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RMP (human)

Overview RMP Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein. Homodimer. Component of the URI complex that contains PFDN2, POLR2E/RPB5, RUVBL2, RUVBL1 and URI1. Interacts with PPP1CC; the interaction is phosphorylation-dependent and occurs in a growth factor-dependent manner. Interacts with PFDN2, PFDN4 and STAP1; the interactions are phosphorylation-dependent and occurs in a growth-dependent manner in the mitochondrion. Interacts (via the middle C-terminus region) with GTF2F1 and GTF2F2. Interacts with DMAP1, POLR2E/RPB5 and UXT. Ubiquitous. Expressed in ovarian cancers. Expressed strongly in skeletal muscle. Expressed weakly in brain, heart, pancreas and in prostate epithelial cells. Belongs to the RNA polymerase II subunit 5-mediating protein family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Transcription, coactivator/corepressor Cellular Component: mitochondrion; dendrite; cytoplasm; DNA-directed RNA polymerase II, core complex; prefoldin complex; nucleus Molecular Function: protein binding; unfolded protein binding; chromatin binding; protein phosphatase inhibitor activity Biological Process: regulation of apoptosis; regulation of transcription from RNA polymerase II promoter; protein folding; response to virus; regulation of cell growth; negative regulation of transcription from RNA polymerase II promoter Reference #:  O94763 (UniProtKB) Alt. Names/Synonyms: C19orf2; chromosome 19 open reading frame 2; FLJ10575; NNX3; Protein NNX3; RMP; RNA polymerase II subunit 5-mediating protein; RNA polymerase II, subunit 5-mediating protein; RPB5-mediating protein; Unconventional prefoldin RPB5 interactor; URI Gene Symbols: URI1 Molecular weight: 59,832 Da Basal Isoelectric point: 4.92  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below RMP

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K180	AKHRIAHKPHSKPKT
0	1		K208-u	SKDLLADkELWARLE
0	1		T241-p	VIANGEDttssEEEK
0	1		T242-p	IANGEDttssEEEKE
0	1		S243-p	ANGEDttssEEEKED
0	1		S244-p	NGEDttssEEEKEDR
0	1		T354-p	RINTGKNttLKFSEK
0	1		T355-p	INTGKNttLKFSEKK
0	1		S359	KNttLKFSEKKEEAK
0	1		N371	EAKRKRKNstGsGHs
2	15		S372-p	AKRKRKNstGsGHsA
0	2		T373-p	KRKRKNstGsGHsAQ
0	4		S375-p	KRKNstGsGHsAQEL
0	1		S378-p	NstGsGHsAQELPTI
0	8		Y403-p	VDVVNGEyVPRKsIL
0	1		S408-p	GEyVPRKsILKSRSR
0	9		S418-p	KSRSRENsVCSDTSE
0	5		S440-p	DRRGVLRsIsCEEAt
0	3		I441	RRGVLRsIsCEEAtC
0	11		S442-p	RGVLRsIsCEEAtCS
0	1		T447-p	sIsCEEAtCSDTSES
0	1		S454	tCSDTSESILEEEPQ
0	1		S471-p	QKKLLPLsVtPEAFS
0	2		T473-p	KLLPLsVtPEAFSGt
0	1		T480-p	tPEAFSGtVIEKEFV
0	1		S488-p	VIEKEFVsPSLTPPP

	mouse
K178-a	GKQRIAHkPHSKPKT
D206	PKNTFDADELWARLE
R239	VIANGEDRVSsEEEK
V240	IANGEDRVSsEEEKE
S241	ANGEDRVSsEEEKEG
S242-p	NGEDRVSsEEEKEGA
T352	RINTGKNTTLKFsEK
T353	INTGKNTTLKFsEKK
S357-p	KNTTLKFsEKKEEAK
S369-p	EAKRKRKsGAGSHAT
G370	AKRKRKsGAGSHATH
A371	KRKRKsGAGSHATHE
S373	KRKsGAGSHATHELP
A375	KsGAGSHATHELPAI
Y400	VDVVNGEYVPRKSIL
S405	GEYVPRKSILKSRSR
S415	KSRSRENSVCSDTSE
S437-p	DRRGLLRstsSEEAV
T438-p	RRGLLRstsSEEAVA
S439-p	RGLLRstsSEEAVAT
V444	stsSEEAVATEAGGs
S451-p	VATEAGGsSLDELQE
G468	PKKPLPSGVsEAFSG
S470-p	KPLPSGVsEAFSGTV
T476	VsEAFSGTVIEKEFL
S484	VIEKEFLSPSLAPYS

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