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rictor (human)

Overview rictor a novel regulatory binding partner of the kinase mTOR. Part of a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Shares homology with pianissimo from D. discoidieum, STE20p from S. pombe, and AVO3p from S. cerevisiae. Note: This description may include information from UniProtKB. Protein type: Cell cycle regulation; Adaptor/scaffold Cellular Component: TORC2 complex; cytosol Molecular Function: protein binding; ribosome binding Biological Process: epidermal growth factor receptor signaling pathway; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; regulation of protein kinase B signaling cascade; positive regulation of peptidyl-tyrosine phosphorylation; embryonic development; positive regulation of actin filament polymerization; regulation of actin cytoskeleton organization and biogenesis; T cell costimulation; actin cytoskeleton reorganization; regulation of Rac GTPase activity; positive regulation of TOR signaling pathway Reference #:  Q6R327 (UniProtKB) Alt. Names/Synonyms: AVO3 homolog; DKFZp686B11164; hAVO3; KIAA1999; mAVO3; MGC39830; PIA; pianissimo; Rapamycin-insensitive companion of mTOR; RICTOR; RICTR; RPTOR independent companion of MTOR, complex 2; TORC2-specific protein AVO3 Gene Symbols: RICTOR Molecular weight: 192,218 Da Basal Isoelectric point: 7.22  Predict pI for various phosphorylation states CST Pathways:  Insulin Receptor Signaling  |  mTOR Signaling  |  PI3K/Akt Signaling  |  Translation: eIF4E and p70S6K Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below rictor

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	Sites Implicated In
molecular association, regulation: T1135‑p phosphorylation: T1135‑p ubiquitination: T1135‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	49		S21-p	RVRGRNDsGEENVPL
0	1		S35-p	LDLTREPsDNLREIL
0	1		Y109-p	AGLRALRyLIQDSSI
0	3		K213-a	GGLNTILkNVIDCQL
0	1		Y243-p	NHPKTRQyVRADVEL
0	2		S265-p	TDFHYRHsPDTAEGQ
0	1		K274-u	DTAEGQLkEDREARF
0	1		S284-p	REARFLAsKMGIIAT
0	1		K374-u	GFVAAEAkTILPHRA
0	1		S383-p	ILPHRARsRPDLMDN
0	5		T424-p	DHISVRAtILLGELL
0	1		K582-a	RRLLYFYkPSSKLYA
0	1		T733-p	DACRLYAtKHLRVLL
0	2		Y835-p	LEKWHREyNsKYVDL
0	1		S837-p	KWHREyNsKYVDLIE
0	48		Y863-p	KPVDGDNyVRRSNQR
0	1		S1026-p	PSTLSLNsEsTssRH
0	1		S1028-p	TLSLNsEsTssRHNs
0	1		S1030-p	SLNsEsTssRHNsEs
