Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling. Belongs to the ribonucleoside diphosphate reductase small chain family. Note: This description may include information from UniProtKB.
Protein type: Nucleotide Metabolism - purine; EC 188.8.131.52; Other Amino Acids Metabolism - glutathione; Oxidoreductase; Nucleotide Metabolism - pyrimidine
Cellular Component: nucleoplasm; cytosol
Molecular Function: protein binding; metal ion binding; ribonucleoside-diphosphate reductase activity
Biological Process: G1/S-specific transcription in mitotic cell cycle; deoxyribonucleoside diphosphate metabolic process; nucleobase, nucleoside and nucleotide interconversion; nucleobase, nucleoside and nucleotide metabolic process; protein heterotetramerization; deoxyribonucleotide biosynthetic process; mitotic cell cycle; DNA replication; G1/S transition of mitotic cell cycle
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.