Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
UBE2B (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
UBE2B a ubiquitin-protein ligase, a member of the ubiquitin-conjugating enzyme family. Homologous to the yeast DNA repair gene RAD6. Interacts with RAD18. Required for postreplication repair of UV-damaged DNA.. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin ligase; Ubiquitin conjugating system; EC 6.3.2.19; Ligase
Cellular Component: XY body; cytoplasm; nuclear chromatin; plasma membrane; replication fork; nucleus; chromatin
Molecular Function: protein binding; acid-amino acid ligase activity; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; ATP binding
Biological Process: ubiquitin-dependent protein catabolic process; protein monoubiquitination; response to drug; proteasomal ubiquitin-dependent protein catabolic process; protein autoubiquitination; protein polyubiquitination; protein stabilization; in utero embryonic development; postreplication repair; protein ubiquitination; Wnt receptor signaling pathway through beta-catenin; DNA repair; negative regulation of histone phosphorylation; cellular response to insulin stimulus; sperm axoneme assembly; response to hypoxia; maintenance of chromatin silencing; spermatogenesis; chiasma formation; response to DNA damage stimulus; histone H2A ubiquitination; negative regulation of apoptosis; response to UV
Reference #:  P63146 (UniProtKB)
Alt. Names/Synonyms: E2 protein; E2-17kDa; hHR6B; HR6B; RAD6 homolog B; RAD6B; UBC2; UBE2B; Ubiquitin carrier protein B; Ubiquitin-conjugating enzyme E2 B; Ubiquitin-conjugating enzyme E2-17 kDa; ubiquitin-conjugating enzyme E2B (RAD6 homolog); Ubiquitin-protein ligase B
Gene Symbols: UBE2B
Molecular weight: 17,312 Da
Basal Isoelectric point: 4.91  Predict pI for various phosphorylation states
Select Structure to View Below

UBE2B

Protein Structure Not Found.


STRING  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K66-ac FSEEYPNkPPtVRFL
0 1 T69-p EYPNkPPtVRFLSKM
0 1 S120-p LDEPNPNsPANSQAA
  mouse

 
K66 FSEEYPNKPPTVRFL
T69 EYPNKPPTVRFLSKM
S120 LDEPNPNSPANSQAA
  rat

 
K66-ac FSEEYPNkPPTVRFL
T69 EYPNkPPTVRFLSKM
S120 LDEPNPNSPANSQAA
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.