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PKCD (human)

Overview PKCD an AGC kinase of the PKC family. A novel PKC: Ca2 independent but still regulated by PS, DAG and phorbol esters. Caspase-3 appears to liberate a sphingosine-activated catalytic fragment that has altered regulatory mechanisms and substrate specificities. Note: This description may include information from UniProtKB. Protein type: Protein kinase, AGC; Kinase, protein; EC 2.7.10.2; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.13; AGC group; PKC family; Delta subfamily Cellular Component: nucleoplasm; nuclear matrix; mitochondrion; perinuclear region of cytoplasm; endoplasmic reticulum; cytoplasm; plasma membrane; intercellular junction; nucleus; cytosol Molecular Function: protein C-terminus binding; protein serine/threonine kinase activity; identical protein binding; calcium-independent protein kinase C activity; protein binding; protein kinase C activity; enzyme binding; metal ion binding; insulin receptor substrate binding; enzyme activator activity; non-membrane spanning protein tyrosine kinase activity; ATP binding Biological Process: B cell proliferation; negative regulation of MAP kinase activity; interleukin-12 production; nerve growth factor receptor signaling pathway; apoptosis; negative regulation of insulin receptor signaling pathway; signal transduction; protein amino acid phosphorylation; positive regulation of protein amino acid dephosphorylation; negative regulation of filopodium formation; RNA metabolic process; positive regulation of superoxide release; regulation of receptor activity; negative regulation of protein binding; cell structure disassembly during apoptosis; epidermal growth factor receptor signaling pathway; negative regulation of peptidyl-tyrosine phosphorylation; platelet activation; fibroblast growth factor receptor signaling pathway; neutrophil activation; protein stabilization; negative regulation of actin filament polymerization; cytokine and chemokine mediated signaling pathway; peptidyl-threonine phosphorylation; cell cycle; mRNA metabolic process; phospholipase C activation; negative regulation of inflammatory response; defense response to