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Protein Page:
PPP2R5D (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
PPP2R5D The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with SGOL1. By retinoic acid; in neuroblastoma cell lines. Isoform Delta-2 is widely expressed. Isoform Delta-1 is highly expressed in brain. Belongs to the phosphatase 2A regulatory subunit B56 family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit
Cellular Component: nucleoplasm; protein phosphatase type 2A complex; nucleus; cytosol
Molecular Function: protein binding; protein phosphatase type 2A regulator activity; protein serine/threonine phosphatase activity
Biological Process: nervous system development; glycolysis; nerve growth factor receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; stress-activated MAPK cascade; glucose metabolic process; toll-like receptor 3 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; dephosphorylation; regulation of catalytic activity; carbohydrate metabolic process; energy reserve metabolic process; toll-like receptor signaling pathway; innate immune response; toll-like receptor 9 signaling pathway; toll-like receptor 4 signaling pathway
Reference #:  Q14738 (UniProtKB)
Alt. Names/Synonyms: 2A5D; B56D; MGC2134; MGC8949; PP2A B subunit isoform B'-delta; PP2A B subunit isoform B56-delta; PP2A B subunit isoform PR61-delta; PP2A B subunit isoform R5-delta; PP2A, B subunit, B' delta isoform; PP2A, B subunit, B56 delta isoform; PP2A, B subunit, PR61 delta isoform; PP2A, B subunit, R5 delta isoform; PPP2R5D; protein phosphatase 2, regulatory subunit B (B56), delta isoform; protein phosphatase 2, regulatory subunit B', delta; protein phosphatase 2, regulatory subunit B', delta isoform; Serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, delta isoform; Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
Gene Symbols: PPP2R5D
Molecular weight: 69,992 Da
Basal Isoelectric point: 8.24  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PPP2R5D

Protein Structure Not Found.


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Sites Implicated In
cell cycle regulation: S60‑p
molecular association, regulation: S60‑p
phosphorylation: S60‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 - gap
0 5 S50 QPQPQAQSQPPsSNK
0 2 S54-p QAQSQPPsSNKRPsN
0 1 S55 AQSQPPsSNKRPsNs
5 0 S60-p PsSNKRPsNstPPPT
0 3 S62-p SNKRPsNstPPPTQL
0 9 T63-p NKRPsNstPPPTQLS
0 4 Y74-p TQLSKIKysGGPQIV
4 1 S75-p QLSKIKysGGPQIVK
3 115 S88-p VKKERRQsssRFNLS
0 201 S89-p KKERRQsssRFNLSK
0 57 S90-p KERRQsssRFNLSKN
0 1 K121-u REELFIQkLRQCCVL
0 3 K367-u PVIVGLLkFWPKTHS
0 4 Y451-p PIMFPALyRNSKSHW
0 1 T461-p SKSHWNKtIHGLIYN
0 27 Y488-p FDDCTQQyKAEKQKG
0 1 K508-u EREEMWQkIEELARL
0 3 Y519-p LARLNPQyPMFRAPP
0 7 Y532-p PPPLPPVySMETEtP
0 5 T538-p VySMETEtPTAEDIQ
0 1 K548-u AEDIQLLkRTVEtEA
0 1 T553-p LLkRTVEtEAVQMLK
4 335 S573-p KVLLRRKsELPQDVy
0 94 Y580-p sELPQDVytIkALEA
0 21 T581-p ELPQDVytIkALEAH
0 1 K583-u PQDVytIkALEAHKR
0 5 S598-p AEEFLTAsQEAL___
  mouse

 
S43-p EAQPQPQsQsPssNK
S45-p QPQPQsQsPssNKRP
S47-p QPQsQsPssNKRPsN
S48-p PQsQsPssNKRPsNS
S53-p PssNKRPsNStPPPT
S55 sNKRPsNStPPPTQL
T56-p NKRPsNStPPPTQLS
Y67 TQLSKIKYsGGPQIV
S68-p QLSKIKYsGGPQIVK
S81-p VKKERRQssFPFNLN
S82-p KKERRQssFPFNLNK
F83 KERRQssFPFNLNKN
K114 REELFIQKLRQCCVL
K360-u PVIVGLLkFWPKTHS
Y444 PIMFPALYRNSKSHW
T454-p SKSHWNKtIHGLIYN
Y481-p FDDCTQQyKAEKQKG
K501 EREEMWQKIEELARL
Y512 LARLNPQYPMFRAPP
Y525 PPPLPPVYSMETEtP
T531-p VYSMETEtPTAEDIQ
K541 AEDIQLLKRTVETEA
T546 LLKRTVETEAVQMLK
S566-p KVLLRRKsELPQDVy
Y573-p sELPQDVytIKALEA
T574-p ELPQDVytIKALEAH
K576 PQDVytIKALEAHKR
S591 AEEFLTASQEAL___
  rat

 
- gap
- gap
S74 QPQPQPPSSNKRPSN
S75 PQPQPPSSNKRPSNS
S80 PSSNKRPSNSTPPPT
S82 SNKRPSNSTPPPTQL
T83 NKRPSNSTPPPTQLS
Y94-p TQLSKIKySGGPQIV
S95 QLSKIKySGGPQIVK
S108 VKKERRQSSSRFNLS
S109 KKERRQSSSRFNLSK
S110 KERRQSSSRFNLSKN
K141 REELFIQKLRQCCVL
K387 PVIVGLLKFWPKTHS
Y471 PIMFPALYRNSKSHW
T481 SKSHWNKTIHGLIYN
Y508 FDDCTQQYKAEKQKG
K528 EREEMWQKIEELARL
Y539 LARLNPQYPMFRAPP
Y552 PPPLPPVYSMETETP
T558 VYSMETETPTAEDIQ
K568 AEDIQLLKRTVETEA
T573 LLKRTVETEAVQMLK
S593-p KVLLRRKsELPQDVy
Y600-p sELPQDVyTIKALEA
T601 ELPQDVyTIKALEAH
K603 PQDVyTIKALEAHKR
S618 AEEFLTASQEAL___
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