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Protein Page:
Nogo (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Nogo Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex. Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; Inhibitor protein; Membrane protein, integral; Endoplasmic reticulum; Membrane protein, multi-pass; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2p16.3
Cellular Component: cell projection; cell soma; endoplasmic reticulum; plasma membrane; integral to endoplasmic reticulum membrane; nuclear envelope; intracellular
Molecular Function: protein binding
Biological Process: regulation of apoptosis; nerve growth factor receptor signaling pathway; apoptosis; cerebral cortex radial glia guided migration; axonal fasciculation; negative regulation of axonogenesis; negative regulation of cell growth; negative regulation of axon extension; angiogenesis; regulation of axonogenesis; regulation of cell migration
Reference #:  Q9NQC3 (UniProtKB)
Alt. Names/Synonyms: ASY; Foocen; Human NogoA; KIAA0886; My043 protein; Nbla00271; Nbla10545; neurite growth inhibitor 220; Neurite outgrowth inhibitor; Neuroendocrine-specific protein; Neuroendocrine-specific protein C homolog; NI220/250; NOGO; Nogo protein; NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; reticulon 4; reticulon 5; Reticulon-4; Reticulon-5; RTN-x; RTN4; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C
Gene Symbols: RTN4
Molecular weight: 129,931 Da
Basal Isoelectric point: 4.43  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Nogo

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 11 S7-p _MEDLDQsPLVsssD
0 3 S11-p LDQsPLVsssDsPPR
0 6 S12-p DQsPLVsssDsPPRP
0 3 S13-p QsPLVsssDsPPRPQ
1 32 S15-p PLVsssDsPPRPQPA
0 1 Y25-p RPQPAFKyQFVREPE
0 2 R29 AFKyQFVREPEDEEE
0 1 K58-ub ELEVLERkPAAGLSA
0 1 D84-ca PLMDFGNdFVPPAPR
0 39 V100 PLPAAPPVAPERQPs
1 349 S107-p VAPERQPsWDPsPVs
0 46 S111-p RQPsWDPsPVsstVP
0 2 S114-p sWDPsPVsstVPAPs
0 4 S115-p WDPsPVsstVPAPsP
0 1 T116-p DPsPVsstVPAPsPL
0 9 S121-p sstVPAPsPLSAAAV
0 4 S129-p PLSAAAVsPSKLPED
0 1 S131 SAAAVsPSKLPEDDE
0 11 S152-p PPPPASVsPQAEPVW
0 1 T160-p PQAEPVWtPPAPAPA
1 4 T172 APAAPPSTPAAPKRR
0 33 S181-p AAPKRRGssGsVDEt
0 15 S182-p APKRRGssGsVDEtL
