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Protein Page:
NOT2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
NOT2 The CCR4-NOT complex functions as general transcription regulation complex. Subunit of the CCR4-NOT core complex that contains CHAF1A, CHAF1B, CNOT1, CNOT2, CNOT3, CNOT4, CNOT6 and CNOT8. Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes. Belongs to the CNOT2/3/5 family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Cellular Component: cytoplasm; nucleus; cytosol; CCR4-NOT complex
Molecular Function: protein binding; poly(A)-specific ribonuclease activity
Biological Process: regulation of translation; transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; poly(A) tail shortening; RNA metabolic process; gene expression; RNA-mediated gene silencing; negative regulation of transcription from RNA polymerase II promoter; mRNA catabolic process, deadenylation-dependent decay; negative regulation of estrogen receptor signaling pathway; mRNA metabolic process; trophectodermal cell differentiation
Reference #:  Q9NZN8 (UniProtKB)
Alt. Names/Synonyms: CCR4-associated factor 2; CCR4-NOT transcription complex subunit 2; CCR4-NOT transcription complex, subunit 2; CDC36; CNOT2; FLJ26456; HSPC131; NOT2; NOT2 (negative regulator of transcription 2, yeast) homolog; NOT2H
Gene Symbols: CNOT2
Molecular weight: 59,738 Da
Basal Isoelectric point: 7.23  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NOT2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 34 S35-p KFVEGVDsDyHDENM
0 98 Y37-p VEGVDsDyHDENMyy
0 110 Y43-p DyHDENMyysQssMF
0 41 Y44-p yHDENMyysQssMFP
0 11 S45-p HDENMyysQssMFPH
0 5 S47-p ENMyysQssMFPHRS
0 3 S48-p NMyysQssMFPHRSE
0 1 K56-ac MFPHRSEkDMLASPS
0 1 S65-p MLASPSTsGQLsQFG
0 1 S69-p PSTsGQLsQFGASLY
0 1 S90-p GLPMRGMsNNtPQLN
0 14 T93-p MRGMsNNtPQLNRsL
0 9 S99-p NtPQLNRsLsQGtQL
0 13 S101-p PQLNRsLsQGtQLPs
0 4 T104-p NRsLsQGtQLPsHVt
0 2 S108-p sQGtQLPsHVtPttG
0 1 T111-p tQLPsHVtPttGVPT
0 1 T113-p LPsHVtPttGVPTMs
0 1 T113 LPsHVtPTtGVPTMs
0 2 T114-p PsHVtPttGVPTMsL
0 1 T114 PsHVtPtTGVPTMsL
0 1 T118 tPttGVPTMsLHtPP
0 3 S120-p ttGVPTMsLHtPPsP
0 1 T123-p VPTMsLHtPPsPsRG
0 39 S126-p MsLHtPPsPsRGILP
0 8 S128-p LHtPPsPsRGILPMN
0 5 S143-p PRNMMNHsQVGQGIG
0 2 T155-p GIGIPSRtNsMsssG
0 13 S157-p GIPSRtNsMsssGLG
0 2 S159-p PSRtNsMsssGLGsP
0 3 S160-p SRtNsMsssGLGsPN
