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Protein Page:
p67phox (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
p67phox NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). Interacts with SYTL1 and RAC1. Interacts with NCF4. May interact with NOXO1. Belongs to the NCF2/NOXA1 family. Note: This description may include information from UniProtKB.
Protein type: Oxidoreductase
Chromosomal Location of Human Ortholog: 1q25
Cellular Component: cytoplasm; acrosome; nucleolus; cytosol; NADPH oxidase complex
Molecular Function: protein C-terminus binding; protein binding; electron carrier activity; Rac GTPase binding
Biological Process: respiratory burst; response to drug; interaction with host; superoxide metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; response to lipopolysaccharide; cellular response to hormone stimulus; antigen processing and presentation of peptide antigen via MHC class I; response to hyperoxia; positive regulation of neuron apoptosis; response to glucose stimulus; antigen processing and presentation of exogenous peptide antigen via MHC class I; innate immune response; cellular defense response; response to activity; response to progesterone stimulus; superoxide release; positive regulation of blood pressure; aging
Reference #:  P19878 (UniProtKB)
Alt. Names/Synonyms: 67 kDa neutrophil oxidase factor; chronic granulomatous disease, autosomal 2; FLJ93058; NADPH oxidase activator 2; NCF-2; NCF2; Neutrophil cytosol factor 2; neutrophil cytosolic factor 2; neutrophil cytosolic factor 2 (65kD, chronic granulomatous disease, autosomal 2); Neutrophil NADPH oxidase factor 2; NOXA2; p67-phox; P67PHOX
Gene Symbols: NCF2
Molecular weight: 59,762 Da
Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

p67phox

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 A224 FAPLQPQAAEPPPRP
1 27 T233-p EPPPRPKtPEIFRAL
0 1 Q305 ELRIHPQQQPQEESs
0 1 S311 QQQPQEESsPQsDIP
0 1 S312-p QQPQEESsPQsDIPA
0 2 S315-p QEESsPQsDIPAPPS
0 2 S323 DIPAPPSSKAPGRPQ
0 3 K324 IPAPPSSKAPGRPQL
0 7 S332-p APGRPQLsPGQKQKE
0 1 K355 VPMPYTLKVHYKYTV
0 1 Y358 PYTLKVHYKYTVVMK
0 1 R386 VSKKLELRLEHTKLS
0 2 K391 ELRLEHTKLSYRPRD
0 1 S399 LSYRPRDSNELVPLS
  mouse

 
S224-p FAPLQPQsAEPPPRP
T233-p EPPPRPKtPEIFRAL
S305-p ELRIHPQsQPQEDts
T311-p QsQPQEDtsPEsDIP
S312-p sQPQEDtsPEsDIPP
S315-p QEDtsPEsDIPPPPN
S323-p DIPPPPNssPPGRLQ
S324-p IPPPPNssPPGRLQL
S332-p PPGRLQLsPGHKQKE
K354-ub VPMPYMLkVHyKYTV
Y357-p PYMLkVHyKYTVVME
S385-p VSKKLALsPEHTkLS
K390-ac ALsPEHTkLSYRRRD
S398-p LSYRRRDsHELLLLS
  rat

 
S216 FAPLQPQSAEPPPRP
T225-p EPPPRPKtPEIFRAL
S297 ELRIHPQSQPQEDTS
T303 QSQPQEDTSLESDIP
S304 SQPQEDTSLESDIPP
S307 QEDTSLESDIPPPPN
S315 DIPPPPNSSPPERLQ
S316 IPPPPNSSPPERLQL
S324 PPERLQLSPGWCQQL
K356 VPMPYMLKVHYKYTV
Y359 PYMLKVHYKYTVVME
L387 VSKKLELLPEHTKLS
K392 ELLPEHTKLSYQRRD
S400 LSYQRRDSPELLLLS
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