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Protein Page:
RAB5A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
RAB5A Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension. Binds EEA1. Interacts with RIN1 and GAPVD1, which regulate its pathway, probably by acting as a GEF. Interacts with ALS2CL, RABEP1, SUN2, ZFYVE20 and RUFY1. Interacts with SGSM1 and SGSM3. Interacts with PIK3CB. Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Belongs to the small GTPase superfamily. Rab family. Note: This description may include information from UniProtKB.
Protein type: G protein, monomeric; G protein; Motility/polarity/chemotaxis; G protein, monomeric, Rab
Chromosomal Location of Human Ortholog: 3p24-p22
Cellular Component: zymogen granule membrane; protein complex; dendrite; early endosome; terminal button; phagocytic vesicle; cytosol; lipid raft; actin cytoskeleton; ruffle; recycling endosome; synaptic vesicle; cell soma; endocytic vesicle; axon; perinuclear region of cytoplasm; cytoplasm; plasma membrane; melanosome; endosome membrane; nerve terminal; endosome
Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding; GDP-dissociation inhibitor binding
Biological Process: regulation of long-term neuronal synaptic plasticity; intracellular protein transport; regulation of endosome size; early endosome to late endosome transport; positive regulation of smooth muscle cell proliferation; regulation of endocytosis; regulation of filopodium formation; endocytosis; Rab protein signal transduction; blood coagulation; positive regulation of smooth muscle cell migration; positive regulation of exocytosis
Reference #:  P20339 (UniProtKB)
Alt. Names/Synonyms: RAB5; RAB5A; RAB5A, member RAS oncogene family; RAS-associated protein RAB5A; Ras-related protein Rab-5A
Gene Symbols: RAB5A
Molecular weight: 23,659 Da
Basal Isoelectric point: 8.32  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

RAB5A

Protein Structure Not Found.


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Sites Implicated In
cell motility, induced: T7‑p
cytoskeletal reorganization: T7‑p
intracellular localization: T7‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S3-p _____MAsRGAtRPN
1 0 T7-p _MAsRGAtRPNGPNT
0 1 K22-ac GNKICQFkLVLLGEs
0 3 S29-p kLVLLGEsAVGKSSL
1 4 S84-p AGQERYHsLAPMYYR
0 33 K116-ub ARAKNWVkELQRQAs
2 3 S123-p kELQRQAsPNIVIAL
0 1 K134 VIALSGNKADLANKR
0 1 S193 PQNPGANSARGRGVD
0 1 T202-p RGRGVDLtEPtQPtR
0 1 T205-p GVDLtEPtQPtRNQC
0 1 T208-p LtEPtQPtRNQCCSN
  mouse

 
N3 _____MANRGATRPN
T7 _MANRGATRPNGPNT
K22 GNKICQFKLVLLGEs
S29-p KLVLLGEsAVGKSSL
S84 AGQERYHSLAPMYYR
K116-ub ARAKNWVkELQRQAs
S123-p kELQRQAsPNIVIAL
K134-ub VIALSGNkADLANKR
S193-p PQNPGANsARGRGVD
T202 RGRGVDLTEPAQPAR
A205 GVDLTEPAQPARSQC
A208 LTEPAQPARSQCCSN
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