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ITGA2b (human)

Overview ITGA2b Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. Belongs to the integrin alpha chain family. Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-IIb associates with beta-3. Directly interacts with RNF181. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, integral Cellular Component: platelet alpha granule membrane; focal adhesion; integral to plasma membrane; plasma membrane; integrin complex; external side of plasma membrane Molecular Function: identical protein binding; protein binding; extracellular matrix binding; metal ion binding Biological Process: integrin-mediated signaling pathway; platelet activation; axon guidance; platelet degranulation; cell-matrix adhesion; blood coagulation; cell adhesion Reference #:  P08514 (UniProtKB) Alt. Names/Synonyms: CD41; CD41B; GP2B; GPalpha IIb; GPIIb; GTA; HPA3; integrin alpha 2b; Integrin alpha-IIb; Integrin alpha-IIb heavy chain; Integrin alpha-IIb light chain, form 1; Integrin alpha-IIb light chain, form 2; integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41); ITA2B; ITGA2B; ITGAB; platelet fibrinogen receptor, alpha subunit; Platelet membrane glycoprotein IIb; platelet-specific antigen BAK Gene Symbols: ITGA2B Molecular weight: 113,377 Da Basal Isoelectric point: 5.21  Predict pI for various phosphorylation states CST Pathways:  GPCRs Signaling to MAPK/Erk  |  MAPK/Erk in Growth and Differentiation  |  PI3K/Akt Signaling  |  Regulation of Actin Dynamics Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ITGA2b 1DPK - A=1020-1039 (human) 1DPQ - A=1020-1039 (human) 1JX5 - A=32-483 (human) 1KUP - A=1018-1028 (human) 1KUZ - A=1018-1028 (human) 1M8O - A=1020-1039 (human) 1RN0 - A=32-482 (human) 1S4W - A=1020-1039 (human) 1TXV - A=32-483 (human) 1TY3 - A=32-483 (human) 1TY5 - A=32-483 (human) 1TY6 - A=32-483 (human) 1TY7 - A=32-483 (human) 1TYE - A/C/E=32-483 (human) 1UV9 - A=32-973 (human) 2K1A - A=989-1029 (human) 2K9J - A=989-1029 (human) 2KNC - A=991-1039 (human) 2VC2 - A=32-483 (human) 2VDK - A=32-483 (human) 2VDL - A=32-483 (human) 2VDM - A=32-483 (human) 2VDN - A=32-483 (human) 2VDO - A=32-483 (human) 2VDP - A=32-483 (human) 2VDQ - A=32-483 (human) 2VDR - A=32-483 (human) 3FCS - A/C=32-989 (human) 3FCU - A/C/E=32-488 (human) 3NID - A/C=32-488 (human) 3NIF - A/C=32-488 (human) 3NIG - A/C=32-488 (human) 3T3M - A/C=32-488 (human) 3T3P - A/C=32-488 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1DPK 1DPQ 1JX5 1KUP 1KUZ 1M8O 1RN0 1S4W 1TXV 1TY3 1TY5 1TY6 1TY7 1TYE 1UV9 2K1A 2K9J 2KNC 2VC2 2VDK 2VDL 2VDM 2VDN 2VDO 2VDP 2VDQ 2VDR 3FCS 3FCU 3NID 3NIF 3NIG 3T3M 3T3P  |  Phospho3D  |  DISEASE 273800 607759  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		L5	___MARALCPLQALW
0	1		A10	RALCPLQALWLLEWV
0	1		S60-p	SLDFHKDsHGRVAIV
0	1		Y197-p	DFSWDKRyCEAGFSS
0	1		S253	HVSSQSLSFDSSNPE
0	1		F254	VSSQSLSFDSSNPEY
0	1		S257	QSLSFDSSNPEYFDG
0	1		Y265	NPEYFDGYWGYSVAV
0	2		Y319-p	RGEQMASyFGHSVAV
0	2		Y344-p	LLVGAPLyMESRADR
0	1		Y360-p	LAEVGRVyLFLQPRG
0	1		Y384-p	LLTGTQLyGRFGSAI
0	1		S841	LPGQSQPSDLLYILD
0	1		Y845	SQPSDLLYILDIQPQ

	mouse
S5-p	___MARAsCAWHsLW
S10-p	RAsCAWHsLWLLQWT
K60	SVDFHKDKHGSVSIV
Y196	SFRGDKRYCEAGFSL
T252-p	HVSNQRFtyDNsNPV
Y253-p	VSNQRFtyDNsNPVF
S256-p	QRFtyDNsNPVFFDG
Y264-p	NPVFFDGyRGYSVAV
Y318	HGEQMASYFGHSVAV
Y343	LLVGAPLYMESRADR
Y359	LAEVGRVYLFLQPKG
Y383	LLTGTQLYGRFGSAI
S840-p	IPGQSQPsDLLyILD
Y844-p	SQPsDLLyILDVQPQ

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