0	1		S1031-p	LNsEsTssRHNsEsE
0	2		S1035-p	sTssRHNsEsESVPS
0	1		S1037-p	ssRHNsEsESVPSSM
0	1		Y1073-p	EDTEPTFyDRSGPIK
0	1		K1092-u	FPFFASSkLVKNRIL
0	1		S1101-p	VKNRILNsLtLPNkK
0	2		T1103-p	NRILNsLtLPNkKHR
0	1		K1107-u	NsLtLPNkKHRSSSD
0	38		T1133-p	TSNRRIRtLtEPsVD
6	175		T1135-p	NRRIRtLtEPsVDFN
1	24		S1138-p	IRtLtEPsVDFNHsD
0	2		S1144-p	PsVDFNHsDDFtPIS
0	1		T1148-p	FNHsDDFtPISTVQK
0	2		T1156	PISTVQKTLQLETSF
0	2		T1172-p	GNKHIEDtGstPsIG
0	2		S1174-p	KHIEDtGstPsIGEN
0	9		T1175-p	HIEDtGstPsIGEND
1	7		S1177-p	EDtGstPsIGENDLk
0	1		K1184-u	sIGENDLkFTKNFGT
0	1		S1217-p	SSHMKIRsQsFNtDt
1	5		S1219-p	HMKIRsQsFNtDttt
0	2		T1222-p	IRsQsFNtDtttsGI
0	1		T1224-p	sQsFNtDtttsGIss
0	1		T1225-p	QsFNtDtttsGIssM
0	1		T1226-p	sFNtDtttsGIssMS
0	1		S1227-p	FNtDtttsGIssMSS
0	1		S1230-p	DtttsGIssMSSsPS
0	1		S1231-p	tttsGIssMSSsPSR
1	5		S1235-p	GIssMSSsPSRETVG
0	2		S1267-p	STKTIKTsHyLtPQs
0	52		Y1269-p	KTIKTsHyLtPQsNH
0	10		T1271-p	IKTsHyLtPQsNHLS
0	1		S1274-p	sHyLtPQsNHLSLSK
0	4		S1282-p	NHLSLSKsNsVsLVP
0	8		S1284-p	LSLSKsNsVsLVPPG
0	1		S1286-p	LSKsNsVsLVPPGss
0	2		S1292-p	VsLVPPGssHtLPRR
0	2		S1293-p	sLVPPGssHtLPRRA
0	3		T1295-p	VPPGssHtLPRRAQs
0	12		S1302-p	tLPRRAQsLKAPsIA
0	1		S1307-p	AQsLKAPsIATIksL
0	4		K1312-a	APsIATIksLADCNF
0	2		S1313-p	PsIATIksLADCNFs
0	7		S1320-p	sLADCNFsyTSSRDA
0	6		Y1321-p	LADCNFsyTSSRDAF
0	69		Y1330-p	SSRDAFGyAtLKRLQ
0	10		T1332-p	RDAFGyAtLKRLQQQ
0	1		S1344-p	QQQRMHPsLsHsEAL
0	1		S1346-p	QRMHPsLsHsEALAs
0	1		S1348-p	MHPsLsHsEALAsPA
0	2		S1353-p	sHsEALAsPAKDVLF
0	1		T1361-p	PAKDVLFtDTITMKA
0	2		S1370-p	TITMKANsFESRLtP
0	5		T1376-p	NsFESRLtPSRFMKA
0	1		K1382	LtPSRFMKALsyAsL
0	27		S1385-p	SRFMKALsyAsLDkE
0	16		Y1386-p	RFMKALsyAsLDkED
0	40		S1388-p	MKALsyAsLDkEDLL
0	2		K1391-u	LsyAsLDkEDLLsPI
0	18		S1396-p	LDkEDLLsPINQNtL
0	1		T1402-p	LsPINQNtLQRssSV
0	1		S1406-p	NQNtLQRssSVRsMV
0	1		S1407-p	QNtLQRssSVRsMVs
0	1		S1411-p	QRssSVRsMVssAty
0	2		S1414-p	sSVRsMVssAtyGGs
0	2		S1415-p	SVRsMVssAtyGGsD
0	3		T1417-p	RsMVssAtyGGsDDY
0	1		Y1418-p	sMVssAtyGGsDDYI
0	1		S1421-p	ssAtyGGsDDYIGLA
0	1		Y1444-p	FQVKDIPyFQtKNIP
0	1		T1447-p	KDIPyFQtKNIPPHD
0	1		A1462	DRGARAFAHDAGGLP
0	1		S1470-p	HDAGGLPsGtGGLVK
0	1		T1472-p	AGGLPsGtGGLVKNs
0	2		S1479-p	tGGLVKNsFHLLRQQ
0	1		S1571-p	EVVPSKFsGIsGCsD
0	1		S1574-p	PSKFsGIsGCsDGVS
0	3		S1577-p	FsGIsGCsDGVSQEG
0	1		S1581	sGCsDGVSQEGSASS
0	1		S1585	DGVSQEGSASSTKst
0	3		S1591-p	GSASSTKstELLLGV
