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CaMK4 (human)

Overview CaMK4 a protein kinase of the CAMK1 family. Implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. Two alternatively sliced isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.17; CAMK group; CAMK1 family Cellular Component: nucleoplasm; nucleolus; cytosol; nucleus Molecular Function: calmodulin binding; calmodulin-dependent protein kinase activity; ATP binding Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; positive regulation of transcription, DNA-dependent; regulation of T cell differentiation in the thymus; myeloid dendritic cell differentiation; nucleocytoplasmic transport; signal transduction; protein amino acid phosphorylation; positive regulation of protein export from nucleus; synaptic transmission; regulation of osteoclast differentiation; long-term memory; phospholipase C activation; nerve-nerve synaptic transmission; inflammatory response; myeloid dendritic cell cytokine production Reference #:  Q16566 (UniProtKB) Alt. Names/Synonyms: brain Ca(2+)-calmodulin-dependent protein kinase type IV; brain Ca++-calmodulin-dependent protein kinase type IV; calcium/calmodulin-dependent protein kinase IV; Calcium/calmodulin-dependent protein kinase type IV; calcium/calmodulin-dependent protein kinase type IV catalytic chain; CAM kinase IV; CAM kinase- GR; CaM kinase-GR; CaMK IV; CaMK-GR; CAMK4; KCC4; MGC36771 Gene Symbols: CAMK4 Molecular weight: 51,926 Da Basal Isoelectric point: 5.6  Predict pI for various phosphorylation states CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCRs Signaling to MAPK/Erk  |  Regulation of Microtubule Dynamics  |  T Cell Receptor Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CaMK4 2W4O - A=15-340 (human) Substrate Sequence Logo

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	Sites Implicated In
transcription, altered: S12‑p, S13‑p, T200‑p enzymatic activity, induced: T200‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T5	___MLKVTVPSCSAs
1	1		S8	MLKVTVPSCSAssCS
1	2		A11	VTVPSCSAssCSSVT
1	2		S12-p	TVPSCSAssCSSVTA
1	0		S13-p	VPSCSAssCSSVTAS
1	0		S15	SCSAssCSSVTASAA
0	2		Y32-p	TASLVPDyWIDGSNR
1	0		T57-g	SELGRGAtsIVYRCK
1	0		S58-g	ELGRGAtsIVYRCKQ
0	3		K70	CKQKGTQKPYALKVL
0	1		K75	TQKPYALKVLKKTVD
0	3		K133	LFDRIVEKGYYsERD
1	0		S137-g	IVEKGYYsERDAADA
0	2		K166	GIVHRDLKPENLLyA
0	5		Y172-p	LKPENLLyATPAPDA
0	4		K182	PAPDAPLKIADFGLs
1	0		S189-g	KIADFGLskIVEHQV
0	1		K190-a	IADFGLskIVEHQVL
0	1		K190	IADFGLsKIVEHQVL
0	1		K199	VEHQVLMKtVCGTPG
10	12		T200-p	EHQVLMKtVCGTPGY
1	0		T204	LMKtVCGTPGYCAPE
0	1		K286	KLIVLDPKKRLTTFQ
0	1		K287	LIVLDPKKRLTTFQA
0	2		K303	QHPWVTGKAANFVHM
0	5		K331	RKLKAAVKAVVASSR
1	0		S336	AVKAVVASSRLGsAs
1	0		S337	VKAVVASSRLGsAss
1	2		S341-p	VASSRLGsAsssHGS
0	1		S343-p	SSRLGsAsssHGSIQ
1	0		S344-g	SRLGsAsssHGSIQE
0	1		S344-p	SRLGsAsssHGSIQE
1	0		S345	RLGsAssSHGSIQES
1	0		S345-g	RLGsAsssHGSIQES
1	0		S356-g	IQESHKAsRDPsPIQ
0	1		S356-p	IQESHKAsRDPsPIQ
1	0		R357	QESHKAsRDPsPIQD
0	4		S360-p	HKAsRDPsPIQDGNE
0	3		-	gap
1	0		A437	LELEEGLAEEKLKTV
0	2		T443	LAEEKLKTVEEAAAP
0	1		-	gap

