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Protein Page:
CSFR (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CSFR an oncogenic tyrosine kinase receptor for CSF-1 (M-CSF). Drives growth and development of monocytes. Binding of CSF-1 induces receptor dimerization, activation and autophosphorylation of cytoplasmic tyrosine residues used as docking sites for SH2-containing signaling proteins. There are at least five major tyrosine autophosphorylation sites. Two point mutations seen in 10-20% of patients with acute myeloid leukemia, chronic myelomonocytic leukemia or myelodysplasia. One mutation appears to be both somatic and germline, and disrupts Cbl binding and receptor turnover. v-fms lacks the Cbl binding site and causes feline leukemia. Mutations may also develop after chemotherapy for lymphoma. A distinct point mutation was found in some cases of hepatocellular carcinoma and related to increased expression, and another mutation was found in 2 of 40 patients with idiopathic myelofibrosis. Expression is elevated in breast tumors and cell lines, and expression in xenografts and transgenic mice has been correlated with xenograft growth and breast cancer development. Inhibitors: Ki-20227 and other Kit/PDGFR inhibitors. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.1; Kinase, protein; Protein kinase, tyrosine (receptor); Protein kinase, TK; Membrane protein, integral; TK group; PDGFR family
Cellular Component: cell surface; integral to plasma membrane; plasma membrane; receptor complex
Molecular Function: macrophage colony stimulating factor receptor activity; protein homodimerization activity; cytokine binding; protein phosphatase binding; ATP binding
Biological Process: regulation of bone resorption; phosphoinositide-mediated signaling; peptidyl-tyrosine phosphorylation; macrophage differentiation; monocyte differentiation; protein amino acid autophosphorylation; cytokine and chemokine mediated signaling pathway; multicellular organismal development; osteoclast differentiation; signal transduction; positive regulation of tyrosine phosphorylation of Stat3 protein; cell proliferation; regulation of cell shape; positive regulation of cell proliferation; ruffle organization and biogenesis; innate immune response; hemopoiesis; phosphatidylinositol metabolic process; positive regulation of protein amino acid phosphorylation; inflammatory response; intercellular junction maintenance; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration
Reference #:  P07333 (UniProtKB)
Alt. Names/Synonyms: C-FMS; CD115; CD115 antigen; colony stimulating factor 1 receptor; CSF-1-R; CSF1R; CSFR; FIM2; FMS; FMS proto-oncogene; macrophage colony stimulating factor I receptor; Macrophage colony-stimulating factor 1 receptor; McDonough feline sarcoma viral (v-fms) oncogene homolog; Proto-oncogene c-Fms
Gene Symbols: CSF1R
Molecular weight: 107,984 Da
Basal Isoelectric point: 5.93  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CSFR

Protein Structure Not Found.