0	2		T1592-p	SASSTKstELLLGVK
0	1		T1605-p	VKTIPDDtPMCRILL
0	1		S1626	LVINLSSSVSTKCHE

	mouse
S21-p	RIRGRNDsGEENVPL
S35	LDLTREPSDNLREIL
Y109	AGLRALRYLIQDSSI
K213	GGLNTILKNVIDCQL
Y243	NHPKTRQYVRADVEL
S265	TDFHYRHSPDTAEGQ
K274	DTAEGQLKEDREARF
S284	REARFLASKMGIIAT
K374	GFVAAEAKTILPHRA
S383	ILPHRARSRPDLMDN
T424	DHISVRATILLGELL
K582	RRLLYFYKPSSKLYA
T733	DACRLYATKHLRVLL
Y835	LEKWHKEYNSKYVDL
S837	KWHKEYNSKYVDLIE
Y863-p	KPIDGDNyVRRSNQR
S1026	PSTLSLNSESTSSRH
S1028	TLSLNSESTSSRHNS
S1030	SLNSESTSSRHNSES
S1031	LNSESTSSRHNSESE
S1035	STSSRHNSESESAPS
S1037	SSRHNSESESAPSSM
Y1073	EDAEPAFYDRPGPIK
K1092	FPFFGSSKLVKNRIL
S1101	VKNRILNSLTLPTKK
T1103	NRILNSLTLPTKKHR
K1107	NSLTLPTKKHRSSSD
T1133-p	TSNRRIRtLtEPsVD
T1135-p	NRRIRtLtEPsVDLN
S1138-p	IRtLtEPsVDLNHSE
S1144	PsVDLNHSEDFTSSS
T1148	LNHSEDFTSSSAQKs
S1155-p	TSSSAQKsLQLEPSF
A1171	GNKHLEDAGstPsIG
S1173-p	KHLEDAGstPsIGEN
T1174-p	HLEDAGstPsIGEND
S1176-p	EDAGstPsIGENDLK
K1183	sIGENDLKFPKSFGT
S1216	SSHIKIRSQsFNTDT
S1218-p	HIKIRSQsFNTDTTT
T1221	IRSQsFNTDTTTSGI
T1223	SQsFNTDTTTSGISS
T1224	QsFNTDTTTSGISSM
T1225	sFNTDTTTSGISSMS
S1226	FNTDTTTSGISSMSS
S1229	DTTTSGISSMSSsPS
S1230	TTTSGISSMSSsPSR
S1234-p	GISSMSSsPSRETVA
S1266	STKTVKTSHYLTPQS
Y1268	KTVKTSHYLTPQSNH
T1270	VKTSHYLTPQSNHLS
S1273	SHYLTPQSNHLSLSK
S1281-p	NHLSLSKsNsVSLVP
S1283-p	LSLSKsNsVSLVPPG
S1285	LSKsNsVSLVPPGsS
S1291-p	VSLVPPGsSHtLPRR
S1292	SLVPPGsSHtLPRRA
T1294-p	VPPGsSHtLPRRAQs
S1301-p	tLPRRAQsLKAPSIA
S1306	AQsLKAPSIATIksL
K1311-a	APSIATIksLADCNF
S1312-p	PSIATIksLADCNFS
S1319	sLADCNFSYTSSRDA
Y1320	LADCNFSYTSSRDAF
Y1329	SSRDAFGYAtLKRLQ
T1331-p	RDAFGYAtLKRLQQQ
S1343	QQQRMHPSLSHSEAL
S1345	QRMHPSLSHSEALAS
S1347	MHPSLSHSEALASPA
S1352	SHSEALASPAKDVLF
T1360	PAKDVLFTDTITMKA
S1369	TITMKANSFESRLTP
T1375	NSFESRLTPSRFMkA
K1381-u	LTPSRFMkALsyAsL
S1384-p	SRFMkALsyAsLDkE
Y1385-p	RFMkALsyAsLDkED
S1387-p	MkALsyAsLDkEDLL
K1390-u	LsyAsLDkEDLLsPI
S1395-p	LDkEDLLsPINHNTL
T1401	LsPINHNTLQRSSSV
S1405	NHNTLQRSSSVRSMV
S1406	HNTLQRSSSVRSMVs
S1410	QRSSSVRSMVssAtY
S1413-p	SSVRSMVssAtYGGS
S1414-p	SVRSMVssAtYGGSD
T1416-p	RSMVssAtYGGSDDY
Y1417	SMVssAtYGGSDDYI
S1420	ssAtYGGSDDYIGLA
Y1443	FQIKDVPYFQSKHVP
S1446	KDVPYFQSKHVPPPD
S1461-p	DRGARMFsHDGAGLS
S1469	HDGAGLSSGAGGLVK
A1471	GAGLSSGAGGLVKNs
S1478-p	AGGLVKNsFHLLRQQ
S1570	EVVPSKFSGISGCsD
S1573	PSKFSGISGCsDGAs
S1576-p	FSGISGCsDGAsQEE
S1580-p	SGCsDGAsQEEGsAS
S1585-p	GAsQEEGsASSTKst
S1591-p	GsASSTKstELLLGV
T1592-p	sASSTKstELLLGVK