0 22 S184-p KRRGssGsVDEtLFA
0 20 T188-p ssGsVDEtLFALPAA
0 1 S202 ASEPVIRSSAENMDL
0 2 S203 SEPVIRSSAENMDLK
0 1 T282-p EVSEKAKtLLIDRDL
0 2 S307-p MGSSFSVsPKAESAV
0 1 K328 EEIIVKNKDEEEKLV
0 2 N342 VSNNILHNQQELPTA
0 3 L346 ILHNQQELPTALTKL
0 7 S361 VKEDEVVSSEKAKDS
0 4 A365 EVVSSEKAKDSFNEK
0 19 Y384-p EAPMREEyADFKPFE
0 1 K388 REEyADFKPFERVWE
0 1 K388 REEyADFKPFERVWE
0 1 K397 FERVWEVKDSKEDSD
0 1 S418-p KIESNLEsKVDKKCF
0 2 K423 LEsKVDKKCFADSLE
0 2 S428 DKKCFADSLEQTNHE
0 3 S446 ESSNDDTSFPStPEG
0 1 S449 NDDTSFPStPEGIKD
0 3 T450-p DDTSFPStPEGIKDR
0 1 K455 PStPEGIKDRSGAYI
0 1 T506 EKKAQIVTEKNTSTK
0 10 T510 QIVTEKNTSTKTsNP
0 18 S511 IVTEKNTSTKTsNPF
0 1 S515-p KNTSTKTsNPFLVAA
0 2 S525-p FLVAAQDsETDyVTT
0 1 Y529-p AQDsETDyVTTDNLT
0 1 Y646-p LEASSVNyESIKHEP
0 5 Y659-p EPENPPPyEEAMSVS
0 2 K674 LKKVSGIKEEIKEPE
0 3 K678 SGIKEEIKEPENINA
0 1 N682 EEIKEPENINAALQE
1 0 Y694-p LQETEAPyISIACDL
0 1 T705 ACDLIKETKLSAEPA
0 6 K706 CDLIKETKLSAEPAP
0 1 S708 LIKETKLSAEPAPDF
0 1 A709 IKETKLSAEPAPDFS
0 7 A712 TKLSAEPAPDFSDyS
0 9 Y718-p PAPDFSDySEMAKVE
0 1 K723 SDySEMAKVEQPVPD
0 1 S738-p HSELVEDssPDsEPV
0 2 S739-p SELVEDssPDsEPVD
0 2 S742-p VEDssPDsEPVDLFs
0 2 S749-p sEPVDLFsDDsIPDV
0 2 S752-p VDLFsDDsIPDVPQK
0 1 T763-p VPQKQDEtVMLVKES
0 1 S778-p LTETSFEsMIEyENK
0 1 Y782-p SFEsMIEyENKEKLS
0 1 K785 sMIEyENKEKLSALP
0 4 S789 yENKEKLSALPPEGG
0 6 L791 NKEKLSALPPEGGKP
0 1 K797 ALPPEGGKPYLESFK
0 1 K824 DEVSTLSKKEKIPLQ
0 2 Y840-p EELSTAVySNDDLFI
0 1 T856 KEAQIRETETFsDss
0 2 T858 AQIRETETFsDssPI
0 5 S860-p IRETETFsDssPIEI
0 4 S862-p ETETFsDssPIEIID
0 10 S863-p TETFsDssPIEIIDE
0 1 S876-p DEFPTLIsSKTDsFS
0 15 S881-p LIsSKTDsFSKLARE
0 6 Y889-p FSKLAREyTDLEVSH
0 1 T890 SKLAREyTDLEVSHK
0 1 D905-ca SEIANAPdGAGSLPC
0 3 S920-p TELPHDLsLKNIQPK
0 1 S935 VEEKISFSDDFSKNG
0 3 S943-p DDFSKNGsAtsKVLL
0 2 T945-p FSKNGsAtsKVLLLP
0 2 S946-p SKNGsAtsKVLLLPP
0 1 K947 KNGsAtsKVLLLPPD
0 1 L951 AtsKVLLLPPDVSAL
0 1 K969 AEIESIVKPKVLVKE
0 6 S983-p EAEKKLPsDTEKEDR
0 2 T985 EKKLPsDTEKEDRsP
0 4 S991-p DTEKEDRsPsAIFSA
0 1 S993-p EKEDRsPsAIFSAEL
0 1 S997 RsPsAIFSAELSKTS
0 1 K1066-ub GVIQAIQkSDEGHPF
0 8 K1090-ub ISEELVQkYSNSALG
0 2 K1104-ac GHVNCTIkELRRLFL
0 6 K1104-ub GHVNCTIkELRRLFL
0 4 K1171-ub HYLGLANkNVkDAMA
0 1 K1174 GLANkNVKDAMAkIQ
0 6 K1174-ub GLANkNVkDAMAkIQ
0 1 K1174-sc GLANkNVkDAMAkIQ
