Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. May also be required for some polarization process involved in dendrite formation. May be a homodimer, which associates with multiple calmodulin or myosin light chains. Binds MLPH and MYRIP. Interacts with RIPL2, the interaction is required for its role in dendrite formation. Detected in melanocytes. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Motor protein
Molecular Function: protein dimerization activity; motor activity; nucleotide binding; calcium ion binding; actin binding; calcium-dependent protein binding; calmodulin binding; microfilament motor activity; ATP-dependent protein binding; SNARE binding; protein binding; protein heterodimerization activity; syntaxin-1 binding; Rab GTPase binding; ATP binding
Biological Process: myelination; exocytosis; melanin metabolic process; metabolic process; pigmentation during development; long-chain fatty acid biosynthetic process; locomotion during locomotory behavior; odontogenesis; synaptic transmission; vesicle transport along actin filament; protein transport; visual perception; transport; melanocyte differentiation; synapse organization and biogenesis; regulation of inositol-1,4,5-triphosphate receptor activity; neuromuscular process controlling balance; ER localization; actin filament-based movement; melanosome localization; melanosome transport; vesicle-mediated transport; regulation of exocytosis; melanin biosynthetic process; cellular response to insulin stimulus; pigmentation; insulin secretion; anagen; secretory granule localization
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.