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FOXK1 (human)

Overview FOXK1 Transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin gene. Has a role in myogenic differentiation and in remodeling processes of adult muscles that occur in response to physiological stimuli. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: DNA binding protein; Transcription factor Cellular Component: transcription factor complex; nucleolus; nucleus Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; sequence-specific DNA binding; double-stranded DNA binding; magnesium ion binding; transcription factor binding; DNA bending activity Biological Process: tissue development; muscle development; embryonic development; regulation of transcription factor activity; positive regulation of transcription, DNA-dependent; negative regulation of cell growth; negative regulation of transcription, DNA-dependent; cell differentiation; pattern specification process Reference #:  P85037 (UniProtKB) Alt. Names/Synonyms: FLJ14977; forkhead box K1; Forkhead box protein K1; FOXK1; FOXK1L; MNF; Myocyte nuclear factor Gene Symbols: FOXK1 Molecular weight: 75,457 Da Basal Isoelectric point: 9.41  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below FOXK1 2A3S - A=287-387 (mouse) 2D2W - A=287-387 (mouse)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	10		S101-p	AAASVRQsPGPALAR
0	1		K186-u	APALQLPkQCTFRFP
0	1		S203-p	AIKIQFTsLyHKEEA
0	1		Y205-p	KIQFTsLyHKEEAPA
0	51		S213-p	HKEEAPAsPLRPLyP
0	5		Y219-p	AsPLRPLyPQIsPLK
0	46		S223-p	RPLyPQIsPLKIHIP
0	3		S236	IPEPDLRSMVsPVPs
0	5		S239-p	PDLRSMVsPVPsPtG
0	7		S243-p	SMVsPVPsPtGtIsV
0	5		T245-p	VsPVPsPtGtIsVPN
0	3		T247-p	PVPsPtGtIsVPNsC
0	2		S249-p	PsPtGtIsVPNsCPA
0	4		S253-p	GtIsVPNsCPAsPRG
0	13		S257-p	VPNsCPAsPRGAGSS
0	1		T273-p	YRFVQNVtSDLQLAA
0	2		S288-p	EFAAKAAsEQQADts
0	1		T294-p	AsEQQADtsGGDsPK
0	3		S295-p	sEQQADtsGGDsPKD
0	5		S299-p	ADtsGGDsPKDESKP
0	1		F308	KDESKPPFSyAQLIV
0	2		Y310-p	ESKPPFSyAQLIVQA
0	1		Y339-p	YAHITKHyPyyRTAD
0	1		Y341-p	HITKHyPyyRTADKG
0	1		Y342-p	ITKHyPyyRTADKGW
0	2		K375-a	RSQEEPGkGSFWRID
0	1		K388	IDPASEAKLVEQAFR
0	2		T407-p	RGVSCFRtPFGPLSS
0	33		S416-p	FGPLSSRsAPAsPtH
0	40		S420-p	SSRsAPAsPtHPGLM
0	8		T422-p	RsAPAsPtHPGLMsP
0	43		S428-p	PtHPGLMsPRsGGLQ
0	27		S431-p	PGLMsPRsGGLQtPE
0	113		T436-p	PRsGGLQtPECLsRE
0	132		S441-p	LQtPECLsREGsPIP
0	156		S445-p	ECLsREGsPIPHDPE
0	4		S455-p	PHDPEFGsKLASVPE
0	1		Y465-p	ASVPEYRySQsAPGs
0	3		S468-p	PEYRySQsAPGsPVs
0	6		S472-p	ySQsAPGsPVsAQPV
0	1		S475-p	sAPGsPVsAQPVIMA
0	1		T643	AGNAYALTSPLQLLA
0	1		S644	GNAYALTSPLQLLAT
0	1		S656	LATQASSSAPVVVTR
0	8		T716-p	EPSGAVTtPAGVIAA