T1605	VKTIPDDTPMCRILL
S1626-p	LVVNLSSsVSTKCHE

	rat
S6-p	__MGRNDsGEENVPL
S20	LDLTREPSDNLREIL
Y94	AGLRALRYLIQDSSI
K198	GGLNTILKNVIDCQL
Y228	NHPKTRQYVRADVEL
S250	TDFHYRHSPDTAEGQ
K259	DTAEGQLKEDREARF
S269	REARFLASKMGIIAT
K359	GFVAAEAKTILPHRA
S368	ILPHRARSRPDLMDN
T409	DHISVRATILLGELL
K567	RRLLYFYKPSSKLYA
T718	DACRLYATKHLRVLL
Y820	LEKWHKEYNSKYVDL
S822	KWHKEYNSKYVDLIE
Y848	KPIDGDNYVRRSNQR
S1011	PSTLSLNSESTSSRH
S1013	TLSLNSESTSSRHNS
S1015	SLNSESTSSRHNSES
S1016	LNSESTSSRHNSESE
S1020	STSSRHNSESESAPS
S1022	SSRHNSESESAPSSM
Y1058	EDAEPAFYDRPGPIK
K1077	FPFFASSKLVKNRIL
S1086	VKNRILNSLTLPTKK
T1088	NRILNSLTLPTKKHR
K1092	NSLTLPTKKHRSSSD
T1118	TSNRRIRTFTEPSVD
T1120	NRRIRTFTEPSVDFN
S1123	IRTFTEPSVDFNHSD
S1129	PSVDFNHSDDFTNIS
T1133	FNHSDDFTNISPAQK
T1141	NISPAQKTLQLETSF
T1157	GNKHLEDTGSTPSIG
S1159	KHLEDTGSTPSIGDN
T1160	HLEDTGSTPSIGDND
S1162	EDTGSTPSIGDNDLK
K1169	SIGDNDLKFPKSFGP
S1202	GSHMKIRSQSFNTDT
S1204	HMKIRSQSFNTDTTT
T1207	IRSQSFNTDTTTSGI
T1209	SQSFNTDTTTSGISS
T1210	QSFNTDTTTSGISSM
T1211	SFNTDTTTSGISSMS
S1212	FNTDTTTSGISSMSS
S1215	DTTTSGISSMSSSPS
S1216	TTTSGISSMSSSPSR
S1220	GISSMSSSPSRETVA
S1252	STKTVKTSHYLTPQA
Y1254	KTVKTSHYLTPQANH
T1256	VKTSHYLTPQANHLS
A1259	SHYLTPQANHLSLSK
S1267	NHLSLSKSNSVSLVP
S1269	LSLSKSNSVSLVPPG
S1271	LSKSNSVSLVPPGSS
S1277	VSLVPPGSSHTLPRR
S1278	SLVPPGSSHTLPRRA
T1280	VPPGSSHTLPRRAQS
S1287	TLPRRAQSLKAPSIA
S1292	AQSLKAPSIATIKSL
K1297	APSIATIKSLADCNF
S1298	PSIATIKSLADCNFS
S1305	SLADCNFSYTSSRDA
Y1306	LADCNFSYTSSRDAF
Y1315	SSRDAFGYATLKRLQ
T1317	RDAFGYATLKRLQQQ
S1329	QQQRMHPSLSHSEAL
S1331	QRMHPSLSHSEALAS
S1333	MHPSLSHSEALASPA
S1338	SHSEALASPAKDVLF
T1346	PAKDVLFTDTITMKA
S1355	TITMKANSFESRLTP
T1361	NSFESRLTPSRFMKA
K1367	LTPSRFMKALSYASL
S1370	SRFMKALSYASLDKE
Y1371	RFMKALSYASLDKED
S1373	MKALSYASLDKEDLL
K1376	LSYASLDKEDLLSPI
S1381	LDKEDLLSPINQNTL
T1387	LSPINQNTLQRSSSV
S1391	NQNTLQRSSSVRSMV
S1392	QNTLQRSSSVRSMVS
S1396	QRSSSVRSMVSSATY
S1399	SSVRSMVSSATYGGS
S1400	SVRSMVSSATYGGSD
T1402	RSMVSSATYGGSDDY
Y1403	SMVSSATYGGSDDYI
S1406	SSATYGGSDDYIGLA
Y1429	FQVKDIPYFQSKHVP
S1432	KDIPYFQSKHVPPPD
S1447	DRGARTFSHDGGGLP
S1455	HDGGGLPSGTGSLVK
T1457	GGGLPSGTGSLVKNS
S1464	TGSLVKNSFHLLRQQ
S1556	EVVPSKFSGISGCSD
S1559	PSKFSGISGCSDGAS
S1562	FSGISGCSDGASQEE
S1566	SGCSDGASQEEGSAS
S1571	GASQEEGSASSTKST
S1577	GSASSTKSTELLLGV
T1578	SASSTKSTELLLGVK
T1591	VKTIPDDTPMCRILL
S1612	LVVNLSSSVSTKCHE

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