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NOT2 (human)

Overview NOT2 The CCR4-NOT complex functions as general transcription regulation complex. Subunit of the CCR4-NOT core complex that contains CHAF1A, CHAF1B, CNOT1, CNOT2, CNOT3, CNOT4, CNOT6 and CNOT8. Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes. Belongs to the CNOT2/3/5 family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Transcription, coactivator/corepressor Cellular Component: nucleus; cytosol Biological Process: regulation of transcription from RNA polymerase II promoter; poly(A) tail shortening; RNA metabolic process; gene expression; mRNA catabolic process, deadenylation-dependent decay; mRNA metabolic process Reference #:  Q9NZN8 (UniProtKB) Alt. Names/Synonyms: CCR4-associated factor 2; CCR4-NOT transcription complex subunit 2; CCR4-NOT transcription complex, subunit 2; CDC36; CNOT2; FLJ26456; HSPC131; NOT2; NOT2 (negative regulator of transcription 2, yeast) homolog; NOT2H Gene Symbols: CNOT2 Molecular weight: 59,738 Da Basal Isoelectric point: 7.23  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below NOT2

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	34		S35-p	KFVEGVDsDyHDENM
0	110		Y37-p	VEGVDsDyHDENMyy
0	127		Y43-p	DyHDENMyysQssMF
0	52		Y44-p	yHDENMyysQssMFP
0	11		S45-p	HDENMyysQssMFPH
0	5		S47-p	ENMyysQssMFPHRS
0	3		S48-p	NMyysQssMFPHRSE
0	1		K56-a	MFPHRSEkDMLASPS
0	1		S65-p	MLASPSTsGQLSQFG
0	1		S90-p	GLPMRGMsNNtPQLN
0	9		T93-p	MRGMsNNtPQLNRsL
0	9		S99-p	NtPQLNRsLsQGtQL
0	15		S101-p	PQLNRsLsQGtQLPs
0	4		T104-p	NRsLsQGtQLPsHVT
0	1		S108-p	sQGtQLPsHVTPttG
0	1		T113-p	LPsHVTPttGVPTMs
0	1		T113	LPsHVTPTtGVPTMs
0	1		T114-p	PsHVTPttGVPTMsL
0	1		T114	PsHVTPtTGVPTMsL
0	1		T118	TPttGVPTMsLHTPP
0	2		S120-p	ttGVPTMsLHTPPsP
0	39		S126-p	MsLHTPPsPsRGILP
0	8		S128-p	LHTPPsPsRGILPMN
0	4		S143-p	PRNMMNHsQVGQGIG
0	2		T155-p	GIGIPSRtNsMsssG
0	11		S157-p	GIPSRtNsMsssGLG
0	2		S159-p	PSRtNsMsssGLGsP
0	3		S160-p	SRtNsMsssGLGsPN
0	3		S161-p	RtNsMsssGLGsPNR
0	50		S165-p	MsssGLGsPNRssPS
0	2		S169-p	GLGsPNRssPSIICM
0	5		S170-p	LGsPNRssPSIICMP
0	1		S242-p	DRNRREGsGNPtPLI
0	1		T246-p	REGsGNPtPLINPLA
0	1		S293-p	SSYKDPTssNDDSkS
0	2		S294-p	SYKDPTssNDDSkSN
0	1		K299-a	TssNDDSkSNLNtsG
0	1		T304-p	DSkSNLNtsGKTTSS
0	1		S305-p	SkSNLNtsGKTTSST
0	4		Y396-p	LNSPENLyPKFASPW
0	1		K490-u	PGMEPTMkTNTyERG
0	1		Y494-p	PTMkTNTyERGTYyF
0	1		Y500-p	TyERGTYyFFDCLNW

	mouse
S35	KFVEGVDSDYHDENM
Y37	VEGVDSDYHDENMyY
Y43-p	DYHDENMyYSQSSMF
Y44	YHDENMyYSQSSMFP
S45	HDENMyYSQSSMFPH
S47	ENMyYSQSSMFPHRS
S48	NMyYSQSSMFPHRSE
K56	MFPHRSEKDMLASPS
S65	MLASPSTSGQLSQFG
S90	GLPMRGMSNNTPQLN
T93	MRGMSNNTPQLNRSL
S99	NTPQLNRSLSQGTQL
S101	PQLNRSLSQGTQLPS
T104	NRSLSQGTQLPSHVT
S108	SQGTQLPSHVTPttG
T113-p	LPSHVTPttGVPtMS
T113-gl	LPSHVTPttGVPtMS
T114	PSHVTPtTGVPtMSL
T114-gl	PSHVTPttGVPtMSL
T118-gl	TPttGVPtMSLHTPP
S120	ttGVPtMSLHTPPsP
S126-p	MSLHTPPsPsRGILP
S128-p	LHTPPsPsRGILPMN
S143-p	PRNMMNHsQVGQGIG
T155-p	GIGIPSRtNsMsSsG
S157-p	GIPSRtNsMsSsGLG
S159-p	PSRtNsMsSsGLGsP
S160	SRtNsMsSsGLGsPN
S161-p	RtNsMsSsGLGsPNR
S165-p	MsSsGLGsPNRssPS
S169-p	GLGsPNRssPSIICM
S170-p	LGsPNRssPSIICMP
S242	DRNRREGSGNPTPLI
T246	REGSGNPTPLINPLA
S293	SSYKDPTSSNDDSKS
S294	SYKDPTSSNDDSKSN
K299	TSSNDDSKSNLSTSG
T304	DSKSNLSTSGKTTSS
S305	SKSNLSTSGKTTSST
Y396-p	LNSPENLyPKFASPW
K490	PGMEPTMKTNTYERG
Y494	PTMKTNTYERGTYYF
Y500	TYERGTYYFFDCLNW

	rat
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
S5	___MRGMSNNTPQLN
T8	MRGMSNNTPQLNRSL
S14	NTPQLNRSLSQGTQL
S16	PQLNRSLSQGTQLPS
T19	NRSLSQGTQLPSHVT
S23	SQGTQLPSHVTPTTG
T28	LPSHVTPTTGVPTMS
T28	LPSHVTPTTGVPTMS
T29	PSHVTPTTGVPTMSL
T29	PSHVTPTTGVPTMSL
T33	TPTTGVPTMSLHTPP
S35	TTGVPTMSLHTPPSP
S41	MSLHTPPSPSRGILP
S43	LHTPPSPSRGILPMN
S58	PRNMMNHSQVGQGIG
T70	GIGIPSRTNSMSSSG
S72	GIPSRTNSMSSSGLG
S74	PSRTNSMSSSGLGsP
S75	SRTNSMSSSGLGsPN
S76	RTNSMSSSGLGsPNR
S80-p	MSSSGLGsPNRSSPS
S84	GLGsPNRSSPSIICM
S85	LGsPNRSSPSIICMP
S157	DRNRREGSGNPTPLI
T161	REGSGNPTPLINPLA
S208	SSYKDPTSSNDDSKS
S209	SYKDPTSSNDDSKSN
K214	TSSNDDSKSNLSTSG
T219	DSKSNLSTSGKTTSS
S220	SKSNLSTSGKTTSST
Y311	LNSPENLYPKFASPW
K405	PGMEPTMKTNTYERG
Y409	PTMKTNTYERGTYYF
Y415	TYERGTYYFFDCLNW

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