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Protein Page:
RMP (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
RMP Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein. Homodimer. Component of the URI complex that contains PFDN2, POLR2E/RPB5, RUVBL2, RUVBL1 and URI1. Interacts with PPP1CC; the interaction is phosphorylation-dependent and occurs in a growth factor-dependent manner. Interacts with PFDN2, PFDN4 and STAP1; the interactions are phosphorylation-dependent and occurs in a growth-dependent manner in the mitochondrion. Interacts (via the middle C-terminus region) with GTF2F1 and GTF2F2. Interacts with DMAP1, POLR2E/RPB5 and UXT. Ubiquitous. Expressed in ovarian cancers. Expressed strongly in skeletal muscle. Expressed weakly in brain, heart, pancreas and in prostate epithelial cells. Belongs to the RNA polymerase II subunit 5-mediating protein family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Cellular Component: mitochondrion; dendrite; cytoplasm; DNA-directed RNA polymerase II, core complex; prefoldin complex; nucleus
Molecular Function: protein binding; unfolded protein binding; chromatin binding; protein phosphatase inhibitor activity
Biological Process: regulation of transcription from RNA polymerase II promoter; protein folding; response to virus; negative regulation of transcription from RNA polymerase II promoter; regulation of cell growth
Reference #:  O94763 (UniProtKB)
Alt. Names/Synonyms: C19orf2; chromosome 19 open reading frame 2; FLJ10575; NNX3; Protein NNX3; RMP; RNA polymerase II subunit 5-mediating protein; RNA polymerase II, subunit 5-mediating protein; RPB5-mediating protein; Unconventional prefoldin RPB5 interactor; URI
Gene Symbols: URI1
Molecular weight: 59,832 Da
Basal Isoelectric point: 4.92  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

RMP

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K208-u SKDLLADkELWARLE
0 2 T241-p VIANGEDttssEEEK
0 2 T242-p IANGEDttssEEEKE
0 2 S243-p ANGEDttssEEEKED
0 2 S244-p NGEDttssEEEKEDR
0 1 S359 KNTTLKFSEKKEEAK
0 1 N371 EAKRKRKNstGsGHS
2 17 S372-p AKRKRKNstGsGHSA
0 3 T373-p KRKRKNstGsGHSAQ
0 4 S375-p KRKNstGsGHSAQEL
0 8 Y403-p VDVVNGEyVPRKSIL
0 9 S418-p KSRSRENsVCSDTSE
0 5 S440-p DRRGVLRsIsCEEAT
0 4 I441 RRGVLRsIsCEEATC
0 13 S442-p RGVLRsIsCEEATCS
0 2 T473-p KLLPLSVtPEAFSGT
0 1 S488-p VIEKEFVsPSLTPPP
  mouse

 
D206 PKNTFDADELWARLE
R239 VIANGEDRVSsEEEK
V240 IANGEDRVSsEEEKE
S241 ANGEDRVSsEEEKEG
S242-p NGEDRVSsEEEKEGA
S357-p KNTTLKFsEKKEEAK
S369-p EAKRKRKsGAGSHAT
G370 AKRKRKsGAGSHATH
A371 KRKRKsGAGSHATHE
S373 KRKsGAGSHATHELP
Y400 VDVVNGEYVPRKSIL
S415 KSRSRENSVCSDTSE
S437-p DRRGLLRstsSEEAV
T438-p RRGLLRstsSEEAVA
S439-p RGLLRstsSEEAVAT
S470-p KPLPSGVsEAFSGTV
S484 VIEKEFLSPSLAPYS
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