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Protein Page:
SMARCE1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SMARCE1 Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Required for the coactivation of estrogen responsive promoters by Swi/Snf complexes and the SRC/p160 family of histone acetyltransferases (HATs). Also specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Defects in SMARCE1 may be a cause of Coffin-Siris syndrome, a highly variable disease characterized by mental retardation associated with a broad spectrum of different clinical features. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Cellular Component: nuclear chromosome; SWI/SNF complex; protein complex; transcriptional repressor complex; nuclear chromatin; nucleolus; nucleus
Molecular Function: ligand-dependent nuclear receptor binding; N-acetyltransferase activity; protein binding; nucleosomal DNA binding; RNA binding; transcription coactivator activity; protein N-terminus binding; chromatin binding
Biological Process: chromatin remodeling; regulation of transcription from RNA polymerase II promoter; nervous system development; nucleosome disassembly; metabolic process; ATP-dependent chromatin remodeling; negative regulation of transcription, DNA-dependent
Reference #:  Q969G3 (UniProtKB)
Alt. Names/Synonyms: BAF57; BRG1-associated factor 57; chromatin remodeling complex BRG1-associated factor 57; SMARCE1; SMCE1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin e1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
Gene Symbols: SMARCE1
Molecular weight: 46,649 Da
Basal Isoelectric point: 4.85  Predict pI for various phosphorylation states
Select Structure to View Below

SMARCE1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K3-m3 _____MSkrPsyAPP
0 1 R4-m1 ____MSkrPsyAPPP
0 3 S6-p __MSkrPsyAPPPtP
0 5 Y7-p _MSkrPsyAPPPtPA
0 22 T12-p PsyAPPPtPAPAtQM
0 1 T17-p PPtPAPAtQMPstPG
0 25 S21-p APAtQMPstPGFVGy
0 26 T22-p PAtQMPstPGFVGyN
0 2 Y28-p stPGFVGyNPysHLA
0 3 Y31-p GFVGyNPysHLAYNN
0 1 S32-p FVGyNPysHLAYNNY
0 1 R40-m1 HLAYNNYrLGGNPGT
0 1 T58-p VTASSGItIPKPPKP
0 3 Y73-p PDKPLMPyMRYSRKV
0 9 K92-ub KASNPDLkLWEIGKI
0 1 K131-ub IEYNESMkAYHNSPA
0 3 Y139-p AYHNSPAyLAyINAk
0 2 Y142-p NSPAyLAyINAkSRA
0 1 K146-ub yLAyINAkSRAEAAL
0 2 S157-p EAALEEEsRQRQSRM
0 4 Y170-p RMEKGEPyMSIQPAE
0 1 K189 YDDGFSMKHtAtARF
0 1 T191-p DGFSMKHtAtARFQR
0 1 T193-p FSMKHtAtARFQRNH
0 2 K240-ub SLMVHQRkLEAELLQ
0 1 K258-ub RHQEKKRkFLEStDs
0 1 T263-p KRkFLEStDsFNNEL
0 3 S265-p kFLEStDsFNNELkR
0 3 K271-ub DsFNNELkRLCGLKV
0 1 K284-ub KVEVDMEkIAAEIAQ
0 2 S314-p AAEQAERsQSSIVPE
0 1 T350-p EETHLEEtTEsQQNG
0 2 S353-p HLEEtTEsQQNGEEG
0 1 S362-p QNGEEGTstPEDKES
0 9 T363-p NGEEGTstPEDKESG
  mouse

 
K3 _____MSKRPSYAPP
R4 ____MSKRPSYAPPP
S6 __MSKRPSYAPPPTP
Y7 _MSKRPSYAPPPTPA
T12 PSYAPPPTPAPATQM
T17 PPTPAPATQMPsTPG
S21-p APATQMPsTPGFVGY
T22 PATQMPsTPGFVGYN
Y28 sTPGFVGYNPYSHLA
Y31 GFVGYNPYSHLAYNN
S32 FVGYNPYSHLAYNNY
R40 HLAYNNYRLGGNPGT
T58 VTASSGITIPKPPKP
Y73-p PDKPLMPyMRYSRKV
K92-ub KASNPDLkLWEIGKI
K131 IEYNESMKAYHNSPA
Y139 AYHNSPAYLAYINAK
Y142 NSPAYLAYINAKSRA
K146 YLAYINAKSRAEAAL
S157-p EAALEEEsRQRQSRM
Y170 RMEKGEPYMSIQPAE
K189-ub YDDGFSMkHTATARF
T191 DGFSMkHTATARFQR
T193 FSMkHTATARFQRNH
K240-ub SLMVHQRkLEAELLQ
K258 RHQEKKRKFLESTDS
T263 KRKFLESTDSFNNEL
S265 KFLESTDSFNNELkR
K271-ub DSFNNELkRLCGLKV
K284 KVEVDMEKIAAEIAQ
S314 AAEQAERSQSSMAPE
T350 EETHLEDTAESQQNG
S353 HLEDTAESQQNGEEG
S362 QNGEEGTSTPEDKES
T363 NGEEGTSTPEDKESG
  rat

 
K3 _____MSKRPSYAPP
R4 ____MSKRPSYAPPP
S6 __MSKRPSYAPPPTP
Y7 _MSKRPSYAPPPTPA
T12 PSYAPPPTPAPATAS
T17 PPTPAPATASSGITI
- gap
- gap
- gap
- gap
- gap
- gap
T23 ATASSGITIPKPPKP
Y38 PDKPLMPYMRYSRKV
K57 KASNPDLKLWEIGKI
K96 IEYNESMKAYHNSPA
Y104 AYHNSPAYLAYINAK
Y107 NSPAYLAYINAKSRA
K111 YLAYINAKSRAEAAL
S122 EAALEEESRQRQSRM
Y135 RMEKGEPYMSIQPAE
K154 YDDGFSMKHTATARF
T156 DGFSMKHTATARFQR
T158 FSMKHTATARFQRNH
K205 SLMVHQRKLEAELLQ
K223 RHQEKKRKFLESTDS
T228 KRKFLESTDSFNNEL
S230 KFLESTDSFNNELKR
K236 DSFNNELKRLCGLKV
K249 KVEVDMEKIAAEIAQ
S279 AAEQAERSQGSIAPE
T315 EETHLEDTAENQQNG
N318 HLEDTAENQQNGEEG
S327 QNGEEGTSTPEDKES
T328 NGEEGTSTPEDKESG
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