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MIB1 (human)

Overview MIB1 E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF- induced apoptosis. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation. Widely expressed at low level. Expressed at higher level in spinal cord, ovary, whole brain, and all specific brain regions examined. Note: This description may include information from UniProtKB. Protein type: Ubiquitin ligase; Ligase; Ubiquitin conjugating system; EC 6.3.2.19; EC 6.3.2.- Cellular Component: centrosome; nuclear membrane; intracellular membrane-bound organelle; postsynaptic density; plasma membrane; cytoplasmic vesicle Molecular Function: protein binding; zinc ion binding; ubiquitin-protein ligase activity Biological Process: blood vessel development; somitogenesis; Notch signaling pathway; negative regulation of neuron differentiation; in utero embryonic development; positive regulation of endocytosis; heart looping; neural tube formation Reference #:  Q86YT6 (UniProtKB) Alt. Names/Synonyms: DAPK-interacting protein 1; DIP-1; DIP1; DKFZp686I0769; DKFZp761M1710; E3 ubiquitin-protein ligase MIB1; FLJ90676; KIAA1323; MGC129659; MGC129660; MIB; MIB1; Mind bomb homolog 1; mindbomb homolog 1 (Drosophila); ubiquitin ligase mind bomb; ubiquitin ligase protein MIB1; Zinc finger ZZ type with ankyrin repeat domain protein 2; ZZANK2; ZZZ6 Gene Symbols: MIB1 Molecular weight: 110,136 Da Basal Isoelectric point: 6.47  Predict pI for various phosphorylation states CST Pathways:  Notch Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below MIB1

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	80		K28-u	GPDWKWGkQDGGEGH
0	2		K79-u	DSAPTGIkHDGTMCD
0	1		Y106-p	KCAECTNyDLCTVCY
0	3		Y194-p	SSPHSAAyVLWDNGA
0	1		K202-a	VLWDNGAkNLYRVGF
0	11		K202-u	VLWDNGAkNLYRVGF
0	1		K216-a	FEGMSDLkCVQDAkG
0	14		K222-u	LkCVQDAkGGSFYRD
0	1		K313-u	FNPAVLTkANIVRSG
0	4		K368-u	AMLPTLGkVGRVQQI
0	1		K399-u	YNPAAVSkVAsAGsA
0	1		S402-p	AAVSkVAsAGsAIsN
0	1		S405-p	SkVAsAGsAIsNAsG
0	2		S408-p	AsAGsAIsNAsGERL
0	1		S411-p	GsAIsNAsGERLsQL
0	13		S416-p	NAsGERLsQLLKkLF
0	41		K421-u	RLsQLLKkLFETQES
0	12		K437-u	DLNEELVkAAANGDV
0	1		K481-u	NGHVDILkLLLkQNV
0	50		K485-u	DILkLLLkQNVDVEA
0	5		K495-u	VDVEAEDkDGDRAVH
0	2		K618-u	AMRVLLSkLPRPWIV
0	2		K691-u	LLVRAGAkLDIQDKD
0	16		K726-u	QDMQDVGkVDAAWEP
0	4		K735-u	DAAWEPSkNTLIMGL
0	6		K749-u	LGTQGAEkkSAASIA
0	1		K750-u	GTQGAEkkSAASIAC
0	25		K772-u	DLSIRNKkGQSPLDL
0	28		K787-u	CPDPNLCkALAkCHK
0	4		K791-u	NLCkALAkCHKEkVS
0	4		K796-u	LAkCHKEkVSGQVGS
0	1		S805	SGQVGSRSPSMISND
0	1		K826-u	CMVCSDMkRDTLFGP
0	10		K854-u	VKKCLICkEQVQSRT
0	8		K872-u	ECVVCSDkkAAVLFQ
0	14		K873-u	CVVCSDkkAAVLFQP
0	1		K895-u	ENCANLMkkCVQCRA
0	2		K896-u	NCANLMkkCVQCRAV
0	1		K917-u	FIMCCGGkSSEDATD
0	29		K936-u	GNIPVLQkDkDNTNV
0	46		K938-u	IPVLQkDkDNTNVNA
0	22		K949-u	NVNADVQkLQQQLQD
0	1		K958-u	QQQLQDIkEQTMCPV

	mouse
K28-u	GPDWKWGkQDGGEGH
K79	DSAPTGIKHDGTMCD
Y106	KCAECTNYDLCTVCY
Y194	SSPHSAAYVLWDNGA
K202	VLWDNGAKNLYRVGF
K202	VLWDNGAKNLYRVGF
K216	FEGMSDLKCVQDAkG
K222-u	LKCVQDAkGGSFYRD
K313	FNPAVLTKANIVRSG
K368	AMLPTLGKVGRVQQI
K399	YNPAAVSKVAPAGSA
P402	AAVSKVAPAGSAIsN
S405	SKVAPAGSAIsNASG
S408-p	APAGSAIsNASGERL
S411	GSAIsNASGERLsQL
S416-p	NASGERLsQLLKkLF
K421-u	RLsQLLKkLFETQES
K437	DLNEELVKAAANGDV
K481	NGHVDILKLLLkQNV
K485-u	DILKLLLkQNVDVEA
K495	VDVEAEDKDGDRAVH
K618	AMRVLLSKLPRPWIV
K691	LLVRAGAKLDIQDKD
K726-u	QDMQDVGkVDAAWEP
K735	DAAWEPSKNTLIMGL
K749	LGTQGAEKKSAASIA
K750	GTQGAEKKSAASIAC
K772	DLSIRNKKGQSPLDL
K787	CPDPSLCKALAKCHK
K791	SLCKALAKCHKEKVS
K796	LAKCHKEKVSGQVGS
S805-p	SGQVGSRsPSMISND
K826	CMVCSDMKRDTLFGP
K854	VKKCLICKEQVQSRT
K872	ECVVCSDKKAAVLFQ
K873	CVVCSDKKAAVLFQP
K895	ENCASLMKKCVQCRA
K896	NCASLMKKCVQCRAV
K917	FITCCGGKSSEDPSD
K936-u	GNIPVLQkDkDNTNV
K938-u	IPVLQkDkDNTNVNA
K949-u	NVNADVQkLQQQLQD
K958	QQQLQDIKEQTMCPV

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