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Protein Page:
ARID1B (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ARID1B Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Binds DNA non-specifically. Defects in ARID1B are the cause of mental retardation autosomal dominant type 12 (MRD12). A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. MRD12 patients present with moderate to severe psychomotor retardation, and most show evidence of muscular hypotonia. In many patients, expressive speech is more severely affected than receptive function. Additional common findings include short stature, abnormal head shape and low-set, posteriorly rotated, and abnormally shaped ears, downslanting palpebral fissures, a bulbous nasal tip, a thin upper lip, minor teeth anomalies, and brachydactyly or single palmar creases. Autistic features are uncommon. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Nuclear receptor co-regulator
Cellular Component: SWI/SNF complex; cytoplasm; nucleolus; nucleus
Molecular Function: protein binding; DNA binding; transcription coactivator activity
Biological Process: nervous system development; transcription, DNA-dependent; chromatin-mediated maintenance of transcription
Reference #:  Q8NFD5 (UniProtKB)
Alt. Names/Synonyms: 6A3-5; ARI1B; ARID domain-containing protein 1B; ARID1B; AT rich interactive domain 1B (SWI1-like); AT-rich interactive domain-containing protein 1B; BAF250B; BRG1-associated factor 250b; BRG1-binding protein ELD/OSA1; BRG1-binding protein hELD/OSA1; BRIGHT; DAN15; Eld (eyelid)/Osa protein; ELD/OSA1; hOsa2; KIAA1235; Osa homolog 2; OSA2; p250R
Gene Symbols: ARID1B
Molecular weight: 236,123 Da
Basal Isoelectric point: 6.26  Predict pI for various phosphorylation states
Select Structure to View Below

ARID1B

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 N4 ____MAHNAGAAAAA
0 1 S268 PGMGMMHSASAAAAG
0 1 S270 MGMMHSASAAAAGAP
0 1 R404 SAAGGFQRFAGQNQH
0 1 S413-p AGQNQHPsGATPTLN
0 1 S425-p TLNQLLTsPsPMMRS
0 1 S427-p NQLLTsPsPMMRSYG
0 1 Y483-p GKDMGAQyAAAsPAW
0 5 S487-p GAQyAAAsPAWAAAQ
0 1 S497-p WAAAQQRsHPAMsPG
0 3 S502-p QRsHPAMsPGtPGPt
0 2 T505-p HPAMsPGtPGPtMGR
0 1 T509-p sPGtPGPtMGRsQGs
0 1 S513-p PGPtMGRsQGsPMDP
0 4 S516-p tMGRsQGsPMDPMVM
