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Protein Page:
MYH10 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MYH10 Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with PLEKHG6. Interacts with ECM29. Interacts with KIF26B. Interacts with LARP6. Isoform 1 is expressed in cerebellum and spinal chord. Isoform 2 is expressed in cerebrum and retina. Isoform 3 is expressed in the cerebrum and to a much lower extent in cerebellum. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motor protein; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 17p13
Cellular Component: myosin II complex; dendritic spine; actomyosin; cell cortex; growth cone; cell soma; axon; lamellipodium; cytoplasm; stress fiber; plasma membrane; spindle; midbody; myosin complex; nucleus; neuromuscular junction; cleavage furrow
Molecular Function: microfilament motor activity; calmodulin binding; actin filament binding; protein binding; actin binding; ADP binding; actin-dependent ATPase activity; ATP binding
Biological Process: ATP catabolic process; adult heart development; axon guidance; exocytosis; in utero embryonic development; actin filament-based movement; actomyosin structure organization and biogenesis; ventricular cardiac muscle cell development; fourth ventricle development; cerebellar Purkinje cell layer development; neuron migration; cardiac myofibril assembly; substrate-bound cell migration, cell extension; third ventricle development; regulation of cell shape; cell proliferation; cytokinesis after mitosis; plasma membrane repair; retina development in camera-type eye; cell adhesion; neuromuscular process controlling balance; nuclear migration; lateral ventricle development
Reference #:  P35580 (UniProtKB)
Alt. Names/Synonyms: Cellular myosin heavy chain, type B; cellular myosin heavy chain, type B type B; MGC134913; MGC134914; MYH10; Myosin heavy chain 10; Myosin heavy chain, non-muscle IIb; myosin heavy chain, nonmuscle type B; myosin, heavy chain 10, non-muscle; myosin, heavy polypeptide 10, non-muscle; Myosin-10; near to the ATP binding region; NMMHC II-b; NMMHC-B; NMMHC-IIB; NMMHCB; Non-muscle myosin heavy chain B; Non-muscle myosin heavy chain IIb; nonmuscle myosin heavy chain IIB; nonmuscle myosin heavy chain-B; nonmuscle myosin II heavy chain-B
Gene Symbols: MYH10
