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PLA2G6
Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F- actin polymerization at the pseudopods. Defects in PLA2G6 are the cause of neurodegeneration with brain iron accumulation type 2B (NBIA2B). A neurodegenerative disorder associated with iron accumulation in the brain, primarily in the basal ganglia. It is characterized by progressive extrapyramidal dysfunction leading to rigidity, dystonia, dysarthria and sensorimotor impairment. Defects in PLA2G6 are the cause of neurodegeneration with brain iron accumulation type 2A (NBIA2A); also known as Seitelberger disease. NBIA2A is a neurodegenerative disease characterized by pathologic axonal swelling and spheroid bodies in the central nervous system. Onset is within the first 2 years of life with death by age 10 years. Defects in PLA2G6 are the cause of Parkinson disease type 14 (PARK14). An adult-onset progressive neurodegenerative disorder characterized by parkinsonism, dystonia, severe cognitive decline, cerebral and cerebellar atrophy and absent iron in the basal ganglia on magnetic resonance imaging. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: Lipid Metabolism - glycerophospholipid; Lipid Metabolism - arachidonic acid; Lipid Metabolism - ether lipid; EC 3.1.1.4; Lipid Metabolism - alpha-linolenic acid; Phospholipase; Lipid Metabolism - linoleic acid |
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Cellular Component: centrosome; membrane; cytoplasm; cytosol
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Molecular Function: calmodulin binding; phospholipase A2 activity; calcium-independent phospholipase A2 activity
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Biological Process: cardiolipin biosynthetic process; cell death; phospholipid metabolic process; glycerophospholipid biosynthetic process; chemotaxis; lipid catabolic process
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Reference #:
O60733 (UniProtKB)
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| Alt. Names/Synonyms: 85 kDa calcium-independent phospholipase A2; CaI-PLA2; calcium-independent phospholipase A2; cytosolic, calcium-independent phospholipase A2; Group VI phospholipase A2; GVI; GVI PLA2; INAD1; IPLA2; IPLA2-VIA; NBIA2A; NBIA2B; PA2G6; PARK14; patatin-like phospholipase domain containing 9; phospholipase A2, group VI (cytosolic, calcium-independent); PLA2; PLA2G6; PNPLA9 |
| Gene Symbols: PLA2G6 |
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Molecular weight: 89,903 Da
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Basal Isoelectric point: 6.86
Predict pI for various phosphorylation states
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