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Protein Page:
4E-T (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
4E-T Nucleoplasmic shuttling protein. Mediates the nuclear import of EIF4E by a piggy-back mechanism. Interacts with EIF4E. Interacts with importin beta only in the presence of importin alpha, suggesting a direct interaction with importin alpha. Widely expressed. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Nuclear import; Translation; Karyopherin
Cellular Component: PML body; intracellular membrane-bound organelle; cytoplasm; nuclear speck; nucleus; cytosol
Molecular Function: protein binding; protein transporter activity
Reference #:  Q9NRA8 (UniProtKB)
Alt. Names/Synonyms: 2610509L04Rik; 4E-T; 4ET; Clast4; eIF4E transporter; eIF4E-transporter; EIF4ENIF1; Eukaryotic translation initiation factor 4E nuclear import factor 1; Eukaryotic translation initiation factor 4E transporter; FLJ21601; FLJ26551
Gene Symbols: EIF4ENIF1
Molecular weight: 108,201 Da
Basal Isoelectric point: 8.45  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

4E-T
Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: S301‑p, S374‑p, S513‑p, S587‑p, S693‑p, S752‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
0 2 S5-p ___MDRRsMGETESG
0 1 K32 KCPHRYTKEELLDIK
0 1 K39 KEELLDIKELPHSKQ
0 2 Y71-p EKWHASLyPAsGRss
0 15 S74-p HASLyPAsGRssPVE
0 7 S77-p LyPAsGRssPVEsLK
0 10 S78-p yPAsGRssPVEsLKK
0 1 S82-p GRssPVEsLKKELDT
1 1 S115-p DDLDVVLsPQRRsFG
0 1 S120-p VLsPQRRsFGGGCHV
0 1 S136-p AAVSSRRsGsPLEKD
0 1 S138-p VSSRRsGsPLEKDSD
0 6 K202-a RREFGDSkRVFGERR
0 134 S213-p GERRRNDsytEEEPE
0 17 Y214-p ERRRNDsytEEEPEW
0 21 T215-p RRRNDsytEEEPEWF
0 1 S223-p EEEPEWFsAGPtSQS
0 1 T227-p EWFsAGPtSQSETIE
0 1 T253-p DHKGRKRtRRRtAsV
0 98 T257-p RKRtRRRtAsVKEGI
0 111 S259-p RtRRRtAsVKEGIVE
1 13 S301-p DAVLPEQsPGDFDFN
0 1 S321-p DKVPCLAsMIEDVLG
0 7 S342-p SRFSRWFsNPsRSGS
0 11 S345-p SRWFsNPsRSGSRSS
0 2 S353-p RSGSRSSsLGstPHE
0 2 S356-p SRSSsLGstPHEELE
0 2 T357-p RSSsLGstPHEELER
1 26 S374-p GLEQAILsPGQNsGN
0 8 S379-p ILsPGQNsGNyFAPI
0 23 Y382-p PGQNsGNyFAPIPLE
0 1 S417-p KPLLSSLsANKEKLK
0 1 S454-p VDQQVKNstPFMAEH
0 2 T455-p DQQVKNstPFMAEHL
0 1 T465-p MAEHLEEtLsAVTNN
0 1 S467-p EHLEEtLsAVTNNRQ
0 1 K486-a GDMTAFNkLVSTMKA
1 4 S513-p NLESHLMsPAEIPGQ
0 2 S541-p PVQRPASsNLLSGLM
0 128 S564-p LLGQRAPsPPLsQVF
0 3 S568-p RAPsPPLsQVFQTRA
0 42 S577-p VFQTRAAsADyLRPR
0 97 Y580-p TRAAsADyLRPRIPs
1 116 S587-p yLRPRIPsPIGFtPG
0 3 T592-p IPsPIGFtPGPQQLL
0 12 S611-p QGMRKPMsPItAQMs
0 2 T614-p RKPMsPItAQMsQLE
0 1 S618-p sPItAQMsQLELQQA
0 16 S670-p RQQRVTKsPAPVHRG
0 1 S680-p PVHRGNSssPAPAAS
0 4 S681-p VHRGNSssPAPAASI
1 2 S693-p ASITSMLsPSFTPTS
1 1 S752-p PSADRDSsPTTNSKL
0 2 S768-p ALQRSSCstPLsQAN
0 28 T769-p LQRSSCstPLsQANR
0 1 S772-p SSCstPLsQANRYTK
0 1 S797-p RKTPTLAsPVPtTPF
0 1 T801-p TLAsPVPtTPFLRPV
0 1 S914-p LHPPGSGsHAAAVsV
0 1 S920-p GsHAAAVsVQTtPQN
0 1 T924-p AAVsVQTtPQNVPSR
0 2 S946-p SQLEHRPsQRSSsPV
0 14 S951-p RPsQRSSsPVGLAKW
0 18 Y983-p ISVDELEyRQ_____
  mouse

