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Protein Page:
EEA1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
EEA1 Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. Homodimer. Binds STX6. Binds RAB5A, RAB5B, RAB5C and RAB22A that have been activated by GTP-binding. Interacts with ERBB2. Note: This description may include information from UniProtKB.
Protein type: Vesicle; C2H2-type zinc finger protein
Chromosomal Location of Human Ortholog: 12q22
Cellular Component: extrinsic to plasma membrane; recycling endosome; membrane; early endosome membrane; cytoplasm; early endosome; cytoplasmic vesicle; cytosol; serine-pyruvate aminotransferase, type 2B complex
Molecular Function: calmodulin binding; protein binding; protein homodimerization activity; zinc ion binding; GTP-dependent protein binding; phosphatidylinositol binding
Biological Process: vesicle fusion; early endosome to late endosome transport; synaptic vesicle to endosome fusion; endocytosis
Reference #:  Q15075 (UniProtKB)
Alt. Names/Synonyms: Early endosome antigen 1; early endosome antigen 1, 162kD; early endosome-associated protein; EEA1; Endosome-associated protein p162; MST105; MSTP105; ZFYVE2; Zinc finger FYVE domain-containing protein 2
Gene Symbols: EEA1
Molecular weight: 162,466 Da
Basal Isoelectric point: 5.55  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

EEA1

Protein Structure Not Found.


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Sites Implicated In
activity, induced: T1392‑p
intracellular localization: T1392‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T9-p LRRILQRtPGRVGsQ
0 7 S15-p RtPGRVGsQGsDLDs
0 1 S18-p GRVGsQGsDLDssAt
0 1 S22-p sQGsDLDssAtPINT
0 1 S23-p QGsDLDssAtPINTV
0 1 T25-p sDLDssAtPINTVDV
0 4 S52-p QCMKSLGsADELFkH
0 1 K58-ub GsADELFkHYEAVHD
0 5 S70-p VHDAGNDsGHGGESN
0 1 S98-p EVQDLQAsLkEEKWy
0 2 K100-ub QDLQAsLkEEKWySE
0 1 Y105-p sLkEEKWySEELKKE
0 1 K115 ELKKELEKYQGLQQQ
0 1 D127-ca QQQEAKPdGLVTDSS
0 2 K158-ac NFNIKQMkDLFEQkA
0 2 K164-ac MkDLFEQkAAQLATE
0 1 K178 EIADIKSKYDEERSL
0 1 K211 ATVIQDLKTELLQRP
0 1 K228 EDVAVLKKELVQVQT
0 1 Y286-p GPQEVAVyVQELQKL
0 1 S295-p QELQKLKssVNELtQ
0 1 S296-p ELQKLKssVNELtQK
0 1 T301-p KssVNELtQKNQTLT
0 1 N310 KNQTLTENLLKKEQD
0 1 K324 DYTKLEEKHNEESVS
0 1 S354-p QQLQSRLsAsETSLH
0 5 S356-p LQSRLsAsETSLHRI
0 1 K378 GEATQKLKEELSEVE
0 1 K392 ETKYQHLKAEFKQLQ
0 1 K422 EINQLHSKLLETERQ
0 1 K451 SSEKLMDKEQQVADL
0 1 K461 QVADLQLKLSRLEEQ
0 1 K485 ELQHQLDKTKQQHQE
0 1 K524 QIGDKDQKIQNLEAL
0 1 K534 NLEALLQKSKENISL
0 1 K536 EALLQKSKENISLLE
0 1 K583 QVTQLTEKLKNQSES
0 1 S618-p AAQDRVLsLEtSVNE
0 2 T621-p DRVLsLEtSVNELNs
0 1 S628-p tSVNELNsQLNESkE
0 1 K634-ac NsQLNESkEKVSQLD
0 1 K645-ac SQLDIQIkAKTELLL
0 2 S720 EYKEKYLSLEQKTEE
0 1 K724 KYLSLEQKTEELEGQ
0 1 K743 EADSLEVKASKEQAL
0 1 T761-p QQQRQLNtDLELRAT
0 1 R785 KEIVSSTRLDLQKKS
0 1 K791 TRLDLQKKSEALESI
0 1 K813 EEEKKILKQDFETLS
0 1 K848-m2 LQKVKMEkEALMtEL
0 1 T853-p MEkEALMtELsTVKD
0 1 S856-p EALMtELsTVKDKLs
0 2 S863-p sTVKDKLsKVSDSLK
0 1 K882 EFEKENQKGkAAILD
0 1 K884-ub EKENQKGkAAILDLE
0 1 K895 LDLEKTCKELKHQLQ
0 1 K895-ub LDLEKTCkELKHQLQ
0 1 K898 EKTCkELKHQLQVQM
0 1 T908-p LQVQMENtLKEQKEL
0 2 K952 NTLKQNEKEEQQLQG
0 1 K973 QSSEQKKKQIEALQG
0 1 K983 EALQGELKIAVLQKT
0 1 K995 QKTELENKLQQQLTQ
0 1 K995 QKTELENKLQQQLTQ
0 1 S1015-p AAEKEKIsVLQNNyE
0 1 Y1021-p IsVLQNNyEKsQEtF
0 1 S1024-p LQNNyEKsQEtFKQL
0 1 T1027-p NyEKsQEtFKQLQSD
0 1 T1045 RESELLATRQDLKSV
0 1 K1093 TLEQDSAKKEQQLQE
0 1 K1133-ac LAEIEEIkCRQEkEI
0 1 K1133 LAEIEEIKCRQEkEI
0 2 K1138-ac EIkCRQEkEITkLNE
0 2 K1142-ac RQEkEITkLNEELKS
0 1 K1148 TkLNEELKSHKLESI
0 1 K1151 NEELKSHKLESIKEI
0 1 T1159-p LESIKEItNLKDAKQ
0 1 K1162 IKEItNLKDAKQLLI
0 1 K1165 ItNLKDAKQLLIQQK
0 1 K1165 ItNLKDAKQLLIQQK
0 1 K1172 KQLLIQQKLELQGKA
0 1 K1178 QKLELQGKADSLKAA
0 1 K1183 QGKADSLKAAVEQEK
0 1 K1190 KAAVEQEKRNQQILK
0 1 T1252-p ALNENLGtVKKEWQS
0 1 K1254 NENLGtVKKEWQSSQ
0 2 S1265-p QSSQRRVsELEKQTD
0 1 K1301 ALLERCLKGEGEIEK
0 1 K1308 KGEGEIEKLQTKVLE
0 1 K1312 EIEKLQTKVLELQRK
1 0 T1392-p CSAKNALtPSSKKPV
  mouse