0 1 K1179 NVkDAMAKIQAkIPG
0 1 K1179-ub NVkDAMAkIQAkIPG
0 1 K1183-ub AMAkIQAkIPGLKRK
0 1 K1188 QAkIPGLKRKAE___
  Nogo iso2  
S7 _MEDLDQSPLVSSSD
S11 LDQSPLVSSSDSPPR
S12 DQSPLVSSSDSPPRP
S13 QSPLVSSSDSPPRPQ
S15 PLVSSSDSPPRPQPA
Y25 RPQPAFKYQFVREPE
R29 AFKYQFVREPEDEEE
K58 ELEVLERKPAAGLSA
D84 PLMDFGNDFVPPAPR
V100 PLPAAPPVAPERQPs
S107-p VAPERQPsWDPSPVS
S111 RQPsWDPSPVSSTVP
S114 sWDPSPVSSTVPAPS
S115 WDPSPVSSTVPAPSP
T116 DPSPVSSTVPAPSPL
S121 SSTVPAPSPLSAAAV
S129 PLSAAAVSPSKLPED
S131 SAAAVSPSKLPEDDE
S152 PPPPASVSPQAEPVW
T160 PQAEPVWTPPAPAPA
T172 APAAPPSTPAAPKRR
S181-p AAPKRRGssGsVVVD
S182-p APKRRGssGsVVVDL
S184-p KRRGssGsVVVDLLY
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- under review  
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K247 GVIQAIQKSDEGHPF
K271 ISEELVQKYSNSALG
K285 GHVNCTIKELRRLFL
K285 GHVNCTIKELRRLFL
K352 HYLGLANKNVKDAMA
K355 GLANKNVKDAMAKIQ
K355 GLANKNVKDAMAKIQ
K355 GLANKNVKDAMAKIQ
K360 NVKDAMAKIQAKIPG
K360 NVKDAMAKIQAKIPG
K364 AMAKIQAKIPGLKRK
K369 QAKIPGLKRKAE___
  Nogo iso3  
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- under review  
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K73 GVIQAIQKSDEGHPF
K97 ISEELVQKYSNSALG
K111 GHVNCTIKELRRLFL
K111 GHVNCTIKELRRLFL
K178 HYLGLANKNVKDAMA
K181 GLANKNVKDAMAKIQ
K181 GLANKNVKDAMAKIQ
K181 GLANKNVKDAMAKIQ
K186 NVKDAMAKIQAKIPG
K186 NVKDAMAKIQAKIPG
K190 AMAKIQAKIPGLKRK
K195 QAKIPGLKRKAE___
  Nogo iso4  
S7 _MEDLDQSPLVSSSD
S11 LDQSPLVSSSDSPPR
S12 DQSPLVSSSDSPPRP
S13 QSPLVSSSDSPPRPQ
- gap
Y25 RPQPAFKYQFVREPE
R29 AFKYQFVREPEDEEE
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
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- gap
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- gap
- gap
S75 MGSSFSVSPKAESAV
K96 EEIIVKNKDEEEKLV
N110 VSNNILHNQQELPTA
L114 ILHNQQELPTALTKL
S129 VKEDEVVSSEKAKDS
A133 EVVSSEKAKDSFNEK
Y152 EAPMREEYADFKPFE
K156 REEYADFKPFERVWE
K156 REEYADFKPFERVWE
K165 FERVWEVKDSKEDSD
S186 KIESNLESKVDKKCF
K191 LESKVDKKCFADSLE
S196 DKKCFADSLEQTNHE
S214 ESSNDDTSFPSTPEG
S217 NDDTSFPSTPEGIKD
T218 DDTSFPSTPEGIKDR
K223 PSTPEGIKDRSGAYI
T274 EKKAQIVTEKNTSTK
T278 QIVTEKNTSTKTSNP
S279 IVTEKNTSTKTSNPF
S283 KNTSTKTSNPFLVAA
S293 FLVAAQDSETDYVTT
Y297 AQDSETDYVTTDNLT
Y414 LEASSVNYESIKHEP
Y427 EPENPPPYEEAMSVS
