an AGC kinase of the PKC family. A novel PKC: Ca2 independent but still regulated by PS, DAG and phorbol esters. Caspase-3 appears to liberate a sphingosine-activated catalytic fragment that has altered regulatory mechanisms and substrate specificities. Note: This description may include information from UniProtKB.
Protein type: EC 220.127.116.11; Kinase, protein; Protein kinase, AGC; EC 18.104.22.168; Protein kinase, Ser/Thr (non-receptor); AGC group; PKC family; Delta subfamily
Cellular Component: nucleoplasm; nuclear matrix; mitochondrion; perinuclear region of cytoplasm; endoplasmic reticulum; cytoplasm; plasma membrane; intercellular junction; nucleus; cytosol
Molecular Function: protein C-terminus binding; calcium-independent protein kinase C activity; identical protein binding; protein serine/threonine kinase activity; protein binding; protein kinase C activity; enzyme binding; metal ion binding; insulin receptor substrate binding; enzyme activator activity; non-membrane spanning protein tyrosine kinase activity; protein kinase binding; ATP binding
Biological Process: negative regulation of MAP kinase activity; interleukin-12 production; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; negative regulation of insulin receptor signaling pathway; protein amino acid phosphorylation; response to organic cyclic substance; positive regulation of protein amino acid dephosphorylation; positive regulation of MAP kinase activity; cellular response to glucose starvation; positive regulation of glucose import; positive regulation of superoxide release; response to glucose stimulus; negative regulation of protein binding; response to drug; negative regulation of peptidyl-tyrosine phosphorylation; platelet activation; fibroblast growth factor receptor signaling pathway; neutrophil activation; collagen metabolic process; aspartate transport; response to amino acid stimulus; mRNA metabolic process; response to ethanol; cellular response to insulin stimulus; response to mechanical stimulus; phospholipase C activation; response to heat; defense response to bacterium; immunoglobulin mediated immune response; B cell proliferation; apoptosis; protein amino acid autophosphorylation; signal transduction; negative regulation of filopodium formation; RNA metabolic process; regulation of receptor activity; cell structure disassembly during apoptosis; epidermal growth factor receptor signaling pathway; protein stabilization; negative regulation of actin filament polymerization; cytokine and chemokine mediated signaling pathway; peptidyl-threonine phosphorylation; cell cycle; response to hydrogen peroxide; negative regulation of inflammatory response; response to hypoxia; interleukin-10 production; innate immune response; gene expression; blood coagulation
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.