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Sites Implicated In
cell cycle regulation: Y809‑p
cell growth, altered: Y809‑p
transcription, altered: Y809‑p
activity, induced: Y561‑p, Y708‑p, Y809‑p
molecular association, regulation: Y546‑p, Y561‑p, Y699‑p, Y708‑p, Y723‑p
phosphorylation: Y809‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S178-p QSQDYQCsALMGGRK
0 1 H362 TTKDTYRHtFtLSLP
0 2 T363-p TKDTYRHtFtLSLPR
0 1 T365-p DTYRHtFtLSLPRLK
0 1 A497 SVGSGSWAFIPISAG
4 0 Y546-p KYKQKPKyQVRWKII
0 1 S555-p VRWKIIEsyEGNsyt
0 7 Y556-p RWKIIEsyEGNsytF
0 1 S560-p IEsyEGNsytFIDPt
10 7 Y561-p EsyEGNsytFIDPtQ
0 1 T562-p syEGNsytFIDPtQL
0 1 T567-p sytFIDPtQLPyNEK
0 5 Y571-p IDPtQLPyNEKWEFP
0 2 K574 tQLPyNEKWEFPRNN
0 3 K586-ub RNNLQFGkTLGAGAF
0 3 K606 ATAFGLGKEDAVLKV
0 1 K612 GKEDAVLKVAVKMLK
0 1 S686-p AEAMLGPsLsPGQDP
0 2 S688-p AMLGPsLsPGQDPEG
0 1 P693 sLsPGQDPEGGVDyK
0 2 V697 GQDPEGGVDyKNIHL
0 1 D698 QDPEGGVDyKNIHLE
14 36 Y699-p DPEGGVDyKNIHLEK
0 1 K700 PEGGVDyKNIHLEKK
12 0 Y708-p NIHLEKKyVRRDsGF
0 5 S713-p KKyVRRDsGFsSQGV
0 2 S716-p VRRDsGFsSQGVDTy
14 1 Y723-p sSQGVDTyVEMRPVS
0 1 E739 SSNDSFSEQDLDKED
0 1 K793 LTNGHVAKIGDFGLA
21 14 Y809-p DIMNDSNyIVkGNAR
0 3 K812-ub NDSNyIVkGNARLPV
0 2 K870-ub SKFYKLVkDGyQMAQ
0 7 Y873-p YKLVkDGyQMAQPAF
3 2 Y923-p EDRRERDyTNLPSSS
2 0 Y969 PLLQPNNYQFC____
3083 : Phospho-M-CSF Receptor (Tyr546) Antibody
3399 : Phospho-M-CSF Receptor (Tyr699) Antibody
12251 : Phospho-M-CSF Receptor (Tyr699) (D10B11) Rabbit mAb
3080 : Phospho-M-CSF Receptor (Tyr708) Antibody
3151 : Phospho-M-CSF Receptor (Tyr723) Antibody
3155 : Phospho-M-CSF Receptor (Tyr723) (49C10) Rabbit mAb
3154 : Phospho-M-CSF Receptor (Tyr809) Antibody
3406 : Phospho-M-CSF Receptor (Tyr923) Antibody
  mouse

 
T179 SNTYVCKTMVNGRES
Y360-p TQRAIYRytFKLFLN
T361-p QRAIYRytFKLFLNR
K363 AIYRytFKLFLNRVK
Y495-p SVGNSSQyFRAVSLG
Y544-p KYKQKPKyQVRWKII
R553 VRWKIIERYEGNSyT
Y554 RWKIIERYEGNSyTF
S558 IERYEGNSyTFIDPT
Y559-p ERYEGNSyTFIDPTQ
T560 RYEGNSyTFIDPTQL
T565 SyTFIDPTQLPYNEk
Y569 IDPTQLPYNEkWEFP
K572-ub TQLPYNEkWEFPRNN
K584-ub RNNLQFGkTLGAGAF
K604-ub ATAFGLGkEDAVLkV
K610-ub GkEDAVLkVAVKMLK
S684 AEAMLGPSLSPGQDs
S686 AMLGPSLSPGQDsEG
S691-p SLSPGQDsEGDssyk
S695-p GQDsEGDssykNIHL
S696-p QDsEGDssykNIHLE
Y697-p DsEGDssykNIHLEK
K698-ub sEGDssykNIHLEKK
Y706-p NIHLEKKyVRRDsGF
S711-p KKyVRRDsGFsSQGV
S714-p VRRDsGFsSQGVDTy
Y721-p sSQGVDTyVEMRPVS
K737-ub SSSDSFFkQDLDKEA
K791-ub LTSGHVAkIGDFGLA
Y807-p DIMNDSNyVVkGNAR
K810-ub NDSNyVVkGNARLPV
K868-ub NKFYKLVkDGYQMAQ
Y871 YKLVkDGYQMAQPVF
Y921-p LERRDQDyANLPSSG
Y974-p PLLQPNNyQFC____
3083 : Phospho-M-CSF Receptor (Tyr546) Antibody
3399 : Phospho-M-CSF Receptor (Tyr699) Antibody
3080 : Phospho-M-CSF Receptor (Tyr708) Antibody
3151 : Phospho-M-CSF Receptor (Tyr723) Antibody
3155 : Phospho-M-CSF Receptor (Tyr723) (49C10) Rabbit mAb
3154 : Phospho-M-CSF Receptor (Tyr809) Antibody
3406 : Phospho-M-CSF Receptor (Tyr923) Antibody
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