K442 LKKVSGIKEEIKEPE
K446 SGIKEEIKEPENINA
N450 EEIKEPENINAALQE
Y462 LQETEAPYISIACDL
T473 ACDLIKETKLSAEPA
K474 CDLIKETKLSAEPAP
S476 LIKETKLSAEPAPDF
A477 IKETKLSAEPAPDFS
A480 TKLSAEPAPDFSDYS
Y486 PAPDFSDYSEMAKVE
K491 SDYSEMAKVEQPVPD
S506 HSELVEDSSPDSEPV
S507 SELVEDSSPDSEPVD
S510 VEDSSPDSEPVDLFS
S517 SEPVDLFSDDSIPDV
S520 VDLFSDDSIPDVPQK
T531 VPQKQDETVMLVKES
S546 LTETSFESMIEYENK
Y550 SFESMIEYENKEKLS
K553 SMIEYENKEKLSALP
S557 YENKEKLSALPPEGG
L559 NKEKLSALPPEGGKP
K565 ALPPEGGKPYLESFK
K592 DEVSTLSKKEKIPLQ
Y608 EELSTAVYSNDDLFI
T624 KEAQIRETETFSDSS
T626 AQIRETETFSDSSPI
S628 IRETETFSDSSPIEI
S630 ETETFSDSSPIEIID
S631 TETFSDSSPIEIIDE
S644 DEFPTLISSKTDSFS
S649 LISSKTDSFSKLARE
Y657 FSKLAREYTDLEVSH
T658 SKLAREYTDLEVSHK
D673 SEIANAPDGAGSLPC
S688 TELPHDLSLKNIQPK
- under review  
S711 DDFSKNGSATSKVLL
T713 FSKNGSATSKVLLLP
S714 SKNGSATSKVLLLPP
K715 KNGSATSKVLLLPPD
L719 ATSKVLLLPPDVSAL
K737 AEIESIVKPKVLVKE
S751 EAEKKLPSDTEKEDR
T753 EKKLPSDTEKEDRSP
S759 DTEKEDRSPSAIFSA
S761 EKEDRSPSAIFSAEL
S765 RSPSAIFSAELSKTS
K834 GVIQAIQKSDEGHPF
K858 ISEELVQKYSNSALG
K872 GHVNCTIKELRRLFL
K872 GHVNCTIKELRRLFL
K939 HYLGLANKNVKDAMA
K942 GLANKNVKDAMAKIQ
K942 GLANKNVKDAMAKIQ
K942 GLANKNVKDAMAKIQ
K947 NVKDAMAKIQAKIPG
K947 NVKDAMAKIQAKIPG
K951 AMAKIQAKIPGLKRK
K956 QAKIPGLKRKAE___
  Nogo iso5  
S7 _MEDLDQSPLVSSSD
S11 LDQSPLVSSSDSPPR
S12 DQSPLVSSSDSPPRP
S13 QSPLVSSSDSPPRPQ
S15 PLVSSSDSPPRPQPA
Y25 RPQPAFKYQFVREPE
R29 AFKYQFVREPEDEEE
K58 ELEVLERKPAAGLSA
D84 PLMDFGNDFVPPAPR
- gap
S107 VAPERQPSWDPSPVS
S111 RQPSWDPSPVSSTVP
S114 SWDPSPVSSTVPAPS
S115 WDPSPVSSTVPAPSP
T116 DPSPVSSTVPAPSPL
S121 SSTVPAPSPLSAAAV
S129 PLSAAAVSPSKLPED
S131 SAAAVSPSKLPEDDE
S152 PPPPASVSPQAEPVW
T160 PQAEPVWTPPAPAPA
T172 APAAPPSTPAAPKRR
S181 AAPKRRGSSGSVDET
S182 APKRRGSSGSVDETL
S184 KRRGSSGSVDETLFA
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- under review  
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K266 GVIQAIQKSDEGHPF
K290 ISEELVQKYSNSALG
K304 GHVNCTIKELRRLFL
K304 GHVNCTIKELRRLFL
K371 HYLGLANKNVKDAMA
K374 GLANKNVKDAMAKIQ
K374 GLANKNVKDAMAKIQ
K374 GLANKNVKDAMAKIQ
K379 NVKDAMAKIQAKIPG
K379 NVKDAMAKIQAKIPG
K383 AMAKIQAKIPGLKRK
K388 QAKIPGLKRKAE___
  Nogo iso6  
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T76 EVSEKAKTLLIDRDL
S101 MGSSFSVSPKAESAV
