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Protein Page:
CaMK4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CaMK4 a protein kinase of the CAMK1 family. Implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. Two alternatively sliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, CAMK; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.17; CAMK group; CAMK1 family
Cellular Component: nucleoplasm; nucleolus; nucleus; cytosol
Molecular Function: calmodulin binding; calmodulin-dependent protein kinase activity; ATP binding
Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; positive regulation of transcription, DNA-dependent; regulation of T cell differentiation in the thymus; nucleocytoplasmic transport; myeloid dendritic cell differentiation; signal transduction; protein amino acid phosphorylation; positive regulation of protein export from nucleus; synaptic transmission; regulation of osteoclast differentiation; long-term memory; phospholipase C activation; innate immune response; nerve-nerve synaptic transmission; inflammatory response; myeloid dendritic cell cytokine production
Reference #:  Q16566 (UniProtKB)
Alt. Names/Synonyms: brain Ca(2+)-calmodulin-dependent protein kinase type IV; brain Ca++-calmodulin-dependent protein kinase type IV; calcium/calmodulin-dependent protein kinase IV; Calcium/calmodulin-dependent protein kinase type IV; calcium/calmodulin-dependent protein kinase type IV catalytic chain; CAM kinase IV; CAM kinase- GR; CaM kinase-GR; CaMK IV; CaMK-GR; CAMK4; KCC4; MGC36771
Gene Symbols: CAMK4
Molecular weight: 51,926 Da
Basal Isoelectric point: 5.6  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  Microtubule Dynamics  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CaMK4

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
transcription, altered: S12‑p, S13‑p, T200‑p
transcription, induced: T200‑p
enzymatic activity, induced: T200‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T5 ___MLKVTVPSCSAs
1 1 S8 MLKVTVPSCSAssCS
1 1 A11 VTVPSCSAssCSSVT
1 1 S12-p TVPSCSAssCSSVTA
1 0 S13-p VPSCSAssCSSVTAS
1 0 S15 SCSAssCSSVTASAA
0 2 Y32-p TASLVPDyWIDGSNR
1 0 T57-gl SELGRGAtsIVYRCK
1 0 S58-gl ELGRGAtsIVYRCKQ
0 3 K70 CKQKGTQKPYALKVL
0 1 K75 TQKPYALKVLKKTVD
0 3 K133 LFDRIVEKGYYsERD
1 0 S137-gl IVEKGYYsERDAADA
0 2 K166 GIVHRDLKPENLLYA
0 5 Y172 LKPENLLYATPAPDA
0 4 K182 PAPDAPLKIADFGLs
1 0 S189-gl KIADFGLskIVEHQV
0 1 K190-ac IADFGLskIVEHQVL
0 1 K190 IADFGLsKIVEHQVL
0 1 K199 VEHQVLMKtVCGTPG
10 12 T200-p EHQVLMKtVCGTPGY
1 0 T204 LMKtVCGTPGYCAPE
0 1 K286 KLIVLDPKKRLTTFQ
0 1 K287 LIVLDPKKRLTTFQA
0 2 K303 QHPWVTGKAANFVHM
0 5 K331 RKLKAAVKAVVASSR
1 0 S336 AVKAVVASSRLGsAs
1 0 S337 VKAVVASSRLGsAss
1 3 S341-p VASSRLGsAsssHGS
0 1 S343-p SSRLGsAsssHGSIQ
1 0 S344-gl SRLGsAsssHGSIQE
0 1 S344-p SRLGsAsssHGSIQE
1 0 S345 RLGsAssSHGSIQES
1 0 S345-gl RLGsAsssHGSIQES
1 0 S356-gl IQESHKAsRDPsPIQ
0 1 S356-p IQESHKAsRDPsPIQ
1 0 R357 QESHKAsRDPsPIQD
0 6 S360-p HKAsRDPsPIQDGNE
0 3 - gap
1 0 A437 LELEEGLAEEKLKTV
0 2 T443 LAEEKLKTVEEAAAP
0 1 - gap
  mouse

