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Protein Page:
MAP6 (mouse)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
MAP6 Involved in microtubule stabilization in many cell types, including neuronal cells. Specifically has microtubule cold stabilizing activity. Interacts with calmodulin (via C-terminus); the interaction is dependent on Ca(2+). Expressed in brain. Expressed in spinal chord. Isoform 2 expression is up-regulated in the prefrontal cortex (Brodmann's area 46) of patients with schizophrenia (postmortem brain study). Belongs to the STOP family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal protein
Cellular Component: Golgi apparatus; microtubule; cytoskeleton; perinuclear region of cytoplasm; cytoplasm
Molecular Function: calmodulin binding; microtubule binding
Biological Process: negative regulation of microtubule depolymerization
Reference #:  O55129 (UniProtKB)
Alt. Names/Synonyms: 2810411E12Rik; MAP-6; Map6; Microtubule-associated protein 6; Mtap6; Stable tubule-only polypeptide; STOP
Gene Symbols: Map6
Molecular weight: 96,450 Da
Basal Isoelectric point: 9.51  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MAP6
Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        mouse

► Hide Isoforms 		 
0 2 K21-u RFWNQLDkADIAVPL
0 1 K32-u AVPLVFTkYSEATEH
0 3 S86-p TGPAPGPsVDRETVA
0 1 S98-p TVAAPGRsGLGLGAA
0 1 S108-p GLGAASAstSGsGPA
0 1 T109-p LGAASAstSGsGPAD
0 1 S112-p ASAstSGsGPADSVM
0 4 K127 RQDYRAWKVQRPEPS
0 1 S139-p EPSCRPRsEyQPSDA
0 25 Y141-p SCRPRsEyQPSDAPF
0 1 K156-u ERETQYQkDFRAWPL
0 1 K174-u GDHPWIPkPVQIPAt
0 1 T181-p kPVQIPAtSQPSQPV
0 1 K193-u QPVLGVPkRRPQsQE
0 3 S198-p VPkRRPQsQERGPMQ
0 4 S207-p ERGPMQLsADARDPE
0 3 K226-u AGVLAAGkASGVDQR
0 11 K254-u RNEGHEEkPLPPAQS
0 10 K272-u EGGPAAGkASGADQR
0 1 S294-g PAWMVTRsEGHEEkP
0 1 S294-p PAWMVTRsEGHEEkP
0 11 K300-u RsEGHEEkPLPPAQS
0 10 K318-u EGGPAAGkASGADQR
0 2 K364-u EGGPAAGkAsGADER
0 1 S366-p GPAAGkAsGADERDT
0 1 K376-u DERDTRRkAGPAWMV
0 5 S386-p PAWMVRRsEGHEQtP
0 1 S386-g PAWMVRRsEGHEQtP
0 2 T392-p RsEGHEQtPAAHAQG
0 1 K406 GTGPEGGKGRAVADA
0 6 K406-u GTGPEGGkGRAVADA
0 8 K441-u FRAWTDIkPVkPIKA
0 1 K444-u WTDIkPVkPIKAKPQ
0 1 K458 QYKPPDDKMVHETSY
0 1 K475 QFKGEANKPSAADNk
0 4 K475-u QFKGEANkPSAADNk
0 5 K482-u kPSAADNkAMDRRRI
0 10 S491-p MDRRRIRsLYSEPFk
0 1 K498-u sLYSEPFkECPKVEK
0 1 K512 KPSVQSSKPKKTSTS
0 2 K525 TSHKPPRKAKDKQVV
0 2 K527 HKPPRKAKDKQVVSG
0 1 K567 NNKLAEAKESRVKPT
0 1 S627-p QVPVVPGsLKGQsPT
1 8 S632-p PGsLKGQsPTAPGPt
0 1 T639-p sPTAPGPtKDQGAVL
0 1 G643 PGPtKDQGAVLLGPV
0 9 S687-p LAPAKAQsPLLPEPL
0 2 S698-p PEPLKNQsPVVPASt
0 1 T705-g sPVVPAStKDQsFPT
0 1 S709-p PAStKDQsFPTPAPR
0 1 P754 ASLKNEAPMVPESVK
0 1 K785-m1 TTAPRYLkGHDSVFV
0 2 S832-p PEPPKNQsPVVLGPI
0 6 S905-p HTEYIEGsP______
  MAP6 iso3  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S4 ____MQLSADARDPE
K23 AGVLAAGKASGVDQR
K51 RNEGHEEKPLPPAQS
K69 EGGPAAGKASGADQR
S91 PAWMVTRSEGHEEKP
S91 PAWMVTRSEGHEEKP
K97 RSEGHEEKPLPPAQS
K115 EGGPAAGKASGADQR
K161 EGGPAAGKASGADER
S163 GPAAGKASGADERDT
K173 DERDTRRKAGPAWMV
S183-p PAWMVRRsEGHEQtP
S183 PAWMVRRSEGHEQtP
T189-p RsEGHEQtPAAHAQG
K203-a GTGPEGGkGRAVADA
K203 GTGPEGGKGRAVADA
K238 FRAWTDIKPVKPIKA
K241 WTDIKPVKPIKAKPQ
K255 QYKPPDDKMVHETSY
K272 QFKGEANKPSAADNK
K272 QFKGEANKPSAADNK
K279 KPSAADNKAMDRRRI
S288-p MDRRRIRsLYSEPFK
K295 sLYSEPFKECPKEPG
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  human