0 2 R525-m2 MDPMVMKrPQLYGMG
0 3 R557-m2 YGPPGPQrYPIGIQG
0 2 R565-m2 YPIGIQGrTPGAMAG
0 9 S632-p YQPQQDMsQEGYGTR
0 1 S664-p IQQERPSsLPDLSGS
0 4 S742-p QSRSGPIsPASIPGS
0 1 S745 SGPIsPASIPGSQMP
0 1 S749 sPASIPGSQMPPQPP
0 1 S758 MPPQPPGSQSESSSH
0 1 S760 PQPPGSQSESSSHPA
0 1 S762 PPGSQSESSSHPALS
0 1 S763 PGSQSESSSHPALSQ
0 1 S764 GSQSESSSHPALSQS
0 1 S800 GPQQTGPSMSPHPSP
0 1 S802 QQTGPSMSPHPSPGG
0 1 S806 PSMSPHPSPGGQMHA
0 1 S816 GQMHAGISSFQQSNS
0 1 S821 GISSFQQSNSSGTYG
0 1 S823 SSFQQSNSSGTYGPQ
0 1 S824 SFQQSNSSGTYGPQM
0 1 S888-p VPLGRMPsAGMQNRP
0 1 S906-p NMSSMTPsSPGMSQQ
0 1 K928 PMPTVNRKAQEAAAA
0 1 S946-p AAANSAQsRQGSFPG
0 1 T1024-p ADGKEEGtPQPESKS
0 1 - gap
0 1 S1036-p SKSKKSSsSTTtGEK
0 1 T1038 SKKSSsSTTtGEKIT
0 1 T1040-p KSSsSTTtGEKITKV
0 1 Y1091-p PLDLFRLyVCVKEIG
0 1 S1169-p QPKLQPPsPANSGSL
0 6 T1181-p GSLQGPQtPQSTGSN
0 1 T1211-p STPHGQMtPMQGGRS
0 2 S1240-p SSFPKRNsMtPNAPY
0 3 T1242-p FPKRNsMtPNAPYQQ
0 18 Y1367-p KRHMDGMyGPPAKRH
0 14 S1542-p NHISRAPsPASFQRs
0 1 S1549-p sPASFQRsLENRMsP
0 20 S1555-p RsLENRMsPsKsPFL
0 6 S1557-p LENRMsPsKsPFLPs
0 17 S1559-p NRMsPsKsPFLPsMk
0 2 S1564-p sKsPFLPsMkMQKVM
0 1 K1566-ac sPFLPsMkMQKVMPT
0 1 S1710-p ARKDDSQsLADDsGK
0 6 S1715-p SQsLADDsGKEEEDA
0 1 S1748 KTESDEKSSIALTAP
0 2 S1749 TESDEKSSIALTAPD
0 1 K1773-ac KQASKFDkLPIkIVk
0 1 K1777-ac KFDkLPIkIVkKNNL
0 1 K1780-ac kLPIkIVkKNNLFVV
0 1 T1813 WQLGGGDTTEHIQTH
0 1 T1814 QLGGGDTTEHIQTHF
0 1 R1842 PPLSSAGRKKEQEGK
0 1 K1858-ac DSEEQQEkSIIATID
0 2 S1869-p ATIDDVLsARPGALP
0 1 S1887-p NPGPQTEsSKFPFGI
0 1 S1941-p CVSNIVRsLsFVPGN
0 1 S1943-p SNIVRsLsFVPGNDA
0 1 S1953-p PGNDAEMsKHPGLVL
0 1 T2011-p LEVLRDNtLVTLANI
0 1 T2028-p QLDLSAYtESICLPI
0 1 T2072-p PQRLVLEtLCKLSIQ
0 1 K2097-ub PPFSRQEkFYATLVR
0 1 S2142 AIAVQKGSIGNLISF
0 1 K2187-ub DMMCRAAkALLAMAR
  ARID1B iso3  
N4 ____MAHNAGAAAAA
S268 PGMGMMHSASAAAAG
S270 MGMMHSASAAAAGAP
R404 SAAGGFQRFAGQNQH
S413 AGQNQHPSGATPTLN
S425 TLNQLLTSPSPMMRS
S427 NQLLTSPSPMMRSYG
Y483 GKDMGAQYAAASPAW
S487 GAQYAAASPAWAAAQ
S497 WAAAQQRSHPAMSPG
S502 QRSHPAMSPGTPGPT
T505 HPAMSPGTPGPTMGR
T509 SPGTPGPTMGRSQGS
S513 PGPTMGRSQGSPMDP
S516 TMGRSQGSPMDPMVM
R525 MDPMVMKRPQLYGMG
R557 YGPPGPQRYPIGIQG
R565 YPIGIQGRTPGAMAG
S632 YQPQQDMSQEGYGTR
S664 IQQERPSSLPDLSGS
S742 QSRSGPISPASIPGS
S745 SGPISPASIPGSQMP
S749 SPASIPGSQMPPQPP
