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Protein Page:
FOXK1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FOXK1 Transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin gene. Has a role in myogenic differentiation and in remodeling processes of adult muscles that occur in response to physiological stimuli. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription factor
Chromosomal Location of Human Ortholog: 7p22.1
Cellular Component: nucleolus; nucleus
Molecular Function: protein binding; sequence-specific DNA binding; transcription factor activity
Biological Process: regulation of transcription from RNA polymerase II promoter; muscle development; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; negative regulation of cell growth; negative regulation of transcription, DNA-dependent; cell differentiation
Reference #:  P85037 (UniProtKB)
Alt. Names/Synonyms: FLJ14977; forkhead box K1; Forkhead box protein K1; FOXK1; FOXK1L; MNF; Myocyte nuclear factor
Gene Symbols: FOXK1
Molecular weight: 75,457 Da
Basal Isoelectric point: 9.41  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FOXK1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 20 S101-p AAASVRQsPGPALAR
0 1 R161-m1 QEPHFYLrCLGKNGV
0 1 R177-m1 VDGAFQRrGAPALQL
0 1 K186-ub APALQLPkQCTFrFP
0 1 R191-m1 LPkQCTFrFPSTAIK
0 1 R191 LPkQCTFRFPSTAIK
0 1 S203-p AIKIQFTsLyHKEEA
0 1 Y205-p KIQFTsLyHKEEAPA
0 62 S213-p HKEEAPAsPLRPLyP
0 6 Y219-p AsPLRPLyPQIsPLK
0 55 S223-p RPLyPQIsPLKIHIP
0 4 S236-p IPEPDLRsMVsPVPs
0 10 S239-p PDLRsMVsPVPsPtG
0 11 S243-p sMVsPVPsPtGtIsV
0 7 T245-p VsPVPsPtGtIsVPN
0 4 T247-p PVPsPtGtIsVPNsC
0 4 S249-p PsPtGtIsVPNsCPA
0 5 S253-p GtIsVPNsCPAsPRG
0 20 S257-p VPNsCPAsPRGAGSS
0 1 T273-p YRFVQNVtSDLQLAA
0 2 S288-p EFAAKAAsEQQADts
0 1 T294-p AsEQQADtsGGDsPK
0 4 S295-p sEQQADtsGGDsPKD
0 9 S299-p ADtsGGDsPKDESKP
0 1 F308 KDESKPPFSyAQLIV
0 2 Y310-p ESKPPFSyAQLIVQA
0 1 Y339-p YAHITKHyPyyRTAD
0 1 Y341-p HITKHyPyyRTADKG
0 1 Y342-p ITKHyPyyRTADKGW
0 2 K375-ac RSQEEPGkGSFWRID
0 1 K388 IDPASEAKLVEQAFR
0 2 S403-p KRRQRGVsCFRtPFG
0 3 T407-p RGVsCFRtPFGPLSS
0 50 S416-p FGPLSSRsAPAsPtH
0 57 S420-p SSRsAPAsPtHPGLM
0 13 T422-p RsAPAsPtHPGLMsP
0 58 S428-p PtHPGLMsPRsGGLQ
0 28 S431-p PGLMsPRsGGLQtPE
0 125 T436-p PRsGGLQtPECLsRE
0 144 S441-p LQtPECLsREGsPIP
0 173 S445-p ECLsREGsPIPHDPE
0 5 S455-p PHDPEFGsKLAsVPE
0 2 S459-p EFGsKLAsVPEYRyS
0 1 Y465-p AsVPEYRySQsAPGs
0 3 S468-p PEYRySQsAPGsPVs
0 9 S472-p ySQsAPGsPVsAQPV
0 1 S475-p sAPGsPVsAQPVIMA
0 1 T643 AGNAYALTsPLQLLA
0 2 S644-p GNAYALTsPLQLLAT
0 1 S656 LATQASSSAPVVVTR
0 1 T683-p VAATATTtPAtATTA
0 1 T686-p TATTtPAtATTASAS
0 1 S695-p TTASASAssTGEPEV
