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GTF2E1 (human)

Overview GTF2E1 Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. Belongs to the TFIIE alpha subunit family. Note: This description may include information from UniProtKB. Protein type: Transcription initiation complex Cellular Component: nucleoplasm Molecular Function: protein binding; zinc ion binding; sequence-specific DNA binding Biological Process: transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; regulation of transcription, DNA-dependent; viral reproduction; virus-host interaction; RNA elongation from RNA polymerase II promoter; gene expression Reference #:  P29083 (UniProtKB) Alt. Names/Synonyms: FE; General transcription factor IIE 56 kDa subunit; General transcription factor IIE subunit 1; general transcription factor IIE, polypeptide 1, alpha 56kDa; GTF2E1; T2EA; TF2E1; TFIIE-A; TFIIE-alpha; Transcription initiation factor IIE subunit alpha Gene Symbols: GTF2E1 Molecular weight: 49,452 Da Basal Isoelectric point: 4.74  Predict pI for various phosphorylation states CST Pathways:  Protein Acetylation

Select Structure to View Below GTF2E1 1VD4 - A=113-174 (human) 2JTX - A=336-439 (human) 2RNQ - A=378-439 (human) 2RNR - A=378-439 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1VD4 2JTX 2RNQ 2RNR  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T8-p	MADPDVLtEVPAALK
0	1		K67-a	RSVLNNLkGDKFIKC
0	1		T80-p	KCRMRVEtAADGkTT
0	1		K85-a	VEtAADGkTTRHNyy
0	26		Y91-p	GkTTRHNyyFINYRT
0	2		Y92-p	kTTRHNyyFINYRTL
0	42		Y188-p	NEQIEPIyALLRETE
0	2		Y201-p	TEDVNLAyEILEPEP
0	2		Y246-p	WATKGPSyEDLyTQN
0	2		Y250-p	GPSyEDLyTQNVVIN
0	3		S268-p	QEDLHRAsLEGKSAK
0	1		T285-p	PIWLREStVQGAYGS
0	3		T332-p	LLIHEKKtssAMAGs
0	2		S333-p	LIHEKKtssAMAGsV
0	3		S334-p	IHEKKtssAMAGsVG
0	2		S339-p	tssAMAGsVGAAAPV
0	1		T347-p	VGAAAPVtAANGsDS
0	1		S352-p	PVtAANGsDSESETS
0	1		S354	tAANGsDSESETSEs
0	1		T358	GsDSESETSEsDDDs
0	1		S361-p	SESETSEsDDDsPPR
0	1		S365-p	TSEsDDDsPPRPAAV

	mouse
T8	MADPDVLTEVPAALK
K67	RSVLNNLKGDKFIKC
T80	KCRMRVETAADGKTT
K85	VETAADGKTTRHNyY
Y91-p	GKTTRHNyYFINYRT
Y92	KTTRHNyYFINYRTL
Y188-p	NEQIEPIyALLRETE
Y201	TEDVNLAYEILEPEP
Y246	WTNKGPSYEDLYTQN
Y250	GPSYEDLYTQNVVIN
S268	QDDVHRPSLEGKAAK
T285	PIWLRESTVQGAYSS
T332	LLIHEKKTSSVTAGS
S333	LIHEKKTSSVTAGSV
S334	IHEKKTSSVTAGSVG
S339	TSSVTAGSVGAAAPV
T347	VGAAAPVTAANGSDS
S352	PVTAANGSDSESETS
S354	TAANGSDSESETSES
T358	GSDSESETSESDDDS
S361	SESETSESDDDSPPR
S365	TSESDDDSPPRPAAA

	rat
-	under review
-	gap
-	gap
-	gap
-	gap
-	gap
Y74	NEQIEPIYALLRETE
Y87	TEDVNLAYEILEPEP
Y132	WTNKGPSYEDLYTQN
Y136	GPSYEDLYTQNVVIS
S154	QDDVHRTSLEGKAAK
T171	PIWLRESTVQGAYGS
T218-p	LLIHEKKtssATAGS
S219-p	LIHEKKtssATAGSV
S220-p	IHEKKtssATAGSVG
S225	tssATAGSVGAAAPV
T233	VGAAAPVTAANGSDs
S238	PVTAANGSDsESEtS
S240-p	TAANGSDsESEtSES
T244-p	GSDsESEtSESDDDS
S247	sESEtSESDDDSPPR
S251	tSESDDDSPPRPAAA

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