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VPS35 (human)

Overview VPS35 Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Defects in VPS35 are the cause of Parkinson disease type 17 (PARK17). PARK17 is an autosomal dominant, adult- onset form of Parkinson disease. Parkinson disease is a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. Belongs to the VPS35 family. Note: This description may include information from UniProtKB. Protein type: Vesicle protein Cellular Component: membrane; intracellular membrane-bound organelle; cytosol; endosome Molecular Function: protein binding Biological Process: cell death; protein transport; retrograde transport, endosome to Golgi Reference #:  Q96QK1 (UniProtKB) Alt. Names/Synonyms: DKFZp434E1211; DKFZp434P1672; FLJ10752; FLJ13588; FLJ20388; hVPS35; Maternal-embryonic 3; MEM3; vacuolar protein sorting 35 homolog (S. cerevisiae); Vacuolar protein sorting-associated protein 35; Vesicle protein sorting 35; VPS35 Gene Symbols: VPS35 Molecular weight: 91,707 Da Basal Isoelectric point: 5.32  Predict pI for various phosphorylation states

Select Structure to View Below VPS35 2R17 - C/D=483-780 (human)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	7		S7-p	_MPTTQQsPQDEQEk
0	4		K14-u	sPQDEQEkLLDEAIQ
0	6		K24-u	DEAIQAVkVQSFQMK
0	1		K44	NKLMDALKHASNMLG
0	1		S56	MLGELRTSMLSPKSY
0	1		S59	ELRTSMLSPKSYYEL
0	1		Y67-p	PKSYYELyMAISDEL
0	1		K87	YLTDEFAKGRKVADL
0	1		S177-p	EETTGDIsDSMDFVL
0	1		S353-p	DVVSLQVsLINLAMK
0	1		T390-p	LNLEHIAtSSAVSkE
0	3		K396-u	AtSSAVSkELTRLLK
0	1		T399	SAVSkELTRLLKIPV
0	1		K403	kELTRLLKIPVDTYN
0	1		K417	NNILTVLKLKHFHPL
0	1		S432-p	FEYFDYEsRKsMsCY
0	1		S435-p	FDYEsRKsMsCYVLS
0	1		S437-p	YEsRKsMsCYVLSNV
0	20		Y507-p	SEDPDQQyLILNTAR
0	1		T528	GNQRIRFTLPPLVFA
0	1		K659	QCALAASKLLKKPDQ
0	8		K694-a	GEELHGGkRVMECLk
0	3		K694-u	GEELHGGkRVMECLk
0	1		K701-a	kRVMECLkKALKIAN
0	1		S714-p	ANQCMDPsLQVQLFI
0	7		S783-p	HLRLRREsPESEGPI
0	1		S786	LRREsPESEGPIyEG
0	81		Y791-p	PESEGPIyEGLIL__

	mouse
S7-p	_MPTTQQsPQDEQEk
K14-u	sPQDEQEkLLDEAIQ
K24-u	DEAIQAVkVQSFQMK
K44-u	NKLMDALkHASNMLG
S56-p	MLGELRTsMLsPKSY
S59-p	ELRTsMLsPKSYYEL
Y67	PKSYYELYMAISDEL
K87-u	YLTDEFAkGRKVADL
S177	EETTGDISDSMDFVL
S353	DVVSLQVSLINLAMK
T390	LNLEHIATSSAVSkE
K396-u	ATSSAVSkELtRLLk
T399-p	SAVSkELtRLLkIPV
K403-u	kELtRLLkIPVDTYN
K417-u	NNILTVLkLKHFHPL
S432	FEYFDYESRKSMSCY
S435	FDYESRKSMSCYVLS
S437	YESRKSMSCYVLSNV
Y507-p	SDDPDQQyLILNTAR
T528-p	GNQRIRFtLPPLVFA
K659-u	QCALAASkLLKKPDQ
K694-a	GEELHGGkRVMECLK
K694	GEELHGGKRVMECLK
K701	kRVMECLKKALKIAN
S714	ANQCMDPSLQVQLFI
S783-p	HLRSRREsPEsEGPI
S786-p	SRREsPEsEGPIyEG
Y791-p	PEsEGPIyEGLIL__

	rat
S7	_MPTTQQSPQDEQEK
K14	SPQDEQEKLLDEAIQ
K24	DEAIQAVKVQSFQMK
K44	NKLMDALKHASNMLG
S56	MLGELRTSMLSPKSY
S59	ELRTSMLSPKSYYEL
Y67	PKSYYELYMAISDEL
K87	YLTDEFAKGRKVADL
S177	EETTGDISDSMDFVL
S353	DVVSLQVSLINLAMK
T390	LNLEHIATSSAVSKE
K396	ATSSAVSKELTRLLK
T399	SAVSKELTRLLKIPV
K403	KELTRLLKIPVDTYN
K417	NNILTVLKLKHFHPL
S432	FEYFDYESRKSMSCY
S435	FDYESRKSMSCYVLS
S437	YESRKSMSCYVLSNV
Y507	SEDPDQQYLILNTAR
T528	GNQRIRFTLPPLVFA
K659	QCALAASKLLKKPDQ
K694	GEELHGGKRVMECLK
K694	GEELHGGKRVMECLK
K701	KRVMECLKKALKIAN
S714	ANQCMDPSLQVQLFI
S783	HLRSRRESPESEGPI
S786	SRRESPESEGPIYEG
Y791	PESEGPIYEGLIL__

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