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Protein Page:
ABCC1 (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ABCC1 a multi-pass membrane protein. A multidrug resistance member of the ABC transporter family that confers resistance to anticancer drugs. A multi-pass membrane protein. Exports sphingosine-1-phosphate (S1P), a potent inflammatory mediator, from mast cells during mast cell-mediated immune responses. Nine alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Transporter; Membrane protein, multi-pass; Transporter, ABC family
Cellular Component: membrane; integral to plasma membrane; basolateral plasma membrane; cytoplasm; plasma membrane; integral to membrane
Molecular Function: lipid-transporting ATPase activity; hydrolase activity; transporter activity; ATPase activity; nucleotide binding; long-chain fatty acid transporter activity; sphingolipid transporter activity; glutathione S-conjugate-exporting ATPase activity; xenobiotic-transporting ATPase activity; efflux transmembrane transporter activity; ATPase activity, coupled to transmembrane movement of substances; drug transporter activity; ATP binding
Biological Process: daunorubicin transport; response to drug; ATP catabolic process; phospholipid efflux; transport; drug export; multidrug transport; xenobiotic transport; response to oxidative stress; plasma membrane long-chain fatty acid transport; transmembrane transport; positive regulation of cell migration
Reference #:  O35379 (UniProtKB)
Alt. Names/Synonyms: Abcc1; Abcc1a; Abcc1b; ATP-binding cassette sub-family C member 1; ATP-binding cassette, sub-family C (CFTR/MRP), member 1; ATP-binding cassette, sub-family C (CFTR/MRP), member 1a; ATP-binding cassette, sub-family C (CFTR/MRP), member 1b; Leukotriene C(4) transporter; LTC4 transporter; Mdrap; Mrp; Mrp1; Multidrug resistance-associated protein 1; multiple drug resistance-associated protein
Gene Symbols: Abcc1
Molecular weight: 171,185 Da
Basal Isoelectric point: 7.03  Predict pI for various phosphorylation states
Select Structure to View Below

ABCC1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 1 K72 IQMTHLNKTKTALGF
0 1 K246 SDLWSLNKEDTSEEV
1 0 T249 WSLNKEDTSEEVVPV
0 1 N259 EVVPVLVNNWKKECD
0 19 Y277-p KQPVRIVyAPPKDPs
0 1 P279 PVRIVyAPPKDPsKP
0 1 K281 RIVyAPPKDPsKPKG
