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Protein Page:
CTBP2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CTBP2 Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Cellular Component: transcriptional repressor complex; synapse; cell junction; nucleus
Molecular Function: protein binding; transcription corepressor activity; NAD binding; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Biological Process: negative regulation of cell proliferation; transcription, DNA-dependent; white fat cell differentiation; viral genome replication; negative regulation of transcription, DNA-dependent
Reference #:  P56545 (UniProtKB)
Alt. Names/Synonyms: C-terminal binding protein 2; C-terminal-binding protein 2; CTBP2; ribeye
Gene Symbols: CTBP2
Molecular weight: 48,945 Da
Basal Isoelectric point: 6.47  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CTBP2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
1 0 K6-ac __MALVDkHkVkRQR
1 0 K8-ac MALVDkHkVkRQRLD
1 0 K10-ac LVDkHkVkRQRLDRI
0 1 - gap
0 1 - gap
0 1 - gap
0 1 - gap
0 2 - gap
0 1 - gap
0 1 - gap
0 2 - gap
0 1 - gap
0 3 - gap
0 1 - gap
0 1 R22-m2 DRICEGIrPQIMNGP
0 6 Y108-p IVRIGSGyDNVDIKA
1 0 S164-p REGTRVQsVEQIREV
0 4 K279-ub RGGLVDEkALAQALk
0 15 K286-ub kALAQALkEGRIRGA
0 1 S369-p FVTSAPWsVIDQQAI
0 1 T414-p IPGGIPVtHNLPTVA
0 2 S424-p LPTVAHPsQAPsPNQ
0 3 S428-p AHPsQAPsPNQPTKH
0 1 T433 APsPNQPTKHGDNRE
  CTBP2 iso2  
- gap
- gap
- gap
S94-p PDFTFYDsRQAVMsG
S100-p DsRQAVMsGRSPLLP
T179-p MIPQGRQtQsRAAsP
S181-p PQGRQtQsRAAsPGR
S185-p QtQsRAAsPGRYGRE
T196-p YGREQPDtRyGAEVP
Y198-p REQPDtRyGAEVPAY
Y257-p PGALNRGyGPARESI
S266-p PARESIPsKMAyETy
Y270-p SIPsKMAyETyEADL
Y273-p sKMAyETyEADLSTF
R562 LAPEPSIRPQIMNGP
Y648 IVRIGSGYDNVDIKA
S704 REGTRVQSVEQIREV
K819 RGGLVDEKALAQALK
K826 KALAQALKEGRIRGA
S909 FVTSAPWSVIDQQAI
T954 IPGGIPVTHNLPTVA
S964 LPTVAHPSQAPSPNQ
S968 AHPSQAPSPNQPTKH
T973 APSPNQPTKHGDNRE
  mouse

 
K6 __MALVDKHKVKRQR
K8 MALVDKHKVKRQRLD
K10 LVDKHKVKRQRLDRI
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
R22-m2 DRICEGIrPQIMNGP
Y108 IVRIGSGYDNVDIKA
S164 REGTRVQSVEQIREV
K279-ub RGGLVDEkALAQALk
K286-ub kALAQALkEGRIRGA
S369 FVTSAPWSVIDQQAI
T414 IPGGIPVTHNLPTVA
S424-p LPTVAHPsQAPsPNQ
S428-p AHPsQAPsPNQPtKH
T433-p APsPNQPtKHGDNRE
  rat

► Hide Isoforms
 
K6 __MALVDKHKVKRQR
K8 MALVDKHKVKRQRLD
K10 LVDKHKVKRQRLDRI
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
R22 DRICEGIRPQIMNGP
Y108 IVRIGSGYDNVDIKA
S164 REGTRVQSVEQIREV
K279 RGGLVDEKALAQALK
K286 KALAQALKEGRIRGA
S369 FVTSTPWSVIDQQAI
T414 IPGGIPVTHNLPTVA
S424 LPTVAHPSQAPSPNQ
S428 AHPSQAPSPNQPTKH
T433 APSPNQPTKHGDNRE
  CTBP2 iso2  
- gap
- gap
- gap
S86 PDFTFYDSRQAVMSG
S92 DSRQAVMSGRGSVLP
T171 TVLHGQRTHCRAPSP
C173 LHGQRTHCRAPSPGR
S177 RTHCRAPSPGRYGRE
S188 YGREQPDSRLGIEVP
L190 REQPDSRLGIEVPTY
Y251 PGSLNRGYGPTRESI
S260 PTRESIHSKLAYENY
Y264 SIHSKLAYENYEADL
Y267 SKLAYENYEADLSTF
R565 LTPEPSIRPQIMNGP
Y651 IVRIGSGYDNVDIKA
S707 REGTRVQSVEQIREV
K822 RGGLVDEKALAQALK
K829 KALAQALKEGRIRGA
S912 FVTSTPWSVIDQQAI
T957 IPGGIPVTHNLPTVA
S967 LPTVAHPSQAPSPNQ
S971 AHPSQAPSPNQPTKH
T976 APSPNQPTKHGDNRE
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