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Protein Page:
JAK1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
JAK1 a widely expressed non-receptor tyrosine-kinase involved in the interferon-alpha/beta and -gamma signal transduction pathways. Couples cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs. A selective Jak1 inhibitor induces apoptosis in NRP-154 prostate cancer cell line. A single mutation seen in tyrosine kinome screen of colon cancers. Activated in B cell lines from patients with post-transplant lymphoproliferative disorder, and in a mouse Lck-driven T cell lymphoma. Inhibitor: Piceatannol. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, TK; EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); Kinase, protein; TK group; JakA family
Chromosomal Location of Human Ortholog: 1p32.3-p31.3
Cellular Component: cytoskeleton; membrane; cytoplasm; endomembrane system; cytosol; nucleus
Molecular Function: protein binding; growth hormone receptor binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; protein phosphatase binding; ATP binding; CCR5 chemokine receptor binding
Biological Process: response to antibiotic; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; cytokine and chemokine mediated signaling pathway; protein amino acid phosphorylation; enzyme linked receptor protein signaling pathway
Reference #:  P23458 (UniProtKB)
Alt. Names/Synonyms: JAK-1; JAK1; JAK1A; JAK1B; Janus kinase 1; Janus kinase 1 (a protein tyrosine kinase); JTK3; Tyrosine-protein kinase JAK1
Gene Symbols: JAK1
Molecular weight: 133,277 Da
Basal Isoelectric point: 7.48  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

JAK1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y3-p _____MQyLNIKEDC
0 2 Y107 KMSLRLHYRMRFYFT
0 3 K213-ub MQLPELPkDIsyKRy
0 1 S216-p PELPkDIsyKRyIPE
0 2 Y217-p ELPkDIsyKRyIPET
0 2 Y220-p kDIsyKRyIPETLNk
0 2 K227-ub yIPETLNksIRQRNL
0 2 S228-p IPETLNksIRQRNLL
0 2 K245-ub MRINNVFkDFLkEFN
0 73 K249-ub NVFkDFLkEFNNKTI
0 1 K269-ac STHDLKVkYLATLET
0 1 K269-ub STHDLKVkYLATLET
0 1 S333-p RHKPNVVsVEKEKNK
0 1 K342 EKEKNKLKRKKLENK
0 1 K504 NFQIEVQKGRYSLHG
0 1 Y568-p AQEWQPVyPMSQLsF
0 1 S574-p VyPMSQLsFDRILKK
0 1 Y605-p YSGTLMDyKDDEGTS
0 1 T687-p HRKSDVLttPWKFKV
0 1 T688-p RKSDVLttPWKFKVA
0 1 K691 DVLttPWKFKVAKQL
0 1 K696 PWKFKVAKQLASALS
0 1 K718 VHGNVCTKNLLLARE
0 1 K736-ub SECGPFIkLsDPGIP
0 1 S738-p CGPFIkLsDPGIPIT
0 1 S857-p EQNPDIVsEKKPATE
0 1 K859 NPDIVsEKKPATEVD
1 0 Y940 YHENIVKYKGICTED
0 1 Y967-p PSGSLKEyLPKNKNK
0 1 Y993-p QICKGMDyLGSRQYV
0 2 T1030-p GLTKAIEtDKEyytV
21 173 Y1034-p AIEtDKEyytVKDDR
21 52 Y1035-p IEtDKEyytVKDDRD
0 5 T1036-p EtDKEyytVKDDRDs
0 2 S1043-p tVKDDRDsPVFWYAP
0 1 T1107-p TVTRLVNtLkEGkRL
0 1 K1109-ac TRLVNtLkEGkRLPC
0 2 K1109-ub TRLVNtLkEGkRLPC
0 1 K1112-ac VNtLkEGkRLPCPPN
0 38 Y1125-p PNCPDEVyQLMRKCW
3331 : Phospho-Jak1 (Tyr1022/1023) Antibody
3331 : Phospho-Jak1 (Tyr1022/1023) Antibody
  mouse