Molecular weight: 228,999 Da
Basal Isoelectric point: 5.44  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MYH10

Protein Structure Not Found.


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Sites Implicated In
activity, inhibited: S1937‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 213 Y13-p GLEDPERyLFVDRAV
0 1 R18 ERyLFVDRAVIyNPA
0 294 Y22-p FVDRAVIyNPAtQAD
0 1 T26-p AVIyNPAtQADWtAK
0 1 T31-p PAtQADWtAKKLVWI
0 1 S40-p KKLVWIPsERHGFEA
0 1 K78-ac VNKDDIQkMNPPKFS
0 3 Y155-p HEMPPHIyAISESAY
0 2 Y194 NTKKVIQYLAHVASS
0 9 - gap
0 1 S227-p QANPILEsFGNAktV
0 4 K232-ub LEsFGNAktVKNDNS
0 2 T233-p EsFGNAktVKNDNSS
0 1 K244 DNSSRFGKFIRINFD
0 4 Y285-p ERTFHIFyQLLSGAG
0 1 S352 SMLKVVSSVLQFGNI
0 1 S360 VLQFGNISFkKERNT
0 1 K362-ac QFGNISFkKERNTDQ
0 3 K410-ub VGRDYVQkAQTKEQA
0 1 K442-ac WLVHRINkALDRTKR
0 1 T447 INkALDRTKRQGASF
0 1 K552-ac TDKTFVEkLVQEQGS
0 1 K587 YAGKVDYKADEWLMk
0 1 K594-m1 KADEWLMkNMDPLND
0 1 K658-sc RTVGQLYkESLTKLM
0 1 T667-p SLTKLMAtLRNTNPN
0 4 K689-ub NHEKRAGkLDPHLVL
0 1 K817-ub QQQLSALkVLQRNCA
0 5 K828-ub RNCAAYLkLRHWQWW
0 1 K840-ub QWWRVFTkVKPLLQV
0 1 K857 QEEELQAKDEELLKV
0 5 S1013-p DRIAECSsQLAEEEE
0 2 S1037-p NKQEVMIsDLEERLK
0 4 S1145-p EKQKRDLsEELEALK
0 1 T1170-p AAQQELRtKREQEVA
0 1 T1187-p KKALEEEtKNHEAQI
0 6 T1203-p DMRQRHAtALEELSE
0 1 K1224-ac RFKANLEkNKQGLEt
0 1 K1226 KANLEkNKQGLEtDN
0 1 T1231-p kNKQGLEtDNKELAC
0 1 K1247-ac VKVLQQVkAESEHKR
0 1 S1335-p TRQKLNLsSRIRQLE
0 1 K1345-ac IRQLEEEkNSLQEQQ
0 1 T1376-p LQSQLADtKKkVDDD
0 1 K1377 QSQLADtKKkVDDDL
0 1 K1379-ac QLADtKKkVDDDLGT
0 1 K1396-ac SLEEAKKkLLKDAEA
0 453 Y1415-p LEEKALAyDKLEKTK
0 1 S1444-p DHQRQVAsNLEKKQk
0 1 K1451-ac sNLEKKQkkFDQLLA
0 1 K1452-ac NLEKKQkkFDQLLAE
0 1 K1461-ac DQLLAEEkSISARYA
0 1 S1464 LAEEkSISARYAEER
0 1 K1484-ac EAREKETkALSLARA
0 1 K1520 MEDLMSSKDDVGKNV
0 1 K1645-ac KARDEVIkQLRKLQA
0 1 S1698-p QLQEELAssERARRH
0 1 S1699-p LQEELAssERARRHA
0 1 T1768-p KTTLQVDtLNAELAA
0 1 K1800-ub QNKELKAkLQELEGA
0 1 K1874-ac QYKEQMEkANARMKQ
0 2 S1899-p EATRANAsRRKLQRE
0 8 S1922-p EGLSREVstLKNRLR
0 3 T1923-p GLSREVstLKNRLRr
0 5 R1930-m1 tLKNRLRrGGPIsFs
0 8 S1935-p LRrGGPIsFsssRSG
1 9 S1937-p rGGPIsFsssRSGRR
0 9 S1938-p GGPIsFsssRSGRRQ
0 13 S1939-p GPIsFsssRSGRRQL
0 1 R1940 PIsFsssRSGRRQLH
1 23 S1952-p QLHLEGAsLELsDDD
1 44 S1956-p EGAsLELsDDDtEsK
1 8 T1960-p LELsDDDtEsKtsDV