 
T9 FRRILQRTPGRVGsQ
S15-p RTPGRVGsQGSDLDs
S18 GRVGsQGSDLDsSAT
S22-p sQGSDLDsSATPINT
S23 QGSDLDsSATPINTV
T25 SDLDsSATPINTVDV
S52-p QCMKSLGsADELFKH
K58 GsADELFKHYQAVHD
S70-p VHDAGNDsGHGGEAG
S98 EVQDLQASLkEEKWY
K100-ub QDLQASLkEEKWYSE
Y105 SLkEEKWYSEELKKE
K115-ub ELKKELEkYQGLQQQ
D127 QQQEAKSDGLVTDSS
K158 NFNIKQMKDLFEQKA
K164 MKDLFEQKAAQLATE
K178 EIADIKSKYDEEKSL
K211-ac TTVIQDLkTELLQRP
K228-ub EDVAVLKkELVQVQT
Y286 GPQEVAVYVQEIQKL
G295 QEIQKLKGSINELTQ
S296 EIQKLKGSINELTQK
T301 KGSINELTQKNQNLT
K310 KNQNLTEKLQKKDLD
K324 DYTHLEEKHNEESAS
T354 QQLQARLTASESSLQ
S356 LQARLTASESSLQRA
R378 AEAAQKLREELREVE
K392 ESTRQHLKVEVKQLQ
K422 EVSQLHCKLLETERQ
K451 SSEKLMEKEQQVADL
K461 QVADLQLKLSRLEEQ
K485 ELQHQLEKSKQQHQE
K524 QIGDKDQKIQNLEAL
K534 NLEALLQKGKESVSL
K536 EALLQKGKESVSLLE
K583-ac QLTQLTEkLKNQSES
S618 AAQDRVLSLETSVSE
T621 DRVLSLETSVSELSS
S628 TSVSELSSQLNESKE
K634 SSQLNESKEKVSQLD
K645 SQLDIQIKAKTELLL
S720-p DHKEKHLsLEQKVED
K724 KHLsLEQKVEDLEGH
K743 EADALEVKASKEQAL
T761 QQQRQLSTDLELRNA
K785 EEVVSCTKLDLQNKS
K791 TKLDLQNKSEILENI
K813 EEENVVLKQEFEKLS
K848 LTAVKAQKDALLAEL
A853 AQKDALLAELSTTKE
S856 DALLAELSTTKEKLS
S863 STTKEKLSKVSDSLK
K882-ac EFEKENQkGKAAVLD
K884 EKENQkGKAAVLDLE
K895-ac LDLEKACkELKHQLQ
K895 LDLEKACKELKHQLQ
K898 EKACkELKHQLQVQA
A908 LQVQAESALKEQEDL
K952-ac NTLKQKEkDEQQLQG
K973-ac QSAEQKKkQIEALQG
K983 EALQGEVKNAVSQKT
K995 QKTVLENKLQQQSSQ
K995-ub QKTVLENkLQQQSSQ
S1015 AAEKGKLSALQSNYE
Y1021 LSALQSNYEKCQADL
C1024 LQSNYEKCQADLKQL
D1027 NYEKCQADLKQLQSD
T1045-p KESELLAtRQDLKSV
K1093 SLEQDSAKKEALLKE
K1133 LAEMEEIKCRQEKEI
K1133 LAEMEEIKCRQEKEI
K1138 EIKCRQEKEITKLNE
K1142 RQEKEITKLNEELKS
K1148 TKLNEELKSHKQESI
K1151 NEELKSHKQESIKEI
T1159 QESIKEITNLKDAkQ
K1162 IKEITNLKDAkQLLI
K1165 ITNLKDAKQLLIQQK
K1165-sc ITNLKDAkQLLIQQK
K1172 kQLLIQQKLELQGRV
R1178 QKLELQGRVDSLKAA
K1183 QGRVDSLKAALEQEK
K1190 KAALEQEKESQQLMR
T1252 TLNENLGTVkKEWQS
K1254-ub NENLGTVkKEWQSSQ
S1265 QSSQRRVSELEKQTD
K1301 ALLERCLKGEGEIEK
K1308 KGEGEIEKLQTkALE
K1312-ub EIEKLQTkALELQRK
T1392 CSTKNALTPSSKKPV
  rat

