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PPP2R5D (human)

Overview PPP2R5D The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with SGOL1. By retinoic acid; in neuroblastoma cell lines. Isoform Delta-2 is widely expressed. Isoform Delta-1 is highly expressed in brain. Belongs to the phosphatase 2A regulatory subunit B56 family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Protein phosphatase, regulatory subunit; Motility/polarity/chemotaxis Cellular Component: protein phosphatase type 2A complex; cytoplasm; nucleus Molecular Function: protein binding; protein phosphatase type 2A regulator activity Biological Process: nervous system development; signal transduction Reference #:  Q14738 (UniProtKB) Alt. Names/Synonyms: 2A5D; B56D; MGC2134; MGC8949; PP2A B subunit isoform B'-delta; PP2A B subunit isoform B56-delta; PP2A B subunit isoform PR61-delta; PP2A B subunit isoform R5-delta; PP2A, B subunit, B' delta isoform; PP2A, B subunit, B56 delta isoform; PP2A, B subunit, PR61 delta isoform; PP2A, B subunit, R5 delta isoform; PPP2R5D; protein phosphatase 2, regulatory subunit B (B56), delta isoform; protein phosphatase 2, regulatory subunit B', delta; protein phosphatase 2, regulatory subunit B', delta isoform; Serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, delta isoform; Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform Gene Symbols: PPP2R5D Molecular weight: 69,992 Da Basal Isoelectric point: 8.24  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PPP2R5D

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	Sites Implicated In
cell cycle regulation: S60‑p molecular association, regulation: S60‑p phosphorylation: S60‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		P42	EAQPQPQPQPQPQAQ
0	5		S50-p	QPQPQAQsQPPsSNK
0	2		S54-p	QAQsQPPsSNKRPsN
0	1		S55	AQsQPPsSNKRPsNs
5	0		S60-p	PsSNKRPsNstPPPT
0	3		S62-p	SNKRPsNstPPPTQL
0	8		T63-p	NKRPsNstPPPTQLS
0	4		Y74-p	TQLSKIKysGGPQIV
4	0		S75-p	QLSKIKysGGPQIVK
3	112		S88-p	VKKERRQsssRFNLs
0	197		S89-p	KKERRQsssRFNLsK
0	55		S90-p	KERRQsssRFNLsKN
0	1		S95-p	sssRFNLsKNRELQK
0	1		K121-u	REELFIQkLRQCCVL
0	1		K140-u	SDPLSDLkFKEVKRA
0	3		K367-u	PVIVGLLkFWPKTHS
0	1		Y430	LYYWNNEYIMSLISD
0	1		S433	WNNEYIMSLISDNAA
0	1		S436	EYIMSLISDNAARVL
0	4		Y451-p	PIMFPALyRNSKSHW
0	1		T461-p	SKSHWNKtIHGLIYN
0	27		Y488-p	FDDCTQQyKAEKQKG
0	1		K508-u	EREEMWQkIEELARL
0	3		Y519-p	LARLNPQyPMFrAPP
0	1		R523-m1	NPQyPMFrAPPPLPP
0	7		Y532-p	PPPLPPVysMEtEtP
0	1		S533-p	PPLPPVysMEtEtPT
0	1		T536-p	PPVysMEtEtPTAED
0	5		T538-p	VysMEtEtPTAEDIQ
0	1		K548-u	AEDIQLLkRTVEtEA
0	1		T553-p	LLkRTVEtEAVQMLK
4	331		S573-p	KVLLRRKsELPQDVy
0	94		Y580-p	sELPQDVytIkALEA
0	21		T581-p	ELPQDVytIkALEAH
0	1		K583-u	PQDVytIkALEAHKR
0	4		S598-p	AEEFLTAsQEAL___

	mouse
S43-p	EAQPQPQsQsPssNK
S45-p	QPQPQsQsPssNKRP
S47-p	QPQsQsPssNKRPsN
S48-p	PQsQsPssNKRPsNS
S53-p	PssNKRPsNStPPPT
S55	sNKRPsNStPPPTQL
T56-p	NKRPsNStPPPTQLS
Y67	TQLSKIKYsGGPQIV
S68-p	QLSKIKYsGGPQIVK
S81-p	VKKERRQssFPFNLN
S82-p	KKERRQssFPFNLNK
F83	KERRQssFPFNLNKN
N88	ssFPFNLNKNRELQK
K114	REELFIQKLRQCCVL
K133	SDPLSDLKCKEVKRA
K360-u	PVIVGLLkFWPKTHS
Y423-p	LYYWNNEyIMsLIsD
S426-p	WNNEyIMsLIsDNAA
S429-p	EyIMsLIsDNAARIL
Y444	PIMFPALYRNSKSHW
T454-p	SKSHWNKtIHGLIYN
Y481-p	FDDCTQQyKAEKQKG
K501	EREEMWQKIEELARL
Y512	LARLNPQYPMFRAPP
R516	NPQYPMFRAPPPLPP
Y525	PPPLPPVYSMETEtP
S526	PPLPPVYSMETEtPT
T529	PPVYSMETEtPTAED
T531-p	VYSMETEtPTAEDIQ
K541	AEDIQLLKRTVETEA
T546	LLKRTVETEAVQMLK
S566-p	KVLLRRKsELPQDVy
Y573-p	sELPQDVytIKALEA
T574-p	ELPQDVytIKALEAH
K576	PQDVytIKALEAHKR
S591	AEEFLTASQEAL___

	rat
P70	EAQPQPQPQPPSSNK
-	gap
S74	QPQPQPPSSNKRPSN
S75	PQPQPPSSNKRPSNS
S80	PSSNKRPSNSTPPPT
S82	SNKRPSNSTPPPTQL
T83	NKRPSNSTPPPTQLS
Y94-p	TQLSKIKySGGPQIV
S95	QLSKIKySGGPQIVK
S108	VKKERRQSSSRFNLS
S109	KKERRQSSSRFNLSK
S110	KERRQSSSRFNLSKN
S115	SSSRFNLSKNRELQK
K141	REELFIQKLRQCCVL
K160	SDPLSDLKFKEVKRA
K387	PVIVGLLKFWPKTHS
Y450	LYYWNNEYIMSLISD
S453	WNNEYIMSLISDNAA
S456	EYIMSLISDNAARVL
Y471	PIMFPALYRNSKSHW
T481	SKSHWNKTIHGLIYN
Y508	FDDCTQQYKAEKQKG
K528	EREEMWQKIEELARL
Y539	LARLNPQYPMFRAPP
R543	NPQYPMFRAPPPLPP
Y552	PPPLPPVYSMETETP
S553	PPLPPVYSMETETPT
T556	PPVYSMETETPTAED
T558	VYSMETETPTAEDIQ
K568	AEDIQLLKRTVETEA
T573	LLKRTVETEAVQMLK
S593-p	KVLLRRKsELPQDVy
Y600-p	sELPQDVyTIKALEA
T601	ELPQDVyTIKALEAH
K603	PQDVyTIKALEAHKR
S618	AEEFLTASQEAL___

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