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Protein Page:
PKCD (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PKCD an AGC kinase of the PKC family. A novel PKC: Ca2 independent but still regulated by PS, DAG and phorbol esters. Caspase-3 appears to liberate a sphingosine-activated catalytic fragment that has altered regulatory mechanisms and substrate specificities. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, AGC; Kinase, protein; EC 2.7.10.2; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.13; AGC group; PKC family; Delta subfamily
Cellular Component: nucleoplasm; nuclear matrix; mitochondrion; endoplasmic reticulum; perinuclear region of cytoplasm; cytoplasm; plasma membrane; intercellular junction; cytosol; nucleus
Molecular Function: protein C-terminus binding; calcium-independent protein kinase C activity; protein serine/threonine kinase activity; protein binding; protein kinase C activity; enzyme binding; insulin receptor substrate binding; metal ion binding; enzyme activator activity; non-membrane spanning protein tyrosine kinase activity; ATP binding
Biological Process: B cell proliferation; negative regulation of MAP kinase activity; peptidyl-tyrosine phosphorylation; interleukin-12 production; nerve growth factor receptor signaling pathway; apoptosis; negative regulation of insulin receptor signaling pathway; signal transduction; protein amino acid phosphorylation; positive regulation of protein amino acid dephosphorylation; negative regulation of filopodium formation; RNA metabolic process; positive regulation of superoxide release; regulation of receptor activity; negative regulation of protein binding; cell structure disassembly during apoptosis; epidermal growth factor receptor signaling pathway; platelet activation; negative regulation of peptidyl-tyrosine phosphorylation; fibroblast growth factor receptor signaling pathway; protein stabilization; neutrophil activation; negative regulation of actin filament polymerization; cytokine and chemokine mediated signaling pathway; peptidyl-threonine phosphorylation; cell cycle; mRNA metabolic process; phospholipase C activation; negative regulation of inflammatory response; defense response to bacterium; interleukin-10 production; innate immune response; gene expression; immunoglobulin mediated immune response; blood coagulation
Reference #:  Q05655 (UniProtKB)
Alt. Names/Synonyms: KPCD; MAY1; MGC49908; nPKC-delta; PKCD; PRKCD; Protein kinase C delta type; protein kinase C delta VIII; protein kinase C, delta