S758 MPPQPPGSQSESSSH
S760 PQPPGSQSESSSHPA
S762 PPGSQSESSSHPALS
S763 PGSQSESSSHPALSQ
S764 GSQSESSSHPALSQS
S800 GPQQTGPSMSPHPSP
S802 QQTGPSMSPHPSPGG
S806 PSMSPHPSPGGQMHA
S816 GQMHAGISSFQQSNS
S821 GISSFQQSNSSGTYG
S823 SSFQQSNSSGTYGPQ
S824 SFQQSNSSGTYGPQM
S888 VPLGRMPSAGMQNRP
S906 NMSSMTPSSPGMSQQ
K928 PMPTVNRKAQEAAAA
S946 AAANSAQSRQGSFPG
T1024 ADGKEEGTPQPESKS
S1084-p GWPKTPSsPKSSSSt
S1089 PSsPKSSSStTTGEK
T1091-p sPKSSSStTTGEKIT
T1093 KSSSStTTGEKITKV
Y1144 PLDLFRLYVCVKEIG
S1222 QPKLQPPSPANSGSL
T1234 GSLQGPQTPQSTGSN
T1264 STPHGQMTPMQGGRS
S1293 SSFPKRNSMTPNAPY
T1295 FPKRNSMTPNAPYQQ
Y1420 KRHMDGMYGPPAKRH
S1595 NHISRAPSPASFQRS
S1602 SPASFQRSLENRMSP
S1608 RSLENRMSPSKSPFL
S1610 LENRMSPSKSPFLPS
S1612 NRMSPSKSPFLPSMK
S1617 SKSPFLPSMKMQKVM
K1619 SPFLPSMKMQKVMPT
S1763 ARKDDSQSLADDSGK
S1768 SQSLADDSGKEEEDA
S1801 KTESDEKSSIALTAP
S1802 TESDEKSSIALTAPD
K1826 KQASKFDKLPIKIVK
K1830 KFDKLPIKIVKKNNL
K1833 KLPIKIVKKNNLFVV
T1866 WQLGGGDTTEHIQTH
T1867 QLGGGDTTEHIQTHF
R1895 PPLSSAGRKKEQEGK
K1911 DSEEQQEKSIIATID
S1922 ATIDDVLSARPGALP
S1940 NPGPQTESSKFPFGI
S1994 CVSNIVRSLSFVPGN
S1996 SNIVRSLSFVPGNDA
S2006 PGNDAEMSKHPGLVL
T2064 LEVLRDNTLVTLANI
T2081 QLDLSAYTESICLPI
T2125 PQRLVLETLCKLSIQ
K2150 PPFSRQEKFYATLVR
S2195 AIAVQKGSIGNLISF
K2240 DMMCRAAKALLAMAR
  mouse

 
S4-p ____MAHsASAAAAA
S265-p PGMGMMHsAsAAAGA
S267-p MGMMHsAsAAAGAPS
R410-m2 AAAGGFQrFAGQNQH
S419 AGQNQHPSGATPTLN
S431 TLNQLLTSPSPMMRS
S433 NQLLTSPSPMMRSYG
Y487 GKDLGAQYAAASPAW
S491 GAQYAAASPAWAAAQ
S501 WAAAQQRSHPAMsPG
S506-p QRSHPAMsPGtPGPT
T509-p HPAMsPGtPGPTMGR
T513 sPGtPGPTMGRSQGS
S517 PGPTMGRSQGSPMDP
S520 TMGRSQGSPMDPMVM
R529-m2 MDPMVMKrPQLYGMG
R561-m2 YGPPGAQrYPLGMQG
R569-m2 YPLGMQGrAPGALGG
S639 YQPQQDMSQEGYGTR
S671 IQQERPSSLPDLSGS
S749-p QSRSGPIsPAsIPGs
S752-p SGPIsPAsIPGsQMP
S756-p sPAsIPGsQMPPQPP
S765-p MPPQPPGsQsEsssH
S767-p PQPPGsQsEsssHPA
S769-p PPGsQsEsssHPALS
S770-p PGsQsEsssHPALSQ
S771-p GsQsEsssHPALSQS
S807-p GPQQTGPsMsPHPsP
S809-p QQTGPsMsPHPsPGG
S813-p PsMsPHPsPGGQMHP
S823-p GQMHPGIsNFQQsNs
S828-p GIsNFQQsNssGTYG
S830-p sNFQQsNssGTYGPQ
S831-p NFQQsNssGTYGPQM
S895 MPLGRMPSAGMQNRP
S913 TMSSVTPSSPGMSQQ
K935-ub PMPTVNRkAQEAAAA
S953 AAANSAQSRQGSFPG
V1031 ADGKEEGVSQPESKS
- gap
S1043 SKSKKSSSSSTTGEK
S1045 SKKSSSSSTTGEKIT
T1047 KSSSSSTTGEKITKV
Y1098 PLDLFRLYVCVKEIG