K122 EEIIVKNKDEEEKLV
N136 VSNNILHNQQELPTA
L140 ILHNQQELPTALTKL
S155 VKEDEVVSSEKAKDS
A159 EVVSSEKAKDSFNEK
Y178 EAPMREEYADFKPFE
K182 REEYADFKPFERVWE
K182 REEYADFKPFERVWE
K191 FERVWEVKDSKEDSD
S212 KIESNLESKVDKKCF
K217 LESKVDKKCFADSLE
S222 DKKCFADSLEQTNHE
S240 ESSNDDTSFPSTPEG
S243 NDDTSFPSTPEGIKD
T244 DDTSFPSTPEGIKDR
K249 PSTPEGIKDRSGAYI
T300 EKKAQIVTEKNTSTK
T304 QIVTEKNTSTKTSNP
S305 IVTEKNTSTKTSNPF
S309 KNTSTKTSNPFLVAA
S319 FLVAAQDSETDYVTT
Y323 AQDSETDYVTTDNLT
Y440 LEASSVNYESIKHEP
Y453 EPENPPPYEEAMSVS
K468 LKKVSGIKEEIKEPE
K472 SGIKEEIKEPENINA
N476 EEIKEPENINAALQE
Y488 LQETEAPYISIACDL
T499 ACDLIKETKLSAEPA
K500 CDLIKETKLSAEPAP
S502 LIKETKLSAEPAPDF
A503 IKETKLSAEPAPDFS
A506 TKLSAEPAPDFSDYS
Y512 PAPDFSDYSEMAKVE
K517 SDYSEMAKVEQPVPD
S532 HSELVEDSSPDSEPV
S533 SELVEDSSPDSEPVD
S536 VEDSSPDSEPVDLFS
S543 SEPVDLFSDDSIPDV
S546 VDLFSDDSIPDVPQK
T557 VPQKQDETVMLVKES
S572 LTETSFESMIEYENK
Y576 SFESMIEYENKEKLS
K579 SMIEYENKEKLSALP
S583 YENKEKLSALPPEGG
L585 NKEKLSALPPEGGKP
K591 ALPPEGGKPYLESFK
K618 DEVSTLSKKEKIPLQ
Y634 EELSTAVYSNDDLFI
T650 KEAQIRETETFSDSS
T652 AQIRETETFSDSSPI
S654 IRETETFSDSSPIEI
S656 ETETFSDSSPIEIID
S657 TETFSDSSPIEIIDE
S670 DEFPTLISSKTDSFS
S675 LISSKTDSFSKLARE
Y683 FSKLAREYTDLEVSH
T684 SKLAREYTDLEVSHK
D699 SEIANAPDGAGSLPC
S714 TELPHDLSLKNIQPK
- under review  
S737 DDFSKNGSATSKVLL
T739 FSKNGSATSKVLLLP
S740 SKNGSATSKVLLLPP
K741 KNGSATSKVLLLPPD
L745 ATSKVLLLPPDVSAL
K763 AEIESIVKPKVLVKE
S777 EAEKKLPSDTEKEDR
T779 EKKLPSDTEKEDRSP
S785 DTEKEDRSPSAIFSA
S787 EKEDRSPSAIFSAEL
S791 RSPSAIFSAELSKTS
K860 GVIQAIQKSDEGHPF
K884 ISEELVQKYSNSALG
K898 GHVNCTIKELRRLFL
K898 GHVNCTIKELRRLFL
K965 HYLGLANKNVKDAMA
K968 GLANKNVKDAMAKIQ
K968 GLANKNVKDAMAKIQ
K968 GLANKNVKDAMAKIQ
K973 NVKDAMAKIQAKIPG
K973 NVKDAMAKIQAKIPG
K977 AMAKIQAKIPGLKRK
K982 QAKIPGLKRKAE___
  mouse

► Hide Isoforms
 
S7 _MEDIDQSSLVSSsA
S11 IDQSSLVSSsADsPP
S12 DQSSLVSSsADsPPR
S13-p QSSLVSSsADsPPRP
S16-p LVSSsADsPPRPPPA
Y26 RPPPAFKYQFVtEPE
T30-p AFKYQFVtEPEDEED
K59 ELEVLERKPAAGLSA
D82 PLLDFSSDSVPPAPR
T98-p PLPAAPPtAPERQPs
S105-p tAPERQPsWERsPAA
S109-p RQPsWERsPAAsAPs
A112 sWERsPAAsAPsLPP
S113-p WERsPAAsAPsLPPA
A114 ERsPAAsAPsLPPAA
S116-p sPAAsAPsLPPAAAV
L124 LPPAAAVLPsKLPED
S126-p PAAAVLPsKLPEDDE
S145-p PPAPAGAsPLAEPAA
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T156-p EPAAPPStPAAPKRR