Gene Symbols: PRKCD
Molecular weight: 77,505 Da
Basal Isoelectric point: 7.93  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis  |  Phospholipase Signaling  |  Protein Kinase C Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PKCD

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
apoptosis, altered: Y52‑p, Y64‑p, Y187‑p, Y313‑p, T507‑p
apoptosis, induced: Y64‑p, Y187‑p, Y334‑p
transcription, inhibited: Y313‑p
activity, inhibited: Y52‑p, Y64‑p, Y187‑p
enzymatic activity, induced: T141‑p, T295‑p, T507‑p
intracellular localization: S299‑p
molecular association, regulation: Y334‑p
phosphorylation: Y64‑p, Y187‑p, Y313‑p, T507‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 T43-p LSTERGKtLVQKKPt
0 1 K47 RGKtLVQKKPtMyPE
0 2 T50-p tLVQKKPtMyPEWKS
4 0 Y52-p VQKKPtMyPEWKSTF
7 29 Y64-p STFDAHIyEGRVIQI
0 6 S130-p EDVDCKQsMRSEDEA
1 6 T141-p EDEAKFPtMNRRGAI
8 0 Y155-p IKQAKIHyIKNHEFI
0 2 K184-ub DFVWGLNkQGyKCRQ
6 0 Y187-p WGLNkQGyKCRQCNA
1 3 T218-p TAANSRDtIFQkERF
0 3 K222-ub SRDtIFQkERFNIDM
0 2 H236 MPHRFKVHNYMSPTF
0 1 K271-ub CGMNVHHkCREKVAN
1 0 T295-p AEALNQVtQRAsRRs
0 1 T295 AEALNQVTQRAsRRs
1 28 S299-p NQVtQRAsRRsDsAs
0 1 R301 VtQRAsRRsDsAssE
2 64 S302-p tQRAsRRsDsAssEP
2 372 S304-p RAsRRsDsAssEPVG
0 78 S306-p sRRsDsAssEPVGIy
0 50 S307-p RRsDsAssEPVGIyQ
0 4 P309 sDsAssEPVGIyQGF
30 1699 Y313-p ssEPVGIyQGFEKkT
0 1 K319-ub IyQGFEKkTGVAGED
0 1 E325 KkTGVAGEDMQDNsG
0 3 S331-p GEDMQDNsGtyGkIW
0 15 T333-p DMQDNsGtyGkIWEG
12 529 Y334-p MQDNsGtyGkIWEGs
0 1 K336-ub DNsGtyGkIWEGssK
0 1 S341-p yGkIWEGssKCNINN
0 1 S342-p GkIWEGssKCNINNF
0 1 I350 KCNINNFIFHKVLGK
0 1 S359 HKVLGKGSFGkVLLG
0 1 K362-ub LGKGSFGkVLLGELk
0 5 K369-ub kVLLGELkGRGEyFA
2 493 Y374-p ELkGRGEyFAIKALK
0 1 Y448-p DKGRFELyRAtFyAA
0 1 T451-p RFELyRAtFyAAEIM
0 1 Y453-p ELyRAtFyAAEIMCG
0 1 Y471-p LHSKGIIyRDLKLDN
0 2 R472 HSKGIIyRDLKLDNV
0 4 K496-ub IADFGMCkENIFGEs
1 13 S503-p kENIFGEsRAstFCG
0 50 S506-p IFGEsRAstFCGtPD
38 119 T507-p FGEsRAstFCGtPDy
0 4 T511-p RAstFCGtPDyIAPE
3 1 Y514-p tFCGtPDyIAPEILQ
3 0 Y525-p EILQGLKyTFSVDWW
5 0 Y567-p IRVDTPHyPRWITKE
0 1 T594-p PTKRLGVtGNIKIHP
0 1 T594 PTKRLGVTGNIKIHP
0 1 T605-p KIHPFFKtINWtLLE
0 1 T609-p FFKtINWtLLEkRRL
0 1 K613-ub INWtLLEkRRLEPPF
1 26 Y630-p KVKSPRDysNFDQEF
0 1 S631-p VKSPRDysNFDQEFL
0 3 K641-ub DQEFLNEkARLsysD
19 93 S645-p LNEkARLsysDKNLI
0 17 Y646-p NEkARLsysDKNLID
0 38 S647-p EkARLsysDKNLIDs
0 11 S654-p sDKNLIDsMDQsAFA
0 4 S658-p LIDsMDQsAFAGFsF
7 87 S664-p QsAFAGFsFVNPKFE
2055 : Phospho-PKCdelta (Tyr311) Antibody
2060 : Phospho-PKC (pan) (zeta Thr410) (190D10) Rabbit mAb