0 2 S1962-p LsDDDtEsKtsDVNE
0 1 T1964-p DDDtEsKtsDVNETQ
1 2 S1965-p DDtEsKtsDVNETQP
1 7 S1975-p NETQPPQsE______
  MYH10 iso2  
Y13 GLEDPERYLFVDRAV
R18 ERYLFVDRAVIYNPA
Y22 FVDRAVIYNPATQAD
T26 AVIYNPATQADWTAK
T31 PATQADWTAKKLVWI
S40 KKLVWIPSERHGFEA
K78 VNKDDIQKMNPPKFS
Y155 HEMPPHIYAISESAY
Y194 NTKKVIQYLAHVASS
S214-p DHNIPQEsPKPVKHQ
S243 QANPILESFGNAKTV
K248 LESFGNAKTVKNDNS
T249 ESFGNAKTVKNDNSS
K260 DNSSRFGKFIRINFD
Y301 ERTFHIFYQLLSGAG
S368 SMLKVVSSVLQFGNI
S376 VLQFGNISFKKERNT
K378 QFGNISFKKERNTDQ
K426 VGRDYVQKAQTKEQA
K458 WLVHRINKALDRTKR
T463 INKALDRTKRQGASF
K568 TDKTFVEKLVQEQGS
K603 YAGKVDYKADEWLMK
K610 KADEWLMKNMDPLND
K674 RTVGQLYKESLTKLM
T683 SLTKLMATLRNTNPN
K705 NHEKRAGKLDPHLVL
K833 QQQLSALKVLQRNCA
K844 RNCAAYLKLRHWQWW
K856 QWWRVFTKVKPLLQV
K873 QEEELQAKDEELLKV
S1029 DRIAECSSQLAEEEE
S1053 NKQEVMISDLEERLK
S1161 EKQKRDLSEELEALK
T1186 AAQQELRTKREQEVA
T1203 KKALEEETKNHEAQI
T1219 DMRQRHATALEELSE
K1240 RFKANLEKNKQGLET
K1242 KANLEKNKQGLETDN
T1247 KNKQGLETDNKELAC
K1263 VKVLQQVKAESEHKR
S1351 TRQKLNLSSRIRQLE
K1361 IRQLEEEKNSLQEQQ
T1392 LQSQLADTKKKVDDD
K1393 QSQLADTKKKVDDDL
K1395 QLADTKKKVDDDLGT
K1412 SLEEAKKKLLKDAEA
Y1431 LEEKALAYDKLEKTK
S1460 DHQRQVASNLEKKQK
K1467 SNLEKKQKKFDQLLA
K1468 NLEKKQKKFDQLLAE
K1477 DQLLAEEKSISARYA
S1480 LAEEKSISARYAEER
K1500 EAREKETKALSLARA
K1536 MEDLMSSKDDVGKNV
K1661 KARDEVIKQLRKLQA
S1714 QLQEELASSERARRH
S1715 LQEELASSERARRHA
T1784 KTTLQVDTLNAELAA
K1816 QNKELKAKLQELEGA
K1890 QYKEQMEKANARMKQ
S1915 EATRANASRRKLQRE
S1938 EGLSREVSTLKNRLR
T1939 GLSREVSTLKNRLRR
R1946 TLKNRLRRGGPISFS
S1951 LRRGGPISFSSSRSG
S1953 RGGPISFSSSRSGRR
S1954 GGPISFSSSRSGRRQ
S1955 GPISFSSSRSGRRQL
R1956 PISFSSSRSGRRQLH
S1968 QLHLEGASLELSDDD
S1972 EGASLELSDDDTESK
T1976 LELSDDDTESKTSDV
S1978 LSDDDTESKTSDVNE
T1980 DDDTESKTSDVNETQ
S1981 DDTESKTSDVNETQP
S1991 NETQPPQSE______
  mouse

► Hide Isoforms
 
Y13 GLEDPERYLFVDrAV
R18-m1 ERYLFVDrAVIyNPA
Y22-p FVDrAVIyNPATQAD
T26 AVIyNPATQADWTAK
T31 PATQADWTAKKLVWI
S40 KKLVWIPSERHGFEA
K78 VNKDDIQKMNPPKFS
Y155 HEMPPHIYAISESAY
Y194-p NTKKVIQyLAHVASS
- gap
S227 QANPILESFGNAkTV
K232-ub LESFGNAkTVKNDNS
T233 ESFGNAkTVKNDNSS
K244-ac DNSSRFGkFIRINFD
Y285 ERTFHIFYQLLSGAG
S352-p SMLKVVSsVLQFGNI
S360-p VLQFGNIsFKKERNT
K362 QFGNIsFKKERNTDQ
K410-ub VGRDYVQkAQTKEQA
K442 WLVHRINKALDRtKR
T447-p INKALDRtKRQGASF
K552 TDKTFVEKLVQEQGS
K587-ac YAGKVDYkADEWLMK
K594 kADEWLMKNMDPLND
