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Protein Page:
VPS35 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
VPS35 Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Defects in VPS35 are the cause of Parkinson disease type 17 (PARK17). PARK17 is an autosomal dominant, adult- onset form of Parkinson disease. Parkinson disease is a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. Belongs to the VPS35 family. Note: This description may include information from UniProtKB.
Protein type: Vesicle protein
Cellular Component: retromer complex; lysosomal membrane; cytosol; endosome
Molecular Function: protein binding
Biological Process: cell death; protein transport; retrograde transport, endosome to Golgi
Reference #:  Q96QK1 (UniProtKB)
Alt. Names/Synonyms: DKFZp434E1211; DKFZp434P1672; FLJ10752; FLJ13588; FLJ20388; hVPS35; Maternal-embryonic 3; MEM3; vacuolar protein sorting 35 homolog (S. cerevisiae); Vacuolar protein sorting-associated protein 35; Vesicle protein sorting 35; VPS35
Gene Symbols: VPS35
Molecular weight: 91,707 Da
Basal Isoelectric point: 5.32  Predict pI for various phosphorylation states
Select Structure to View Below

VPS35

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 9 S7-p _MPTTQQsPQDEQEk
0 4 K14-ub sPQDEQEkLLDEAIQ
0 6 K24-ub DEAIQAVkVQSFQMK
0 1 K44 NKLMDALKHASNMLG
0 1 S56 MLGELRTSMLSPKSY
0 1 S59 ELRTSMLSPKSYYEL
0 1 Y67-p PKSYYELyMAISDEL
0 1 K87 YLTDEFAKGRKVADL
0 1 S177-p EETTGDIsDSMDFVL
0 1 S353-p DVVSLQVsLINLAMK
0 1 T390-p LNLEHIAtSSAVSkE
0 3 K396-ub AtSSAVSkELTRLLK
0 1 T399 SAVSkELTRLLKIPV
0 1 K403 kELTRLLKIPVDTYN
0 1 K417 NNILTVLKLKHFHPL
0 1 K417 NNILTVLKLKHFHPL
0 1 S432-p FEYFDYEsRKsMsCY
0 1 S435-p FDYEsRKsMsCYVLS
0 1 S437-p YEsRKsMsCYVLSNV
0 21 Y507-p SEDPDQQyLILNTAR
0 1 T528 GNQRIRFTLPPLVFA
0 1 K552 ENSKVDDKWEKKCQK
0 1 K659 QCALAASKLLKKPDQ
0 1 T683-p LFWSGRNtDKNGEEL
0 8 K694-ac GEELHGGkRVMECLk
0 3 K694-ub GEELHGGkRVMECLk
0 1 K701-ac kRVMECLkKALKIAN
0 1 S714-p ANQCMDPsLQVQLFI
0 1 K749 VLNQLIQKIREDLPN
0 9 S783-p HLRLRREsPESEGPI
0 1 S786 LRREsPESEGPIyEG
0 72 Y791-p PESEGPIyEGLIL__
  mouse

 
S7-p _MPTTQQsPQDEQEk
K14-ub sPQDEQEkLLDEAIQ
K24-ub DEAIQAVkVQSFQMK
K44-ub NKLMDALkHASNMLG
S56-p MLGELRTsMLsPKSY
S59-p ELRTsMLsPKSYYEL
Y67 PKSYYELYMAISDEL
K87-ub YLTDEFAkGRKVADL
S177 EETTGDISDSMDFVL
S353 DVVSLQVSLINLAMK
T390 LNLEHIATSSAVSkE
K396-ub ATSSAVSkELtRLLk
T399-p SAVSkELtRLLkIPV
K403-ub kELtRLLkIPVDTYN
K417-ac NNILTVLkLKHFHPL
K417-ub NNILTVLkLKHFHPL
S432 FEYFDYESRKSMSCY
S435 FDYESRKSMSCYVLS
S437 YESRKSMSCYVLSNV
Y507-p SDDPDQQyLILNTAR
T528-p GNQRIRFtLPPLVFA
K552-ac ENSQMDDkWEKKCQK
K659-ub QCALAASkLLKKPDQ
T683 LFWSGRNTDKNGEEL
K694-ac GEELHGGkRVMECLK
K694 GEELHGGKRVMECLK
K701 kRVMECLKKALKIAN
S714 ANQCMDPSLQVQLFI
K749-ac VLNQLIQkIREDLPN
S783-p HLRSRREsPEsEGPI
S786-p SRREsPEsEGPIyEG
Y791-p PEsEGPIyEGLIL__
  rat

 
S7-p _MPTTQQsPQDEQEK
K14 sPQDEQEKLLDEAIQ
K24 DEAIQAVKVQSFQMK
K44 NKLMDALKHASNMLG
S56 MLGELRTSMLSPKSY
S59 ELRTSMLSPKSYYEL
Y67 PKSYYELYMAISDEL
K87 YLTDEFAKGRKVADL
S177 EETTGDISDSMDFVL
S353 DVVSLQVSLINLAMK
T390 LNLEHIATSSAVSKE
K396 ATSSAVSKELTRLLK
T399 SAVSKELTRLLKIPV
K403 KELTRLLKIPVDTYN
K417 NNILTVLKLKHFHPL
K417 NNILTVLKLKHFHPL
S432 FEYFDYESRKSMSCY
S435 FDYESRKSMSCYVLS
S437 YESRKSMSCYVLSNV
Y507 SEDPDQQYLILNTAR
T528 GNQRIRFTLPPLVFA
K552-ac ENSQMDDkWEKKCQK
K659 QCALAASKLLKKPDQ
T683 LFWSGRNTDKNGEEL
K694 GEELHGGKRVMECLK
K694 GEELHGGKRVMECLK
K701 KRVMECLKKALKIAN
S714 ANQCMDPSLQVQLFI
K749 VLNQLIQKIREDLPN
S783-p HLRSRREsPESEGPI
S786 SRREsPESEGPIYEG
Y791 PESEGPIYEGLIL__
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