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Protein Page:
EEA1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
EEA1 Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. Homodimer. Binds STX6. Binds RAB5A, RAB5B, RAB5C and RAB22A that have been activated by GTP-binding. Interacts with ERBB2. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; Vesicle protein
Cellular Component: extrinsic to plasma membrane; membrane; early endosome membrane; early endosome; cytoplasm; plasma membrane; cytosol; serine-pyruvate aminotransferase, type 2B complex
Molecular Function: calmodulin binding; protein binding; protein homodimerization activity; zinc ion binding; GTP-dependent protein binding; phosphatidylinositol binding
Biological Process: vesicle fusion; early endosome to late endosome transport; synaptic vesicle to endosome fusion; endocytosis
Reference #:  Q15075 (UniProtKB)
Alt. Names/Synonyms: Early endosome antigen 1; early endosome antigen 1, 162kD; early endosome-associated protein; EEA1; Endosome-associated protein p162; MST105; MSTP105; ZFYVE2; Zinc finger FYVE domain-containing protein 2
Gene Symbols: EEA1
Molecular weight: 162,466 Da
Basal Isoelectric point: 5.55  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

EEA1
Protein Structure Not Found.


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Sites Implicated In
activation: T1392‑p
intracellular localization: T1392‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
0 5 S15-p RTPGRVGsQGSDLDS
0 1 S52-p QCMKSLGsADELFkH
0 1 K58-u GsADELFkHYEAVHD
0 2 S70-p VHDAGNDsGHGGESN
0 2 K100-u QDLQASLkEEKWySE
0 1 Y105-p SLkEEKWySEELKKE
0 1 K115 ELKKELEKYQGLQQQ
0 1 D127-ca QQQEAKPdGLVTDSS
0 1 K158-a NFNIKQMkDLFEQkA
0 1 K164-a MkDLFEQkAAQLATE
0 1 K178 EIADIKSKYDEERSL
0 1 K228 EDVAVLKKELVQVQT
0 1 S295-p QELQKLKssVNELtQ
0 1 S296-p ELQKLKssVNELtQK
0 1 T301-p KssVNELtQKNQTLT
0 4 S356-p LQSRLSAsETSLHRI
0 1 T621-p DRVLSLEtSVNELNs
0 1 S628-p tSVNELNsQLNESkE
0 1 K634-a NsQLNESkEKVSQLD
0 1 K645-a SQLDIQIkAKTELLL
0 1 S720 EYKEKYLSLEQKTEE
0 1 T761-p QQQRQLNtDLELRAT
0 1 T836-p ELNNRIQttVtELQK
0 1 T837-p LNNRIQttVtELQKV
0 1 T839-p NRIQttVtELQKVKM
0 1 T853-p MEKEALMtELsTVKD
0 1 S856-p EALMtELsTVKDKLs
0 2 S863-p sTVKDKLsKVSDSLK
0 1 K882 EFEKENQKGkAAILD
0 1 K884-u EKENQKGkAAILDLE
0 1 K895 LDLEKTCKELKHQLQ
0 1 K895-u LDLEKTCkELKHQLQ
0 1 T908-p LQVQMENtLKEQKEL
0 1 K995 QKTELENKLQQQLTQ
0 1 T1045 RESELLATRQDLKSV
0 1 K1133-a LAEIEEIkCRQEkEI
0 1 K1133 LAEIEEIKCRQEkEI
0 1 K1138-a EIkCRQEkEITkLNE
0 1 K1142-a RQEkEITkLNEELKS
0 1 T1159-p LESIKEItNLKDAKQ
0 1 T1252-p ALNENLGtVKKEWQS
0 1 K1254 NENLGtVKKEWQSSQ
0 1 S1265-p QSSQRRVsELEKQTD
0 1 K1312 EIEKLQTKVLELQRK
1 0 T1392-p CSAKNALtPSSKKPV
  mouse