S1176 QPKLQPPSPANSGSL
T1188 GSLQGPQTPQSTGSN
T1218 STPHGQMTPMQSGRS
S1247 SAYPKRNSMtPNAPY
T1249-p YPKRNSMtPNAPYQQ
Y1374 KRHMDGMYGPPAKRH
S1549-p NHISRAPsPASFQRS
S1556 sPASFQRSLESRMsP
S1562-p RSLESRMsPsKsPFL
S1564-p LESRMsPsKsPFLPt
S1566-p SRMsPsKsPFLPtMK
T1571-p sKsPFLPtMKMQKVM
K1573 sPFLPtMKMQKVMPT
S1717 GKKDDSQSLEDDsGK
S1722-p SQSLEDDsGKEDDDA
S1755-p KIESEGKssPALAAP
S1756-p IESEGKssPALAAPD
K1780 KQASKFDKLPIKIVK
K1784 KFDKLPIKIVKKNKL
K1787 KLPIKIVKKNKLFVV
T1820 WQLGGGDTTEHIQTH
T1821 QLGGGDTTEHIQTHF
K1849-ac PPLSSTGkKKELEGK
K1865 DSEEQPEKSIIATID
S1876 ATIDDVLSARPGALP
S1894 NPGPQTDSGKFPFGI
S1948 CVSNIVRSLSFVPGN
S1950 SNIVRSLSFVPGNDA
S1960 PGNDAEMSKHPGLVL
T2018 LEVLRDNTLVTLANI
T2035 QLDLSAYTESICLPI
T2079 PQRLVLETLCKLSIQ
K2104 PPFSRQEKFYATLVR
S2149-gl AIAVQKGsIGNLISF
K2194 DMMCRAAKALLAMAR
  rat

 
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S4 ____MGRSQGSPMDP
S7 _MGRSQGSPMDPMVM
R16 MDPMVMKRPQLYGMG
R48 YGPPGAQRYPLGMQG
R56 YPLGMQGRAPGALGG
S123 YQPQQDMSQEGYGTR
S155 IQQERPSSLPDLSGS
S233 QSRSGPISPASIPGF
S236 SGPISPASIPGFMAG
- gap
- gap
- gap
- gap
- gap
- gap
S261 GPQQTGPSMSPHPSP
S263 QQTGPSMSPHPSPGG
S267 PSMSPHPSPGGQMHA
S277 GQMHAGISRFQQSNS
S282 GISRFQQSNSSGTYG
S284 SRFQQSNSSGTYGPQ
S285 RFQQSNSSGTYGPQM
S349 VPLGRMPSAGMQNRP
S367 NMRSMPPSSPGMSQQ
K393 PMPTVNRKAQEAAAA
S411 AAANSAQSRQGSFPG
V489 ADGKEEGVPQPESKS
S549 GWPKTPSSPKSSSSS
S554 PSSPKSSSSSTTGEK
S556 SPKSSSSSTTGEKIT
T558 KSSSSSTTGEKITKV
Y609 PLDLFRLYVCVKEIG
S687 QPKLQPPSPANSGSL
T699 GSLQGPQTPQSTGSS
T729 STPHGQGTPMQSGRS
S758 SAYPKRNSTTPNAPY
T760 YPKRNSTTPNAPYQQ
Y885 KRHMDGMYGPPAKRH
S1060-p NHISRAPsPASFPRS
S1067 sPASFPRSLESRMSP
S1073 RSLESRMSPSKSPFL
S1075 LESRMSPSKSPFLPA
S1077 SRMSPSKSPFLPAMK
A1082 SKSPFLPAMKMQKVM
K1084 SPFLPAMKMQKVMPT
S1228 GKKDDSQSSEDDSGK
S1233 SQSSEDDSGKEEEDA
S1270 KTESEGKSSSALAAP
S1271 TESEGKSSSALAAPD
K1295 RQASKFDKLPIKIVK
K1299 KFDKLPIKIVKKNNL
K1302 KLPIKIVKKNNLFVV
T1335-p WQLGGGDttEHILTH
T1336-p QLGGGDttEHILTHF
K1364 APLSSTGKKKELAGK
K1380 DSEEQPEKSIIATID
S1391 ATIDDVLSARPGALP
S1409 NPGPQTESGKFPFGI
S1463 CVSNIVRSLSFVPGN
S1465 SNIVRSLSFVPGNDA
S1475 PGNDAEMSKHPGLVP
T1533 LEVLRDNTLVTLANI
T1550 QLDLSAYTESICLPI
T1594 PQRLVLETLCKLSIQ
K1619 PPFSRQEKFYATLVR
S1664 AIAVQKGSIGNLIGF
K1709 DMMCRAAKALLAMAR
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