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Protein Page:
EEA1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
EEA1 Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. Homodimer. Binds STX6. Binds RAB5A, RAB5B, RAB5C and RAB22A that have been activated by GTP-binding. Interacts with ERBB2. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; Vesicle protein
Cellular Component: extrinsic to plasma membrane; recycling endosome; membrane; early endosome membrane; early endosome; cytoplasm; cytoplasmic vesicle; cytosol; serine-pyruvate aminotransferase, type 2B complex
Molecular Function: calmodulin binding; protein binding; protein homodimerization activity; zinc ion binding; GTP-dependent protein binding; phosphatidylinositol binding
Biological Process: vesicle fusion; early endosome to late endosome transport; endocytosis; synaptic vesicle to endosome fusion
Reference #:  Q15075 (UniProtKB)
Alt. Names/Synonyms: Early endosome antigen 1; early endosome antigen 1, 162kD; early endosome-associated protein; EEA1; Endosome-associated protein p162; MST105; MSTP105; ZFYVE2; Zinc finger FYVE domain-containing protein 2
Gene Symbols: EEA1
Molecular weight: 162,466 Da
Basal Isoelectric point: 5.55  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

EEA1

Protein Structure Not Found.


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Sites Implicated In
activity, induced: T1392‑p
intracellular localization: T1392‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T9-p LRRILQRtPGRVGsQ
0 7 S15-p RtPGRVGsQGsDLDs
0 1 S18-p GRVGsQGsDLDssAt
0 1 S22-p sQGsDLDssAtPINT
0 1 S23-p QGsDLDssAtPINTV
0 1 T25-p sDLDssAtPINTVDV
0 3 S52-p QCMKSLGsADELFkH
0 1 K58-ub GsADELFkHYEAVHD
0 4 S70-p VHDAGNDsGHGGESN
0 1 S98-p EVQDLQAsLkEEKWy
0 2 K100-ub QDLQAsLkEEKWySE
0 1 Y105-p sLkEEKWySEELKKE
0 1 K115 ELKKELEKYQGLQQQ
0 1 D127-ca QQQEAKPdGLVTDSS
0 1 K158-ac NFNIKQMkDLFEQkA
0 1 K164-ac MkDLFEQkAAQLATE
0 1 K178 EIADIKSKYDEERSL
0 1 K211 ATVIQDLKTELLQRP
0 1 K228 EDVAVLKKELVQVQT
0 1 Y286-p GPQEVAVyVQELQKL
0 1 S295-p QELQKLKssVNELtQ
0 1 S296-p ELQKLKssVNELtQK
0 1 T301-p KssVNELtQKNQTLT
0 1 S354-p QQLQSRLsAsETSLH
0 5 S356-p LQSRLsAsETSLHRI
0 1 K583 QVTQLTEKLKNQSES
0 1 S618-p AAQDRVLsLEtSVNE
0 2 T621-p DRVLsLEtSVNELNs
0 1 S628-p tSVNELNsQLNESkE
0 1 K634-ac NsQLNESkEKVSQLD
0 1 K645-ac SQLDIQIkAKTELLL
0 1 S720 EYKEKYLSLEQKTEE
0 1 T761-p QQQRQLNtDLELRAT
0 1 K848-m2 LQKVKMEkEALMtEL
0 1 T853-p MEkEALMtELsTVKD
0 1 S856-p EALMtELsTVKDKLs
0 2 S863-p sTVKDKLsKVSDSLK
0 1 K882 EFEKENQKGkAAILD
0 1 K884-ub EKENQKGkAAILDLE
0 1 K895 LDLEKTCKELKHQLQ
0 1 K895-ub LDLEKTCkELKHQLQ
0 1 T908-p LQVQMENtLKEQKEL
0 1 K952 NTLKQNEKEEQQLQG
0 1 K973 QSSEQKKKQIEALQG
0 1 K995 QKTELENKLQQQLTQ
0 1 S1015-p AAEKEKIsVLQNNyE
0 1 Y1021-p IsVLQNNyEKsQEtF
0 1 S1024-p LQNNyEKsQEtFKQL
0 1 T1027-p NyEKsQEtFKQLQSD
0 1 T1045 RESELLATRQDLKSV
0 1 K1133-ac LAEIEEIkCRQEkEI
0 1 K1133 LAEIEEIKCRQEkEI
0 1 K1138-ac EIkCRQEkEITkLNE
0 1 K1142-ac RQEkEITkLNEELKS
0 1 T1159-p LESIKEItNLKDAKQ
0 1 K1165 ItNLKDAKQLLIQQK
0 1 T1252-p ALNENLGtVKKEWQS
0 1 K1254 NENLGtVKKEWQSSQ
0 1 S1265-p QSSQRRVsELEKQTD
0 1 K1312 EIEKLQTKVLELQRK
1 0 T1392-p CSAKNALtPSSKKPV
  mouse