0 3 S161-p RtNsMsssGLGsPNR
0 56 S165-p MsssGLGsPNRssPS
0 3 S169-p GLGsPNRssPSIICM
0 8 S170-p LGsPNRssPSIICMP
0 3 S242-p DRNRREGsGNPtPLI
0 2 T246-p REGsGNPtPLINPLA
0 1 S293-p SSYKDPTssNDDSkS
0 2 S294-p SYKDPTssNDDSkSN
0 1 K299-ac TssNDDSkSNLNtsG
0 1 T304-p DSkSNLNtsGKtTSS
0 2 S305-p SkSNLNtsGKtTSST
0 1 T308-p NLNtsGKtTSSTDGP
0 4 Y396-p LNSPENLyPKFASPW
0 1 K490-ub PGMEPTMkTNTyERG
0 1 Y494-p PTMkTNTyERGTYyF
0 1 Y500-p TyERGTYyFFDCLNW
  mouse

 
S35 KFVEGVDSDYHDENM
Y37 VEGVDSDYHDENMyY
Y43-p DYHDENMyYSQSSMF
Y44 YHDENMyYSQSSMFP
S45 HDENMyYSQSSMFPH
S47 ENMyYSQSSMFPHRS
S48 NMyYSQSSMFPHRSE
K56 MFPHRSEKDMLASPS
S65 MLASPSTSGQLSQFG
S69 PSTSGQLSQFGASLY
S90 GLPMRGMSNNTPQLN
T93 MRGMSNNTPQLNRSL
S99 NTPQLNRSLSQGTQL
S101 PQLNRSLSQGTQLPS
T104 NRSLSQGTQLPSHVT
S108 SQGTQLPSHVTPttG
T111 TQLPSHVTPttGVPt
T113-p LPSHVTPttGVPtMS
T113-gl LPSHVTPttGVPtMS
T114 PSHVTPtTGVPtMSL
T114-gl PSHVTPttGVPtMSL
T118-gl TPttGVPtMSLHTPP
S120 ttGVPtMSLHTPPsP
T123 VPtMSLHTPPsPsRG
S126-p MSLHTPPsPsRGILP
S128-p LHTPPsPsRGILPMN
S143-p PRNMMNHsQVGQGIG
T155-p GIGIPSRtNsMsssG
S157-p GIPSRtNsMsssGLG
S159-p PSRtNsMsssGLGsP
S160-p SRtNsMsssGLGsPN
S161-p RtNsMsssGLGsPNR
S165-p MsssGLGsPNRssPS
S169-p GLGsPNRssPSIICM
S170-p LGsPNRssPSIICMP
S242 DRNRREGSGNPTPLI
T246 REGSGNPTPLINPLA
S293 SSYKDPTSSNDDSKS
S294 SYKDPTSSNDDSKSN
K299 TSSNDDSKSNLSTSG
T304 DSKSNLSTSGKTTSS
S305 SKSNLSTSGKTTSST
T308 NLSTSGKTTSSTDGP
Y396-p LNSPENLyPKFASPW
K490 PGMEPTMKTNTYERG
Y494 PTMKTNTYERGTYYF
Y500 TYERGTYYFFDCLNW
  rat

 
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S5 ___MRGMSNNTPQLN
T8 MRGMSNNTPQLNRSL
S14 NTPQLNRSLSQGTQL
S16 PQLNRSLSQGTQLPS
T19 NRSLSQGTQLPSHVT
S23 SQGTQLPSHVTPTTG
T26 TQLPSHVTPTTGVPT
T28 LPSHVTPTTGVPTMS
T28 LPSHVTPTTGVPTMS
T29 PSHVTPTTGVPTMSL
T29 PSHVTPTTGVPTMSL
T33 TPTTGVPTMSLHTPP
S35 TTGVPTMSLHTPPSP
T38 VPTMSLHTPPSPSRG
S41 MSLHTPPSPSRGILP
S43 LHTPPSPSRGILPMN
S58 PRNMMNHSQVGQGIG
T70 GIGIPSRTNSMSSSG
S72 GIPSRTNSMSSSGLG
S74 PSRTNSMSSSGLGsP
S75 SRTNSMSSSGLGsPN
S76 RTNSMSSSGLGsPNR
S80-p MSSSGLGsPNRSSPS
S84 GLGsPNRSSPSIICM
S85 LGsPNRSSPSIICMP
S157 DRNRREGSGNPTPLI
T161 REGSGNPTPLINPLA
S208 SSYKDPTSSNDDSKS
S209 SYKDPTSSNDDSKSN
K214 TSSNDDSKSNLSTSG
T219 DSKSNLSTSGKTTSS
S220 SKSNLSTSGKTTSST
T223 NLSTSGKTTSSTDGP
Y311 LNSPENLYPKFASPW
K405 PGMEPTMKTNTYERG
Y409 PTMKTNTYERGTYYF
Y415 TYERGTYYFFDCLNW
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