	mouse
T5-g	___MLKVtVPsCPsS
S8-p	MLKVtVPsCPsSPCS
S11-p	VtVPsCPsSPCSSVT
S12	tVPsCPsSPCSSVTA
P13	VPsCPsSPCSSVTAS
S15	sCPsSPCSSVTASTE
Y28	TENLVPDYWIDGSNR
T53	SELGRGATSIVYRCK
S54	ELGRGATSIVYRCKQ
K66	CKQKGTQKPYALkVL
K71-u	TQKPYALkVLKKTVD
K129-u	LFDRIVEkGYYSERD
S133	IVEkGYYSERDARDA
K162	GIVHRDLKPENLLYA
Y168	LKPENLLYATPAPDA
K178-u	PAPDAPLkIADFGLS
S185	kIADFGLSkIVEHQV
K186	IADFGLSKIVEHQVL
K186-u	IADFGLSkIVEHQVL
K195	VEHQVLMKtVCGTPG
T196-p	EHQVLMKtVCGTPGY
T200	LMKtVCGTPGYCAPE
K282	KLIVLDPKKRLTTFQ
K283	LIVLDPKKRLTTFQA
K299	QHPWVTGKAANFVHM
K327-u	RKLKAAVkAVVASSR
S332	AVkAVVASSRLGSAS
S333	VkAVVASSRLGSASS
S337	VASSRLGSASSSHTS
S339	SSRLGSASSSHTSIQ
S340	SRLGSASSSHTSIQE
S340	SRLGSASSSHTSIQE
S341	RLGSASSSHTSIQEN
S341	RLGSASSSHTSIQEN
S352	IQENHKASSDPPSTQ
S352	IQENHKASSDPPSTQ
S353	QENHKASSDPPSTQD
P356	HKASSDPPSTQDAKD
K370-a	DSTDLLGkKMQEEDQ
S433	DPEMKRDSEEKLKsV
S439-p	DSEEKLKsVEEEMDP
T448-p	EEEMDPMtEEEAPDA

	rat
T5	___MLKVTVPsCPss
S8-p	MLKVTVPsCPssPCs
S11-p	VTVPsCPssPCsSVT
S12-p	TVPsCPssPCsSVTS
P13	VPsCPssPCsSVTSS
S15-p	sCPssPCsSVTSSTE
Y28	TENLVPDYWIDGSKR
T53	SELGRGATSIVYRCK
S54	ELGRGATSIVYRCKQ
K66-u	CKQKGTQkPYALKVL
K71	TQkPYALKVLKKTVD
K129-u	LFDRIVEkGYYSERD
S133	IVEkGYYSERDAADA
K162-u	GIVHRDLkPENLLyA
Y168-p	LkPENLLyATPAPDA
K178-u	PAPDAPLkIADFGLS
S185	kIADFGLSKIVEHQV
K186	IADFGLSKIVEHQVL
K186	IADFGLSKIVEHQVL
K195-u	VEHQVLMktVCGtPG
T196-p	EHQVLMktVCGtPGY
T200-p	LMktVCGtPGYCAPE
K282-u	KLIVLDPkkRLTTFQ
K283-u	LIVLDPkkRLTTFQA
K299-u	QHPWVTGkAANFVHM
K327-u	RKLKAAVkAVVAssR
S332-p	AVkAVVAssRLGsAS
S333-p	VkAVVAssRLGsASS
S337-p	VAssRLGsASSsHTN
S339	ssRLGsASSsHTNIQ
S340	sRLGsASSsHTNIQE
S340	sRLGsASSsHTNIQE
S341-p	RLGsASSsHTNIQES
S341	RLGsASSSHTNIQES
S352	IQESNKASsEAQPAQ
S352	IQESNKASsEAQPAQ
S353-p	QESNKASsEAQPAQD
Q356	NKASsEAQPAQDGKD
-	gap
S437-p	DQEMKRNsEETLKSV
S443	NsEETLKSVEEEMDP
A452	EEEMDPKAEEEAAAV

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