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Protein Page:
Rictor (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Rictor a regulatory binding partner of the kinase mTOR. Part of a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Rictor interacts with Cullin1-Rbx1 to form an E3 ubiquitin ligase complex, and promotes ubiquitination and degradation of SGK1. Shares homology with pianissimo from D. discoidieum, STE20p from S. pombe, and AVO3p from S. cerevisiae. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin conjugating system; Cell cycle regulation; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 5p13.1
Cellular Component: TORC2 complex; cytosol
Molecular Function: protein binding; ribosome binding
Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; TOR signaling pathway; nerve growth factor receptor signaling pathway; regulation of protein kinase B signaling cascade; positive regulation of protein kinase B signaling cascade; embryonic development; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of actin filament polymerization; regulation of actin cytoskeleton organization and biogenesis; actin cytoskeleton reorganization; T cell costimulation; innate immune response; positive regulation of endothelial cell proliferation; regulation of Rac GTPase activity; positive regulation of TOR signaling pathway
Reference #:  Q6R327 (UniProtKB)
Alt. Names/Synonyms: AVO3 homolog; DKFZp686B11164; hAVO3; KIAA1999; mAVO3; MGC39830; PIA; pianissimo; Rapamycin-insensitive companion of mTOR; RICTOR; RICTR; RPTOR independent companion of MTOR, complex 2; TORC2-specific protein AVO3
Gene Symbols: RICTOR
Molecular weight: 192,218 Da
Basal Isoelectric point: 7.22  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Rictor

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: T1135‑p
phosphorylation: T1135‑p
ubiquitination: T1135‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 67 S21-p RVRGRNDsGEENVPL
0 1 S35-p LDLTREPsDNLREIL
0 1 Y109-p AGLRALRyLIQDSSI
0 3 K213-ac GGLNTILkNVIDCQL
0 1 Y243-p NHPKTRQyVRADVEL
0 3 S265-p TDFHYRHsPDTAEGQ
0 1 K274-ub DTAEGQLkEDREARF
0 1 S284-p REARFLAsKMGIIAT
0 1 K374-ub GFVAAEAkTILPHRA
0 1 S383-p ILPHRARsRPDLMDN
0 5 T424-p DHISVRAtILLGELL
0 1 K582-ac RRLLYFYkPSSKLYA
0 1 T733-p DACRLYAtKHLRVLL
0 1 Y835-p LEKWHREyNsKYVDL
0 1 S837-p KWHREyNsKYVDLIE
0 53 Y863-p KPVDGDNyVRRSNQR
0 1 S1026-p PSTLSLNsEsTssRH
0 1 S1028-p TLSLNsEsTssRHNs
0 1 S1030-p SLNsEsTssRHNsEs
0 1 S1031-p LNsEsTssRHNsEsE
0 3 S1035-p sTssRHNsEsESVPS
0 1 S1037-p ssRHNsEsESVPSSM
