Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
p67phox (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
p67phox NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). Interacts with SYTL1 and RAC1. Interacts with NCF4. May interact with NOXO1. Belongs to the NCF2/NOXA1 family. Note: This description may include information from UniProtKB.
Protein type: Oxidoreductase
Cellular Component: acrosome; cytosol; NADPH oxidase complex
Molecular Function: protein C-terminus binding; protein binding; electron carrier activity; Rac GTPase binding
Biological Process: response to drug; respiratory burst; interaction with host; superoxide metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; response to lipopolysaccharide; cellular response to hormone stimulus; antigen processing and presentation of peptide antigen via MHC class I; response to hyperoxia; positive regulation of neuron apoptosis; response to glucose stimulus; innate immune response; cellular defense response; antigen processing and presentation of exogenous peptide antigen via MHC class I; response to activity; response to progesterone stimulus; superoxide release; positive regulation of blood pressure; aging
Reference #:  P19878 (UniProtKB)
Alt. Names/Synonyms: 67 kDa neutrophil oxidase factor; chronic granulomatous disease, autosomal 2; FLJ93058; NADPH oxidase activator 2; NCF-2; NCF2; Neutrophil cytosol factor 2; neutrophil cytosolic factor 2; neutrophil cytosolic factor 2 (65kD, chronic granulomatous disease, autosomal 2); Neutrophil NADPH oxidase factor 2; NOXA2; p67-phox; P67PHOX
Gene Symbols: NCF2
Molecular weight: 59,762 Da
Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

p67phox

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 25 T233-p EPPPRPKtPEIFRAL
0 1 S315-p QEESSPQsDIPAPPS
0 1 S323 DIPAPPSSKAPGRPQ
0 2 K324 IPAPPSSKAPGRPQL
0 4 S332-p APGRPQLsPGQKQKE
0 2 K391 ELRLEHTKLSYRPRD
0 1 S399 LSYRPRDSNELVPLS
  mouse

 
T233-p EPPPRPKtPEIFRAL
S315-p QEDTSPEsDIPPPPN
S323-p DIPPPPNssPPGRLQ
S324-p IPPPPNssPPGRLQL
S332-p PPGRLQLsPGHKQKE
K390-a ALSPEHTkLSYRRRD
S398-p LSYRRRDsHELLLLS
  rat

 
T225 EPPPRPKTPEIFRAL
S307 QEDTSLESDIPPPPN
S315 DIPPPPNSSPPERLQ
S316 IPPPPNSSPPERLQL
S324 PPERLQLSPGWCQQL
K392 ELLPEHTKLSYQRRD
S400 LSYQRRDSPELLLLS
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.