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Protein Page:
MYO5A (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MYO5A Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. May also be required for some polarization process involved in dendrite formation. May be a homodimer, which associates with multiple calmodulin or myosin light chains. Binds MLPH and MYRIP. Interacts with RIPL2, the interaction is required for its role in dendrite formation. Detected in melanocytes. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motor protein; Motility/polarity/chemotaxis
Cellular Component: Golgi apparatus; neuron projection; cell; actomyosin; intermediate filament; secretory granule; ruffle; synaptic vesicle; actomyosin, myosin complex part; photoreceptor outer segment; cell soma; membrane; axon; cytoplasm; melanosome; myosin complex
Molecular Function: protein dimerization activity; calmodulin binding; microfilament motor activity; ATP-dependent protein binding; protein binding; SNARE binding; protein heterodimerization activity; nucleotide binding; motor activity; syntaxin-1 binding; calcium ion binding; actin binding; calcium-dependent protein binding; Rab GTPase binding; ATP binding
Biological Process: myelination; exocytosis; melanin metabolic process; metabolic process; pigmentation during development; long-chain fatty acid biosynthetic process; locomotion during locomotory behavior; odontogenesis; synaptic transmission; vesicle transport along actin filament; protein transport; visual perception; transport; melanocyte differentiation; synapse organization and biogenesis; regulation of inositol-1,4,5-triphosphate receptor activity; neuromuscular process controlling balance; ER localization; actin filament-based movement; melanosome localization; melanosome transport; melanin biosynthetic process; vesicle-mediated transport; regulation of exocytosis; pigmentation; cellular response to insulin stimulus; insulin secretion; anagen; secretory granule localization
Reference #:  Q99104 (UniProtKB)
Alt. Names/Synonyms: 9630007J19Rik; AI413174; AI661011; d; d-120J; Dbv; Dilute; dilute lethal-20J protein; Dilute myosin heavy chain, non-muscle; flail; flailer; flr; MVa; Myo5; Myo5a; myosin VA; Myosin-Va; MyoVA; Sev-1
Gene Symbols: Myo5a
Molecular weight: 215,538 Da
Basal Isoelectric point: 8.82  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MYO5A

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: S1650‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 1 Y31 SAELLKDYKPGDKVL
0 1 S199 VEEKVLASNPIMESI
0 1 S205 ASNPIMESIGNAkTT
0 1 K210-ub MESIGNAkTTRNDNS
0 18 S600-p QDDEKAIsPtSATSS
0 1 T602-p DEKAIsPtSATSSGR
0 1 T610 SATSSGRTPLTRVPV
0 1 V615 GRTPLTRVPVKPTKG
0 2 Y757 FRAGQVAYLEKLRAD
0 1 Y828 IQKYWRMYVVRRRYK
0 1 Y834 MYVVRRRYKIRRAAT
0 1 K865 RKILREYKAVIIQKR
0 2 K902-ac CFRRMMAkRELKKLk
0 1 K909-ac kRELKKLkIEARSVE
0 1 Y918 EARSVERYkKLHIGM
0 1 K919-ac ARSVERYkKLHIGME
0 2 K941-ac RKVDEQNkDYKCLME
0 1 K979-ub QLSEEEAkVATGRVL
0 2 S987 VATGRVLSLQEEIAK
0 1 T1032 SNLKEENTLLKQEKE
0 1 R1058 EMTETMERKLVEETK
0 1 Y1078 LNDERLRYQNLLNEF
0 1 S1086 QNLLNEFSRLEERYD
0 2 T1113-p PKPGHKRtDstHssN
0 12 S1115-p PGHKRtDstHssNEs
0 4 T1116-p GHKRtDstHssNEsE
0 7 S1118-p KRtDstHssNEsEyT
0 2 S1119-p RtDstHssNEsEyTF
0 2 S1122-p stHssNEsEyTFSSE
0 2 Y1124-p HssNEsEyTFSSEFA
0 30 Y1203 IRGAELEYESLkRQE
0 1 K1207 ELEYESLKRQELESE
0 1 K1207-ub ELEYESLkRQELESE
0 1 S1213 LkRQELESENKKLKN
0 1 K1232-ub LRKALSEkSAPEVTA
0 1 Y1245 TAPGAPAYRVLMEQL
0 1 K1263-ac SEELDVRkEEVLILR
0 2 K1277-ub RSQLVSQkEAIQPKD
0 1 K1283 QkEAIQPKDDKNTMT
0 1 - gap
0 11 S1450-p VGQMENIsPGQIIDE
0 1 S1529 NDDQKVRSLLTSTIN
0 1 T1532 QKVRSLLTSTINSIK
0 1 S1533 KVRSLLTSTINSIKK
0 1 T1534 VRSLLTSTINSIKKV
0 2 S1537 LLTSTINSIKKVLKK
0 1 K1539 TSTINSIKKVLKKRG
0 1 S1570 LHCLKQYSGEEGFMK
0 2 T1648-p PTGLRKRtssIADEG
0 7 S1649-p TGLRKRtssIADEGt
2 20 S1650-p GLRKRtssIADEGty
0 6 T1656-p ssIADEGtyTLDSIL
0 1 Y1657-p sIADEGtyTLDSILR
0 1 S1668-p SILRQLNsFHsVMCQ
0 1 S1671-p RQLNsFHsVMCQHGM
0 1 T1741 MNSGAKETLEPLIQA
0 1 K1755 AAQLLQVKKKTDDDA
  human

