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Protein Page:
BIRC4BP (human)

Overview
BIRC4BP Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti- caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha- induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondra, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells. 7 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Apoptosis
Cellular Component: mitochondrion; cytosol; nucleus
Molecular Function: zinc ion binding
Biological Process: apoptosis; cytokine and chemokine mediated signaling pathway; negative regulation of protein complex assembly
Reference #:  Q6GPH4 (UniProtKB)
Alt. Names/Synonyms: BIRC4 binding protein; BIRC4-binding protein; BIRC4BP; HSXIAPAF1; XAF1; XIAP associated factor 1; XIAP-associated factor 1; XIAPAF1
Gene Symbols: XAF1
Molecular weight: 34,626 Da
Basal Isoelectric point: 8.57  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

BIRC4BP

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 Y104-p KLELHESyCGSRTEL
0 2 Y152-p SAPEREIyCHyCNQM
0 2 Y155-p EREIyCHyCNQMIPE
0 1 S224-p INRFPLHsESSSKKA
0 9 Y261-p PRGDKAAyDILRRCs
0 5 S268-p yDILRRCsQCGILLP
  mouse

 
H85 NLDVHESHCGSRTEH
R134 SSPGRKTRCDLCKQM
L137 GRKTRCDLCKQMIPE
- gap
Y235 PTGDETAYDTLQNCC
C242 YDTLQNCCQCRILLP
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