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MKK6 (human)

Overview MKK6 a dual-specificity protein kinase of the STE7 family. Activates p38 MAP kinase by phosphorylating a Thr and a Tyr residue in the activation loop. Is activated by cytokines and environmental stress in vivo. Three alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB. Protein type: Protein kinase, STE; Kinase, protein; EC 2.7.12.2; Protein kinase, dual-specificity; STE group; STE7 family Cellular Component: nucleoplasm; cytoskeleton; cytosol Molecular Function: MAP kinase kinase activity; protein serine/threonine kinase activity; protein-tyrosine kinase activity; protein kinase binding; ATP binding Biological Process: transcription, DNA-dependent; DNA damage induced protein phosphorylation; activation of MAPK activity; apoptosis; MyD88-independent toll-like receptor signaling pathway; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; signal transduction; Toll signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 1 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; muscle cell differentiation; regulation of transcription, DNA-dependent; toll-like receptor signaling pathway; innate immune response; positive regulation of muscle cell differentiation; cell cycle arrest; toll-like receptor 4 signaling pathway Reference #:  P52564 (UniProtKB) Alt. Names/Synonyms: Dual specificity mitogen-activated protein kinase kinase 6; MAP kinase kinase 6; MAP2K6; MAPK/ERK kinase 6; MAPKK 6; MAPKK6; MEK 6; MEK6; mitogen-activated protein kinase kinase 6; MKK6; MP2K6; PRKMK6; protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6); SAPKK3 Gene Symbols: MAP2K6 Molecular weight: 37,492 Da Basal Isoelectric point: 7.01  Predict pI for various phosphorylation states CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCRs Signaling to MAPK/Erk  |  Jak/Stat/IL-6 Signaling  |  Regulation of Actin Dynamics  |  Signaling Pathways Activating p38 MAPK  |  TGF-ß Signaling  |  Toll-like Receptors Pathway Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below MKK6 2Y8O - B=4-17 (human) 3AN0 - A=1-334 (human) 3ENM - A/D/C/B=45-332 (human) 3FME - A=47-334 (human) 3VN9 - A=1-334 (human)

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2Y8O 3AN0 3ENM 3FME 3VN9  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
transcription, altered: S207‑p, T211‑p enzymatic activity, induced: S207‑p, T211‑p enzymatic activity, inhibited: S207‑a, T211‑a molecular association, regulation: Y219‑p phosphorylation: S207‑a, T211‑a

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		K5-a	___MSQSkGKkRNPG
0	1		K8-a	MSQSkGKkRNPGLKI
0	2		S27-p	FEQPQTSstPPRDLD
0	10		T28-p	EQPQTSstPPRDLDS
0	3		Y64-p	MELGRGAyGVVEKMR
0	2		K82-a	SGQIMAVkRIRATVN
0	1		S201-p	KMCDFGIsGYLVDsV
1	0		S207-a	IsGYLVDsVAKtIDA
11	51		S207-p	IsGYLVDsVAKtIDA
1	0		T211-a	LVDsVAKtIDAGCKP
2	2		T211-p	LVDsVAKtIDAGCKP
1	0		Y219-p	IDAGCKPyMAPERIN
0	1		K232	INPELNQKGYSVKSD

	MKK6 iso2
-	gap
-	gap
-	gap
-	gap
Y8	MELGRGAYGVVEKMR
K26	SGQIMAVKRIRATVN
S145	KMCDFGISGYLVDsV
S151	ISGYLVDSVAKtIDA
S151-p	ISGYLVDsVAKtIDA
T155	LVDsVAKTIDAGCKP
T155-p	LVDsVAKtIDAGCKP
Y163	IDAGCKPYMAPERIN
K176	INPELNQKGYSVKSD

	mouse
K5	___MSQSKGKKRNPG
K8	MSQSKGKKRNPGLKI
S27-p	FEQPQTSstPPRDLD
T28-p	EQPQTSstPPRDLDS
Y64	VELGRGAYGVVEKMR
K82	SGQIMAVKRIRATVN
S201	KMCDFGISGYLVDsV
S207	ISGYLVDSVAKtIDA
S207-p	ISGYLVDsVAKtIDA
T211	LVDsVAKTIDAGCKP
T211-p	LVDsVAKtIDAGCKP
Y219	IDAGCKPYMAPERIN
K232-u	INPELNQkGYSVKSD

	rat
K5	___MSQSKGKKRNPG
K8	MSQSKGKKRNPGLKI
S27	FEQPQTSSTPPRDLD
T28	EQPQTSSTPPRDLDS
Y64	VELGRGAYGVVEKMR
K82	SGQIMAVKRIRATVN
S201	KMCDFGISGYLVDsV
S207	ISGYLVDSVAKTIDA
S207-p	ISGYLVDsVAKTIDA
T211	LVDsVAKTIDAGCKP
T211	LVDsVAKTIDAGCKP
Y219	IDAGCKPYMAPERIN
K232	INPELNQKGYSVKSD

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