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Protein Page:
PKAR1B (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PKAR1B Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. The inactive holoenzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP releases the two active catalytic monomers and the regulatory dimer. Interacts with PRKX; regulates this cAMP-dependent protein kinase. Four types of regulatory chains are found: I- alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible. Belongs to the cAMP-dependent kinase regulatory chain family. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, regulatory subunit
Cellular Component: plasma membrane; cytosol; cAMP-dependent protein kinase complex
Molecular Function: cAMP-dependent protein kinase inhibitor activity; cAMP-dependent protein kinase regulator activity; cAMP binding
Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; water transport; activation of protein kinase A; signal transduction; protein amino acid phosphorylation; learning and/or memory; phospholipase C activation; energy reserve metabolic process; innate immune response; blood coagulation; regulation of insulin secretion; transmembrane transport
Reference #:  P31321 (UniProtKB)
Alt. Names/Synonyms: cAMP-dependent protein kinase type I-beta regulatory subunit; KAP1; PRKAR1; PRKAR1B; protein kinase, cAMP-dependent, regulatory, type I, beta
Gene Symbols: PRKAR1B
Molecular weight: 43,073 Da
Basal Isoelectric point: 5.53  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  AMPK Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Hedgehog Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  Parkinson's Disease
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PKAR1B

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S3-p _____MAsPPACPsE
0 3 S9-p AsPPACPsEEDESLK
0 11 S71-p QILARQKsNsQsDsH
0 6 S73-p LARQKsNsQsDsHDE
0 7 S75-p RQKsNsQsDsHDEEV
0 14 S77-p KsNsQsDsHDEEVsP
0 16 S83-p DsHDEEVsPtPPNPV
0 4 T85-p HDEEVsPtPPNPVVK
0 1 K92 tPPNPVVKARRRRGG
0 1 R97 VVKARRRRGGVSAEV
0 1 K134 ALAKAISKNVLFAHL
0 1 K218 RAATVKAKTDLKLWG
0 2 K222 VKAKTDLKLWGIDRD
0 4 K244-ub GSTLRKRkMYEEFLS
0 1 K252 MYEEFLSKVSILESL
0 27 K261-ub SILESLEkWERLTVA
0 117 Y312-p RRSPNEEyVEVGRLG
0 2 T338-p LNRPRAAtVVARGPL
0 5 K346-ub VVARGPLkCVkLDRP
0 40 K349-ub RGPLkCVkLDRPRFE
  mouse

 
S3 _____MASPSCFHsE
S9-p ASPSCFHsEDEDSLK
S71-p QILARQKsNsQCDsH
S73-p LARQKsNsQCDsHDE
C75 RQKsNsQCDsHDEEI
S77-p KsNsQCDsHDEEIsP
S83-p DsHDEEIsPtPPNPV
T85-p HDEEIsPtPPNPVVk
K92-ub tPPNPVVkARRRrGG
R97-m1 VVkARRRrGGVSAEV
K134-ac ALAKAISkNVLFSHL
K218-ub RAATVKAkTDLkLWG
K222-ub VKAkTDLkLWGIDRD
K244-ub GSTLRKRkMYEEFLS
K252-ub MYEEFLSkVSILESL
K261-ub SILESLEkWERLTVA
Y312-p RRSPNEEyVEVGRLG
T338-p LNRPRAAtVVARGPL
K346-ub VVARGPLkCVkLDRP
K349-ub RGPLkCVkLDRPRFE
  rat

 
S3 _____MASPSCFHSE
S9 ASPSCFHSEDEDSLK
S71 QILARQKSNSQCDSH
S73 LARQKSNSQCDSHDE
C75 RQKSNSQCDSHDEEI
S77 KSNSQCDSHDEEISP
S83 DSHDEEISPTPPNPV
T85 HDEEISPTPPNPVVK
K92 TPPNPVVKARRRRGG
R97 VVKARRRRGGVSAEV
K134 ALAKAISKNVLFSHL
K218 RAATVKAKTDLKLWG
K222 VKAKTDLKLWGIDRD
K244 GSTLRKRKMYEEFLS
K252 MYEEFLSKVSILESL
K261-ub SILESLEkWERLTVA
Y312-p RRSPNEEyVEVGRLG
T338 LNRPRAATVVARGPL
K346 VVARGPLKCVkLDRP
K349-ub RGPLKCVkLDRPRFE
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