K658 RTVGQLYKESLTKLM
T667 SLTKLMATLRNTNPN
K689-ub NHEKRAGkLDPHLVL
K817 QQQLSALKVLQRNCA
K828 RNCAAYLKLRHWQWW
K840 QWWRVFTKVKPLLQV
K857-ub QEEELQAkDEELLKV
S1013 DRIAECSSQLAEEEE
S1037-p NKQEVMIsDLEERLK
S1145-p EKQKRDLsEELEALK
T1170 AAQQELRTKREQEVA
T1187 KKALEDETKNHEAQI
T1203-p DMRQRHAtALEELSE
K1224 RFKANLEKNKQGLET
K1226 KANLEKNKQGLETDN
T1231 KNKQGLETDNKELAC
K1247 VKVLQQVKAESEHKR
S1335 TRQKLNLSSRIRQLE
K1345 IRQLEEEKNSLQEQQ
T1376 LQSQLADTkKKVDDD
K1377-ac QSQLADTkKKVDDDL
K1379 QLADTkKKVDDDLGT
K1396 SLEEAKKKLLKDVEA
Y1415-p LEEKVLAyDKLEKTK
S1444 DHQRQIVSNLEKKQK
K1451 SNLEKKQKKFDQLLA
K1452 NLEKKQKKFDQLLAE
K1461 DQLLAEEKGIsARYA
S1464-p LAEEKGIsARYAEER
K1484 EAREKETKALSLARA
K1520-ac MEDLMSSkDDVGKNV
K1645 KARDEVIKQLRKLQA
S1698 QLQEELASSERARRH
S1699 LQEELASSERARRHA
T1768 KTTLQVDTLNTELAA
K1800 QNKELKAKLQELEGA
K1874 QYKEQMEKANARMKQ
S1899 EATRANASRRKLQRE
S1922 EGLSREVSTLKNRLR
T1923 GLSREVSTLKNRLRr
R1930-m1 TLKNRLRrGGPIsFs
S1935-p LRrGGPIsFsssrSG
S1937-p rGGPIsFsssrSGRR
S1938-p GGPIsFsssrSGRRQ
S1939-p GPIsFsssrSGRRQL
R1940-m1 PIsFsssrSGRRQLH
S1952-p QLHIEGAsLELsDDD
S1956-p EGAsLELsDDDtEsK
T1960-p LELsDDDtEsKTSDV
S1962-p LsDDDtEsKTSDVND
T1964 DDDtEsKTSDVNDTQ
S1965 DDtEsKTSDVNDTQP
S1975-p NDTQPPQsE______
  MYH10 iso3  
Y13 GLEDPERYLFVDRAV
R18 ERYLFVDRAVIYNPA
Y22 FVDRAVIYNPATQAD
T26 AVIYNPATQADWTAK
T31 PATQADWTAKKLVWI
S40 KKLVWIPSERHGFEA
K78 VNKDDIQKMNPPKFS
Y155 HEMPPHIYAISESAY
Y194 NTKKVIQYLAHVASS
S214-p DHNIPQEsPKPVKPQ
S237 QANPILESFGNAKTV
K242 LESFGNAKTVKNDNS
T243 ESFGNAKTVKNDNSS
K254 DNSSRFGKFIRINFD
Y295 ERTFHIFYQLLSGAG
S362 SMLKVVSSVLQFGNI
S370 VLQFGNISFKKERNT
K372 QFGNISFKKERNTDQ
K420 VGRDYVQKAQTKEQA
K452 WLVHRINKALDRTKR
T457 INKALDRTKRQGASF
K562 TDKTFVEKLVQEQGS
K597 YAGKVDYKADEWLMK
K604 KADEWLMKNMDPLND
K689 RTVGQLYKESLTKLM
T698 SLTKLMATLRNTNPN
K720 NHEKRAGKLDPHLVL
K848 QQQLSALKVLQRNCA
K859 RNCAAYLKLRHWQWW
K871 QWWRVFTKVKPLLQV
K888 QEEELQAKDEELLKV
S1044 DRIAECSSQLAEEEE
S1068 NKQEVMISDLEERLK
S1176 EKQKRDLSEELEALK
T1201 AAQQELRTKREQEVA
T1218 KKALEDETKNHEAQI
T1234 DMRQRHATALEELSE
K1255 RFKANLEKNKQGLET
K1257 KANLEKNKQGLETDN
T1262 KNKQGLETDNKELAC
K1278 VKVLQQVKAESEHKR
S1366 TRQKLNLSSRIRQLE
K1376 IRQLEEEKNSLQEQQ
T1407 LQSQLADTKKKVDDD
K1408 QSQLADTKKKVDDDL
K1410 QLADTKKKVDDDLGT
K1427 SLEEAKKKLLKDVEA
Y1446 LEEKVLAYDKLEKTK
S1475 DHQRQIVSNLEKKQK
K1482 SNLEKKQKKFDQLLA
K1483 NLEKKQKKFDQLLAE