S165-p AAPKRRGsGsVDEtL
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S167-p PKRRGsGsVDEtLFA
T171-p GsGsVDEtLFALPAA
S185-p ASEPVIPssAEKIMD
S186-p SEPVIPssAEKIMDL
N266 ELPERATNPFVNRES
S291-p MGSSFNGsPKGESAM
K312-ub EEVIVRSkDKEDLVC
N325 VCSAALHNPQEsPAT
S329-p ALHNPQEsPATLTKV
S344-p VKEDGVMsPEKtMDI
T348-p GVMsPEKtMDIFNEM
Y367 VAPVREEYADFkPFE
K371-ub REEYADFkPFEQAWE
K371-ac REEYADFkPFEQAWE
K380-ub FEQAWEVkDTYEGSR
S398 AARANMESKVDKkCF
K403-ub MESKVDKkCFEDsLE
S408-p DKkCFEDsLEQKGHG
S426-p ESRNENAsFPRTPEL
R429 NENAsFPRTPELVkD
T430 ENAsFPRTPELVkDG
K435-ub PRTPELVkDGSRAYI
T485-p ERKAQIItEKtsPKT
T488-p AQIItEKtsPKTSNP
S489-p QIItEKtsPKTSNPF
S493 EKtsPKTSNPFLVAI
S503-p FLVAIHDsEADYVTT
Y507 IHDsEADYVTTDNLS
Y625 EVPSPVSYDGIKLEP
Y638 EPENPPPYEEAMSVA
K652-ub ALKTSDSkEEIkEPE
K656-ub SDSkEEIkEPEsFNA
S660-p EEIkEPEsFNAAAQE
Y672 AQEAEAPYISIACDL
T683-p ACDLIKEtkLstEPs
K684-ub CDLIKEtkLstEPsP
S686-p LIKEtkLstEPsPEF
T687-p IKEtkLstEPsPEFS
S690-p tkLstEPsPEFSNYS
Y696 PsPEFSNYSEIAkFE
K701-ub SNYSEIAkFEKSVPD
S716-p HCELVDDssPEsEPV
S717-p CELVDDssPEsEPVD
S720-p VDDssPEsEPVDLFs
S727-p sEPVDLFsDDsIPEV
S730-p VDLFsDDsIPEVPQT
A741 VPQTQEEAVMLMKES
T755 SLTEVSETVTQHKHk
H759 VSETVTQHKHkERLs
K762-ub TVTQHKHkERLsAsP
S766-p HKHkERLsAsPQEVG
S768-p HkERLsAsPQEVGkP
K774-ub AsPQEVGkPYLESFQ
K800-ub NEIPTLTkKETISLQ
Y816 EEFNTAIYSNDDLLS
S832 KEDKMKESEtFsDss
T834-p DKMKESEtFsDssPI
S836-p MKESEtFsDssPIEI
S838-p ESEtFsDssPIEIID
S839-p SEtFsDssPIEIIDE
S852 DEFPTFVSAKDDsPK
S857-p FVSAKDDsPKEytDL
Y861-p KDDsPKEytDLEVSN
T862-p DDsPKEytDLEVSNK
S877 SEIANVQSGANSLPC
S892-p SELPCDLsFKNTYPK
S905-p PKDEAHVsDEFSKSR
S913 DEFSKSRSSVSkVPL
V915 FSKSRSSVSkVPLLL
S916 SKSRSSVSkVPLLLP
K917-ub KSRSSVSkVPLLLPN
L921 SVSkVPLLLPNVSAL
K939-ub IEMGNIVkPKVLTKE
S953-p EAEEKLPsDtEKEDR
T955-p EEKLPsDtEKEDRsL
S961-p DtEKEDRsLTAVLsA
- gap
S967-p RsLTAVLsAELNKTS
K1036 GVIQAIQKSDEGHPF
K1060-ub ISEELVQkYSNSALG
K1074 GHVNSTIKELRRLFL
K1074-ub GHVNSTIkELRRLFL
K1141-ub HYLGLANkSVKDAMA
K1144 GLANkSVKDAMAKIQ
K1144 GLANkSVKDAMAKIQ
K1144 GLANkSVKDAMAKIQ
K1149 SVKDAMAKIQAKIPG
K1149 SVKDAMAKIQAKIPG
K1153 AMAKIQAKIPGLKRK
K1158 QAKIPGLKRKAE___
  Nogo iso4  
S7 _MEDIDQSSLVSSSA
S11 IDQSSLVSSSADSPP
S12 DQSSLVSSSADSPPR
S13 QSSLVSSSADSPPRP
S16 LVSSSADSPPRPPPA
