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Protein Page:
UBE2A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
UBE2A a ubiquitin-protein ligase, a member of the ubiquitin-conjugating enzyme family. Homologous to the yeast DNA repair gene RAD6. Interacts with RAD18. Required for postreplication repair of UV-damaged DNA.. Note: This description may include information from UniProtKB.
Protein type: Ligase; Ubiquitin ligase; EC 6.3.2.19; Ubiquitin conjugating system
Cellular Component: XY body; nuclear chromatin; cytosol; chromatin
Molecular Function: protein binding; acid-amino acid ligase activity; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; ATP binding
Biological Process: ubiquitin-dependent protein catabolic process; antigen processing and presentation of peptide antigen via MHC class I; protein autoubiquitination; protein polyubiquitination; maternal process involved in pregnancy; postreplication repair; in utero embryonic development; positive regulation of cell proliferation; DNA repair; histone H2A ubiquitination; response to UV
Reference #:  P49459 (UniProtKB)
Alt. Names/Synonyms: hHR6A; HR6A; RAD6 homolog A; RAD6A; UBC2; UBE2A; Ubiquitin carrier protein A; Ubiquitin-conjugating enzyme E2 A; ubiquitin-conjugating enzyme E2A (RAD6 homolog); Ubiquitin-protein ligase A
Gene Symbols: UBE2A
Molecular weight: 17,315 Da
Basal Isoelectric point: 5.06  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

UBE2A

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K66-ac FTEEYPNkPPTVRFV
0 14 K66-ub FTEEYPNkPPTVRFV
0 2 K75-ub PTVRFVSkMFHPNVY
1 1 S120-p LDEPNPNsPANSQAA
  mouse

 
K66 FTEEYPNKPPTVRFV
K66-ub FTEEYPNkPPTVRFV
K75 PTVRFVSKMFHPNVY
S120 LDEPNPNSPANSQAA
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