0 1 S284-p yAPPKDPsKPKGssQ
0 2 S289-p DPsKPKGssQLDVNE
0 7 S290-p PsKPKGssQLDVNEE
0 1 Q291 sKPKGssQLDVNEEV
0 4 K304 EVEALIVKSPHKDRE
0 2 K308 LIVKSPHKDREPSLF
0 1 K316 DREPSLFKVLYKTFG
0 1 K397 FVSGMRIKTAVVGAV
0 1 Y405 TAVVGAVYRKALLIT
0 1 K417 LITNAARKSSTVGEI
0 1 Y491 MAMKTKTYQVAHMkS
0 37 K497-ub TYQVAHMkSKDNRIk
0 1 S498 YQVAHMkSKDNRIkL
0 1 K499 QVAHMkSKDNRIkLM
0 3 K499 QVAHMkSKDNRIkLM
0 2 K504-ac kSKDNRIkLMNEILN
0 2 K504 kSKDNRIKLMNEILN
0 1 K514-ac NEILNGIkVLKLYAW
0 2 K514 NEILNGIKVLKLYAW
0 1 Q526 YAWELAFQDKVMSIR
0 4 K637 SIERRSIKSGEGNSI
0 1 K804 AVDAHVGKHIFEKVV
0 6 M814 FEKVVGPMGLLKNKT
0 1 K818 VGPMGLLKNKTRILV
0 1 S847 VMSGGKISEMGSYQE
0 1 T868-p AFAEFLRtyANAEQD
0 1 Y869-p FAEFLRtyANAEQDL
0 5 S878-p NAEQDLAsEDDsVsG
0 4 S882-p DLAsEDDsVsGSGKE
0 1 S884-p AsEDDsVsGSGKESK
0 1 K888 DsVsGSGKESKPVEN
0 2 K891 sGSGKESKPVENGML
0 3 T902 NGMLVTDTVGKHLQR
0 2 K905 LVTDTVGKHLQRHLs
0 128 S912-p KHLQRHLsNsssHsG
0 12 N913 HLQRHLsNsssHsGD
0 12 S914-p LQRHLsNsssHsGDT
0 44 S915-p QRHLsNsssHsGDTs
0 26 S916-p RHLsNsssHsGDTsQ
0 67 H917 HLsNsssHsGDTsQQ
0 10 S918-p LsNsssHsGDTsQQH
0 2 S922-p ssHsGDTsQQHSsIA
0 67 S927-p DTsQQHSsIAELQKA
0 3 I928 TsQQHSsIAELQKAG
0 1 K933 SsIAELQKAGAKEET
0 1 K948 WKLMEADKAQTGQVQ
0 1 K1075 NLVNRFSKELDTVDS
0 3 K1178 FIHQSDLKVDENQKA
0 1 K1184 LKVDENQKAyYPSIV
0 5 Y1186-p VDENQKAyYPSIVAN
0 1 Y1240 YSLQITAYLNWLVRM
0 1 K1262 IVAVERLKEYSETEK
0 1 K1269 KEYSETEKEAPWQIQ
0 1 K1357 IDGVNIAKIGLHNLR
0 1 K1366 GLHNLRFKITIIPQD
0 4 K1499-ub TRVIVLDkGEVRECG
0 30 C1505 DkGEVRECGAPSELL
0 8 Y1519 LQQRGIFYSMAKDAG
0 3 S1520 QQRGIFYSMAKDAGL
0 1 K1523 GIFYSMAKDAGLV__
  human

 
K72-ub IQMTPLNkTKTALGF
K246-ub SDLWSLNkEDtSEQV
T249-p WSLNkEDtSEQVVPV
K259-ub QVVPVLVkNWKKECA
Y277-p KQPVKVVySskDPAQ
S279-p PVKVVySskDPAQPK
K280-ub VKVVySskDPAQPKE
A283 VySskDPAQPKESsk
S288 DPAQPKESskVDANE
S289-p PAQPKESskVDANEE
K290-ub AQPKESskVDANEEV
K303-ub EVEALIVkSPQkEWN
K307-ub LIVkSPQkEWNPSLF
K315-ub EWNPSLFkVLYKTFG
K396-ub FVSGMRIkTAVIGAV
Y404-p TAVIGAVyRKALVIT
K416-ub VITNSARkSSTVGEI
Y490-p MAMKTKTyQVAHMks
K496-ub TyQVAHMkskDNRIk
S497-p yQVAHMkskDNRIkL
K498-ac QVAHMkskDNRIkLM
K498-ub QVAHMkskDNRIkLM
K503-ac kskDNRIkLMNEILN
K503-ub kskDNRIkLMNEILN
K513 NEILNGIKVLKLYAW
K513-ub NEILNGIkVLKLYAW
K525-ub YAWELAFkDKVLAIR
K636-ub SIERRPVkDGGGTNS
K804-ub AVDAHVGkHIFENVI
K814-ub FENVIGPkGMLkNKT
K818-ub IGPkGMLkNKTRILV
S847-p VMSGGKIsEMGSYQE