 
Y31-p SAELLKDyKPGDKVL
S199-p VEEKVLAsNPIMEsI
S205-p AsNPIMEsIGNAKTT
K210 MEsIGNAKTTRNDNS
S600-p QDDEKAIsPTSATSS
T602 DEKAIsPTSATSSGR
T610-p SATSSGRtPLTRtPA
T615-p GRtPLTRtPAKPTKG
Y757-p FRAGQVAyLEKLRAD
Y828-p IQKYWRMyVVRRRyK
Y834-p MyVVRRRyKIRRAAT
K865 RKILREHKAVIIQKR
K902-ac CFRRMMAkRELKKLK
K909 kRELKKLKIEARSVE
Y918-p EARSVERyKKLHIGM
K919 ARSVERyKKLHIGME
K941 RKVDEQNKDYKCLVE
K979 QLSEEEAKVATGRVL
S987-p VATGRVLsLQEEIAK
T1032-p SNLKEENtLLKQEKE
K1058-ub EMTETMEkKLVEETK
Y1078-p LNDERLRyQNLLNEF
S1086-p QNLLNEFsRLEERYD
T1113-p PKPGHKRtDstHssN
S1115-p PGHKRtDstHssNES
T1116-p GHKRtDstHssNESE
S1118-p KRtDstHssNESEYI
S1119-p RtDstHssNESEYIF
S1122 stHssNESEYIFSSE
Y1124 HssNESEYIFSSEIA
Y1203-p IRGAELEyESLkRQE
K1207-ac ELEyESLkRQELEsE
K1207 ELEyESLKRQELEsE
S1213-p LkRQELEsENKKLKN
K1232 LRKALSEKSAPEVTA
Y1245-p TAPGAPAyRVLMEQL
K1263 SEELDVRKEEVLILR
K1277 RSQLVSQKEAIQPKD
K1283 QKEAIQPKDDKNTMT
Y1339-p DGELWLVyEGLKQAN
S1452-p VGQMENIsPGQIIDE
S1531-p NDDQKVRsLLtstIN
T1534-p QKVRsLLtstINsIK
S1535-p KVRsLLtstINsIKK
T1536-p VRsLLtstINsIKKV
S1539-p LLtstINsIKKVLKK
K1541 tstINsIKKVLKKRG
S1572-p LHCLKQYsGEEGFMK
T1650-p PTGLRKRtssIADEG
S1651-p TGLRKRtssIADEGt
S1652-p GLRKRtssIADEGty
T1658-p ssIADEGtyTLDSIL
Y1659-p sIADEGtyTLDSILR
S1670 SILRQLNSFHSVMCQ
S1673 RQLNSFHSVMCQHGM
T1743-p MNSGAKEtLEPLIQA
K1757 AAQLLQVKKKTDDDA
  rat

 
Y31 SAELLKDYKPGDKVL
S199 VEEKVLASNPIMESI
S205 ASNPIMESIGNAKTT
K210 MESIGNAKTTRNDNS
S600 QDDEKAISPTSATSS
T602 DEKAISPTSATSSGR
T610 SATSSGRTPLTRVPV
V615 GRTPLTRVPVKPTKG
Y757 FRAGQVAYLEKLRAD
Y828 IQKYWRMYVVRRKYK
Y834 MYVVRRKYKIRRAAT
K865-ub RKILREHkAVIIQKR
K902 CFRRMMAKRELKKLK
K909 KRELKKLKIEARSVE
Y918 EARSVERYKKLHIGM
K919 ARSVERYKKLHIGME
K941 RKVDEQNKDYKCLME
K979 QLSEEEAKVATGRVL
S987 VATGRVLSLQEEIAK
T1032-p SNLKEENtLLKQEKE
R1058 EMTETMERKLVEETK
Y1078 LNDERLRYQNLLNEF
S1086 QNLLNEFSRLEERYD
T1113 PKPGHKRTDSTHSSN
S1115 PGHKRTDSTHSSNES
T1116 GHKRTDSTHSSNESE
S1118 KRTDSTHSSNESEYT
S1119 RTDSTHSSNESEYTF
S1122 STHSSNESEYTFSSE
Y1124 HSSNESEYTFSSEFA
Y1203 IRGAELGYESLKRQE
K1207 ELGYESLKRQELESE
K1207 ELGYESLKRQELESE
S1213 LKRQELESENKKLKN
K1232 LRKALSEKSAPEVNA
Y1245 NAPGAPAYRVLMEQL
K1263 SEELDVRKEEVLILR
K1277-ub RSQLVSQkEAIQPkD
K1283-ub QkEAIQPkDDKNTMT
- gap
S1425 VGQMENISPGQIIDE
S1504 DDDQKVRSLLTSTIN
T1507 QKVRSLLTSTINSIk
S1508 KVRSLLTSTINSIkK
T1509 VRSLLTSTINSIkKV
S1512 LLTSTINSIkKVLKK
K1514-ac TSTINSIkKVLKKRG
S1545 LHCLKQYSGEEGFMK
T1623 PTGLRKRTSSIADEG
S1624 TGLRKRTSSIADEGT
S1625 GLRKRTSSIADEGTY
T1631 SSIADEGTYTLDSIL
Y1632 SIADEGTYTLDSILR
S1643 SILRQLNSFHSVMCQ
S1646 RQLNSFHSVMCQHGM
T1716 MNSGAKETLEPLIQA
K1730-ac AAQLLQVkKKTDDDA
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