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Protein Page:
RMP (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
RMP Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein. Homodimer. Component of the URI complex that contains PFDN2, POLR2E/RPB5, RUVBL2, RUVBL1 and URI1. Interacts with PPP1CC; the interaction is phosphorylation-dependent and occurs in a growth factor-dependent manner. Interacts with PFDN2, PFDN4 and STAP1; the interactions are phosphorylation-dependent and occurs in a growth-dependent manner in the mitochondrion. Interacts (via the middle C-terminus region) with GTF2F1 and GTF2F2. Interacts with DMAP1, POLR2E/RPB5 and UXT. Ubiquitous. Expressed in ovarian cancers. Expressed strongly in skeletal muscle. Expressed weakly in brain, heart, pancreas and in prostate epithelial cells. Belongs to the RNA polymerase II subunit 5-mediating protein family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 19q12
Cellular Component: mitochondrion; cytoplasm; dendrite; DNA-directed RNA polymerase II, core complex; nucleus
Molecular Function: phosphatase inhibitor activity; protein binding; chromatin binding; protein phosphatase inhibitor activity
Biological Process: regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; response to virus; negative regulation of transcription from RNA polymerase II promoter; regulation of cell growth
Reference #:  O94763 (UniProtKB)
Alt. Names/Synonyms: C19orf2; chromosome 19 open reading frame 2; FLJ10575; NNX3; Protein NNX3; RMP; RNA polymerase II subunit 5-mediating protein; RNA polymerase II, subunit 5-mediating protein; RPB5-mediating protein; Unconventional prefoldin RPB5 interactor; URI
Gene Symbols: URI1
Molecular weight: 59,832 Da
Basal Isoelectric point: 4.92  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

RMP

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K180 AKHRIAHKPHSKPKT
0 1 K208-ub SKDLLADkELWARLE
0 3 T241-p VIANGEDttssEEEK
0 3 T242-p IANGEDttssEEEKE
0 5 S243-p ANGEDttssEEEKED
0 5 S244-p NGEDttssEEEKEDR
0 1 T350-p PKRVRINtGKNttLK
0 1 T354-p RINtGKNttLKFsEK
0 1 T355-p INtGKNttLKFsEKK
0 2 S359-p KNttLKFsEKKEEAK
0 1 N371 EAKRKRKNstGsGHs
2 19 S372-p AKRKRKNstGsGHsA
0 3 T373-p KRKRKNstGsGHsAQ
0 5 S375-p KRKNstGsGHsAQEL
0 1 S378-p NstGsGHsAQELPTI
0 9 Y403-p VDVVNGEyVPRKsIL
0 3 S408-p GEyVPRKsILKsRSR
0 2 S412-p PRKsILKsRSRENsV
0 1 S414 KsILKsRSRENsVCS
0 11 S418-p KsRSRENsVCSDTSE
0 1 S421 SRENsVCSDTSESsA
0 1 S427-p CSDTSESsAAEFDDR
0 6 S440-p DRRGVLRsIsCEEAt
0 4 I441 RRGVLRsIsCEEAtC
0 20 S442-p RGVLRsIsCEEAtCs
0 1 C443 GVLRsIsCEEAtCsD
0 1 T447-p sIsCEEAtCsDTSES
0 2 S449-p sCEEAtCsDTSESIL
0 1 S454 tCsDTSESILEEEPQ
0 1 S471-p QKKLLPLsVtPEAFS
0 2 T473-p KLLPLsVtPEAFSGt
0 1 T480-p tPEAFSGtVIEKEFV
0 3 S488-p VIEKEFVsPSLtPPP
0 2 T492-p EFVsPSLtPPPAIAH
  RMP iso2  
K104 AKHRIAHKPHSKPKT
K132 SKDLLADKELWARLE
T165 VIANGEDTTSSEEEK
T166 IANGEDTTSSEEEKE
S167 ANGEDTTSSEEEKED
S168 NGEDTTSSEEEKEDR
T274 PKRVRINTGKNTTLK
T278 RINTGKNTTLKFSEK
T279 INTGKNTTLKFSEKK
S283 KNTTLKFSEKKEEAK
N295 EAKRKRKNSTGSGHS
S296 AKRKRKNSTGSGHSA
T297 KRKRKNSTGSGHSAQ
S299 KRKNSTGSGHSAQEL
S302 NSTGSGHSAQELPTI
Y327 VDVVNGEYVPRKSIL
S332 GEYVPRKSILKSRSR
S336 PRKSILKSRSRENSV
S338 KSILKSRSRENSVCS
S342 KSRSRENSVCSDTSE
S345 SRENSVCSDTSESSA
S351 CSDTSESSAAEFDDR
S364 DRRGVLRSISCEEAT
I365 RRGVLRSISCEEATC
S366 RGVLRSISCEEATCS
C367 GVLRSISCEEATCSD
T371 SISCEEATCSDTSES
S373 SCEEATCSDTSESIL
S378 TCSDTSESILEEEPQ
S395 QKKLLPLSVTPEAFS
T397 KLLPLSVTPEAFSGT
T404 TPEAFSGTVIEKEFV
S412 VIEKEFVSPSLTPPP
T416 EFVSPSLTPPPAIAH
  mouse

