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Protein Page:
Rab5A (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
Rab5A Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension. Binds EEA1. Interacts with RIN1 and GAPVD1, which regulate its pathway, probably by acting as a GEF. Interacts with ALS2CL, RABEP1, SUN2, ZFYVE20 and RUFY1. Interacts with SGSM1 and SGSM3. Interacts with PIK3CB. Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Belongs to the small GTPase superfamily. Rab family. Note: This description may include information from UniProtKB.
Protein type: G protein, monomeric; Motility/polarity/chemotaxis; G protein, monomeric, Rab; G protein
Cellular Component: ruffle; endocytic vesicle; early endosome membrane; cytoplasm; early endosome; plasma membrane; melanosome; endosome membrane; cytosol; lipid raft; actin cytoskeleton
Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding
Biological Process: nervous system development; protein transport; GTP catabolic process; small GTPase mediated signal transduction; endocytosis; regulation of filopodium formation; blood coagulation; cell differentiation; positive regulation of exocytosis
Reference #:  P20339 (UniProtKB)
Alt. Names/Synonyms: RAB5; RAB5A; RAB5A, member RAS oncogene family; RAS-associated protein RAB5A; Ras-related protein Rab-5A
Gene Symbols: RAB5A
Molecular weight: 23,659 Da
Basal Isoelectric point: 8.32  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Rab5A

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S29-p KLVLLGEsAVGKSSL
0 33 K116-u ARAKNWVkELQRQAs
1 2 S123-p kELQRQAsPNIVIAL
0 1 K134 VIALSGNKADLANKR
0 1 T202-p RGRGVDLtEPtQPtR
0 1 T205-p GVDLtEPtQPtRNQC
0 1 T208-p LtEPtQPtRNQCCSN
  mouse

 
S29-p KLVLLGEsAVGKSSL
K116-u ARAKNWVkELQRQAs
S123-p kELQRQAsPNIVIAL
K134-u VIALSGNkADLANKR
T202 RGRGVDLTEPAQPAR
A205 GVDLTEPAQPARSQC
A208 LTEPAQPARSQCCSN
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