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Protein Page:
p90RSK (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
p90RSK an AGC kinase of the RSK family. Phosphorylated and activated by Erk1 and -2 in response to many growth factors, polypeptide hormones and neurotransmitters. Several phosphorylation sites are important for its activation. Possesses two kinase domains connected by a regulator linker region. Phosphorylates a wide range of substrates including ribosomal protein S6. Prominently expressed in brain structures essential for cognitive function and learning. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, AGC; Translation; AGC group; RSK family; RSK subfamily
Cellular Component: nucleoplasm; cytoplasm; spindle; cytosol; nucleus
Molecular Function: protein serine/threonine kinase activity; protein binding; caspase inhibitor activity; magnesium ion binding; protein serine/threonine/tyrosine kinase activity; ATP binding
Biological Process: regulation of transcription in response to stress; axon guidance; nerve growth factor receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; regulation of translation in response to stress; stress-activated MAPK cascade; negative regulation of caspase activity; toll-like receptor 3 signaling pathway; signal transduction; cell cycle; positive regulation of cell growth; protein amino acid phosphorylation; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor 5 signaling pathway; synaptic transmission; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; positive regulation of cell differentiation; toll-like receptor 4 signaling pathway; negative regulation of apoptosis
Reference #:  Q15418 (UniProtKB)
Alt. Names/Synonyms: 90 kDa ribosomal protein S6 kinase 1; dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1); HU-1; KS6A1; MAP kinase-activated protein kinase 1a; MAPK-activated protein kinase 1a; MAPKAP kinase 1a; MAPKAPK-1a; MAPKAPK1A; p90-RSK 1; p90RSK1; p90S6K; ribosomal protein S6 kinase alpha 1; Ribosomal protein S6 kinase alpha-1; ribosomal protein S6 kinase, 90kDa, polypeptide 1; Ribosomal S6 kinase 1; RPS6KA1; RSK; RSK-1; RSK1; S6K-alpha 1; S6K-alpha-1
Gene Symbols: RPS6KA1
Molecular weight: 82,723 Da
Basal Isoelectric point: 7.68  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  G2/M DNA Damage Checkpoint  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Inhibition of Apoptosis  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  mTOR Signaling  |  NF-kB Signaling  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

p90RSK

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
enzymatic activity, induced: T359‑p, S363‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 12 - gap
0 1 - gap
0 2 - gap
0 2 S45-p EGVLKEIsITHHVKA
0 1 S54-p THHVKAGsEKADPSH
0 1 K66-ub PSHFELLkVLGQGSF
0 1 K75-ac LGQGSFGkVFLVRKV
0 2 K75-ub LGQGSFGkVFLVRKV
0 1 Y91-p RPDSGHLyAMKVLKK
2 0 S154 GDLFTRLSKEVMFTE
0 2 R186 HSLGIIYRDLKPENI
0 1 S209-p KLTDFGLsKEAIDHE
0 35 Y220-p IDHEKKAysFCGtVE
9 96 S221-p DHEKKAysFCGtVEy
0 51 T225-p KAysFCGtVEyMAPE
0 5 Y228-p sFCGtVEyMAPEVVN
0 1 K278-ub MTLILKAkLGMPQFL
0 1 S307-p NPANRLGsGPDGAEE
0 1 K316-ub PDGAEEIkRHVFYST
35 17 T359-p DTEFTSRtPKDsPGI
36 25 S363-p TSRtPKDsPGIPPsA
0 12 S369-p DsPGIPPsAGAHQLF
46 84 S380-p HQLFRGFsFVATGLM
0 1 S402-p APQAPLHsVVQQLHG
0 4 Y466-p EIEILLRyGQHPNII
0 1 T522-p VLHTIGKtVEYLHSQ
0 3 K562 ICDFGFAKQLRAENG
13 176 T573-p AENGLLMtPCytANF
0 83 Y576-p GLLMtPCytANFVAP
0 26 T577-p LLMtPCytANFVAPE
0 1 S637-p GSGKFTLsGGNWNTV
0 1 T676 VLQHPWVTQKDKLPQ
0 1 S684-p QKDKLPQsQLSHQDL
0 1 T701-p VKGAMAAtysALNSS
0 2 Y702-p KGAMAAtysALNSSK
0 1 S703-p GAMAAtysALNSSKP
3 23 S732-p RRVRKLPsttL____
0 12 T733-p RVRKLPsttL_____
0 1 T734-p VRKLPsttL______
8753 : Phospho-p90RSK (Thr359) (D1E9) Rabbit mAb
9344 : Phospho-p90RSK (Thr359/Ser363) Antibody
8753 : Phospho-p90RSK (Thr359) (D1E9) Rabbit mAb
9344 : Phospho-p90RSK (Thr359/Ser363) Antibody
9335 : Phospho-p90RSK (Ser380) (9D9) Rabbit mAb
9341 : Phospho-p90RSK (Ser380) Antibody
11989 : Phospho-p90RSK (Ser380) (D3H11) Rabbit mAb
12032 : Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb
13397 : Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb (PE Conjugate)
13575 : Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
13588 : Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
9346 : Phospho-p90RSK (Thr573) Antibody
  p90RSK iso2  
S28-p RKQRPRIsQtsLPVP
T30-p QRPRIsQtsLPVPGP
S31-p RPRIsQtsLPVPGPG
S54 EGVLKEISITHHVKA
S63 THHVKAGSEKADPSH
K75 PSHFELLKVLGQGSF
K84 LGQGSFGKVFLVRKV
K84 LGQGSFGKVFLVRKV
Y100 RPDSGHLYAMKVLKK
S163 GDLFTRLSKEVMFTE
R195 HSLGIIYRDLKPENI
S218 KLTDFGLSKEAIDHE
Y229 IDHEKKAYSFCGTVE
S230 DHEKKAYSFCGTVEY
T234 KAYSFCGTVEYMAPE
Y237 SFCGTVEYMAPEVVN
K287 MTLILKAKLGMPQFL
S316 NPANRLGSGPDGAEE
K325 PDGAEEIKRHVFYST
T368 DTEFTSRTPKDSPGI
S372 TSRTPKDSPGIPPSA
S378 DSPGIPPSAGAHQLF
S389 HQLFRGFSFVATGLM
S411 APQAPLHSVVQQLHG
Y475 EIEILLRYGQHPNII
T531 VLHTIGKTVEYLHSQ
K571 ICDFGFAKQLRAENG
T582 AENGLLMTPCYTANF
Y585 GLLMTPCYTANFVAP
T586 LLMTPCYTANFVAPE
S646 GSGKFTLSGGNWNTV
T685 VLQHPWVTQKDKLPQ
S693 QKDKLPQSQLSHQDL
T710 VKGAMAATYSALNSS
Y711 KGAMAATYSALNSSK
S712 GAMAATYSALNSSKP
S741 RRVRKLPSTTL____
T742 RVRKLPSTTL_____
T743 VRKLPSTTL______
  mouse

