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Protein Page:
ITPA (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ITPA Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Defects in ITPA are the cause of inosine triphosphate pyrophosphohydrolase deficiency (ITPAD). It is a common inherited trait characterized by the abnormal accumulation of inosine triphosphate (ITP) in erythrocytes and also leukocytes and fibroblasts. The pathological consequences of ITPA deficiency, if any, are unknown. However, it might have pharmacogenomic implications and be related to increased drug toxicity of purine analog drugs. Three different human populations have been reported with respect to their ITPase activity: high, mean (25% of high) and low activity. The variant Thr-32 is associated with complete loss of enzyme activity, may be by altering the local secondary structure of the protein. Heterozygotes for this polymorphism have 22.5% of the control activity: this is consistent with a dimeric structure of the enzyme. Belongs to the HAM1 NTPase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Xenobiotic Metabolism - drug metabolism - other enzymes; Hydrolase; Nucleotide Metabolism - purine; EC 3.6.1.19; Nucleotide Metabolism - pyrimidine
Cellular Component: cytosol
Molecular Function: metal ion binding; nucleotide binding
Biological Process: deoxyribonucleoside triphosphate catabolic process; nucleobase, nucleoside and nucleotide metabolic process; ITP catabolic process; chromosome organization and biogenesis
Reference #:  Q9BY32 (UniProtKB)
Alt. Names/Synonyms: C20orf37; dJ794I6.3; HLC14-06-P; Inosine triphosphatase; inosine triphosphatase (nucleoside triphosphate pyrophosphatase); inosine triphosphatase-A; Inosine triphosphate pyrophosphatase; inosine triphosphate pyrophosphohydrolase; ITPA; ITPase; My049 protein; nucleoside triphosphate diphosphatase; Putative oncogene protein hlc14-06-p
Gene Symbols: ITPA
Molecular weight: 21,446 Da
Basal Isoelectric point: 5.5  Predict pI for various phosphorylation states
Select Structure to View Below

ITPA

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 5 K9-ub AASLVGKkIVFVtGN
0 2 T14-p GKkIVFVtGNAkKLE
0 1 K18 VFVtGNAKKLEEVVQ
0 1 K18-sc VFVtGNAkKLEEVVQ
0 3 K56-ub PDEISIQkCQEAVRQ
0 1 K96-ub KWFLEKLkPEGLHQL
0 2 S111-p LAGFEDKsAyALCTF
0 11 Y113-p GFEDKsAyALCTFAL
0 1 C146 RIVAPRGCQDFGWDP
0 1 K169-ub QTYAEMPkAEKNAVS
  mouse

 
K9 AASLVGKKIVFVTGN
T14 GKKIVFVTGNAkKLE
K18-ac VFVTGNAkKLEEVIQ
K18 VFVTGNAKKLEEVIQ
K56-ub PDEISIQkCREAARQ
K96 KWFLQKLKPEGLHQL
S111-p LAGFEDKsAYALCTF
Y113 GFEDKsAYALCTFAL
S146-p QIVMPRGsRDFGWDP
K169 QTYAEMPKSEKNTIS
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