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Protein Page:
FANCD2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FANCD2 Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress. Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress. Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching. Interacts directly with FANCE and FANCI. Interacts with USP1 and MEN1. The ubiquitinated form specifically interacts with BRCA1 and BLM. Both the nonubiquitinated and the monoubiquitinated forms interact with BRCA2; this interaction is mediated by phosphorylated FANCG and the complex also includes XCCR3. The ubiquitinated form specifically interacts with MTMR15/FAN1 (via UBZ-type zinc finger), leading to recruit MTMR15/FAN1 to sites of DNA damage. Interacts with DCLRE1B/Apollo. Highly expressed in germinal center cells of the spleen, tonsil, and reactive lymph nodes, and in the proliferating basal layer of squamous epithelium of tonsil, esophagus, oropharynx, larynx and cervix. Expressed in cytotrophoblastic cells of the placenta and exocrine cells of the pancreas. Highly expressed in testis, where expression is restricted to maturing spermatocytes. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage
Chromosomal Location of Human Ortholog: 3p26
Cellular Component: nucleoplasm; Golgi apparatus; intracellular membrane-bound organelle; nucleolus; condensed chromosome; nucleus
Molecular Function: protein binding
Biological Process: gamete generation; synapsis; response to gamma radiation; DNA repair
Reference #:  Q9BXW9 (UniProtKB)
Alt. Names/Synonyms: DKFZp762A223; FA-D2; FA4; FACD; FACD2; FAD; FAD2; FANCD; FANCD2; Fanconi anemia group D2 protein; Fanconi anemia, complementation group D2; FLJ23826; Protein FACD2; type 4 Fanconi pancytopenia
Gene Symbols: FANCD2
Molecular weight: 166,462 Da
Basal Isoelectric point: 5.84  Predict pI for various phosphorylation states
CST Pathways:  G2/M DNA Damage Checkpoint
Select Structure to View Below

FANCD2

Protein Structure Not Found.


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Sites Implicated In
cell cycle regulation: S222‑p, T691‑p, S717‑p
