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Protein Page:
ARID1B (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
ARID1B Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Binds DNA non-specifically. Defects in ARID1B are the cause of mental retardation autosomal dominant type 12 (MRD12). A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. MRD12 patients present with moderate to severe psychomotor retardation, and most show evidence of muscular hypotonia. In many patients, expressive speech is more severely affected than receptive function. Additional common findings include short stature, abnormal head shape and low-set, posteriorly rotated, and abnormally shaped ears, downslanting palpebral fissures, a bulbous nasal tip, a thin upper lip, minor teeth anomalies, and brachydactyly or single palmar creases. Autistic features are uncommon. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Nuclear receptor co-regulator
Cellular Component: SWI/SNF complex
Molecular Function: protein binding; DNA binding; transcription coactivator activity
Biological Process: nervous system development; transcription, DNA-dependent; chromatin-mediated maintenance of transcription
Reference #:  Q8NFD5 (UniProtKB)
Alt. Names/Synonyms: 6A3-5; ARI1B; ARID domain-containing protein 1B; ARID1B; AT rich interactive domain 1B (SWI1-like); AT-rich interactive domain-containing protein 1B; BAF250B; BRG1-associated factor 250b; BRG1-binding protein ELD/OSA1; BRG1-binding protein hELD/OSA1; BRIGHT; DAN15; Eld (eyelid)/Osa protein; ELD/OSA1; hOsa2; KIAA1235; Osa homolog 2; OSA2; p250R
Gene Symbols: ARID1B
Molecular weight: 236,123 Da
Basal Isoelectric point: 6.26  Predict pI for various phosphorylation states
Select Structure to View Below

ARID1B

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 N4 ____MAHNAGAAAAA
0 1 R404 SAAGGFQRFAGQNQH
0 1 Y483-p GKDMGAQyAAAsPAW
0 4 S487-p GAQyAAAsPAWAAAQ
0 2 S502-p QRSHPAMsPGtPGPT
0 1 T505-p HPAMsPGtPGPTMGR
0 1 S513-p PGPTMGRsQGsPMDP
0 3 S516-p TMGRsQGsPMDPMVM
0 2 R525-m2 MDPMVMKrPQLYGMG
0 3 R557-m2 YGPPGPQrYPIGIQG
0 2 R565-m2 YPIGIQGrTPGAMAG
0 9 S632-p YQPQQDMsQEGYGTR
0 3 S742-p QSRSGPIsPASIPGS
0 1 S749 sPASIPGSQMPPQPP
0 1 S758 MPPQPPGSQSESSSH
0 1 S760 PQPPGSQSESSSHPA
0 1 S762 PPGSQSESSSHPALS
0 1 S763 PGSQSESSSHPALSQ
0 1 S764 GSQSESSSHPALSQS
0 1 S800 GPQQTGPSMSPHPSP
0 1 S802 QQTGPSMSPHPSPGG
0 1 S806 PSMSPHPSPGGQMHA
0 1 S816 GQMHAGISSFQQSNS
0 1 S821 GISSFQQSNSSGTYG
0 1 S823 SSFQQSNSSGTYGPQ
0 1 S824 SFQQSNSSGTYGPQM
0 1 K928 PMPTVNRKAQEAAAA
0 6 T1181-p GSLQGPQtPQSTGSN
0 1 S1240-p SSFPKRNsMtPNAPY
0 1 T1242-p FPKRNsMtPNAPYQQ
0 18 Y1367-p KRHMDGMyGPPAKRH
0 12 S1542-p NHISRAPsPASFQRS
0 19 S1555-p RSLENRMsPsKsPFL
0 5 S1557-p LENRMsPsKsPFLPs
0 16 S1559-p NRMsPsKsPFLPsMk
0 2 S1564-p sKsPFLPsMkMQKVM
0 1 K1566-a sPFLPsMkMQKVMPT
0 1 S1710-p ARKDDSQsLADDsGK
0 6 S1715-p SQsLADDsGKEEEDA
0 1 S1748 KTESDEKSSIALTAP
0 1 S1749 TESDEKSSIALTAPD
0 1 K1777-a KFDKLPIkIVKKNNL
0 1 T1813 WQLGGGDTTEHIQTH
0 1 T1814 QLGGGDTTEHIQTHF
0 2 S1869-p ATIDDVLsARPGALP
0 1 K2097-u PPFSRQEkFYATLVR
0 1 S2142 AIAVQKGSIGNLISF
0 1 K2187-u DMMCRAAkALLAMAR
  ARID1B iso3  
N4 ____MAHNAGAAAAA
R404 SAAGGFQRFAGQNQH
Y483 GKDMGAQYAAASPAW
S487 GAQYAAASPAWAAAQ
S502 QRSHPAMSPGTPGPT
T505 HPAMSPGTPGPTMGR
S513 PGPTMGRSQGSPMDP
S516 TMGRSQGSPMDPMVM
R525 MDPMVMKRPQLYGMG
R557 YGPPGPQRYPIGIQG
R565 YPIGIQGRTPGAMAG
S632 YQPQQDMSQEGYGTR
S742 QSRSGPISPASIPGS
S749 SPASIPGSQMPPQPP
S758 MPPQPPGSQSESSSH
S760 PQPPGSQSESSSHPA
S762 PPGSQSESSSHPALS
S763 PGSQSESSSHPALSQ
S764 GSQSESSSHPALSQS
S800 GPQQTGPSMSPHPSP
S802 QQTGPSMSPHPSPGG
S806 PSMSPHPSPGGQMHA
S816 GQMHAGISSFQQSNS
S821 GISSFQQSNSSGTYG
S823 SSFQQSNSSGTYGPQ
S824 SFQQSNSSGTYGPQM
K928 PMPTVNRKAQEAAAA
T1234 GSLQGPQTPQSTGSN
S1293 SSFPKRNSMTPNAPY
T1295 FPKRNSMTPNAPYQQ
Y1420 KRHMDGMYGPPAKRH
S1595 NHISRAPSPASFQRS
S1608 RSLENRMSPSKSPFL
S1610 LENRMSPSKSPFLPS
S1612 NRMSPSKSPFLPSMK
S1617 SKSPFLPSMKMQKVM
K1619 SPFLPSMKMQKVMPT
S1763 ARKDDSQSLADDSGK
S1768 SQSLADDSGKEEEDA
S1801 KTESDEKSSIALTAP
S1802 TESDEKSSIALTAPD
K1830 KFDKLPIKIVKKNNL
T1866 WQLGGGDTTEHIQTH
T1867 QLGGGDTTEHIQTHF
S1922 ATIDDVLSARPGALP
K2150 PPFSRQEKFYATLVR
S2195 AIAVQKGSIGNLISF
K2240 DMMCRAAKALLAMAR
  mouse