 
K178-ac GKQRIAHkPHSKPKT
D206 PKNTFDADELWARLE
R239 VIANGEDRVssEEEK
V240 IANGEDRVssEEEKE
S241-p ANGEDRVssEEEKEG
S242-p NGEDRVssEEEKEGA
T348 PKRVRINTGKNTTLK
T352 RINTGKNTTLKFsEK
T353 INTGKNTTLKFsEKK
S357-p KNTTLKFsEKKEEAK
S369-p EAKRKRKsGAGSHAT
G370 AKRKRKsGAGSHATH
A371 KRKRKsGAGSHATHE
S373 KRKsGAGSHATHELP
A375 KsGAGSHATHELPAI
Y400 VDVVNGEYVPRKSIL
S405 GEYVPRKSILKSRSR
S409 PRKSILKSRSRENsV
S411 KSILKSRSRENsVCs
S415-p KSRSRENsVCsDTSE
S418-p SRENsVCsDTSESSA
S424 CsDTSESSAADVEDR
S437-p DRRGLLRstssEEAV
T438-p RRGLLRstssEEAVA
S439-p RGLLRstssEEAVAt
S440-p GLLRstssEEAVAtE
V444 stssEEAVAtEAGGs
T446-p ssEEAVAtEAGGsSL
S451-p VAtEAGGsSLDELQE
G468 PKKPLPSGVsEAFSG
S470-p KPLPSGVsEAFSGTV
T476 VsEAFSGTVIEKEFL
S484 VIEKEFLSPSLAPYS
A488 EFLSPSLAPYSAIAH
  rat

 
K178 GKQRIAHKPHSKPKT
D206 PQGTFDDDELWARLE
T239 VIANGEDTVssEEEK
V240 IANGEDTVssEEEKE
S241-p ANGEDTVssEEEKED
S242-p NGEDTVssEEEKEDE
T349 PKRVRINTGKNTTLK
T353 RINTGKNTTLKFSEK
T354 INTGKNTTLKFSEKK
S358 KNTTLKFSEKKEEAK
S370 EAKRKRKSGAASHSA
G371 AKRKRKSGAASHSAH
A372 KRKRKSGAASHSAHE
S374 KRKSGAASHSAHELP
S376 KSGAASHSAHELPAI
Y401 VDVVNGEYIPRKSIL
S406 GEYIPRKSILKsRsR
S410-p PRKSILKsRsRENSV
S412-p KSILKsRsRENSVCS
S416 KsRsRENSVCSDTSE
S419 sRENSVCSDTSESSA
S425 CSDTSESSAADVDID
S439 DRRAPLRSPsSEETE
P440 RRAPLRSPsSEETEA
S441-p RAPLRSPsSEETEAG
S442 APLRSPsSEETEAGS
- gap
T445 RSPsSEETEAGSSTL
S450 EETEAGSSTLEELQE
G467 PKKPLPSGVSEAFSG
S469 KPLPSGVSEAFSGTV
T475 VSEAFSGTVIEKEFL
S483 VIEKEFLSPSLAPHS
A487 EFLSPSLAPHSAIAH
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