activity, induced: T691‑p, S717‑p
molecular association, regulation: S331‑p
ubiquitination: S331‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S8-p MVSKRRLsKSEDKEs
0 37 S10 SKRRLsKSEDKEsLT
0 1 S15-p sKSEDKEsLTEDASK
0 1 T17 SEDKEsLTEDASKTR
0 1 K33-ub QPLSKKTkkSHIANE
0 1 K34-ub PLSKKTkkSHIANEV
0 1 K77-ub VDQIAFQkKLFQTLR
0 1 S102 EFVSGLESYIEDEDS
0 1 Y103 FVSGLESYIEDEDSF
0 1 I104 VSGLESYIEDEDSFR
0 2 K133-ub SMGASYSkSLIKLLL
0 1 K156-ub IIKTLFEkLPEYFFE
0 1 K165-ub PEYFFENkNsDEINI
0 1 S167-p YFFENkNsDEINIPR
0 1 S178-p NIPRLIVsQLkWLDR
0 1 K181-ub RLIVsQLkWLDRVVD
0 1 S201-p TKIMQLIsIAPENLQ
3 2 S222-p LPEILGDsQHADVGK
0 1 K261-ub LDPNFLLkVRQLVMD
1 1 S331-p KSKGRASsSGNQESS
0 1 Y389-p LVMLFIIySTNTQTK
0 1 Y458-p ISFGSLLyKYAFKFF
0 1 S483 ALVTHICSGNEAEVD
3 56 K561-ub DMHLVIRkQLSSTVF
0 1 S590-p GIMAADRsEsPsLtQ
0 19 S592-p MAADRsEsPsLtQER
0 1 S594-p ADRsEsPsLtQERAN
1 11 T596-p RsEsPsLtQERANLS
1 0 T608-p NLSDEQCtQVTSLLQ
0 1 Y684-p PFPVKALyGLEEYDt
1 3 T691-p yGLEEYDtQDGIAIN
1 5 S717-p KDGGPVTsQESGQKL
0 1 K878-ub KQKTDGSkTSSSDTL
0 2 S886-p TSSSDTLsEEKNSEC
0 1 T896-p KNSECDPtPSHRGQL
0 1 K913-ub EFTGKEEkTSLLLHN
0 1 S978-p DLSQKLEsMLtPPIA
0 2 T981-p QKLEsMLtPPIARRV
0 1 K1172-ac RVWPSGDkEKSNISN
0 1 K1198-ac EHTESILkAIEEIAG
0 1 K1216-ub PELINSPkDASSSTF
0 1 T1253-p VKKIEPGtAADsQQI
0 4 S1257-p EPGtAADsQQIHEEK
0 1 T1363-p HVPLLKKtLELLVCR
0 1 K1390-ub AFWLGNLkNRDLQGE
0 1 N1403 GEEIKSQNsQEstAD
1 3 S1404-p EEIKSQNsQEstADE
0 1 Q1405 EIKSQNsQEstADEs
0 2 S1407-p KSQNsQEstADEsED
0 1 T1408-p SQNsQEstADEsEDD
0 16 S1412-p QEstADEsEDDMSsQ
0 3 S1418-p EsEDDMSsQASKsKA
0 4 S1423-p MSsQASKsKATEVSL
0 2 T1426 QASKsKATEVSLQNP
0 9 S1436 SLQNPPESGTDGCIL
4945 : Phospho-FANCD2 (Ser222) Antibody
  FANCD2 iso2  
S8 MVSKRRLSKSEDKES
S10 SKRRLSKSEDKESLT
S15 SKSEDKESLTEDASK
T17 SEDKESLTEDASKTR
K33 QPLSKKTKKSHIANE
K34 PLSKKTKKSHIANEV
K77 VDQIAFQKKLFQTLR
S102 EFVSGLESYIEDEDS
Y103 FVSGLESYIEDEDSF
I104 VSGLESYIEDEDSFR
K133 SMGASYSKSLIKLLL
K156 IIKTLFEKLPEYFFE
K165 PEYFFENKNSDEINI
S167 YFFENKNSDEINIPR
S178 NIPRLIVSQLKWLDR
K181 RLIVSQLKWLDRVVD
S201 TKIMQLISIAPENLQ
S222-p LPEILGDsQHADVGK
K261 LDPNFLLKVRQLVMD
S331 KSKGRASSSGNQESS