 
Y3 _____MQYLNIKEDC
Y107 KTSLRLHYRMRFYFT
K213-ub MQLPELPkDISYKRY
S216 PELPkDISYKRYIPE
Y217 ELPkDISYKRYIPET
Y220 kDISYKRYIPETLNk
K227-ub YIPETLNkSIRQRNL
S228 IPETLNkSIRQRNLL
K245-ub MRINNVFkDFLkEFN
K249-ub NVFkDFLkEFNNKTI
K267 SVHDLKVKYLATLET
K267 SVHDLKVKYLATLET
P332 RQKPNVVPVEKEKNK
K341-ac EKEKNKLkRKKLEYN
K503-ub NFQIEVQkGRYSLHG
Y567 AQEWQPVYSMSQLSF
S573 VYSMSQLSFDRILKK
Y604 YSGTLLDYKDEEGIA
T686 HRKSDALTTPWkFKV
T687 RKSDALTTPWkFKVA
K690-ub DALTTPWkFKVAkQL
K695-ub PWkFKVAkQLASALS
K717-ub VHGNVCTkNLLLARE
K735 SDIGPFIKLSDPGIP
S737 IGPFIKLSDPGIPVS
S856 EQNPDIVSEkQPTTE
K858-ub NPDIVSEkQPTTEVD
Y939-p YHENIVKyKGICMED
Y966 PSGSLKEYLPKNKNK
Y992 QICKGMDYLGSRQYV
T1029-p GLTKAIEtDKEyyTV
Y1033-p AIEtDKEyyTVKDDR
Y1034-p IEtDKEyyTVKDDRD
T1035 EtDKEyyTVKDDRDS
S1042 TVKDDRDSPVFWYAP
T1106 TVTRLVKTLKEGKRL
K1108 TRLVKTLKEGKRLPC
K1108 TRLVKTLKEGKRLPC
K1111 VKTLKEGKRLPCPPN
Y1124 PNCPDEVYQLMRKCW
3331 : Phospho-Jak1 (Tyr1022/1023) Antibody
3331 : Phospho-Jak1 (Tyr1022/1023) Antibody
  rat

 
- gap
Y152-p KMSLRLHyRMRFYFT
K258 MQLPELPKDISYKRY
S261 PELPKDISYKRYIPE
Y262 ELPKDISYKRYIPET
Y265 KDISYKRYIPETLNK
K272 YIPETLNKSIRQRNL
S273 IPETLNKSIRQRNLL
K290 MRINNVFKDFLKEFN
K294 NVFKDFLKEFNNKTI
K314 STHDLKVKYLATLET
K314 STHDLKVKYLATLET
P377 RQKPNVLPVEKEKNK
K386 EKEKNKLKRKKLDYN
K548 NFQIEVQKGRYSLHG
Y612 AQEWQPVYSMSQLSF
S618 VYSMSQLSFDRILKK
Y649 YSGTLLDYKDDEGIA
T731 HRKSDALTTPWKFKV
T732 RKSDALTTPWKFKVA
K735 DALTTPWKFKVAKQL
K740 PWKFKVAKQLASALS
K762 VHGNVCTKNLLLARE
K780 SDIGPFIKLSDPGIP
S782 IGPFIKLSDPGIPVS
S901 EQNPDIVSEKQPITE
K903 NPDIVSEKQPITEVD
Y984 YHENIVKYKGICMED
Y1011 PSGSLKEYLPKNKNK
Y1037 QICKGMDYLGSRQYV
T1074 GLTKAIETDKEYYTV
Y1078 AIETDKEYYTVKDDR
Y1079 IETDKEYYTVKDDRD
T1080 ETDKEYYTVKDDRDS
S1087 TVKDDRDSPVFWYAP
T1151 TVTRLVNTLKEGKRL
K1153 TRLVNTLKEGKRLSC
K1153 TRLVNTLKEGKRLSC
K1156 VNTLKEGKRLSCPPN
Y1169 PNCPDEVYQLMRKCW
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