0 3 Y1073-p EDTEPTFyDRSGPIK
0 1 S1090-p NSFPFFAsSkLVKNR
0 1 K1092-ub FPFFAsSkLVKNRIL
0 3 S1101-p VKNRILNsLtLPNkK
0 4 T1103-p NRILNsLtLPNkKHR
0 1 K1107-ub NsLtLPNkKHRSSSD
0 39 T1133-p TSNRRIRtLtEPsVD
7 181 T1135-p NRRIRtLtEPsVDFN
1 26 S1138-p IRtLtEPsVDFNHsD
0 4 S1144-p PsVDFNHsDDFtPIS
0 2 T1148-p FNHsDDFtPISTVQK
0 2 T1156 PISTVQKTLQLEtsF
0 1 T1161-p QKTLQLEtsFMGNKH
0 4 S1162-p KTLQLEtsFMGNKHI
0 2 T1172-p GNKHIEDtGstPsIG
0 3 S1174-p KHIEDtGstPsIGEN
0 10 T1175-p HIEDtGstPsIGEND
1 11 S1177-p EDtGstPsIGENDLk
0 1 K1184-ub sIGENDLkFTKNFGT
0 2 S1211-p VVESSTSsHMKIRsQ
0 1 S1217-p SsHMKIRsQsFNtDt
1 6 S1219-p HMKIRsQsFNtDttt
0 2 T1222-p IRsQsFNtDtttsGI
0 1 T1224-p sQsFNtDtttsGIss
0 1 T1225-p QsFNtDtttsGIssM
0 1 T1226-p sFNtDtttsGIssMS
0 1 S1227-p FNtDtttsGIssMSs
0 1 S1230-p DtttsGIssMSssPS
0 2 S1231-p tttsGIssMSssPSR
0 1 S1234-p sGIssMSssPSRETV
1 5 S1235-p GIssMSssPSRETVG
0 2 S1267-p STKTIKTsHyLtPQs
0 55 Y1269-p KTIKTsHyLtPQsNH
0 12 T1271-p IKTsHyLtPQsNHLs
0 2 S1274-p sHyLtPQsNHLsLSK
0 2 S1278-p tPQsNHLsLSKsNsV
0 8 S1282-p NHLsLSKsNsVsLVP
0 15 S1284-p LsLSKsNsVsLVPPG
0 2 S1286-p LSKsNsVsLVPPGss
0 3 S1292-p VsLVPPGssHtLPRR
0 6 S1293-p sLVPPGssHtLPRRA
0 10 T1295-p VPPGssHtLPRRAQs
0 17 S1302-p tLPRRAQsLKAPsIA
0 1 S1307-p AQsLKAPsIATIksL
0 4 K1312-ac APsIATIksLADCNF
0 4 S1313-p PsIATIksLADCNFs
0 7 S1320-p sLADCNFsyTSSRDA
0 7 Y1321-p LADCNFsyTSSRDAF
0 80 Y1330-p SSRDAFGyAtLKRLQ
0 19 T1332-p RDAFGyAtLKRLQQQ
0 1 S1344-p QQQRMHPsLsHsEAL
0 3 S1346-p QRMHPsLsHsEALAs
0 1 S1348-p MHPsLsHsEALAsPA
0 6 S1353-p sHsEALAsPAKDVLF
0 1 T1361-p PAKDVLFtDTITMkA
0 1 K1367-m1 FtDTITMkANsFEsR
0 4 S1370-p TITMkANsFEsRLtP
0 1 S1373-p MkANsFEsRLtPSRF
0 7 T1376-p NsFEsRLtPSRFMKA
0 1 K1382 LtPSRFMKALsyAsL
0 34 S1385-p SRFMKALsyAsLDkE
0 25 Y1386-p RFMKALsyAsLDkED
0 49 S1388-p MKALsyAsLDkEDLL
0 2 K1391-ub LsyAsLDkEDLLsPI
0 19 S1396-p LDkEDLLsPINQNtL
0 3 T1402-p LsPINQNtLQRssSV
0 1 S1406-p NQNtLQRssSVRsMV
0 1 S1407-p QNtLQRssSVRsMVs
0 1 S1411-p QRssSVRsMVssAty
0 2 S1414-p sSVRsMVssAtyGGs
0 2 S1415-p SVRsMVssAtyGGsD
0 3 T1417-p RsMVssAtyGGsDDY
0 1 Y1418-p sMVssAtyGGsDDYI
0 1 S1421-p ssAtyGGsDDYIGLA
0 1 Y1444-p FQVKDIPyFQtKNIP
0 1 T1447-p KDIPyFQtKNIPPHD
0 1 A1462 DRGARAFAHDAGGLP
0 2 S1470-p HDAGGLPsGtGGLVK
0 1 T1472-p AGGLPsGtGGLVKNs
0 3 S1479-p tGGLVKNsFHLLRQQ
0 1 S1571-p EVVPSKFsGIsGCsD
0 1 S1574-p PSKFsGIsGCsDGVs
0 4 S1577-p FsGIsGCsDGVsQEG
0 2 S1581-p sGCsDGVsQEGsASS
0 2 S1585-p DGVsQEGsASSTKst
0 5 S1591-p GsASSTKstELLLGV
0 4 T1592-p sASSTKstELLLGVK
0 1 T1605-p VKTIPDDtPMCRILL
0 1 S1626 LVINLSSSVSTKCHE
3806 : Phospho-Rictor (Thr1135) (D30A3) Rabbit mAb
