Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox- regulated cell signaling. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Oxidoreductase; Nucleotide Metabolism - pyrimidine; EC 126.96.36.199
Cellular Component: mitochondrion
Molecular Function: protein binding; protein homodimerization activity; thioredoxin-disulfide reductase activity; FAD binding; NADP binding
Biological Process: response to selenium ion; response to oxygen radical; cell redox homeostasis; heart development; hemopoiesis
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.