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p67phox (human)

Overview p67phox NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). Interacts with SYTL1 and RAC1. Interacts with NCF4. May interact with NOXO1. Belongs to the NCF2/NOXA1 family. Note: This description may include information from UniProtKB. Protein type: Oxidoreductase Cellular Component: cytoplasm; acrosome; nucleolus; cytosol; NADPH oxidase complex Molecular Function: protein C-terminus binding; protein binding; electron carrier activity; Rac GTPase binding Biological Process: respiratory burst; response to drug; interaction with host; superoxide metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; response to lipopolysaccharide; cellular response to hormone stimulus; antigen processing and presentation of peptide antigen via MHC class I; response to hyperoxia; positive regulation of neuron apoptosis; response to glucose stimulus; cellular defense response; antigen processing and presentation of exogenous peptide antigen via MHC class I; innate immune response; response to activity; response to progesterone stimulus; superoxide release; positive regulation of blood pressure; aging Reference #:  P19878 (UniProtKB) Alt. Names/Synonyms: 67 kDa neutrophil oxidase factor; chronic granulomatous disease, autosomal 2; FLJ93058; NADPH oxidase activator 2; NCF-2; NCF2; Neutrophil cytosol factor 2; neutrophil cytosolic factor 2; neutrophil cytosolic factor 2 (65kD, chronic granulomatous disease, autosomal 2); Neutrophil NADPH oxidase factor 2; NOXA2; p67-phox; P67PHOX Gene Symbols: NCF2 Molecular weight: 59,762 Da Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below p67phox 1E96 - B=1-203 (human) 1HH8 - A=1-213 (human) 1K4U - S=455-516 (human) 1OEY - A/B/C/D=350-429 (human) 1WM5 - A=1-203 (human) 2DMO - A=242-297 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1E96 1HH8 1K4U 1OEY 1WM5 2DMO  |  Phospho3D  |  DISEASE 233710 608515  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	24		T233-p	EPPPRPKtPEIFRAL
0	1		S315-p	QEESSPQsDIPAPPS
0	1		S323	DIPAPPSSKAPGRPQ
0	2		K324	IPAPPSSKAPGRPQL
0	3		S332-p	APGRPQLsPGQKQKE
0	1		K355-u	VPMPYTLkVHYKYTV
0	1		Y358	PYTLkVHYKYTVVMK
0	2		K391	ELRLEHTKLSYRPRD
0	1		S399	LSYRPRDSNELVPLS

	mouse
T233-p	EPPPRPKtPEIFRAL
S315-p	QEDTSPEsDIPPPPN
S323-p	DIPPPPNssPPGRLQ
S324-p	IPPPPNssPPGRLQL
S332-p	PPGRLQLsPGHKQKE
K354-u	VPMPYMLkVHyKYTV
Y357-p	PYMLkVHyKYTVVME
K390-a	ALSPEHTkLSYRRRD
S398-p	LSYRRRDsHELLLLS

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