 
K21-u RFWNQLDkADIAVPL
K32 AVPLVFTKYSEATEH
T90 TGPAPGPTGEREPAA
S102 PAAGPGRSGPGPGLG
S112 GPGLGSGSTSGPADS
T113 PGLGSGSTSGPADSV
P116 GSGSTSGPADSVMRQ
K129 RQDYRAWKVQRPEPS
S141 EPSCRPRSEyQPSDA
Y143-p SCRPRSEyQPSDAPF
K158 ERETQYQKDFRAWPL
K176 GDHPWIPKPVQISAA
A183 KPVQISAASQASAPI
K195 APILGAPKRRPQsQE
S200-p APKRRPQsQERWPVQ
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K229 AGGLAAGKASGADER
S231 GLAAGKASGADERDT
K241 DERDTRRKAGPAWIV
A251 PAWIVRRAEGLGHEQ
A251 PAWIVRRAEGLGHEQ
T259 EGLGHEQTPLPAAQA
R277 ATGPEAGRGRAAADA
R277 ATGPEAGRGRAAADA
K312-u FRAWTDIkPVKPIKA
K315 WTDIkPVKPIKAKPQ
K329-a QYKPPDDkMVHETSY
K346-a QFKGEASkPTTADNk
K346-u QFKGEASkPTTADNk
K353-u kPTTADNkVIDRRRI
S362 IDRRRIRSLYSEPFK
K369 SLYSEPFKEPPKVEK
K383 KPSVQSSKPKKTSAS
K396-a ASHKPTRkAkDKQAV
K398-a HKPTRkAkDKQAVSG
K438-a NNKLAEAkESLAQPV
P503 LGPMIPLPVKDQDHT
D508 PLPVKDQDHTVPEPL
L515 DHTVPEPLKNEsPVI
S519-p PEPLKNEsPVISAPV
G563 PESLKDQGPRIPEPV
A574 PEPVKNQAPMVPAPV
V581 APMVPAPVKDEGPMV
G585 PAPVKDEGPMVSASV
S663-p APIKNQGsMVSEPVK
K692 VVVPEHAKVHDSAVV
G739 LQPPKNQGRIVPEPL
S812-p HTEYIESsP______
  rat

 
K21 RFWNQLDKADIAVPL
K32 AVPLVFTKYSEATEH
S86 TGPAPGPSGDRETAA
S98 TAAAPGRSGLGLGAA
S108 GLGAASGSTSGSGPA
T109 LGAASGSTSGSGPAD
S112 ASGSTSGSGPADSVM
K127-u RQDYRAWkVQRPEPS
S139 EPSCRPRSEyQPSDA
Y141-p SCRPRSEyQPSDAPF
K156 ERETQYQKDFRAWPL
K174 GDHPWIPKPVQIPAT
T181 KPVQIPATSQPSPPV
K193 PPVLGMPKRRPQSQE
S198 MPKRRPQSQERGPIQ
S207 ERGPIQLSADARDPE
K226-u AGVPAAGkASGADQR
K254-u RTEGHEEkPLPPAQS
K272-u EGGPAAGkASGADQR
T294 PAWMVTRTEGHEEkP
T294 PAWMVTRTEGHEEkP
K300-u RTEGHEEkPLPPAQS
K318-u EGGPAAGkASGADQR
K410-u EGGPAAGkASGADER
S412 GPAAGkASGADERDT
K422 DERDTRRKAGPAWMV
S432 PAWMVRRSEGHEQTT
S432 PAWMVRRSEGHEQTT
T438 RSEGHEQTTAAHAQG
K452 GTGPEGGKGRAVADA
K452-u GTGPEGGkGRAVADA
K487-u FRAWTDIkPVKPIKA
K490 WTDIkPVKPIKAKPQ
K504 QYKPPDDKMVHETSY
K521 QFKGEASKPTTADNk
K521-u QFKGEASkPTTADNk
K528-u kPTTADNkVVDRRRI
S537 VDRRRIRSLYSEPFK
K544 SLYSEPFKESPKVEK
K558-u KPSVQSSkPKKTSTS
K571 TSQKPLRKAKDKQVA
K573 QKPLRKAKDKQVASG
K613 NNKLAEAKESRVKPT
S676 QAPVVPGSLKGQsPT
S681-p PGSLKGQsPTAPGPP
P688 sPTAPGPPKDQGAVL
G692 PGPPKDQGAVLLGPM
S736 LAPAKAQSPLLPEPL
S747 PEPLKNQSPVVPARA
A754 SPVVPARAKDQSFPA
S758 PARAKDQSFPAPAPT
P805 ASLKNEAPVASESVK
K830 KDTGTDLKGHGSVFV
P878 EPPKNQGPPVVLGPI
S951 HAEYIEGSP______
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