Y26 RPPPAFKYQFVTEPE
T30 AFKYQFVTEPEDEED
K59 ELEVLERKPAAGLSA
D82 PLLDFSSDSVPPAPR
T98 PLPAAPPTAPERQPS
S105 TAPERQPSWERSPAA
S109 RQPSWERSPAASAPS
A112 SWERSPAASAPSLPP
S113 WERSPAASAPSLPPA
A114 ERSPAASAPSLPPAA
S116 SPAASAPSLPPAAAV
L124 LPPAAAVLPSKLPED
S126 PAAAVLPSKLPEDDE
S145 PPAPAGASPLAEPAA
- gap
T156 EPAAPPSTPAAPKRR
S165-p AAPKRRGsGSVDETL
- gap
S167 PKRRGsGSVDETLFA
T171 GsGSVDETLFALPAA
S185 ASEPVIPSSAEKIMD
S186 SEPVIPSSAEKIMDL
N266 ELPERATNPFVNRES
S291 MGSSFNGSPKGESAM
K312 EEVIVRSKDKEDLVC
N325 VCSAALHNPQESPAT
S329 ALHNPQESPATLTKV
S344 VKEDGVMSPEKTMDI
T348 GVMSPEKTMDIFNEM
Y367 VAPVREEYADFKPFE
K371 REEYADFKPFEQAWE
K371 REEYADFKPFEQAWE
K380 FEQAWEVKDTYEGSR
S398 AARANMESKVDKKCF
K403 MESKVDKKCFEDSLE
S408 DKKCFEDSLEQKSHG
S426 ESRNENASFPSTPEL
S429 NENASFPSTPELVKD
T430 ENASFPSTPELVKDG
K435 PSTPELVKDGSRAYI
T485 ERKAQIITEKTSPKT
T488 AQIITEKTSPKTSNP
S489 QIITEKTSPKTSNPF
S493 EKTSPKTSNPFLVAI
S503 FLVAIHDSEADYVTT
Y507 IHDSEADYVTTDNLS
Y625 EVPSPVSYDGIKLEP
Y638 EPENPPPYEEAMSVA
K652 ALKTSDAKEEIKEPE
K656 SDAKEEIKEPESFNA
S660 EEIKEPESFNAAAQE
Y672 AQEAEAPYISIACDL
T683 ACDLIKETKLSTEPS
K684 CDLIKETKLSTEPSP
S686 LIKETKLSTEPSPGF
T687 IKETKLSTEPSPGFS
S690 TKLSTEPSPGFSNYS
Y696 PSPGFSNYSEIAKFE
K701 SNYSEIAKFEKSVPD
S716 HCELVDDSSPESEPV
S717 CELVDDSSPESEPVD
S720 VDDSSPESEPVDLFS
S727 SEPVDLFSDDSIPEV
S730 VDLFSDDSIPEVPQT
A741 VPQTQEEAVMLMKES
T755 SLTEVSETVTQHKHK
H759 VSETVTQHKHKERLS
K762 TVTQHKHKERLSASP
S766 HKHKERLSASPQEVG
S768 HKERLSASPQEVGKP
K774 ASPQEVGKPYLESFQ
K800 NEIPTLTKKETISLQ
Y816 EEFNTAIYSNDDLLS
S832 KEDKMKESETFSDSS
T834 DKMKESETFSDSSPI
S836 MKESETFSDSSPIEI
S838 ESETFSDSSPIEIID
S839 SETFSDSSPIEIIDE
S852 DEFPTFVSAKDDSPK
S857 FVSAKDDSPKEYTDL
Y861 KDDSPKEYTDLEVSN
T862 DDSPKEYTDLEVSNK
S877 SEIANVQSGANSLPC
S892 SELPCDLSFKNTYPK
S905 PKDEAHVSDEFSKSR
S913 DEFSKSRSSVSKVPL
V915 FSKSRSSVSKVPLLL
S916 SKSRSSVSKVPLLLP
K917 KSRSSVSKVPLLLPN
L921 SVSKVPLLLPNVSAL
K939 IEMGNIVKPKVLTKE
S953 EAEEKLPSDTEKEDR
T955 EEKLPSDTEKEDRSL
S961 DTEKEDRSLTAVLSA
- gap
S967 RSLTAVLSAELNKTS
K1037 GVIQAIQKSDEGHPF
K1061 ISEELVQKYSNSALG
K1075 GHVNSTIKELRRLFL
K1075 GHVNSTIKELRRLFL
K1142 HYLGLANKSVKDAMA
K1145 GLANKSVKDAMAKIQ
K1145 GLANKSVKDAMAKIQ
K1145 GLANKSVKDAMAKIQ
K1150 SVKDAMAKIQAKIPG
K1150 SVKDAMAKIQAKIPG
K1154 AMAKIQAKIPGLKRK
K1159 QAKIPGLKRKAE___
  Nogo iso5  