 
S4 ____MEKSVAETENG
K31 KSPHRYTKEELLDIK
K38 KEELLDIKERPYSKQ
Y70-p EKWHASLyPAsGRss
S73-p HASLyPAsGRssPVE
S76-p LyPAsGRssPVEsLK
S77-p yPAsGRssPVEsLKK
S81-p GRssPVEsLKKESES
S114-p DDLDVVLsPQRRSFG
S119 VLsPQRRSFGGGCHV
S135 AAVSSRRSGsPLEKD
S137-p VSSRRSGsPLEKDSD
K201 RREFGDSKRVFGERR
S212-p GERRRNDsytEEEPE
Y213-p ERRRNDsytEEEPEW
T214-p RRRNDsytEEEPEWF
S222 EEEPEWFSAGPTSQS
T226 EWFSAGPTSQSETIE
T252 DHKGRKRTRRRtAsV
T256-p RKRTRRRtAsVKEGI
S258-p RTRRRtAsVKEGIVE
S300-p DVILPEQsPGEFDFN
S320 DKVPCLASMIEDVLG
S341-p SRFSRWFsNPsRSGS
S344-p SRWFsNPsRSGSRSS
S352-p RSGSRSSsLGstPHE
S355-p SRSSsLGstPHEELE
T356-p RSSsLGstPHEELER
S373 GLEQAVLSPGQNSGN
S378 VLSPGQNSGNYFAPI
Y381 PGQNSGNYFAPIPSE
S416 KPLLSSLSANKEKLK
S453 VDQQMKNSTPFMAEH
T454 DQQMKNSTPFMAEHL
T464 MAEHLEETLSAASSN
S466 EHLEETLSAASSNRQ
K485 GDMTAFNKLVNTMKA
A512 NVESHLLAPAEIPGQ
S540 PVQRPASSNLLSGLM
S563-p LLSQRAPsPPMSQVF
S567 RAPsPPMSQVFRTQA
S576 VFRTQAASADyLHPR
Y579-p TQAASADyLHPRIPs
S586-p yLHPRIPsPIGFPSG
P591 IPsPIGFPSGPQQLL
S610 QGMRKPMSPVSAQMS
S613 RKPMSPVSAQMSQLE
S617 SPVSAQMSQLELQQA
S669 RQQRMSKSPAPMHGG
S679 PMHGGNSSsPAPAAS
S680-p MHGGNSSsPAPAASI
S692 ASITSMLSPSFTPTS
S751 PNTDQDSSTTNPKLS
S766 TLQRSSCSTPLSQTS
T767 LQRSSCSTPLSQTSR
S770 SSCSTPLSQTSRYTK
S795 RKTPTLASPVPGTPF
G799 TLASPVPGTPFLRPT
S913 LHPPGSSSQAAAISV
S919 SSQAAAISVQTPQNV
T922 AAAISVQTPQNVPSR
S944 SQLEHRTSQRSSsPV
S949-p RTSQRSSsPVGLAKW
Y981 ISVDELEYRQ_____
  rat

 
S5 ___MEKRSVDETENG
K32-u KSPHRYTkEELLDIk
K39-u kEELLDIkERPYSKQ
Y71 EKWHASLYPASGRSS
S74 HASLYPASGRSSPVE
S77 LYPASGRSSPVESLK
S78 YPASGRSSPVESLKK
S82 GRSSPVESLKKEPES
S115 DDLDVVLSPQRRSFG
S120 VLSPQRRSFGGGCHV
S136 AAVSSRRSGSPLEKD
S138 VSSRRSGSPLEKDSD
K202 RREFGDSKRVFGERR
S213 GERRRNDSYTEEEPE
Y214 ERRRNDSYTEEEPEW
T215 RRRNDSYTEEEPEWF
S223 EEEPEWFSAGPTSQS
T227 EWFSAGPTSQSETIE
T253 DHKGRKRTRRRTASV
T257 RKRTRRRTASVREGI
S259 RTRRRTASVREGIVE
S301 DVILPEQSPGEFDFN
S321 DKVPCLASMIEDVLG
S342 SRFSRWFSNPSRSGS
S345 SRWFSNPSRSGSRSS
S353 RSGSRSSSLGSTPHE
S356 SRSSSLGSTPHEELE
T357 RSSSLGSTPHEELER
S374 GLEQAVLSPGQNSGN
S379 VLSPGQNSGNYFAPI
Y382 PGQNSGNYFAPIPSE
S417 KPLLSSLSANKEKLK
S454 VDQQIKNSTPFMAEH
T455 DQQIKNSTPFMAEHL
T465 MAEHLEETLSAVTSN
S467 EHLEETLSAVTSNRQ
K486 GDMTAFNKLVNTMKA
A513 NLESHLLAPAEIPGQ
S541 PVQRPASSNLLSGLM
S564-p LLSQRAPsPPMSQVF
S568 RAPsPPMSQVFRTQA
S577 VFRTQAASADYLHPR
Y580 TQAASADYLHPRIPS
S587 YLHPRIPSPIGFPSG
P592 IPSPIGFPSGPQQLL
S611 QGMRKPMSPVTAQMS
T614 RKPMSPVTAQMSQLE
S618 SPVTAQMSQLELQQA
S670 RQQRMTKSPAPMHRG
S680 PMHRGNSSSPAPAAS
S681 MHRGNSSSPAPAASI
S693 ASITSMLSPSFTPTS
S752 SNSDQDSSPTANPKL
S768 TLQRSSCSTPLSQTN
T769 LQRSSCSTPLSQTNR
S772 SSCSTPLSQTNRYTK
S797 RKTPTLASPVPGTPF
G801 TLASPVPGTPFLRPT
S915 LHPPGSSSQAAAINV
N921 SSQAAAINVQTPPNV
T924 AAAINVQTPPNVPSR
S946 SQLEHRTSQRSSsPV
S951-p RTSQRSSsPVGLAKW
Y983 ISVDELEYRQ_____
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