 
T9 FRRILQRTPGRVGsQ
S15-p RTPGRVGsQGSDLDs
S18 GRVGsQGSDLDsSAT
S22-p sQGSDLDsSATPINT
S23 QGSDLDsSATPINTV
T25 SDLDsSATPINTVDV
S52-p QCMKSLGsADELFKH
K58 GsADELFKHYQAVHD
S70-p VHDAGNDsGHGGEAG
S98 EVQDLQASLkEEKWY
K100-ub QDLQASLkEEKWYSE
Y105 SLkEEKWYSEELKKE
K115-ub ELKKELEkYQGLQQQ
D127 QQQEAKSDGLVTDSS
K158 NFNIKQMKDLFEQKA
K164 MKDLFEQKAAQLATE
K178 EIADIKSKYDEEKSL
K211-ac TTVIQDLkTELLQRP
K228-ub EDVAVLKkELVQVQT
Y286 GPQEVAVYVQEIQKL
G295 QEIQKLKGSINELTQ
S296 EIQKLKGSINELTQK
T301 KGSINELTQKNQNLT
T354 QQLQARLTASESSLQ
S356 LQARLTASESSLQRA
K583-ac QLTQLTEkLKNQSES
S618 AAQDRVLSLETSVSE
T621 DRVLSLETSVSELSS
S628 TSVSELSSQLNESKE
K634 SSQLNESKEKVSQLD
K645 SQLDIQIKAKTELLL
S720-p DHKEKHLsLEQKVED
T761 QQQRQLSTDLELRNA
K848 LTAVKAQKDALLAEL
A853 AQKDALLAELSTTKE
S856 DALLAELSTTKEKLS
S863 STTKEKLSKVSDSLK
K882-ac EFEKENQkGKAAVLD
K884 EKENQkGKAAVLDLE
K895-ac LDLEKACkELKHQLQ
K895 LDLEKACKELKHQLQ
A908 LQVQAESALKEQEDL
K952-ac NTLKQKEkDEQQLQG
K973-ac QSAEQKKkQIEALQG
K995-ub QKTVLENkLQQQSSQ
S1015 AAEKGKLSALQSNYE
Y1021 LSALQSNYEKCQADL
C1024 LQSNYEKCQADLKQL
D1027 NYEKCQADLKQLQSD
T1045-p KESELLAtRQDLKSV
K1133 LAEMEEIKCRQEKEI
K1133 LAEMEEIKCRQEKEI
K1138 EIKCRQEKEITKLNE
K1142 RQEKEITKLNEELKS
T1159 QESIKEITNLKDAkQ
K1165-sc ITNLKDAkQLLIQQK
T1252 TLNENLGTVkKEWQS
K1254-ub NENLGTVkKEWQSSQ
S1265 QSSQRRVSELEKQTD
K1312-ub EIEKLQTkALELQRK
T1392 CSTKNALTPSSKKPV
  rat

 
T9 FRRILQRTPGRVGSQ
S15 RTPGRVGSQGSDLDS
S18 GRVGSQGSDLDSSAT
S22 SQGSDLDSSATPINT
S23 QGSDLDSSATPINTV
T25 SDLDSSATPINTVDV
S52-p QCMKSLGsADELFKH
K58 GsADELFKHYQAVHD
S70 VHDAGNDSGHGGEAS
S98 EVQDLQASLKEEKWY
K100 QDLQASLKEEKWYSE
Y105 SLKEEKWYSEELKKE
K115 ELKKELEKYQGLQQQ
D127 QQQEAKSDGLVTDSS
K158-ac NFNIKQMkDLFEQkA
K164-ac MkDLFEQkAAQLATE
K178-m2 EIADIKSkYDEEKGL
K211 TTVIQDLKTELLQRP
K228 EDVAVLKKELVQVQT
Y286 GPQEVAVYVQEIQKL
G295 QEIQKLKGSVNELTQ
S296 EIQKLKGSVNELTQK
T301 KGSVNELTQKSQTLM
T354 QQLQARLTASEGSLQ
S356 LQARLTASEGSLQRI
K583 QLTQLMEKLKNQSES
S618 AAQDRVLSLETSVSE
T621 DRVLSLETSVSELSS
S628 TSVSELSSQLNESKE
K634 SSQLNESKEKVSQLD
K645 SQLDIQIKAKTELLL
S720 DYKEKHLSLEQKAED
T761 QQQRQLSTDLELRNA
K848 LMVMTAQKDALLAEL
A853 AQKDALLAELSTTKG
S856 DALLAELSTTKGKLS
S863 STTKGKLSKVSDSLQ
K882 EFEKESQKGKAAVLD
K884 EKESQKGKAAVLDLE
K895 LDLEKACKELKHQLQ
K895 LDLEKACKELKHQLQ
A908 LQQQTESALKEQSEL
K952-ac NTLKQKEkEEQQLQG
K973 QATEQKKKQMEALQG
K995 QKAQLESKLQQQAAQ
S1015 AVEKGKLSALQSTYD
Y1021 LSALQSTYDKCQADL
C1024 LQSTYDKCQADLQQL
D1027 TYDKCQADLQQLQSD
T1045 KESELLATRQDLKCV
K1133 LAEMEEIKCRQEkEI
K1133-ub LAEMEEIkCRQEkEI
K1138-ac EIkCRQEkEIAkLKE
K1142-ac RQEkEIAkLKEELKS
T1159 QESIKEVTNLKDAKQ
K1165 VTNLKDAKQLLIQQK
T1252 TLNENLGTVKKEWQS
K1254 NENLGTVKKEWQSSQ
S1265-p QSSQRRVsELEKQTD
K1312 EIEKLQTKVLELQRK
T1392 CSAKNALTPSSKKPV
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