Y389 LVMLFIIYSTNTQTK
Y458 ISFGSLLYKYAFKFF
S483 ALVTHICSGNEAEVD
K561 DMHLVIRKQLSSTVF
S590 GIMAADRSESPSLTQ
S592 MAADRSESPSLTQER
S594 ADRSESPSLTQERAN
T596 RSESPSLTQERANLS
T608 NLSDEQCTQVTSLLQ
Y684 PFPVKALYGLEEYDT
T691 YGLEEYDTQDGIAIN
S717 KDGGPVTSQESGQKL
K878 KQKTDGSKTSSSDTL
S886 TSSSDTLSEEKNSEC
T896 KNSECDPTPSHRGQL
K913 EFTGKEEKTSLLLHN
S978 DLSQKLESMLTPPIA
T981 QKLESMLTPPIARRV
K1172 RVWPSGDKEKSNISN
K1198 EHTESILKAIEEIAG
K1216 PELINSPKDASSSTF
T1253 VKKIEPGTAADSQQI
S1257 EPGTAADSQQIHEEK
T1363 HVPLLKKTLELLVCR
K1390 AFWLGNLKNRDLQGE
N1403 GEEIKSQNSQESTAD
S1404 EEIKSQNSQESTADE
Q1405 EIKSQNSQESTADES
S1407 KSQNSQESTADESED
T1408 SQNSQESTADESEDD
S1412 QESTADESEDDMSSQ
S1418 ESEDDMSSQASKsKA
S1423-p MSSQASKsKAtEDGE
T1426-p QASKsKAtEDGEEDE
S1435-p DGEEDEVsAGEKEQD
  mouse

 
L8 MISKRRRLDsEDKEN
S10-p SKRRRLDsEDKENLt
N15 LDsEDKENLtEDASK
T17-p sEDKENLtEDASKTM
K31 MPLSKLAKKSHNSHE
K32 PLSKLAKKSHNSHEV
R75 VDQVIFQRKLFQALR
S100-p EFVNGLEsytEDSES
Y101-p FVNGLEsytEDSESL
T102-p VNGLEsytEDSESLR
K131 SMGTFYSKSLIKLLL
K154 IIKMLFEKVPQFLFE
E163 PQFLFESENRDGINM
R165 FLFESENRDGINMAR
N176 NMARLIINQLKWLDR
K179 RLIINQLKWLDRIVD
S199 AQMMQLISVAPVNLQ
S220 LPEILGDSQHANVGK
K259 LDPNFLSKIRQLVMG
S329 KSKGLASSSGNQENS
Y387 VVMLLIIYSTSTQTK
Y456 ILFGSLLYKYAFKFF
S481-p ALVTHVCsGTEAEVD
K559-ub DMHLVIRkQLSSTVF
S588 GIMAEDRSVPSNSSQ
S591 AEDRSVPSNSSQRSA
S593 DRSVPSNSSQRSANV
S594 RSVPSNSSQRSANVS
T606 NVSSEQRTQVTSLLQ
Y682 PFPVKALYGLEEYST
T689 YGLEEYSTQDGIVIN
S714 KDASRATSQESSQRS
K876 KQKADSNKASCSDTL
T885 SCSDTLLTEDTSECD
A894 DTSECDMAPSGRSHV
K911 ESTGKEGKTFVSLQN
N976 DLSQKLENMLtAPFA
T979-p QKLENMLtAPFAKRI
K1170 RAWPHGEKEKNPTFN
K1196 EHTDNVLKAIEEITG
K1214 PELVSAPKDAASSTF
T1251 VKGLQAGTAADSQQV
S1255 QAGTAADSQQVHEEK
S1361 HVPLLKKSLELLVCR
K1388 AFWLGTLKNRDLQGE
S1403-p EIISQDPsssEsNAE
S1404-p IISQDPsssEsNAED
S1405-p ISQDPsssEsNAEDs
S1407-p QDPsssEsNAEDsED
N1408 DPsssEsNAEDsEDG
S1412-p sEsNAEDsEDGVTSH
S1418 DsEDGVTSHVSRNRA
N1423 VTSHVSRNRATEDGE
T1426 HVSRNRATEDGEDEA
S1434-p EDGEDEAsDEQKDQD
  rat

 
L8 MVSKRSRLDFEDKET
F10 SKRSRLDFEDKETLA
T15 LDFEDKETLAEDASK
A17 FEDKETLAEDASKIM
K33 QPLSKLAKKSCGSHE
K34 PLSKLAKKSCGSHEV
R77 VDQIIFQRKLFQALR
S102 EFVNGLESYTEDIDS