 
S15-p RTPGRVGsQGSDLDS
S52-p QCMKSLGsADELFKH
K58 GsADELFKHYQAVHD
S70-p VHDAGNDsGHGGEAG
K100-u QDLQASLkEEKWYSE
Y105 SLkEEKWYSEELKKE
K115-u ELKKELEkYQGLQQQ
D127 QQQEAKSDGLVTDSS
K158 NFNIKQMKDLFEQKA
K164 MKDLFEQKAAQLATE
K178 EIADIKSKYDEEKSL
K228-u EDVAVLKkELVQVQT
G295 QEIQKLKGSINELTQ
S296 EIQKLKGSINELTQK
T301 KGSINELTQKNQNLT
S356 LQARLTASESSLQRA
T621 DRVLSLETSVSELSS
S628 TSVSELSSQLNESKE
K634 SSQLNESKEKVSQLD
K645 SQLDIQIKAKTELLL
S720-p DHKEKHLsLEQKVED
T761 QQQRQLSTDLELRNA
A836 ELGDRMQAAVTELTA
A837 LGDRMQAAVTELTAV
T839 DRMQAAVTELTAVKA
A853 AQKDALLAELSTTKE
S856 DALLAELSTTKEKLS
S863 STTKEKLSKVSDSLK
K882-a EFEKENQkGKAAVLD
K884 EKENQkGKAAVLDLE
K895-a LDLEKACkELKHQLQ
K895 LDLEKACKELKHQLQ
A908 LQVQAESALKEQEDL
K995-u QKTVLENkLQQQSSQ
T1045-p KESELLAtRQDLKSV
K1133 LAEMEEIKCRQEKEI
K1133 LAEMEEIKCRQEKEI
K1138 EIKCRQEKEITKLNE
K1142 RQEKEITKLNEELKS
T1159 QESIKEITNLKDAKQ
T1252 TLNENLGTVkKEWQS
K1254-u NENLGTVkKEWQSSQ
S1265 QSSQRRVSELEKQTD
K1312-u EIEKLQTkALELQRK
T1392 CSTKNALTPSSKKPV
  rat

 
S15 RTPGRVGSQGSDLDS
S52 QCMKSLGSADELFKH
K58 GSADELFKHYQAVHD
S70 VHDAGNDSGHGGEAS
K100 QDLQASLKEEKWYSE
Y105 SLKEEKWYSEELKKE
K115 ELKKELEKYQGLQQQ
D127 QQQEAKSDGLVTDSS
K158 NFNIKQMKDLFEQKA
K164 MKDLFEQKAAQLATE
K178-m2 EIADIKSkYDEEKGL
K228 EDVAVLKKELVQVQT
G295 QEIQKLKGSVNELTQ
S296 EIQKLKGSVNELTQK
T301 KGSVNELTQKSQTLM
S356 LQARLTASEGSLQRI
T621 DRVLSLETSVSELSS
S628 TSVSELSSQLNESKE
K634 SSQLNESKEKVSQLD
K645 SQLDIQIKAKTELLL
S720 DYKEKHLSLEQKAED
T761 QQQRQLSTDLELRNA
A836 ELSDRMQAAITELMV
A837 LSDRMQAAITELMVM
T839 DRMQAAITELMVMTA
A853 AQKDALLAELSTTKG
S856 DALLAELSTTKGKLS
S863 STTKGKLSKVSDSLQ
K882 EFEKESQKGKAAVLD
K884 EKESQKGKAAVLDLE
K895 LDLEKACKELKHQLQ
K895 LDLEKACKELKHQLQ
A908 LQQQTESALKEQSEL
K995 QKAQLESKLQQQAAQ
T1045 KESELLATRQDLKCV
K1133 LAEMEEIKCRQEKEI
K1133-u LAEMEEIkCRQEKEI
K1138 EIkCRQEKEIAKLKE
K1142 RQEKEIAKLKEELKS
T1159 QESIKEVTNLKDAKQ
T1252 TLNENLGTVKKEWQS
K1254 NENLGTVKKEWQSSQ
S1265 QSSQRRVSELEKQTD
K1312 EIEKLQTKVLELQRK
T1392 CSAKNALTPSSKKPV
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