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CSFR
an oncogenic tyrosine kinase receptor for CSF-1 (M-CSF). Drives growth and development of monocytes. Binding of CSF-1 induces receptor dimerization, activation and autophosphorylation of cytoplasmic tyrosine residues used as docking sites for SH2-containing signaling proteins. There are at least five major tyrosine autophosphorylation sites. Two point mutations seen in 10-20% of patients with acute myeloid leukemia, chronic myelomonocytic leukemia or myelodysplasia. One mutation appears to be both somatic and germline, and disrupts Cbl binding and receptor turnover. v-fms lacks the Cbl binding site and causes feline leukemia. Mutations may also develop after chemotherapy for lymphoma. A distinct point mutation was found in some cases of hepatocellular carcinoma and related to increased expression, and another mutation was found in 2 of 40 patients with idiopathic myelofibrosis. Expression is elevated in breast tumors and cell lines, and expression in xenografts and transgenic mice has been correlated with xenograft growth and breast cancer development. Inhibitors: Ki-20227 and other Kit/PDGFR inhibitors. Note: This description may include information from UniProtKB.
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| Protein type: Protein kinase, tyrosine (receptor); Protein kinase, TK; Membrane protein, integral; Kinase, protein; EC 2.7.10.1; TK group; PDGFR family |
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Cellular Component: cell surface; integral to plasma membrane; plasma membrane; receptor complex
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Molecular Function: macrophage colony stimulating factor receptor activity; protein homodimerization activity; cytokine binding; ATP binding
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Biological Process: regulation of bone resorption; macrophage differentiation; peptidyl-tyrosine phosphorylation; phosphoinositide-mediated signaling; monocyte differentiation; cytokine and chemokine mediated signaling pathway; protein amino acid autophosphorylation; multicellular organismal development; osteoclast differentiation; signal transduction; positive regulation of tyrosine phosphorylation of Stat3 protein; regulation of cell shape; cell proliferation; positive regulation of cell proliferation; ruffle organization and biogenesis; innate immune response; hemopoiesis; phosphatidylinositol metabolic process; positive regulation of protein amino acid phosphorylation; intercellular junction maintenance; inflammatory response; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration
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Reference #:
P07333 (UniProtKB)
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| Alt. Names/Synonyms: C-FMS; CD115; CD115 antigen; colony stimulating factor 1 receptor; CSF-1-R; CSF1R; CSFR; FIM2; FMS; FMS proto-oncogene; macrophage colony stimulating factor I receptor; Macrophage colony-stimulating factor 1 receptor; McDonough feline sarcoma viral (v-fms) oncogene homolog; Proto-oncogene c-Fms |
| Gene Symbols: CSF1R |
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Molecular weight: 107,984 Da
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Basal Isoelectric point: 5.93
Predict pI for various phosphorylation states
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CST Pathways:
Tyrosine Kinases
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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