 
T5-gl ___MLKVtVPsCPsS
S8-p MLKVtVPsCPsSPCS
S11-p VtVPsCPsSPCSSVT
S12 tVPsCPsSPCSSVTA
P13 VPsCPsSPCSSVTAS
S15 sCPsSPCSSVTASTE
Y28 TENLVPDYWIDGSNR
T53 SELGRGATSIVYRCK
S54 ELGRGATSIVYRCKQ
K66 CKQKGTQKPYALkVL
K71-ub TQKPYALkVLKKTVD
K129-ub LFDRIVEkGYYSERD
S133 IVEkGYYSERDARDA
K162 GIVHRDLKPENLLYA
Y168 LKPENLLYATPAPDA
K178-ub PAPDAPLkIADFGLS
S185 kIADFGLSkIVEHQV
K186 IADFGLSKIVEHQVL
K186-ub IADFGLSkIVEHQVL
K195 VEHQVLMKtVCGTPG
T196-p EHQVLMKtVCGTPGY
T200 LMKtVCGTPGYCAPE
K282 KLIVLDPKKRLTTFQ
K283 LIVLDPKKRLTTFQA
K299 QHPWVTGKAANFVHM
K327-ub RKLKAAVkAVVASSR
S332 AVkAVVASSRLGSAS
S333 VkAVVASSRLGSASS
S337 VASSRLGSASSSHTS
S339 SSRLGSASSSHTSIQ
S340 SRLGSASSSHTSIQE
S340 SRLGSASSSHTSIQE
S341 RLGSASSSHTSIQEN
S341 RLGSASSSHTSIQEN
S352 IQENHKASSDPPSTQ
S352 IQENHKASSDPPSTQ
S353 QENHKASSDPPSTQD
P356 HKASSDPPSTQDAKD
K370-ac DSTDLLGkKMQEEDQ
S433 DPEMKRDSEEKLKsV
S439-p DSEEKLKsVEEEMDP
T448-p EEEMDPMtEEEAPDA
  rat

 
T5 ___MLKVTVPsCPss
S8-p MLKVTVPsCPssPCs
S11-p VTVPsCPssPCsSVT
S12-p TVPsCPssPCsSVTS
P13 VPsCPssPCsSVTSS
S15-p sCPssPCsSVTSSTE
Y28 TENLVPDYWIDGSKR
T53 SELGRGATSIVYRCK
S54 ELGRGATSIVYRCKQ
K66-ub CKQKGTQkPYALKVL
K71 TQkPYALKVLKKTVD
K129-ub LFDRIVEkGYYSERD
S133 IVEkGYYSERDAADA
K162-ub GIVHRDLkPENLLyA
Y168-p LkPENLLyATPAPDA
K178-ub PAPDAPLkIADFGLS
S185 kIADFGLSKIVEHQV
K186 IADFGLSKIVEHQVL
K186 IADFGLSKIVEHQVL
K195-ub VEHQVLMktVCGtPG
T196-p EHQVLMktVCGtPGY
T200-p LMktVCGtPGYCAPE
K282-ub KLIVLDPkkRLTTFQ
K283-ub LIVLDPkkRLTTFQA
K299-ub QHPWVTGkAANFVHM
K327-ub RKLKAAVkAVVAssR
S332-p AVkAVVAssRLGsAS
S333-p VkAVVAssRLGsASS
S337-p VAssRLGsASSsHTN
S339 ssRLGsASSsHTNIQ
S340 sRLGsASSsHTNIQE
S340 sRLGsASSsHTNIQE
S341-p RLGsASSsHTNIQES
S341 RLGsASSSHTNIQES
S352 IQESNKASsEAQPAQ
S352 IQESNKASsEAQPAQ
S353-p QESNKASsEAQPAQD
Q356 NKASsEAQPAQDGKD
- gap
S437-p DQEMKRNsEETLKSV
S443 NsEETLKSVEEEMDP
A452 EEEMDPKAEEEAAAV
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