T868 AFAEFLRTYASTEQE
Y869 FAEFLRTYASTEQEQ
A878 STEQEQDAEENGVTG
G882 EQDAEENGVTGVSGP
S887 ENGVTGVSGPGkEAk
K891-ub TGVSGPGkEAkQMEN
K894-ub SGPGkEAkQMENGML
S905-p NGMLVTDsAGkQLQR
K908-ub LVTDsAGkQLQRQLs
S915-p kQLQRQLsssssysG
S916-p QLQRQLsssssysGD
S917-p LQRQLsssssysGDI
S918-p QRQLsssssysGDIs
S919-p RQLsssssysGDIsR
Y920-p QLsssssysGDIsRH
S921-p LsssssysGDIsRHH
S925-p ssysGDIsRHHNstA
S930-p DIsRHHNstAELQkA
T931-p IsRHHNstAELQkAE
K936-ub NstAELQkAEAKKEE
K952-ub WKLMEADkAQTGQVK
K1078-ub NLVNRFSkELDTVDS
K1181-ub FIHQSDLkVDENQkA
K1187-ub LkVDENQkAYYPSIV
Y1189 VDENQkAYYPSIVAN
Y1243-p YSLQVTTyLNWLVRM
K1265-ub IVAVERLkEYSETEk
K1272-ub kEYSETEkEAPWQIQ
K1360-ub IDGINIAkIGLHDLR
K1369-ub GLHDLRFkITIIPQD
K1502-ub TRVIVLDkGEIQEyG
Y1508-p DkGEIQEyGAPSDLL
Y1522-p LQQRGLFysMAkDAG
S1523-p QQRGLFysMAkDAGL
K1526-ub GLFysMAkDAGLV__
  rat

 
K72 IQMTHLNKAKTALGF
K246 SDLWSLNKEDTSEEV
T249 WSLNKEDTSEEVVPV
N259 EVVPVLVNNWKKECV
Y277 KQPVRIVYAPPKDPT
P279 PVRIVYAPPKDPTKP
K281 RIVYAPPKDPTKPKG
T284 YAPPKDPTKPKGssQ
S289-p DPTKPKGssQLDVNE
S290-p PTKPKGssQLDVNEE
Q291 TKPKGssQLDVNEEV
K304 EVEALIVKSSHKDRD
K308 LIVKSSHKDRDPSLF
K316 DRDPSLFKVLYKTFG
K397 FVTGMRIKTAVVGAV
Y405 TAVVGAVYRKALVIT
K417 VITNSARKSSTVGEI
Y491 MAMKTKTYQVAHMkS
K497-ub TYQVAHMkSKDNRIK
S498 YQVAHMkSKDNRIKL
K499 QVAHMkSKDNRIKLM
K499 QVAHMkSKDNRIKLM
K504 kSKDNRIKLMNEILN
K504 kSKDNRIKLMNEILN
K514 NEILNGIKVLKLYAW
K514 NEILNGIKVLKLYAW
Q526 YAWELAFQDKVMNIR
K637 SIERWSIKDGGGMNS
K805 AVDAHVGKHIFEKVV
M815 FEKVVGPMGLLKNKT
K819 VGPMGLLKNKTRILV
S848 VMSGGKISEMGSYQE
T869 AFAEFVRTYANTEQD
Y870 FAEFVRTYANTEQDL
S879-p NTEQDLAsEDDSKNG
S883 DLAsEDDSKNGVSGL
S888 DDSKNGVSGLGKESK
K892 NGVSGLGKESKPVEN
K895 SGLGKESKPVENGIL
A906 NGILVTDAVGKPLQR
K909 LVTDAVGKPLQRHLS
S916 KPLQRHLSNSSSHSV
N917 PLQRHLSNSSSHSVV
S918 LQRHLSNSSSHSVVT
S919 QRHLSNSSSHSVVTN
S920 RHLSNSSSHSVVTNQ
H921 HLSNSSSHSVVTNQQ
S922 LSNSSSHSVVTNQQH
N926 SSHSVVTNQQHSSTA
S931 VTNQQHSSTAELQKS
T932 TNQQHSSTAELQKSG
K937 SSTAELQKSGVKEET
K952 WKLMEADKAQTGQVK
K1079 NLVNRFSKELDTVDS
K1182 FIRQSDLKVDENQKA
K1188 LKVDENQKAYYPSIV
Y1190 VDENQKAYYPSIVAN
Y1244 YSLQITAYLNWLVRM
K1266 IVAVERLKEYSETEK
K1273 KEYSETEKEASWQIQ
K1361 IDGINIAKIGLHNLR
K1370 GLHNLRFKITIIPQD
K1503 TRVIVLDKGEIRECG
C1509 DKGEIRECGAPSELL
Y1523 LQQRGVFYSMAKDAG
S1524 QQRGVFYSMAKDAGL
K1527 GVFYSMAKDAGLV__
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