  mouse

 
S21-p RIRGRNDsGEENVPL
S35 LDLTREPSDNLREIL
Y109 AGLRALRYLIQDSSI
K213 GGLNTILKNVIDCQL
Y243 NHPKTRQYVRADVEL
S265 TDFHYRHSPDTAEGQ
K274 DTAEGQLKEDREARF
S284 REARFLASKMGIIAT
K374 GFVAAEAKTILPHRA
S383 ILPHRARSRPDLMDN
T424 DHISVRATILLGELL
K582 RRLLYFYKPSSKLYA
T733 DACRLYATKHLRVLL
Y835 LEKWHKEYNSKYVDL
S837 KWHKEYNSKYVDLIE
Y863-p KPIDGDNyVRRSNQR
S1026 PSTLSLNSESTSSRH
S1028 TLSLNSESTSSRHNS
S1030 SLNSESTSSRHNSES
S1031 LNSESTSSRHNSESE
S1035 STSSRHNSESESAPS
S1037 SSRHNSESESAPSSM
Y1073 EDAEPAFYDRPGPIK
S1090 NSFPFFGSSKLVKNR
K1092 FPFFGSSKLVKNRIL
S1101 VKNRILNSLTLPTKK
T1103 NRILNSLTLPTKKHR
K1107 NSLTLPTKKHRSSSD
T1133-p TSNRRIRtLtEPsVD
T1135-p NRRIRtLtEPsVDLN
S1138-p IRtLtEPsVDLNHSE
S1144 PsVDLNHSEDFTSSS
T1148 LNHSEDFTSSSAQKs
S1155-p TSSSAQKsLQLEPSF
P1160 QKsLQLEPSFVGNKH
S1161 KsLQLEPSFVGNKHL
A1171 GNKHLEDAGstPsIG
S1173-p KHLEDAGstPsIGEN
T1174-p HLEDAGstPsIGEND
S1176-p EDAGstPsIGENDLK
K1183 sIGENDLKFPKSFGT
S1210 VVEGSASSHIKIRSQ
S1216 SSHIKIRSQsFNTDT
S1218-p HIKIRSQsFNTDTTT
T1221 IRSQsFNTDTTTSGI
T1223 SQsFNTDTTTSGISS
T1224 QsFNTDTTTSGISSM
T1225 sFNTDTTTSGISSMS
S1226 FNTDTTTSGISSMSS
S1229 DTTTSGISSMSSsPS
S1230 TTTSGISSMSSsPSR
S1233 SGISSMSSsPSRETV
S1234-p GISSMSSsPSRETVA
S1266 STKTVKTSHYLTPQS
Y1268 KTVKTSHYLTPQSNH
T1270 VKTSHYLTPQSNHLS
S1273 SHYLTPQSNHLSLSK
S1277 TPQSNHLSLSKsNsV
S1281-p NHLSLSKsNsVsLVP
S1283-p LSLSKsNsVsLVPPG
S1285-p LSKsNsVsLVPPGsS
S1291-p VsLVPPGsSHtLPRR
S1292 sLVPPGsSHtLPRRA
T1294-p VPPGsSHtLPRRAQs
S1301-p tLPRRAQsLKAPSIA
S1306 AQsLKAPSIATIksL
K1311-ac APSIATIksLADCNF
S1312-p PSIATIksLADCNFS
S1319 sLADCNFSYTSSRDA
Y1320 LADCNFSYTSSRDAF
Y1329 SSRDAFGYAtLKRLQ
T1331-p RDAFGYAtLKRLQQQ
S1343 QQQRMHPSLSHSEAL
S1345 QRMHPSLSHSEALAS
S1347 MHPSLSHSEALASPA
S1352 SHSEALASPAKDVLF
T1360 PAKDVLFTDTITMKA
K1366 FTDTITMKANSFESR
S1369 TITMKANSFESRLTP
S1372 MKANSFESRLTPSRF
T1375 NSFESRLTPSRFMkA
K1381-ub LTPSRFMkALsyAsL
S1384-p SRFMkALsyAsLDkE
Y1385-p RFMkALsyAsLDkED
S1387-p MkALsyAsLDkEDLL
K1390-ub LsyAsLDkEDLLsPI
S1395-p LDkEDLLsPINHNTL
T1401 LsPINHNTLQRSSSV
S1405 NHNTLQRSSSVRSMV
S1406 HNTLQRSSSVRSMVs
S1410 QRSSSVRSMVssAtY
S1413-p SSVRSMVssAtYGGS
S1414-p SVRSMVssAtYGGSD
T1416-p RSMVssAtYGGSDDY
Y1417 SMVssAtYGGSDDYI
S1420 ssAtYGGSDDYIGLA
Y1443 FQIKDVPYFQSKHVP
S1446 KDVPYFQSKHVPPPD
S1461-p DRGARMFsHDGAGLS
S1469 HDGAGLSSGAGGLVK
A1471 GAGLSSGAGGLVKNs
S1478-p AGGLVKNsFHLLRQQ
S1570 EVVPSKFSGISGCsD
S1573 PSKFSGISGCsDGAs
S1576-p FSGISGCsDGAsQEE
S1580-p SGCsDGAsQEEGsAS
S1585-p GAsQEEGsASSTKst
S1591-p GsASSTKstELLLGV
T1592-p sASSTKstELLLGVK
T1605 VKTIPDDTPMCRILL
S1626-p LVVNLSSsVSTKCHE