bacterium; interleukin-10 production; gene expression; immunoglobulin mediated immune response; blood coagulation Reference #:  Q05655 (UniProtKB) Alt. Names/Synonyms: KPCD; MAY1; MGC49908; nPKC-delta; PKCD; PRKCD; Protein kinase C delta type; protein kinase C delta VIII; protein kinase C, delta Gene Symbols: PRKCD Molecular weight: 77,505 Da Basal Isoelectric point: 7.93  Predict pI for various phosphorylation states CST Pathways:  Apoptosis  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCRs Signaling to MAPK/Erk  |  Inhibition of Apoptosis  |  MAPK/Erk in Growth and Differentiation  |  Mitochondrial Control of Apoptosis  |  Phospholipase Signaling  |  Protein Kinase C Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PKCD 1YRK - A=1-123 (human) 2YUU - A=149-218 (human) 1PTQ - A=231-280 (mouse) 1PTR - A=231-280 (mouse) 3UEJ - A/B=231-280 (mouse) 3UEY - A/B=231-280 (mouse) 3UFF - A/B=231-280 (mouse) 3UGD - A/B=231-280 (mouse) 3UGI - A/B=231-280 (mouse) 3UGL - A/B=231-280 (mouse) 1BDY - A/B=1-123 (rat) Substrate Sequence Logo

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1YRK 2YUU  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  Ensembl Protein

	Sites Implicated In
apoptosis, altered: Y52‑p, Y64‑p, Y187‑p, Y313‑p, T507‑p apoptosis, induced: Y64‑p, Y187‑p, Y334‑p transcription, altered: Y313‑p enzymatic activity, induced: T141‑p, T295‑p, T507‑p inhibition: Y52‑p, Y64‑p, Y187‑p intracellular localization: S299‑p molecular association, regulation: Y334‑p phosphorylation: Y64‑p, Y187‑p, Y313‑p, T507‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	3		T43-p	LSTERGKtLVQKKPt
0	1		K47	RGKtLVQKKPtMyPE
0	2		T50-p	tLVQKKPtMyPEWKS
4	0		Y52-p	VQKKPtMyPEWKSTF
6	29		Y64-p	STFDAHIyEGRVIQI
0	4		S130-p	EDVDCKQsMRSEDEA
1	3		T141-p	EDEAKFPtMNRRGAI
7	0		Y155-p	IKQAKIHyIKNHEFI
0	2		K184-u	DFVWGLNkQGyKCRQ
6	0		Y187-p	WGLNkQGyKCRQCNA
1	3		T218-p	TAANSRDtIFQkERF
0	3		K222-u	SRDtIFQkERFNIDM
0	2		H236	MPHRFKVHNYMSPTF
0	1		K271-u	CGMNVHHkCREKVAN
1	0		T295-p	AEALNQVtQRAsRRs
0	1		T295	AEALNQVTQRAsRRs
1	26		S299-p	NQVtQRAsRRsDsAs
0	1		R301	VtQRAsRRsDsAssE
2	65		S302-p	tQRAsRRsDsAssEP
2	385		S304-p	RAsRRsDsAssEPVG
0	81		S306-p	sRRsDsAssEPVGIy
0	53		S307-p	RRsDsAssEPVGIyQ
0	4		P309	sDsAssEPVGIyQGF
