an AGC kinase of the PKC family. A novel PKC: Ca2 independent but still regulated by PS, DAG and phorbol esters. Caspase-3 appears to liberate a sphingosine-activated catalytic fragment that has altered regulatory mechanisms and substrate specificities. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, AGC; Kinase, protein; EC 188.8.131.52; Protein kinase, Ser/Thr (non-receptor); EC 184.108.40.206; AGC group; PKC family; Delta subfamily
Cellular Component: nucleoplasm; nuclear matrix; mitochondrion; perinuclear region of cytoplasm; endoplasmic reticulum; cytoplasm; plasma membrane; intercellular junction; nucleus; cytosol
Molecular Function: protein C-terminus binding; protein serine/threonine kinase activity; identical protein binding; calcium-independent protein kinase C activity; protein binding; protein kinase C activity; enzyme binding; metal ion binding; insulin receptor substrate binding; enzyme activator activity; non-membrane spanning protein tyrosine kinase activity; ATP binding
Biological Process: B cell proliferation; negative regulation of MAP kinase activity; interleukin-12 production; nerve growth factor receptor signaling pathway; apoptosis; negative regulation of insulin receptor signaling pathway; signal transduction; protein amino acid phosphorylation; positive regulation of protein amino acid dephosphorylation; negative regulation of filopodium formation; RNA metabolic process; positive regulation of superoxide release; regulation of receptor activity; negative regulation of protein binding; cell structure disassembly during apoptosis; epidermal growth factor receptor signaling pathway; negative regulation of peptidyl-tyrosine phosphorylation; platelet activation; fibroblast growth factor receptor signaling pathway; neutrophil activation; protein stabilization; negative regulation of actin filament polymerization; cytokine and chemokine mediated signaling pathway; peptidyl-threonine phosphorylation; cell cycle; mRNA metabolic process; phospholipase C activation; negative regulation of inflammatory response; defense response to bacterium; interleukin-10 production; gene expression; immunoglobulin mediated immune response; blood coagulation
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.