S7 _MEDIDQSSLVSSSA
S11 IDQSSLVSSSADSPP
S12 DQSSLVSSSADSPPR
S13 QSSLVSSSADSPPRP
S16 LVSSSADSPPRPPPA
Y26 RPPPAFKYQFVTEPE
T30 AFKYQFVTEPEDEED
K59 ELEVLERKPAAGLSA
D82 PLLDFSSDSVPPAPR
T98 PLPAAPPTAPERQPS
S105 TAPERQPSWERSPAA
S109 RQPSWERSPAASAPS
A112 SWERSPAASAPSLPP
S113 WERSPAASAPSLPPA
A114 ERSPAASAPSLPPAA
S116 SPAASAPSLPPAAAV
L124 LPPAAAVLPSKLPED
S126 PAAAVLPSKLPEDDE
S145 PPAPAGASPLAEPAA
- gap
T156 EPAAPPSTPAAPKRR
S165-p AAPKRRGsGsVVVDL
- gap
S167-p PKRRGsGsVVVDLLY
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- under review  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K230 GVIQAIQKSDEGHPF
K254 ISEELVQKYSNSALG
K268 GHVNSTIKELRRLFL
K268 GHVNSTIKELRRLFL
K335 HYLGLANKSVKDAMA
K338 GLANKSVKDAMAKIQ
K338 GLANKSVKDAMAKIQ
K338 GLANKSVKDAMAKIQ
K343 SVKDAMAKIQAKIPG
K343 SVKDAMAKIQAKIPG
K347 AMAKIQAKIPGLKRK
K352 QAKIPGLKRKAE___
  Nogo iso6  
S7 _MEDIDQSSLVSSSA
S11 IDQSSLVSSSADSPP
S12 DQSSLVSSSADSPPR
S13 QSSLVSSSADSPPRP
S16 LVSSSADSPPRPPPA
Y26 RPPPAFKYQFVTEPE
T30 AFKYQFVTEPEDEED
K59 ELEVLERKPAAGLSA
D82 PLLDFSSDSVPPAPR
T98 PLPAAPPTAPERQPS
S105 TAPERQPSWERSPAA
S109 RQPSWERSPAASAPS
A112 SWERSPAASAPSLPP
S113 WERSPAASAPSLPPA
A114 ERSPAASAPSLPPAA
S116 SPAASAPSLPPAAAV
L124 LPPAAAVLPSKLPED
S126 PAAAVLPSKLPEDDE
S145 PPAPAGASPLAEPAA
- gap
T156 EPAAPPSTPAAPKRR
S165-p AAPKRRGsGsVDETL
- gap
S167-p PKRRGsGsVDETLFA
T171 GsGsVDETLFALPAA
S185 ASEPVIPSSAVVDLL
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- under review  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K249 GVIQAIQKSDEGHPF
K273 ISEELVQKYSNSALG
K287 GHVNSTIKELRRLFL
K287 GHVNSTIKELRRLFL
K354 HYLGLANKSVKDAMA
K357 GLANKSVKDAMAKIQ
K357 GLANKSVKDAMAKIQ
K357 GLANKSVKDAMAKIQ
K362 SVKDAMAKIQAKIPG
K362 SVKDAMAKIQAKIPG
K366 AMAKIQAKIPGLKRK
K371 QAKIPGLKRKAE___
  rat

► Hide Isoforms
 
S7 _MEDIDQSSLVSSST
S11 IDQSSLVSSSTDsPP
S12 DQSSLVSSSTDsPPR
S13 QSSLVSSSTDsPPRP
S16-p LVSSSTDsPPRPPPA
Y26 RPPPAFKYQFVTEPE
T30 AFKYQFVTEPEDEED
K60 ELEVLERKPAAGLSA
D84 PLLDFSSDSVPPAPR
A100 PLPAAPPAAPERQPs
S107-p AAPERQPsWERSPAA
S111 RQPsWERSPAAPAPS
A114 sWERSPAAPAPSLPP
P115 WERSPAAPAPSLPPA
A116 ERSPAAPAPSLPPAA
S118 SPAAPAPSLPPAAAV
L126 LPPAAAVLPSKLPED
S128 PAAAVLPSKLPEDDE
S149-p PPPPAGAsPLAEPAA
- gap
T160 EPAAPPSTPAAPKRR
S169-p AAPKRRGsGSVDEtL
- gap
S171 PKRRGsGSVDEtLFA