	mouse
S87-p	AAASVRQsPGPALAR
Q172	APALQLPQQCTFRFP
S189	AIKIQFTSLYHKEEA
Y191	KIQFTSLYHKEEAPA
S199-p	HKEEAPAsPLRPLyP
Y205-p	AsPLRPLyPQIsPLK
S209-p	RPLyPQIsPLKIHIP
S222-p	IPEPDLRsLVsPIPs
S225-p	PDLRsLVsPIPsPtG
S229-p	sLVsPIPsPtGtIsV
T231-p	VsPIPsPtGtIsVPN
T233-p	PIPsPtGtIsVPNsC
S235-p	PsPtGtIsVPNsCPA
S239-p	GtIsVPNsCPAsPRG
S243-p	VPNsCPAsPRGAGSS
T259	YRFVQNVTSDLQLAA
S274-p	EFAAKAAsEQQADAs
A280	AsEQQADAsGGDsPK
S281-p	sEQQADAsGGDsPKD
S285-p	ADAsGGDsPKDESKP
Y294-p	KDESKPPySyAQLIV
Y296-p	ESKPPySyAQLIVQA
Y325	YAHITKHYPYYRTAD
Y327	HITKHYPYYRTADKG
Y328	ITKHYPYYRTADKGW
K361	RSQEEPGKGSFWRID
K374-u	IDPASEAkLVEQAFR
T393	RGVSCFRTPFGPLSS
S402-p	FGPLSSRsAPAsPtH
S406-p	SSRsAPAsPtHPGLM
T408-p	RsAPAsPtHPGLMsP
S414-p	PtHPGLMsPRsSGLQ
S417-p	PGLMsPRsSGLQtPE
T422-p	PRsSGLQtPECLsRE
S427-p	LQtPECLsREGsPIP
S431-p	ECLsREGsPIPHDPD
S441	PHDPDLGSKLASVPE
Y451	ASVPEYRYSQSAPGs
S454	PEYRYSQSAPGsPVS
S458-p	YSQSAPGsPVSAQPV
S461	SAPGsPVSAQPVIMA
S629-p	TGNAYALssPLQLLA
S630-p	GNAYALssPLQLLAA
S642-p	LAAQASSsTPVVITR
T702	EPGGTATTQPTAMAA

	rat
S87-p	AAASVRQsPGPALAR
Q172	APALQLPQQCTFRFP
S189	AIKIQFTSLYHKEEA
Y191	KIQFTSLYHKEEAPA
S199	HKEEAPASPLRPLYP
Y205	ASPLRPLYPQISPLK
S209	RPLYPQISPLKIHIP
S222-p	IPEPDLRsLVsPIPs
S225-p	PDLRsLVsPIPsPtG
S229-p	sLVsPIPsPtGTISV
T231-p	VsPIPsPtGTISVPN
T233	PIPsPtGTISVPNSC
S235	PsPtGTISVPNSCPA
S239	GTISVPNSCPAsPRG
S243-p	VPNSCPAsPRGAGSS
T259	YRFVQNVTSDLQLAA
S274	EFAAKAASEQQADTS
T280	ASEQQADTSGGDSPK
S281	SEQQADTSGGDSPKD
S285	ADTSGGDSPKDESKP
Y294	KDESKPPYSYAQLIV
Y296	ESKPPYSYAQLIVQA
Y325	YAHITKHYPYYRTAD
Y327	HITKHYPYYRTADKG
Y328	ITKHYPYYRTADKGW
K361	RSQEEPGKGSFWRID
K374	IDPASEAKLVEQAFR
T393	RGVSCFRTPFGPLSS
S402-p	FGPLSSRsAPAsPTH
S406-p	SSRsAPAsPTHPGLM
T408	RsAPAsPTHPGLMsP
S414-p	PTHPGLMsPRSSGLQ
S417	PGLMsPRSSGLQtPE
T422-p	PRSSGLQtPECLsRE
S427-p	LQtPECLsREGsPIP
S431-p	ECLsREGsPIPHDPD
S441	PHDPDLGSKLASVPE
Y451	ASVPEYRYSQSAPGS
S454	PEYRYSQSAPGSPVS
S458	YSQSAPGSPVSAQPV
S461	SAPGSPVSAQPVIMA
T629	TGNAYALTSPLQLLA
S630	GNAYALTSPLQLLAA
S642	LAAQASSSTPVVITR
T702	EPSGTATTQPTAMAA

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