26	1752		Y313-p	ssEPVGIyQGFEKkT
0	1		K319-u	IyQGFEKkTGVAGED
0	1		E325	KkTGVAGEDMQDNsG
0	3		S331-p	GEDMQDNsGtyGkIW
0	16		T333-p	DMQDNsGtyGkIWEG
11	553		Y334-p	MQDNsGtyGkIWEGs
0	1		K336-u	DNsGtyGkIWEGssK
0	1		S341-p	yGkIWEGssKCNINN
0	1		S342-p	GkIWEGssKCNINNF
0	1		I350	KCNINNFIFHKVLGK
0	1		S359	HKVLGKGSFGkVLLG
0	1		K362-u	LGKGSFGkVLLGELk
0	5		K369-u	kVLLGELkGRGEyFA
2	504		Y374-p	ELkGRGEyFAIKALK
0	1		Y448-p	DKGRFELyRAtFyAA
0	1		T451-p	RFELyRAtFyAAEIM
0	1		Y453-p	ELyRAtFyAAEIMCG
0	1		Y471-p	LHSKGIIyRDLKLDN
0	2		R472	HSKGIIyRDLKLDNV
0	4		K496-u	IADFGMCkENIFGEs
1	12		S503-p	kENIFGEsRAstFCG
0	51		S506-p	IFGEsRAstFCGtPD
37	117		T507-p	FGEsRAstFCGtPDY
0	2		T511-p	RAstFCGtPDYIAPE
2	1		Y514	tFCGtPDYIAPEILQ
2	0		Y525-p	EILQGLKyTFSVDWW
4	0		Y567-p	IRVDTPHyPRWITKE
0	1		T594-p	PTKRLGVtGNIKIHP
0	1		T594	PTKRLGVTGNIKIHP
0	1		T605-p	KIHPFFKtINWtLLE
0	1		T609-p	FFKtINWtLLEkRRL
0	1		K613-u	INWtLLEkRRLEPPF
1	28		Y630-p	KVKSPRDysNFDQEF
0	1		S631-p	VKSPRDysNFDQEFL
0	3		K641-u	DQEFLNEkARLsysD
18	88		S645-p	LNEkARLsysDKNLI
0	16		Y646-p	NEkARLsysDKNLID
0	37		S647-p	EkARLsysDKNLIDs
0	11		S654-p	sDKNLIDsMDQsAFA
0	4		S658-p	LIDsMDQsAFAGFsF
7	81		S664-p	QsAFAGFsFVNPKFE

	PKCD iso13
T43	LSTERGKTLVQKKPT
K47	RGKTLVQKKPTMYPE
T50	TLVQKKPTMYPEWKS
Y52	VQKKPTMYPEWKSTF
Y64	STFDAHIYEGRVIQI
S130	EDVDCKQSMRSEDEA
T141	EDEAKFPTMNRRGAI
Y155	IKQAKIHYIKNHEFI
K184	DFVWGLNKQGYKCRQ
Y187	WGLNKQGYKCRQCNA
T218	TAANSRDTIFQKERF
K222	SRDTIFQKERFNIDM
H236	MPHRFKVHNYMSPTF
K271	CGMNVHHKCREKVAN
T295	AEALNQVTQRASRRS
T295	AEALNQVTQRASRRS
S299	NQVTQRASRRSDSAS
R301	VTQRASRRSDSASSE
S302	TQRASRRSDSASSEP
S304	RASRRSDSASSEPVG
S306	SRRSDSASSEPVGIY
S307	RRSDSASSEPVGIYQ
P309	SDSASSEPVGIYQGF
Y313	SSEPVGIYQGFEKKT
K319	IYQGFEKKTGVAGED
E325	KKTGVAGEDMQDNSG
S331	GEDMQDNSGTYGKIW
T333	DMQDNSGTYGKIWEG
Y334	MQDNSGTYGKIWEGS
K336	DNSGTYGKIWEGSSK
S341	YGKIWEGSSKCNINN
S342	GKIWEGSSKCNINNF
I350	KCNINNFIFHKVLGK
S359	HKVLGKGSFGKVLLG
K362	LGKGSFGKVLLGELK
K369	KVLLGELKGRGEYSA
Y374	ELKGRGEYSAIKALK
Y448	DKGRFELYRATFYAA
T451	RFELYRATFYAAEIM
Y453	ELYRATFYAAEIMCG
Y471	LHSKGIIYRDLKLDN
R472	HSKGIIYRDLKLDNV
K496	IADFGMCKENIFGES
S503	KENIFGESRASTFCG
S506	IFGESRASTFCGTPD
T507	FGESRASTFCGTPDY
T511	RASTFCGTPDYIAPE
Y514	TFCGTPDYIAPEILQ
Y525	EILQGLKYTFSVDWW