3806 : Phospho-Rictor (Thr1135) (D30A3) Rabbit mAb
  rat

 
S6-p __MGRNDsGEENVPL
S20 LDLTREPSDNLREIL
Y94 AGLRALRYLIQDSSI
K198 GGLNTILKNVIDCQL
Y228 NHPKTRQYVRADVEL
S250 TDFHYRHSPDTAEGQ
K259 DTAEGQLKEDREARF
S269 REARFLASKMGIIAT
K359 GFVAAEAKTILPHRA
S368 ILPHRARSRPDLMDN
T409 DHISVRATILLGELL
K567 RRLLYFYKPSSKLYA
T718 DACRLYATKHLRVLL
Y820 LEKWHKEYNSKYVDL
S822 KWHKEYNSKYVDLIE
Y848 KPIDGDNYVRRSNQR
S1011 PSTLSLNSESTSSRH
S1013 TLSLNSESTSSRHNS
S1015 SLNSESTSSRHNSES
S1016 LNSESTSSRHNSESE
S1020 STSSRHNSESESAPS
S1022 SSRHNSESESAPSSM
Y1058 EDAEPAFYDRPGPIK
S1075 NSFPFFASSKLVKNR
K1077 FPFFASSKLVKNRIL
S1086 VKNRILNSLTLPTKK
T1088 NRILNSLTLPTKKHR
K1092 NSLTLPTKKHRSSSD
T1118 TSNRRIRTFTEPSVD
T1120 NRRIRTFTEPSVDFN
S1123 IRTFTEPSVDFNHSD
S1129 PSVDFNHSDDFTNIS
T1133 FNHSDDFTNISPAQK
T1141 NISPAQKTLQLETSF
T1146 QKTLQLETSFVGNKH
S1147 KTLQLETSFVGNKHL
T1157 GNKHLEDTGSTPsIG
S1159 KHLEDTGSTPsIGDN
T1160 HLEDTGSTPsIGDND
S1162-p EDTGSTPsIGDNDLK
K1169 sIGDNDLKFPKSFGP
S1196 VVESSAGSHMKIRSQ
S1202 GSHMKIRSQSFNTDT
S1204 HMKIRSQSFNTDTTT
T1207 IRSQSFNTDTTTSGI
T1209 SQSFNTDTTTSGISS
T1210 QSFNTDTTTSGISSM
T1211 SFNTDTTTSGISSMS
S1212 FNTDTTTSGISSMSS
S1215 DTTTSGISSMSSSPS
S1216 TTTSGISSMSSSPSR
S1219 SGISSMSSSPSRETV
S1220 GISSMSSSPSRETVA
S1252 STKTVKTSHYLTPQA
Y1254 KTVKTSHYLTPQANH
T1256 VKTSHYLTPQANHLS
A1259 SHYLTPQANHLSLSK
S1263 TPQANHLSLSKSNSV
S1267 NHLSLSKSNSVSLVP
S1269 LSLSKSNSVSLVPPG
S1271 LSKSNSVSLVPPGSS
S1277 VSLVPPGSSHTLPRR
S1278 SLVPPGSSHTLPRRA
T1280 VPPGSSHTLPRRAQS
S1287 TLPRRAQSLKAPSIA
S1292 AQSLKAPSIATIKSL
K1297 APSIATIKSLADCNF
S1298 PSIATIKSLADCNFS
S1305 SLADCNFSYTSSRDA
Y1306 LADCNFSYTSSRDAF
Y1315 SSRDAFGYATLKRLQ
T1317 RDAFGYATLKRLQQQ
S1329 QQQRMHPSLSHSEAL
S1331 QRMHPSLSHSEALAS
S1333 MHPSLSHSEALASPA
S1338 SHSEALASPAKDVLF
T1346 PAKDVLFTDTITMKA
K1352 FTDTITMKANSFESR
S1355 TITMKANSFESRLTP
S1358 MKANSFESRLTPSRF
T1361 NSFESRLTPSRFMKA
K1367 LTPSRFMKALsYAsL
S1370-p SRFMKALsYAsLDKE
Y1371 RFMKALsYAsLDKED
S1373-p MKALsYAsLDKEDLL
K1376 LsYAsLDKEDLLSPI
S1381 LDKEDLLSPINQNTL
T1387 LSPINQNTLQRSSSV
S1391 NQNTLQRSSSVRSMV
S1392 QNTLQRSSSVRSMVS
S1396 QRSSSVRSMVSSATY
S1399 SSVRSMVSSATYGGS
S1400 SVRSMVSSATYGGSD
T1402 RSMVSSATYGGSDDY
Y1403 SMVSSATYGGSDDYI
S1406 SSATYGGSDDYIGLA
Y1429 FQVKDIPYFQSKHVP
S1432 KDIPYFQSKHVPPPD
S1447 DRGARTFSHDGGGLP
S1455 HDGGGLPSGTGSLVK
T1457 GGGLPSGTGSLVKNS
S1464 TGSLVKNSFHLLRQQ
S1556 EVVPSKFSGISGCSD
S1559 PSKFSGISGCSDGAS
S1562 FSGISGCSDGASQEE
S1566 SGCSDGASQEEGSAS
S1571 GASQEEGSASSTKsT
S1577-p GSASSTKsTELLLGV
T1578 SASSTKsTELLLGVK
T1591 VKTIPDDTPMCRILL
S1612 LVVNLSSSVSTKCHE
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