K1492 DQLLAEEKGISARYA
S1495 LAEEKGISARYAEER
K1515 EAREKETKALSLARA
K1551 MEDLMSSKDDVGKNV
K1676 KARDEVIKQLRKLQA
S1729 QLQEELASSERARRH
S1730 LQEELASSERARRHA
T1799 KTTLQVDTLNTELAA
K1831 QNKELKAKLQELEGA
K1905 QYKEQMEKANARMKQ
S1930 EATRANASRRKLQRE
S1953 EGLSREVSTLKNRLR
T1954 GLSREVSTLKNRLRR
R1961 TLKNRLRRGGPISFS
S1966 LRRGGPISFSSSRSG
S1968 RGGPISFSSSRSGRR
S1969 GGPISFSSSRSGRRQ
S1970 GPISFSSSRSGRRQL
R1971 PISFSSSRSGRRQLH
S1983 QLHIEGASLELSDDD
S1987 EGASLELSDDDTESK
T1991 LELSDDDTESKTSDV
S1993 LSDDDTESKTSDVND
T1995 DDDTESKTSDVNDTQ
S1996 DDTESKTSDVNDTQP
S2006 NDTQPPQSE______
  rat

 
Y13 GLEDPERYLFVDRAV
R18 ERYLFVDRAVIYNPA
Y22 FVDRAVIYNPATQAD
T26 AVIYNPATQADWTAK
T31 PATQADWTAKKLVWI
S40 KKLVWIPSERHGFEA
K78-ac VNKDDIQkMNPPKFS
Y155 HEKPPHIYAISESAY
Y194 NTKKVIQYLAHVASS
- gap
S227 QANPILESFGNAKTV
K232 LESFGNAKTVKNDNS
T233 ESFGNAKTVKNDNSS
K244-ac DNSSRFGkFIRINFD
Y285 ERTFHIFYQLLSGAG
S352 SMLKVVSSVLQFGNI
S360 VLQFGNISFKKERNT
K362 QFGNISFKKERNTDQ
K410 VGRDYVQKAQTKEQA
K442-ac WLVHRINkALDRTKR
T447 INkALDRTKRQGTSF
K552-ac TDKTFVEkLVQEQGS
K587-ac YAGKVDYkADEWLMK
K594 kADEWLMKNMDPLND
K658 RNVGQLYKESLTKLM
T667 SLTKLMATLRNTNPN
K689 NHEKRAGKLDPHLVL
K817 QQQLSALKVLQRNCA
K828 RNCAAYLKLRHWQWW
K840 QWWRVFTKVKPLLQV
K857 QEEELQAKDEELLKV
S1013 DRIAECSSQLAEEEE
S1037 NKQEVMISDLEERLK
S1145-p EKQKRDLsEELEALK
T1170 AAQQELRTKREQEVA
T1187 KKALEDETKNHEAQI
T1203 DMRQRHATALEELSE
K1224 RFKANLEKNkQGLET
K1226-ub KANLEKNkQGLETDN
T1231 KNkQGLETDNKELAC
K1247 VKVLQQVKAESEHKR
S1335 TRQKLNLSSRIRQLE
K1345 IRQLEEEKNSLQEQQ
T1376 LQSQLADTKKKVDDD
K1377 QSQLADTKKKVDDDL
K1379 QLADTKKKVDDDLGT
K1396 GLEEAKKKLLKDVEA
Y1415 LEEKVLAYDKLEKTK
S1444 DHQRQIVSNLEKKQk
K1451-ac SNLEKKQkkFDQLLA
K1452-ac NLEKKQkkFDQLLAE
K1461 DQLLAEEKGISARYA
S1464 LAEEKGISARYAEER
K1484-ac EAREKETkALSLARA
K1520 MEDLMSSKDDVGKNV
K1645-ac KARDEVIkQLRKLQA
S1698 QLQEELASSERARRH
S1699 LQEELASSERARRHA
T1768 KTTLQVDTLNTELAA
K1800 QNKELKAKLQELEGA
K1874-ac QYKEQMEkANARMKQ
S1899 EATRANASRRKLQRE
S1922 EGLSREVSTLKNRLR
T1923 GLSREVSTLKNRLRR
R1930 TLKNRLRRGGPISFS
S1935 LRRGGPISFSsSRSG
S1937 RGGPISFSsSRSGRR
S1938-p GGPISFSsSRSGRRQ
S1939 GPISFSsSRSGRRQL
R1940 PISFSsSRSGRRQLH
S1952-p QLHIEGAsLELsDDD
S1956-p EGAsLELsDDDtESK
T1960-p LELsDDDtESKTSDV
S1962 LsDDDtESKTSDVNE
T1964 DDDtESKTSDVNETQ
S1965 DDtESKTSDVNETQP
S1975-p NETQPPQsE______
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