 
T9 FRRILQRTPGRVGSQ
S15 RTPGRVGSQGSDLDS
S18 GRVGSQGSDLDSSAT
S22 SQGSDLDSSATPINT
S23 QGSDLDSSATPINTV
T25 SDLDSSATPINTVDV
S52-p QCMKSLGsADELFKH
K58 GsADELFKHYQAVHD
S70 VHDAGNDSGHGGEAS
S98 EVQDLQASLKEEKWY
K100 QDLQASLKEEKWYSE
Y105 SLKEEKWYSEELKKE
K115 ELKKELEKYQGLQQQ
D127 QQQEAKSDGLVTDSS
K158-ac NFNIKQMkDLFEQkA
K164-ac MkDLFEQkAAQLATE
K178-m2 EIADIKSkYDEEKGL
K211 TTVIQDLKTELLQRP
K228 EDVAVLKKELVQVQT
Y286 GPQEVAVYVQEIQKL
G295 QEIQKLKGSVNELTQ
S296 EIQKLKGSVNELTQK
T301 KGSVNELTQKSQTLM
K310-ac KSQTLMEkLQKKDLD
K324-ac DYTHLEEkHNEEALS
T354 QQLQARLTASEGSLQ
S356 LQARLTASEGSLQRI
K378-ac GEAAQKLkEELREVE
K392-ac ETKHQHLkVEFKQLQ
K422-ac EVSQLHSkLLETERQ
K451-ac SSEKLMDkEQQVADL
K461-ac QVADLQLkLSRLEEQ
K485-ac ELQHQLEkSKQQHQE
K524-ac QIGDKDQkIQNLEAL
K534-ac NLEALLQkSkENISL
K536-ac EALLQkSkENISLLE
K583 QLTQLMEKLKNQSES
S618 AAQDRVLSLETSVSE
T621 DRVLSLETSVSELSS
S628 TSVSELSSQLNESKE
K634 SSQLNESKEKVSQLD
K645 SQLDIQIKAKTELLL
S720 DYKEKHLSLEQkAED
K724-ac KHLSLEQkAEDLEGQ
K743-ac EANNLEVkASREQAV
T761 QQQRQLSTDLELRNA
K785-ac KEVVSHTkLDLQNkS
K791-ac TkLDLQNkSEALENI
K813-ac EEEKVVLkQEFEKLS
K848 LMVMTAQKDALLAEL
A853 AQKDALLAELSTTKG
S856 DALLAELSTTKGKLS
S863 STTKGKLSKVSDSLQ
K882 EFEKESQKGKAAVLD
K884 EKESQKGKAAVLDLE
K895 LDLEKACKELkHQLQ
K895 LDLEKACKELkHQLQ
K898-ac EKACKELkHQLQQQT
A908 LQQQTESALKEQSEL
K952-ac NTLKQKEkEEQQLQG
K973 QATEQKKKQMEALQG
K983-ac EALQGELkNVTSQKA
K995-ac QKAQLESkLQQQAAQ
K995 QKAQLESKLQQQAAQ
S1015 AVEKGKLSALQSTYD
Y1021 LSALQSTYDKCQADL
C1024 LQSTYDKCQADLQQL
D1027 TYDKCQADLQQLQSD
T1045 KESELLATRQDLKCV
K1093-ac ALEQDLAkKEEVLKE
K1133 LAEMEEIKCRQEkEI
K1133-ub LAEMEEIkCRQEkEI
K1138-ac EIkCRQEkEIAkLKE
K1142-ac RQEkEIAkLKEELkS
K1148-ac AkLKEELkSHkQESI
K1151-ac KEELkSHkQESIKEV
T1159 QESIKEVTNLkDAkQ
K1162-ac IKEVTNLkDAkQLLI
K1165-ac VTNLkDAkQLLIQQk
K1165 VTNLkDAKQLLIQQk
K1172-ac kQLLIQQkLELQGkV
K1178-ac QkLELQGkVDSLkAA
K1183-ac QGkVDSLkAALEQEk
K1190-ac kAALEQEkERQQLMR
T1252 TLNENLGTVKKEWQS
K1254 NENLGTVKKEWQSSQ
S1265-p QSSQRRVsELEKQTD
K1301-ac ALLERCLkGEGEIEk
K1308-ac kGEGEIEkLQTKVLE
K1312 EIEkLQTKVLELQRK
T1392 CSAKNALTPSSKKPV
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