► Hide Isoforms
 
- gap
- gap
- gap
S45 EAILKEISITHHVKA
S54 THHVKAGSEKADPSQ
K66 PSQFELLKVLGQGSF
K75 LGQGSFGKVFLVRKV
K75-ub LGQGSFGkVFLVRKV
Y91 RPDSGHLYAMKVLKK
S154 GDLFTRLSKEVMFTE
R186-m1 HSLGIIYrDLKPENI
S209 KLTDFGLSKEAIDHE
Y220-p IDHEKKAysFCGtVE
S221-p DHEKKAysFCGtVEy
T225-p KAysFCGtVEyMAPE
Y228-p sFCGtVEyMAPEVVN
K267 MTLILKAKLGMPQFL
S296 NPANRLGSGPDGAEE
K305 PDGAEEIKRHIFYST
T348-p DTEFTSRtPRDsPGI
S352-p TSRtPRDsPGIPPsA
S358-p DsPGIPPsAGAHQLF
S369-p HQLFRGFsFVATGLM
S391 TTQAPLHSVVQQLHG
Y455 EIEILLRYGQHPNII
T511 VLHTISKTVEYLHSQ
K551-ub ICDFGFAkQLRAENG
T562-p AENGLLMtPCYTANF
Y565 GLLMtPCYTANFVAP
T566 LLMtPCYTANFVAPE
S626 GSGKFTLSGGNWNTV
T665-p VLQHPWItQKDKLPQ
S673 QKDKLPQSQLSHQDL
T690 VKGAMAATYSALNSS
Y691 KGAMAATYSALNSSK
S692 GAMAATYSALNSSKP
S721-p RRVRKLPstTL____
T722-p RVRKLPstTL_____
T723 VRKLPstTL______
9344 : Phospho-p90RSK (Thr359/Ser363) Antibody
9344 : Phospho-p90RSK (Thr359/Ser363) Antibody
9335 : Phospho-p90RSK (Ser380) (9D9) Rabbit mAb
9341 : Phospho-p90RSK (Ser380) Antibody
11989 : Phospho-p90RSK (Ser380) (D3H11) Rabbit mAb
12032 : Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb
13397 : Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb (PE Conjugate)
13575 : Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
13588 : Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
9346 : Phospho-p90RSK (Thr573) Antibody
  p90RSK iso3  
S28 GKQRSRISQTLPGPG
T30 QRSRISQTLPGPGPG
L31 RSRISQTLPGPGPGP
S51 EAILKEISITHHVKA
S60 THHVKAGSEKADPSQ
K72 PSQFELLKVLGQGSF
K81 LGQGSFGKVFLVRKV
K81 LGQGSFGKVFLVRKV
Y97 RPDSGHLYAMKVLKK
S160 GDLFTRLSKEVMFTE
R192 HSLGIIYRDLKPENI
S215 KLTDFGLSKEAIDHE
Y226 IDHEKKAYSFCGT__
S227 DHEKKAYSFCGT___
T231 KAYSFCGT_______
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  rat

