap
S171 PKRRGsGSVDEtLFA
T175-p GsGSVDEtLFALPAA
S189 ASEPVIPSSAEKIMD
S190 SEPVIPSSAEKIMDL
N270 ELPERATNPFVNRDL
S295 MGSSFKGSPKGESAI
K316 EEVIVRSKDKEDLVC
S329-p VCSAALHsPQEsPVG
S333-p ALHsPQEsPVGKEDR
S343-p GKEDRVVsPEKTMDI
T347 RVVsPEKTMDIFNEM
Y366 VAPVREEYADFKPFE
K370 REEYADFKPFEQAWE
K370 REEYADFKPFEQAWE
K379 FEQAWEVKDTYEGSR
S397 AARANVESKVDRKCL
K402 VESKVDRKCLEDSLE
S407 DRKCLEDSLEQKSLG
S425-p EGRNEDAsFPstPEP
S428-p NEDAsFPstPEPVKD
T429-p EDAsFPstPEPVKDS
K434 PstPEPVKDSSRAYI
T484 ERKAQIITEKTsPKT
T487 AQIITEKTsPKTSNP
S488-p QIITEKTsPKTSNPF
S492 EKTsPKTSNPFLVAV
S502 FLVAVQDSEADYVTT
Y506 VQDSEADYVTTDTLS
Y624 EAPPPVSYDSIKLEP
Y637 EPENPPPYEEAMNVA
K651 ALKALGTKEGIKEPE
K655 LGTKEGIKEPESFNA
S659 EGIKEPESFNAAVQE
Y671 VQETEAPYISIACDL
T682 ACDLIKETKLSTEPs
K683 CDLIKETKLSTEPsP
S685 LIKETKLSTEPsPDF
T686 IKETKLSTEPsPDFS
S689-p TKLSTEPsPDFSNYS
Y695 PsPDFSNYSEIAKFE
K700 SNYSEIAKFEKSVPE
S716-p AELVEDSsPEsEPVD
S719-p VEDSsPEsEPVDLFs
S726-p sEPVDLFsDDsIPEV
S729-p VDLFsDDsIPEVPQT
A740 VPQTQEEAVMLMKES
T754 SLTEVSETVAQHKEE
H758 VSETVAQHKEERLsA
- gap
S764-p QHKEERLsAsPQELG
S766-p KEERLsAsPQELGKP
K772 AsPQELGKPYLESFQ
K798 NDIPTLTKKEKISLQ
Y814 EEFNTAIYSNDDLLS
T832-p DKIKESEtFsDSsPI
S834-p IKESEtFsDSsPIEI
S836 ESEtFsDSsPIEIID
S837-p SEtFsDSsPIEIIDE
S850 DEFPTFVSAKDDSPK
S855 FVSAKDDSPKLAKEY
Y862 SPKLAKEYTDLEVSD
T863 PKLAKEYTDLEVSDK
S878 SEIANIQSGADSLPC
S893 LELPCDLSFKNIYPK
S914 DEFSENRSSVSKASI
V916 FSENRSSVSKASISP
S917 SENRSSVSKASISPS
K918 ENRSSVSKASISPSN
K940 TEMGSIVKSKSLTKE
S954-p EAEKKLPsDTEKEDR
T956 EKKLPsDTEKEDRSL
S962 DTEKEDRSLSAVLSA
S964 EKEDRSLSAVLSAEL
S968 RSLSAVLSAELSKTS
K1037 GVIQAIQKSDEGHPF
K1061 ISEELVQKYSNSALG
K1075-ac GHVNSTIkELRRLFL
K1075 GHVNSTIKELRRLFL
K1142 HYLGLANKSVKDAMA
K1145 GLANKSVKDAMAKIQ
K1145 GLANKSVKDAMAKIQ
K1150 SVKDAMAKIQAKIPG
K1154 AMAKIQAKIPGLKRK
  Nogo iso2  
S7 _MEDIDQSSLVSSST
S11 IDQSSLVSSSTDsPP
S12 DQSSLVSSSTDsPPR
S13 QSSLVSSSTDsPPRP
S16-p LVSSSTDsPPRPPPA
Y26 RPPPAFKYQFVTEPE
T30 AFKYQFVTEPEDEED
K60 ELEVLERKPAAGLSA
D84 PLLDFSSDSVPPAPR
A100 PLPAAPPAAPERQPS
S107 AAPERQPSWERSPAA
S111 RQPSWERSPAAPAPS
A114 SWERSPAAPAPSLPP
P115 WERSPAAPAPSLPPA
A116 ERSPAAPAPSLPPAA
S118 SPAAPAPSLPPAAAV
L126 LPPAAAVLPSKLPED
S128 PAAAVLPSKLPEDDE
S149 PPPPAGASPLAEPAA
- gap
T160 EPAAPPSTPAAPKRR
S169 AAPKRRGSGSVVVDL
- gap
S171 PKRRGSGSVVVDLLY
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- under review  
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- under review  
- gap
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K234 GVIQAIQKSDEGHPF
K258 ISEELVQKYSNSALG
K272 GHVNSTIKELRRLFL
K272 GHVNSTIKELRRLFL
K339 HYLGLANKSVKDAMA
K342 GLANKSVKDAMAKIQ
K342 GLANKSVKDAMAKIQ
K347 SVKDAMAKIQAKIPG
K351 AMAKIQAKIPGLKRK
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