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Protein Page:
GTF2E1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
GTF2E1 Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. Belongs to the TFIIE alpha subunit family. Note: This description may include information from UniProtKB.
Protein type: Transcription initiation complex
Cellular Component: nucleoplasm; intermediate filament cytoskeleton; nucleolus; nucleus
Molecular Function: protein binding; sequence-specific DNA binding; metal ion binding
Biological Process: transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; viral reproduction; regulation of transcription, DNA-dependent; RNA elongation from RNA polymerase II promoter; gene expression
Reference #:  P29083 (UniProtKB)
Alt. Names/Synonyms: FE; General transcription factor IIE 56 kDa subunit; General transcription factor IIE subunit 1; general transcription factor IIE, polypeptide 1, alpha 56kDa; GTF2E1; T2EA; TF2E1; TFIIE-A; TFIIE-alpha; Transcription initiation factor IIE subunit alpha
Gene Symbols: GTF2E1
Molecular weight: 49,452 Da
Basal Isoelectric point: 4.74  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GTF2E1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T8-p MADPDVLtEVPAALK
0 1 K67-ac RSVLNNLkGDKFIKC
0 1 T80-p KCRMRVEtAADGkTT
0 1 K85-ac VEtAADGkTTRHNyy
0 27 Y91-p GkTTRHNyyFINYRT
0 2 Y92-p kTTRHNyyFINYRTL
0 41 Y188-p NEQIEPIyALLRETE
0 5 Y201-p TEDVNLAyEILEPEP
0 2 Y246-p WATKGPSyEDLyTQN
0 2 Y250-p GPSyEDLyTQNVVIN
0 4 S268-p QEDLHRAsLEGKSAK
0 1 T285-p PIWLREStVQGAYGS
0 3 T332-p LLIHEKKtssAMAGs
0 2 S333-p LIHEKKtssAMAGsV
0 3 S334-p IHEKKtssAMAGsVG
0 2 S339-p tssAMAGsVGAAAPV
0 1 T347-p VGAAAPVtAANGsDS
0 1 S352-p PVtAANGsDSESETS
0 1 S354 tAANGsDSESETSEs
0 1 T358 GsDSESETSEsDDDs
0 1 S361-p SESETSEsDDDsPPR
0 1 S365-p TSEsDDDsPPRPAAV
  mouse

 
T8 MADPDVLTEVPAALK
K67 RSVLNNLKGDKFIKC
T80 KCRMRVETAADGKTT
K85 VETAADGKTTRHNyY
Y91-p GKTTRHNyYFINYRT
Y92 KTTRHNyYFINYRTL
Y188-p NEQIEPIyALLRETE
Y201 TEDVNLAYEILEPEP
Y246 WTNKGPSYEDLYTQN
Y250 GPSYEDLYTQNVVIN
S268 QDDVHRPSLEGKAAK
T285 PIWLRESTVQGAYSS
T332 LLIHEKKTSSVTAGS
S333 LIHEKKTSSVTAGSV
S334 IHEKKTSSVTAGSVG
S339 TSSVTAGSVGAAAPV
T347 VGAAAPVTAANGSDS
S352 PVTAANGSDSESETS
S354 TAANGSDSESETSES
T358 GSDSESETSESDDDS
S361 SESETSESDDDSPPR
S365 TSESDDDSPPRPAAA
  rat

 
- gap
- gap
- gap
- gap
- gap
- gap
Y74 NEQIEPIYALLRETE
Y87 TEDVNLAYEILEPEP
Y132 WTNKGPSYEDLYTQN
Y136 GPSYEDLYTQNVVIS
S154 QDDVHRTSLEGKAAK
T171 PIWLRESTVQGAYGS
T218-p LLIHEKKtssATAGS
S219-p LIHEKKtssATAGSV
S220-p IHEKKtssATAGSVG
S225 tssATAGSVGAAAPV
T233 VGAAAPVTAANGSDs
S238 PVTAANGSDsESEtS
S240-p TAANGSDsESEtSES
T244-p GSDsESEtSESDDDS
S247 sESEtSESDDDSPPR
S251 tSESDDDSPPRPAAA
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