Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension. Binds EEA1. Interacts with RIN1 and GAPVD1, which regulate its pathway, probably by acting as a GEF. Interacts with ALS2CL, RABEP1, SUN2, ZFYVE20 and RUFY1. Interacts with SGSM1 and SGSM3. Interacts with PIK3CB. Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Belongs to the small GTPase superfamily. Rab family. Note: This description may include information from UniProtKB.
Protein type: G protein, monomeric (Rab); Motility/polarity/chemotaxis; G protein
Cellular Component: ruffle; endocytic vesicle; early endosome membrane; early endosome; melanosome; plasma membrane; endosome membrane; lipid raft; actin cytoskeleton
Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding
Biological Process: nervous system development; protein transport; GTP catabolic process; small GTPase mediated signal transduction; regulation of filopodium formation; endocytosis; cell differentiation; blood coagulation; positive regulation of exocytosis
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.