5016 : Phospho-PKC (pan) (zeta Thr410) (190D10) Rabbit mAb (Biotinylated)
9374 : Phospho-PKCdelta (Thr505) Antibody
9379 : Phospho-PKC (pan) (gamma Thr514) Antibody
9376 : Phospho-PKCdelta/theta (Ser643/676) Antibody
9371 : Phospho-PKC (pan) (betaII Ser660) Antibody
  mouse

► Hide Isoforms
 
T43-p LSTERGKtLVQkKPT
K47-ac RGKtLVQkKPTMyPE
T50 tLVQkKPTMyPEWKT
Y52-p VQkKPTMyPEWKTTF
Y64-p TTFDAHIyEGRVIQI
S130-p EDGDCKQsMRSEEEA
T141-p EEEAKFPtMNRRGAI
Y155-p IKQAKIHyIKNHEFI
K184-ub EFVWGLNkQGyKCRQ
Y187-p WGLNkQGyKCRQCNA
T218 TATNSRDTIFQkERF
K222-ub SRDTIFQkERFNIDM
Y236-p MPHRFKVyNYMSPTF
K271 CGMNVHHKCREKVAN
T295 AEALNQVTQRSSRkL
T295 AEALNQVTQRSSRkL
S299 NQVTQRSSRkLDTTE
K301-ub VTQRSSRkLDTTEsV
- gap
- gap
T304 RSSRkLDTTEsVGIy
T305 SSRkLDTTEsVGIyQ
S307-p RkLDTTEsVGIyQGF
Y311-p TTEsVGIyQGFEKKP
K317 IyQGFEKKPEVSGsD
S323-p KKPEVSGsDILDNNG
N329 GsDILDNNGTyGKIW
T331 DILDNNGTyGKIWEG
Y332-p ILDNNGTyGKIWEGS
K334 DNNGTyGKIWEGSTR
S339 yGKIWEGSTRCTLEN
T340 GKIWEGSTRCTLENF
T348 RCTLENFTFQKVLGK
S357 QKVLGKGSFGKVLLA
K360 LGKGSFGKVLLAELK
K367 KVLLAELKGKDKyFA
Y372-p ELKGKDKyFAIKCLK
Y446 DKGRFELYRATFYAA
T449 RFELYRATFYAAEII
Y451 ELYRATFYAAEIICG
Y469 LHSKGIIYrDLKLDN
R470-m1 HSKGIIYrDLKLDNV
K494 IADFGMCKENIFGEG
G501 KENIFGEGRAstFCG
S504-p IFGEGRAstFCGtPD
T505-p FGEGRAstFCGtPDy
T509-p RAstFCGtPDyIAPE
Y512-p tFCGtPDyIAPEILQ
Y523 EILQGLKYSFSVDWW
Y565-p IRVDTPHyPRWITKE
T592 PDKRLGVTGNIRIHP
T592 PDKRLGVTGNIRIHP
T603 RIHPFFKTINWSLLE
S607 FFKTINWSLLEKRKV
K611 INWSLLEKRKVEPPF
Y628 KVKSPSDYSNFDPEF
S629 VKSPSDYSNFDPEFL
K639 DPEFLNEKPQLsFsD
S643-p LNEKPQLsFsDKNLI
F644 NEKPQLsFsDKNLID
S645-p EKPQLsFsDKNLIDs
S652-p sDKNLIDsMDQEAFH
E656 LIDsMDQEAFHGFsF
S662-p QEAFHGFsFVNPKFE
2055 : Phospho-PKCdelta (Tyr311) Antibody
2060 : Phospho-PKC (pan) (zeta Thr410) (190D10) Rabbit mAb
5016 : Phospho-PKC (pan) (zeta Thr410) (190D10) Rabbit mAb (Biotinylated)
9374 : Phospho-PKCdelta (Thr505) Antibody
9379 : Phospho-PKC (pan) (gamma Thr514) Antibody
9376 : Phospho-PKCdelta/theta (Ser643/676) Antibody
9371 : Phospho-PKC (pan) (betaII Ser660) Antibody
  PKCD iso2  
T43 LSTERGKTLVQKKPT
K47 RGKTLVQKKPTMYPE
T50 TLVQKKPTMYPEWKT
Y52 VQKKPTMYPEWKTTF
Y64 TTFDAHIYEGRVIQI
S130 EDGDCKQSMRSEEEA
T141 EEEAKFPTMNRRGAI
Y155 IKQAKIHYIKNHEFI
K184 EFVWGLNKQGYKCRQ
Y187 WGLNKQGYKCRQCNA
T218 TATNSRDTIFQKERF
K222 SRDTIFQKERFNIDM
Y236 MPHRFKVYNYMSPTF
K271 CGMNVHHKCREKVAN
T295 AEALNQVTQRSSRKL
T295 AEALNQVTQRSSRKL
S299 NQVTQRSSRKLDTTE
K301 VTQRSSRKLDTTESV
- gap
- gap
T304 RSSRKLDTTESVGIY
T305 SSRKLDTTESVGIYQ
S307 RKLDTTESVGIYQGF
Y311 TTESVGIYQGFEKKP
K317 IYQGFEKKPEVSGSD
S323 KKPEVSGSDILGEAG
