Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. Homodimer. Binds STX6. Binds RAB5A, RAB5B, RAB5C and RAB22A that have been activated by GTP-binding. Interacts with ERBB2. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; Vesicle protein
Chromosomal Location of Human Ortholog: 12q22
Cellular Component: extrinsic to plasma membrane; recycling endosome; membrane; early endosome membrane; cytoplasm; early endosome; cytoplasmic vesicle; cytosol; serine-pyruvate aminotransferase, type 2B complex
Molecular Function: calmodulin binding; protein binding; protein homodimerization activity; zinc ion binding; GTP-dependent protein binding; phosphatidylinositol binding
Biological Process: vesicle fusion; early endosome to late endosome transport; endocytosis; synaptic vesicle to endosome fusion
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.