0 1 S696-p TASASAssTGEPEVK
0 9 T716-p EPSGAVTtPAGVIAA
0 1 T731-p AGPQGPGtGE_____
  mouse

 
S87-p AAASVRQsPGPALAR
R147-m1 QEPHFYLrCLGKNGV
R163 VDGAFQRRGAPALQL
Q172 APALQLPQQCTFrFP
R177-m1 LPQQCTFrFPSTAIK
R177-m2 LPQQCTFrFPSTAIK
S189 AIKIQFTSLYHKEEA
Y191 KIQFTSLYHKEEAPA
S199-p HKEEAPAsPLRPLyP
Y205-p AsPLRPLyPQIsPLK
S209-p RPLyPQIsPLKIHIP
S222-p IPEPDLRsLVsPIPs
S225-p PDLRsLVsPIPsPtG
S229-p sLVsPIPsPtGtIsV
T231-p VsPIPsPtGtIsVPN
T233-p PIPsPtGtIsVPNsC
S235-p PsPtGtIsVPNsCPA
S239-p GtIsVPNsCPAsPRG
S243-p VPNsCPAsPRGAGSS
T259 YRFVQNVTSDLQLAA
S274-p EFAAKAAsEQQADAs
A280 AsEQQADAsGGDsPK
S281-p sEQQADAsGGDsPKD
S285-p ADAsGGDsPKDESKP
Y294-p KDESKPPySyAQLIV
Y296-p ESKPPySyAQLIVQA
Y325 YAHITKHYPYYRTAD
Y327 HITKHYPYYRTADKG
Y328 ITKHYPYYRTADKGW
K361 RSQEEPGKGSFWRID
K374-ub IDPASEAkLVEQAFR
S389 KRRQRGVSCFRTPFG
T393 RGVSCFRTPFGPLSS
S402-p FGPLSSRsAPAsPtH
S406-p SSRsAPAsPtHPGLM
T408-p RsAPAsPtHPGLMsP
S414-p PtHPGLMsPRsSGLQ
S417-p PGLMsPRsSGLQtPE
T422-p PRsSGLQtPECLsRE
S427-p LQtPECLsREGsPIP
S431-p ECLsREGsPIPHDPD
S441-p PHDPDLGsKLASVPE
S445 DLGsKLASVPEYRYS
Y451 ASVPEYRYSQSAPGs
S454 PEYRYSQSAPGsPVS
S458-p YSQSAPGsPVSAQPV
S461 SAPGsPVSAQPVIMA
S629-p TGNAYALssPLQLLA
S630-p GNAYALssPLQLLAA
S642-p LAAQASSsTPVVITR
A669 VSVAANAAPTPAAST
P672 AANAAPTPAASTTTS
S681 ASTTTSASSSGEPEV
S682 STTTSASSSGEPEVK
T702 EPGGTATTQPTAMAA
T717 TGPQGPGTGE_____
  rat

 
S87-p AAASVRQsPGPALAR
R147 QEPHFYLRCLGKNGV
R163 VDGAFQRRGAPALQL
Q172 APALQLPQQCTFRFP
R177 LPQQCTFRFPSTAIK
R177 LPQQCTFRFPSTAIK
S189 AIKIQFTSLYHKEEA
Y191 KIQFTSLYHKEEAPA
S199-p HKEEAPAsPLRPLYP
Y205 AsPLRPLYPQIsPLK
S209-p RPLYPQIsPLKIHIP
S222-p IPEPDLRsLVsPIPs
S225-p PDLRsLVsPIPsPtG
S229-p sLVsPIPsPtGTISV
T231-p VsPIPsPtGTISVPN
T233 PIPsPtGTISVPNSC
S235 PsPtGTISVPNSCPA
S239 GTISVPNSCPAsPRG
S243-p VPNSCPAsPRGAGSS
T259 YRFVQNVTSDLQLAA
S274 EFAAKAASEQQADTS
T280 ASEQQADTSGGDSPK
S281 SEQQADTSGGDSPKD
S285 ADTSGGDSPKDESKP
Y294 KDESKPPYSYAQLIV
Y296 ESKPPYSYAQLIVQA
Y325 YAHITKHYPYYRTAD
Y327 HITKHYPYYRTADKG
Y328 ITKHYPYYRTADKGW
K361 RSQEEPGKGSFWRID
K374 IDPASEAKLVEQAFR
S389 KRRQRGVSCFRTPFG
T393 RGVSCFRTPFGPLSS
S402-p FGPLSSRsAPAsPTH
S406-p SSRsAPAsPTHPGLM
T408 RsAPAsPTHPGLMsP
S414-p PTHPGLMsPRSSGLQ
S417 PGLMsPRSSGLQtPE
T422-p PRSSGLQtPECLsRE
S427-p LQtPECLsREGsPIP
S431-p ECLsREGsPIPHDPD
S441 PHDPDLGSKLASVPE
S445 DLGSKLASVPEYRYS
Y451 ASVPEYRYSQSAPGS
S454 PEYRYSQSAPGSPVS
S458 YSQSAPGSPVSAQPV
S461 SAPGSPVSAQPVIMA
T629 TGNAYALTSPLQLLA
S630 GNAYALTSPLQLLAA
S642 LAAQASSSTPVVITR
A669 VSVAASAAPTPAIST
P672 AASAAPTPAISTTTS
S681 ISTTTSASSSGEPEL
S682 STTTSASSSGEPELK
T702 EPSGTATTQPTAMAA
T717 TGPQGPGTGE_____
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