 
S4-p ____MAHsASAAAAA
R410-m2 AAAGGFQrFAGQNQH
Y487 GKDLGAQYAAASPAW
S491 GAQYAAASPAWAAAQ
S506-p QRSHPAMsPGtPGPT
T509-p HPAMsPGtPGPTMGR
S517 PGPTMGRSQGSPMDP
S520 TMGRSQGSPMDPMVM
R529-m2 MDPMVMKrPQLYGMG
R561-m2 YGPPGAQrYPLGMQG
R569-m2 YPLGMQGrAPGALGG
S639 YQPQQDMSQEGYGTR
S749-p QSRSGPIsPASIPGs
S756-p sPASIPGsQMPPQPP
S765-p MPPQPPGsQsEsssH
S767-p PQPPGsQsEsssHPA
S769-p PPGsQsEsssHPALS
S770-p PGsQsEsssHPALSQ
S771-p GsQsEsssHPALSQS
S807-p GPQQTGPsMsPHPsP
S809-p QQTGPsMsPHPsPGG
S813-p PsMsPHPsPGGQMHP
S823-p GQMHPGIsNFQQsNs
S828-p GIsNFQQsNssGTYG
S830-p sNFQQsNssGTYGPQ
S831-p NFQQsNssGTYGPQM
K935-u PMPTVNRkAQEAAAA
T1188 GSLQGPQTPQSTGSN
S1247 SAYPKRNSMtPNAPY
T1249-p YPKRNSMtPNAPYQQ
Y1374 KRHMDGMYGPPAKRH
S1549-p NHISRAPsPASFQRS
S1562-p RSLESRMsPsKsPFL
S1564-p LESRMsPsKsPFLPt
S1566-p SRMsPsKsPFLPtMK
T1571-p sKsPFLPtMKMQKVM
K1573 sPFLPtMKMQKVMPT
S1717 GKKDDSQSLEDDsGK
S1722-p SQSLEDDsGKEDDDA
S1755-p KIESEGKssPALAAP
S1756-p IESEGKssPALAAPD
K1784 KFDKLPIKIVKKNKL
T1820 WQLGGGDTTEHIQTH
T1821 QLGGGDTTEHIQTHF
S1876 ATIDDVLSARPGALP
K2104 PPFSRQEKFYATLVR
S2149-gl AIAVQKGsIGNLISF
K2194 DMMCRAAKALLAMAR
  rat

 
- gap
- gap
- gap
- gap
- gap
- gap
S4 ____MGRSQGSPMDP
S7 _MGRSQGSPMDPMVM
R16 MDPMVMKRPQLYGMG
R48 YGPPGAQRYPLGMQG
R56 YPLGMQGRAPGALGG
S123 YQPQQDMSQEGYGTR
S233 QSRSGPISPASIPGF
- gap
- gap
- gap
- gap
- gap
- gap
S261 GPQQTGPSMSPHPSP
S263 QQTGPSMSPHPSPGG
S267 PSMSPHPSPGGQMHA
S277 GQMHAGISRFQQSNS
S282 GISRFQQSNSSGTYG
S284 SRFQQSNSSGTYGPQ
S285 RFQQSNSSGTYGPQM
K393 PMPTVNRKAQEAAAA
T699 GSLQGPQTPQSTGSS
S758 SAYPKRNSTTPNAPY
T760 YPKRNSTTPNAPYQQ
Y885 KRHMDGMYGPPAKRH
S1060-p NHISRAPsPASFPRS
S1073 RSLESRMSPSKSPFL
S1075 LESRMSPSKSPFLPA
S1077 SRMSPSKSPFLPAMK
A1082 SKSPFLPAMKMQKVM
K1084 SPFLPAMKMQKVMPT
S1228 GKKDDSQSSEDDSGK
S1233 SQSSEDDSGKEEEDA
S1270 KTESEGKSSSALAAP
S1271 TESEGKSSSALAAPD
K1299 KFDKLPIKIVKKNNL
T1335-p WQLGGGDttEHILTH
T1336-p QLGGGDttEHILTHF
S1391 ATIDDVLSARPGALP
K1619 PPFSRQEKFYATLVR
S1664 AIAVQKGSIGNLIGF
K1709 DMMCRAAKALLAMAR
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