 
- gap
- gap
- gap
S45 EGILKEISITHHVKA
S54 THHVKAGSEKADPSH
K66 PSHFELLKVLGQGSF
K75 LGQGSFGKVFLVRKV
K75 LGQGSFGKVFLVRKV
Y91 RPDNGHLYAMKVLKK
S154-p GDLFTRLsKEVMFTE
R186 HSLGIIYRDLKPENI
S209 KLTDFGLSKEAIDHE
Y220 IDHEKKAYsFCGTVE
S221-p DHEKKAYsFCGTVEY
T225 KAYsFCGTVEYMAPE
Y228 sFCGTVEYMAPEVVN
K278 MTLILKAKLGMPQFL
S307 NPANRLGSGPDGAEE
K316 PDGAEEIKRHIFYST
T359-p DTEFTSRtPRDsPGI
S363-p TSRtPRDsPGIPPSA
S369 DsPGIPPSAGAHQLF
S380-p HQLFRGFsFVATGLM
S402 ATQAPLHSVVQQLHG
Y466 EIEILLRYGQHPNII
T522 VLYTISKTVEYLHSQ
K562 ICDFGFAKQLRAENG
T573-p AENGLLMtPCYTANF
Y576 GLLMtPCYTANFVAP
T577 LLMtPCYTANFVAPE
S637 SSGKFTLSGGNWNTV
T676 VLQHPWITQKDKLPQ
S684 QKDKLPQSQLSHQDL
T701 VKGGMAATYSALSSS
Y702 KGGMAATYSALSSSK
S703 GGMAATYSALSSSKP
S732-p RRVRKLPsTTL____
T733 RVRKLPsTTL_____
T734 VRKLPsTTL______
9344 : Phospho-p90RSK (Thr359/Ser363) Antibody
9344 : Phospho-p90RSK (Thr359/Ser363) Antibody
9335 : Phospho-p90RSK (Ser380) (9D9) Rabbit mAb
9341 : Phospho-p90RSK (Ser380) Antibody
11989 : Phospho-p90RSK (Ser380) (D3H11) Rabbit mAb
12032 : Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb
13397 : Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb (PE Conjugate)
13575 : Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
13588 : Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
9346 : Phospho-p90RSK (Thr573) Antibody
  chicken

 
- gap
- gap
- gap
N63 EGVVKEINITHHVKE
S72 THHVKEGSEKADPSQ
K84 PSQFELLKVLGQGSF
K93 LGQGSFGKVFLVRKI
K93 LGQGSFGKVFLVRKI
Y109 PPDSNHLYAMKVLKK
S172 GDLFTRLSKEVMFTE
R204 HSLGIIYRDLKPENI
S227 KLTDFGLSKEAIDHE
Y238 IDHEKKAYSFCGTVE
S239 DHEKKAYSFCGTVEY
T243 KAYSFCGTVEYMAPE
Y246 SFCGTVEYMAPEVVN
K296 MTLILKAKLGMPQFL
S325 NPANRLGSGPDGAEE
K334 PDGAEEIKRHPFYST
T377 DTEFTSRTPKDsPGI
S381-p TSRTPKDsPGIPPSA
S387 DsPGIPPSAGAHQLF
S398-p HQLFRGFsFVATGLM
S419 PAQPPLHSVVQQLHG
Y483 EIEILLRYGQHPNII
T539 VLHTICKTVEYLHSQ
K579 ICDFGFAKQLRAENG
T590 AENGLLMTPCYTANF
Y593 GLLMTPCYTANFVAP
T594 LLMTPCYTANFVAPE
N654 GGGKFSVNGGNWDTI
T693 VLQHPWITQKDSLPQ
S701 QKDSLPQSQLNYQDV
T718 VKGAMAATYSALNSS
Y719 KGAMAATYSALNSSK
S720 GAMAATYSALNSSKP
S749 RRVKKLPSTTL____
T750 RVKKLPSTTL_____
T751 VKKLPSTTL______
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