Y567	IRVDTPHYPRWITKE
T594	PTKRLGMTGNIKIHP
T594	PTKRLGMTGNIKIHP
T605	KIHPFFKTINWTLLE
T609	FFKTINWTLLEKRRL
K613	INWTLLEKRRLEPPF
Y630	KVKSPRDYSNFDQEF
S631	VKSPRDYSNFDQEFL
K641	DQEFLNEKARLSYSD
S645	LNEKARLSYSDKNLI
Y646	NEKARLSYSDKNLID
S647	EKARLSYSDKNLIDS
S654	SDKNLIDSMDQSAFA
S658	LIDSMDQSAFAGFSF
S664	QSAFAGFSFVNPKFE

	mouse ► Hide Isoforms
T43-p	LSTERGKtLVQkKPT
K47-a	RGKtLVQkKPTMyPE
T50	tLVQkKPTMyPEWKT
Y52-p	VQkKPTMyPEWKTTF
Y64-p	TTFDAHIyEGRVIQI
S130-p	EDGDCKQsMRSEEEA
T141-p	EEEAKFPtMNRRGAI
Y155-p	IKQAKIHyIKNHEFI
K184-u	EFVWGLNkQGyKCRQ
Y187-p	WGLNkQGyKCRQCNA
T218	TATNSRDTIFQkERF
K222-u	SRDTIFQkERFNIDM
Y236-p	MPHRFKVyNYMSPTF
K271	CGMNVHHKCREKVAN
T295	AEALNQVTQRSSRkL
T295	AEALNQVTQRSSRkL
S299	NQVTQRSSRkLDTTE
K301-u	VTQRSSRkLDTTEsV
-	gap
-	gap
T304	RSSRkLDTTEsVGIy
T305	SSRkLDTTEsVGIyQ
S307-p	RkLDTTEsVGIyQGF
Y311-p	TTEsVGIyQGFEKKP
K317	IyQGFEKKPEVSGsD
S323-p	KKPEVSGsDILDNNG
N329	GsDILDNNGTyGKIW
T331	DILDNNGTyGKIWEG
Y332-p	ILDNNGTyGKIWEGS
K334	DNNGTyGKIWEGSTR
S339	yGKIWEGSTRCTLEN
T340	GKIWEGSTRCTLENF
T348	RCTLENFTFQKVLGK
S357	QKVLGKGSFGKVLLA
K360	LGKGSFGKVLLAELK
K367	KVLLAELKGKDKyFA
Y372-p	ELKGKDKyFAIKCLK
Y446	DKGRFELYRATFYAA
T449	RFELYRATFYAAEII
Y451	ELYRATFYAAEIICG
Y469	LHSKGIIYrDLKLDN
R470-m1	HSKGIIYrDLKLDNV
K494	IADFGMCKENIFGEG
G501	KENIFGEGRAstFCG
S504-p	IFGEGRAstFCGtPD
T505-p	FGEGRAstFCGtPDy
T509-p	RAstFCGtPDyIAPE
Y512-p	tFCGtPDyIAPEILQ
Y523	EILQGLKYSFSVDWW
Y565-p	IRVDTPHyPRWITKE
T592	PDKRLGVTGNIRIHP
T592	PDKRLGVTGNIRIHP
T603	RIHPFFKTINWSLLE
S607	FFKTINWSLLEKRKV
K611	INWSLLEKRKVEPPF
Y628	KVKSPSDYSNFDPEF
S629	VKSPSDYSNFDPEFL
K639	DPEFLNEKPQLsFsD
S643-p	LNEKPQLsFsDKNLI
F644	NEKPQLsFsDKNLID
S645-p	EKPQLsFsDKNLIDs
S652-p	sDKNLIDsMDQEAFH
E656	LIDsMDQEAFHGFsF
S662-p	QEAFHGFsFVNPKFE

	PKCD iso2
T43	LSTERGKTLVQKKPT
K47	RGKTLVQKKPTMYPE
T50	TLVQKKPTMYPEWKT
Y52	VQKKPTMYPEWKTTF
Y64	TTFDAHIYEGRVIQI
S130	EDGDCKQSMRSEEEA
T141	EEEAKFPTMNRRGAI
Y155	IKQAKIHYIKNHEFI
K184	EFVWGLNKQGYKCRQ
Y187	WGLNKQGYKCRQCNA
T218	TATNSRDTIFQKERF
K222	SRDTIFQKERFNIDM
Y236	MPHRFKVYNYMSPTF
K271	CGMNVHHKCREKVAN
T295	AEALNQVTQRSSRKL
T295	AEALNQVTQRSSRKL
S299	NQVTQRSSRKLDTTE
K301	VTQRSSRKLDTTESV
-	gap
-	gap
T304	RSSRKLDTTESVGIY
T305	SSRKLDTTESVGIYQ
S307	RKLDTTESVGIYQGF
Y311	TTESVGIYQGFEKKP
K317	IYQGFEKKPEVSGSD
S323	KKPEVSGSDILGEAG
