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PKAR1B (human)

Overview PKAR1B Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. The inactive holoenzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP releases the two active catalytic monomers and the regulatory dimer. Interacts with PRKX; regulates this cAMP-dependent protein kinase. Four types of regulatory chains are found: I- alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible. Belongs to the cAMP-dependent kinase regulatory chain family. Note: This description may include information from UniProtKB. Protein type: Protein kinase, regulatory subunit Cellular Component: cytosol; cAMP-dependent protein kinase complex Molecular Function: cAMP-dependent protein kinase regulator activity; cAMP binding Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; water transport; activation of protein kinase A; signal transduction; protein amino acid phosphorylation; learning and/or memory; phospholipase C activation; energy reserve metabolic process; blood coagulation; regulation of insulin secretion; transmembrane transport Reference #:  P31321 (UniProtKB) Alt. Names/Synonyms: cAMP-dependent protein kinase type I-beta regulatory subunit; KAP1; PRKAR1; PRKAR1B; protein kinase, cAMP-dependent, regulatory, type I, beta Gene Symbols: PRKAR1B Molecular weight: 43,073 Da Basal Isoelectric point: 5.53  Predict pI for various phosphorylation states CST Pathways:  AMPK Signaling  |  GPCRs Signaling to MAPK/Erk  |  Hedgehog Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  MAPK/Erk in Growth and Differentiation  |  Mitochondrial Control of Apoptosis  |  Parkinson's Disease  |  Regulation of Actin Dynamics  |  Regulation of Microtubule Dynamics Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PKAR1B 4DIN - B=1-381 (human) 4F9K - A/D/C/B=11-73 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 4DIN 4F9K  |  DISEASE  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S3-p	_____MAsPPACPsE
0	3		S9-p	AsPPACPsEEDESLK
0	9		S71-p	QILARQKsNsQsDsH
0	6		S73-p	LARQKsNsQsDsHDE
0	5		S75-p	RQKsNsQsDsHDEEV
0	12		S77-p	KsNsQsDsHDEEVsP
0	11		S83-p	DsHDEEVsPtPPNPV
0	3		T85-p	HDEEVsPtPPNPVVK
0	1		K92	tPPNPVVKARRRRGG
0	1		K134	ALAKAISKNVLFAHL
0	1		K218	RAATVKAKTDLKLWG
0	2		K222	VKAKTDLKLWGIDRD
0	4		K244-u	GSTLRKRkMYEEFLS
0	1		K252	MYEEFLSKVSILESL
0	27		K261-u	SILESLEkWERLTVA
0	121		Y312-p	RRSPNEEyVEVGRLG
0	2		T338-p	LNRPRAAtVVARGPL
0	5		K346-u	VVARGPLkCVkLDRP
0	40		K349-u	RGPLkCVkLDRPRFE

	mouse
S3	_____MASPSCFHsE
S9-p	ASPSCFHsEDEDSLK
S71-p	QILARQKsNsQCDsH
S73-p	LARQKsNsQCDsHDE
C75	RQKsNsQCDsHDEEI
S77-p	KsNsQCDsHDEEIsP
S83-p	DsHDEEIsPtPPNPV
T85-p	HDEEIsPtPPNPVVk
K92-u	tPPNPVVkARRRRGG
K134-a	ALAKAISkNVLFSHL
K218-u	RAATVKAkTDLkLWG
K222-u	VKAkTDLkLWGIDRD
K244-u	GSTLRKRkMYEEFLS
K252-u	MYEEFLSkVSILESL
K261-u	SILESLEkWERLTVA
Y312-p	RRSPNEEyVEVGRLG
T338-p	LNRPRAAtVVARGPL
K346-u	VVARGPLkCVkLDRP
K349-u	RGPLkCVkLDRPRFE

	rat
S3	_____MASPSCFHSE
S9	ASPSCFHSEDEDSLK
S71	QILARQKSNSQCDSH
S73	LARQKSNSQCDSHDE
C75	RQKSNSQCDSHDEEI
S77	KSNSQCDSHDEEISP
S83	DSHDEEISPTPPNPV
T85	HDEEISPTPPNPVVK
K92	TPPNPVVKARRRRGG
K134	ALAKAISKNVLFSHL
K218	RAATVKAKTDLKLWG
K222	VKAKTDLKLWGIDRD
K244	GSTLRKRKMYEEFLS
K252	MYEEFLSKVSILESL
K261-u	SILESLEkWERLTVA
Y312-p	RRSPNEEyVEVGRLG
T338	LNRPRAATVVARGPL
K346	VVARGPLKCVkLDRP
K349-u	RGPLKCVkLDRPRFE

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