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Protein Page:
aven (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
aven Protects against apoptosis mediated by Apaf-1. Binds Apaf-1, BCL-2 and BAD (Bcl-xl). Highly expressed in testis, ovary, thymus, prostate, spleen, small intestine, colon, heart, skeletal muscle, liver, kidney and pancreas. Note: This description may include information from UniProtKB.
Protein type: Inhibitor protein; Apoptosis
Cellular Component: membrane; endomembrane system; intracellular
Molecular Function: protein binding
Biological Process: apoptosis; negative regulation of apoptosis
Reference #:  Q9NQS1 (UniProtKB)
Alt. Names/Synonyms: apoptosis, caspase activation inhibitor; AVEN; Cell death regulator Aven; PDCD12; programmed cell death 12
Gene Symbols: AVEN
Molecular weight: 38,506 Da
Basal Isoelectric point: 4.9  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

aven

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 R17-m2 GRGRRPGrGRPGGDR
0 1 R28-m1 GGDRHSErPGAAAAV
0 1 R28-m2 GGDRHSErPGAAAAV
0 4 R37-m1 GAAAAVArGGGGGGG
0 1 R37-m2 GAAAAVArGGGGGGG
0 1 R50-m1 GGGDGGGrRGRGRGR
0 1 W82 SRREPGGWGAGASAP
0 18 S94-p SAPVEDDsDAEtYGE
0 5 A96 PVEDDsDAEtYGEEN
0 1 T98-p EDDsDAEtYGEENDE
0 7 Y109-p ENDEQGNySKRKIVs
0 8 S116-p ySKRKIVsNWDRyQD
0 34 Y121-p IVsNWDRyQDIEKEV
1 0 S135-p VNNESGEsQRGTDFS
0 16 K215-ub PLEVPQVkPkRTDDG
0 5 K217-ub EVPQVkPkRTDDGKG
0 7 K230-m1 KGLGMQLkGPLGPGG
0 2 K245-ub RGPIFELkSVAAGCP
0 1 K257 GCPVLLGKDNPsPGP
0 2 S261-p LLGKDNPsPGPsRDS
0 1 S265-p DNPsPGPsRDSQKPT
0 5 S273-p RDSQKPTsPLQSAGD
0 1 L303 IKEGDNILPDQTsQD
1 0 S308-p NILPDQTsQDLKSKE
  mouse

 
R17 GRGRRGGRERPGGDR
P26 RPGGDREPVGAATAL
P26 RPGGDREPVGAATAL
R35 GAATALARGGCGDGG
R35 GAATALARGGCGDGG
R44 GCGDGGGRRGRGRGF
R70-m1 GRWEPGGrGGGASTR
S82-p STRVEEDsDsEtYGE
S84-p RVEEDsDsEtYGEEN
T86-p EEDsDsEtYGEENDE
F97 ENDEQGNFSRRKIVS
S104 FSRRKIVSNWDRYQD
Y109 IVSNWDRYQDTEKEV
S123 VNGESGESQRGTDFS
K203-ub PLELPQVkPRRNDDG
R205 ELPQVkPRRNDDGKE
R218 KELGMHLRGPISELR
R225 RGPISELRSAAGACP
R237-m2 ACPRSLGrGSLRQSP
R241 SLGrGSLRQSPLEGL
L245 GSLRQSPLEGLQKAP
T253 EGLQKAPTPTQSVAD
S283-p VQEEGNIsPDQTSRD
S288 NIsPDQTSRDQEPEK
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