N355	SSETCDNNGTYGKIW
T357	ETCDNNGTYGKIWEG
Y358	TCDNNGTYGKIWEGS
K360	DNNGTYGKIWEGSTR
S365	YGKIWEGSTRCTLEN
T366	GKIWEGSTRCTLENF
T374	RCTLENFTFQKVLGK
S383	QKVLGKGSFGKVLLA
K386	LGKGSFGKVLLAELK
K393	KVLLAELKGKDKYFA
Y398	ELKGKDKYFAIKCLK
Y472	DKGRFELYRATFYAA
T475	RFELYRATFYAAEII
Y477	ELYRATFYAAEIICG
Y495	LHSKGIIYRDLKLDN
R496	HSKGIIYRDLKLDNV
K520	IADFGMCKENIFGEG
G527	KENIFGEGRASTFCG
S530	IFGEGRASTFCGTPD
T531	FGEGRASTFCGTPDY
T535	RASTFCGTPDYIAPE
Y538	TFCGTPDYIAPEILQ
Y549	EILQGLKYSFSVDWW
Y591	IRVDTPHYPRWITKE
T618	PDKRLGVTGNIRIHP
T618	PDKRLGVTGNIRIHP
T629	RIHPFFKTINWSLLE
S633	FFKTINWSLLEKRKV
K637	INWSLLEKRKVEPPF
Y654	KVKSPSDYSNFDPEF
S655	VKSPSDYSNFDPEFL
K665	DPEFLNEKPQLSFSD
S669	LNEKPQLSFSDKNLI
F670	NEKPQLSFSDKNLID
S671	EKPQLSFSDKNLIDS
S678	SDKNLIDSMDQEAFH
E682	LIDSMDQEAFHGFSF
S688	QEAFHGFSFVNPKFE

	rat
T43	LTTDRGKTLVQKKPT
K47	RGKTLVQKKPTMYPE
T50	TLVQKKPTMYPEWKS
Y52	VQKKPTMYPEWKSTF
Y64-p	STFDAHIyEGRVIQI
S130	EDGDCKQSMRSEEEA
T141	EEEAMFPTMNRRGAI
Y155-p	IKQAKIHyIKNHEFI
K184	EFVWGLNKQGYKCRQ
Y187	WGLNKQGYKCRQCNA
T218	TATNSRDTIFQKERF
K222	SRDTIFQKERFNIDM
Y236	MPHRFKVYNYMSPTF
K271	CGMNVHHKCREKVAN
T295	AEALNQVTQKASRKP
T295-g	AEALNQVtQKASRKP
S299	NQVtQKASRKPETPE
K301	VtQKASRKPETPETV
-	gap
-	gap
T304	KASRKPETPETVGIy
P305	ASRKPETPETVGIyQ
T307	RKPETPETVGIyQGF
Y311-p	TPETVGIyQGFEKKT
K317	IyQGFEKKTAVSGND
N323	KKTAVSGNDIPDNNG
N329	GNDIPDNNGTyGKIW
T331	DIPDNNGTyGKIWEG
Y332-p	IPDNNGTyGKIWEGS
K334	DNNGTyGKIWEGSNR
S339	yGKIWEGSNRCRLEN
N340	GKIWEGSNRCRLENF
T348-g	RCRLENFtFQKVLGK
S357-p	QKVLGKGsFGKVLLA
K360	LGKGsFGKVLLAELK
K367	KVLLAELKGKERyFA
Y372-p	ELKGKERyFAIKYLK
Y446	DKGRFELYRATFYAA
T449	RFELYRATFYAAEII
Y451	ELYRATFYAAEIICG
Y469	LHGKGIIYRDLKLDN
R470	HGKGIIYRDLKLDNV
K494	IADFGMCKENIFGEN
N501	KENIFGENRAstFCG
S504-p	IFGENRAstFCGTPD
T505-p	FGENRAstFCGTPDy
T509	RAstFCGTPDyIAPE
Y512-p	tFCGTPDyIAPEILQ
Y523-p	EILQGLKySFSVDWW
Y565-p	IRVDTPHyPRWITKE
T592	PAKRLGVTGNIRLHP
T592-g	PAKRLGVtGNIRLHP
T603	RLHPFFKTINWNLLE
N607	FFKTINWNLLEKRKV
K611	INWNLLEKRKVEPPF
Y628-p	KVKSPSDySNFDPEF
S629	VKSPSDySNFDPEFL
K639	DPEFLNEKPQLsFSD
S643-p	LNEKPQLsFSDKNLI
F644	NEKPQLsFSDKNLID
S645	EKPQLsFSDKNLIDS
S652	SDKNLIDSMDQTAFK
T656	LIDSMDQTAFKGFsF
S662-p	QTAFKGFsFVNPKYE

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