Y103 FVNGLESYTEDIDSL
T104 VNGLESYTEDIDSLR
K133 SMGTFYSKSLIKLLL
K156 IIKMLFEKVPQFLFE
E165 PQFLFESESRDGISM
R167 FLFESESRDGISMPR
S178 SMPRLIISQLKWLDR
K181 RLIISQLKWLDRIVD
S201 TQMMQLISVAPVNLQ
S222 LPEILGDSQHANVGK
E261 LDPNFLSEIRQLVMG
S331 KSKGLASSSGNQENS
Y389 VAMLLIIYGTSTQTK
C458 ILFGSLLCKYAFKFF
S483 ALVTHVCSGNEAEVD
K561 DMHLVIRKQLSSTVF
T590 GIMAEDRTMPSNSTQ
S593 AEDRTMPSNSTQRSA
S595 DRTMPSNSTQRSASV
T596 RTMPSNSTQRSASVS
T608 SVSSEQHTQVTSLLQ
Y684 PFPVKALYGLEECNT
T691 YGLEECNTQDGIVIN
S716 KDVSQVTSQESSQKS
T878 KQKADSSTASCTDTL
T887 SCTDTLLTEDTSECD
A896 DTSECDVAPSGKSQV
K913 ESTGKEGKTFVSLQN
N978 DLSQKLENRLTPSFT
T981 QKLENRLTPSFTKRV
K1172 RAWPHGDKEKNPTFN
K1198 EHTDNVLKAIEEITG
K1216 PELVNAPKDASSSTF
T1253 VKGLQAGTATDSQQV
S1257 QAGTATDSQQVHEEK
S1363 HVPLLKKSLELLVCR
K1390 AFWLGTLKNRDLQGE
S1405 EIISQHPSSPENTSE
S1406 IISQHPSSPENTSED
- gap
N1409 QHPSSPENTSEDSED
T1410 HPSSPENTSEDSEDG
S1414 PENTSEDSEDGMTSY
S1420 DSEDGMTSYVSRNRA
N1425 MTSYVSRNRAIEDGE
I1428 YVSRNRAIEDGEDEA
N1436 EDGEDEANDGQDRDS
  chicken

 
S8 MVSKRKLSKIDAAEE
I10 SKRKLSKIDAAEESS
- under review  
T19 AAEESSKTDLQSRCP
K29 QSRCPETKRSRISDK
R30 SRCPETKRSRISDKR
K79 VDQTAFQKKLRVALE
S104 EFISGLESHIKDRSQ
H105 FISGLESHIKDRSQF
I106 ISGLESHIKDRSQFK
E136 TLVHSYCESLIKLLL
K159 VVTLLLEKIPEFFFD
V168 PEFFFDVVGTFGTNF
T170 FFFDVVGTFGTNFPR
N181 NFPRLIVNQFKWLDG
K184 RLIVNQFKWLDGLLD
S204 KKLMQMLSVSPVPIQ
S225 LPEILEDSQQNEVAR
E264 LDAELLAEVRQSAMT
S334 KSQAQASSSMSQVTT
H392 LIVLLLIHSTNSKNR
Y461 VSFGSCMYKQAFAVF
S486 ALVTHVCSGNETELD
K563-ub DMHMVIRkWLSSSVP
N592 GSVALKRNEADGGLL
- gap
- gap
L598 RNEADGGLLERPELS
G610 ELSIECDGQLSTLLD
Y688 LFPVKSLYNLDEDET
T695 YNLDEDETQGAIAIN
N721 RVADEMSNSRKRVVS
K876 KRKSDSSKACSAERT
T883 KACSAERTQADESSD
T896 SDGNQPDTELSELEK
N912 ATEKETGNPLAQLQS
H977 DMCWKLEHVLTPGST
T980 WKLEHVLTPGSTRRV
R1172 WMKPGGDREKGSHFN
K1198 EHTDNILKAIEEISS
K1216 PELINSAKDGCSSTY
K1253 VKSIPAGKPSDSGEV
S1257 PAGKPSDSGEVQLEK
S1363 HVPLLKKSLEQFVYR
K1390 AFWVGVLKNRDLQGE
S1404 EEILSQASAAPEEDS
- gap
- gap
- gap
- gap
S1411 SAAPEEDSAEGSEED
S1415 EEDSAEGSEEDTADS
S1422 SEEDTADSAAEEPDG
E1425 DTADSAAEEPDGTDS
S1434 PDGTDSDSGGAGR__
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