N355 SSETCDNNGTYGKIW
T357 ETCDNNGTYGKIWEG
Y358 TCDNNGTYGKIWEGS
K360 DNNGTYGKIWEGSTR
S365 YGKIWEGSTRCTLEN
T366 GKIWEGSTRCTLENF
T374 RCTLENFTFQKVLGK
S383 QKVLGKGSFGKVLLA
K386 LGKGSFGKVLLAELK
K393 KVLLAELKGKDKYFA
Y398 ELKGKDKYFAIKCLK
Y472 DKGRFELYRATFYAA
T475 RFELYRATFYAAEII
Y477 ELYRATFYAAEIICG
Y495 LHSKGIIYRDLKLDN
R496 HSKGIIYRDLKLDNV
K520 IADFGMCKENIFGEG
G527 KENIFGEGRASTFCG
S530 IFGEGRASTFCGTPD
T531 FGEGRASTFCGTPDY
T535 RASTFCGTPDYIAPE
Y538 TFCGTPDYIAPEILQ
Y549 EILQGLKYSFSVDWW
Y591 IRVDTPHYPRWITKE
T618 PDKRLGVTGNIRIHP
T618 PDKRLGVTGNIRIHP
T629 RIHPFFKTINWSLLE
S633 FFKTINWSLLEKRKV
K637 INWSLLEKRKVEPPF
Y654 KVKSPSDYSNFDPEF
S655 VKSPSDYSNFDPEFL
K665 DPEFLNEKPQLSFSD
S669 LNEKPQLSFSDKNLI
F670 NEKPQLSFSDKNLID
S671 EKPQLSFSDKNLIDS
S678 SDKNLIDSMDQEAFH
E682 LIDSMDQEAFHGFSF
S688 QEAFHGFSFVNPKFE
  rat

 
T43 LTTDRGKTLVQKKPT
K47 RGKTLVQKKPTMYPE
T50 TLVQKKPTMYPEWKS
Y52 VQKKPTMYPEWKSTF
Y64-p STFDAHIyEGRVIQI
S130 EDGDCKQSMRSEEEA
T141 EEEAMFPTMNRRGAI
Y155-p IKQAKIHyIKNHEFI
K184 EFVWGLNKQGYKCRQ
Y187 WGLNKQGYKCRQCNA
T218 TATNSRDTIFQKERF
K222 SRDTIFQKERFNIDM
Y236 MPHRFKVYNYMSPTF
K271 CGMNVHHKCREKVAN
T295 AEALNQVTQKASRKP
T295-gl AEALNQVtQKASRKP
S299 NQVtQKASRKPETPE
K301 VtQKASRKPETPETV
- gap
- gap
T304 KASRKPETPETVGIy
P305 ASRKPETPETVGIyQ
T307 RKPETPETVGIyQGF
Y311-p TPETVGIyQGFEKKT
K317 IyQGFEKKTAVSGND
N323 KKTAVSGNDIPDNNG
N329 GNDIPDNNGTyGKIW
T331 DIPDNNGTyGKIWEG
Y332-p IPDNNGTyGKIWEGS
K334 DNNGTyGKIWEGSNR
S339 yGKIWEGSNRCRLEN
N340 GKIWEGSNRCRLENF
T348-gl RCRLENFtFQKVLGK
S357-p QKVLGKGsFGKVLLA
K360 LGKGsFGKVLLAELK
K367 KVLLAELKGKERyFA
Y372-p ELKGKERyFAIKYLK
Y446 DKGRFELYRATFYAA
T449 RFELYRATFYAAEII
Y451 ELYRATFYAAEIICG
Y469 LHGKGIIYRDLKLDN
R470 HGKGIIYRDLKLDNV
K494 IADFGMCKENIFGEN
N501 KENIFGENRAstFCG
S504-p IFGENRAstFCGTPD
T505-p FGENRAstFCGTPDy
T509 RAstFCGTPDyIAPE
Y512-p tFCGTPDyIAPEILQ
Y523-p EILQGLKySFSVDWW
Y565-p IRVDTPHyPRWITKE
T592 PAKRLGVTGNIRLHP
T592-gl PAKRLGVtGNIRLHP
T603 RLHPFFKTINWNLLE
N607 FFKTINWNLLEKRKV
K611 INWNLLEKRKVEPPF
Y628-p KVKSPSDySNFDPEF
S629 VKSPSDySNFDPEFL
K639 DPEFLNEKPQLsFSD
S643-p LNEKPQLsFSDKNLI
F644 NEKPQLsFSDKNLID
S645 EKPQLsFSDKNLIDS
S652 SDKNLIDSMDQTAFK
T656 LIDSMDQTAFKGFsF
S662-p QTAFKGFsFVNPKYE
2060 : Phospho-PKC (pan) (zeta Thr410) (190D10) Rabbit mAb
5016 : Phospho-PKC (pan) (zeta Thr410) (190D10) Rabbit mAb (Biotinylated)
9374 : Phospho-PKCdelta (Thr505) Antibody
9379 : Phospho-PKC (pan) (gamma Thr514) Antibody
9376 : Phospho-PKCdelta/theta (Ser643/676) Antibody
9371 : Phospho-PKC (pan) (betaII Ser660) Antibody
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