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Protein Page:
4E-T (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
4E-T Nucleoplasmic shuttling protein. Mediates the nuclear import of EIF4E by a piggy-back mechanism. Interacts with EIF4E. Interacts with importin beta only in the presence of importin alpha, suggesting a direct interaction with importin alpha. Widely expressed. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Nuclear import; Translation; Karyopherin
Cellular Component: PML body; intracellular membrane-bound organelle; membrane; cytoplasm; nuclear speck; nucleus; cytosol
Molecular Function: protein binding; protein transporter activity
Biological Process: protein transport
Reference #:  Q9NRA8 (UniProtKB)
Alt. Names/Synonyms: 2610509L04Rik; 4E-T; 4ET; Clast4; eIF4E transporter; eIF4E-transporter; EIF4ENIF1; Eukaryotic translation initiation factor 4E nuclear import factor 1; Eukaryotic translation initiation factor 4E transporter; FLJ21601; FLJ26551
Gene Symbols: EIF4ENIF1
Molecular weight: 108,201 Da
Basal Isoelectric point: 8.45  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

4E-T

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: S301‑p, S374‑p, S513‑p, S587‑p, S693‑p, S752‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 5 S5-p ___MDRRsMGETESG
0 1 K32 KCPHRYTKEELLDIK
0 1 K39 KEELLDIKELPHSKQ
0 3 Y71-p EKWHASLyPAsGRss
0 19 S74-p HASLyPAsGRssPVE
0 9 S77-p LyPAsGRssPVEsLK
0 12 S78-p yPAsGRssPVEsLKK
0 2 S82-p GRssPVEsLKKELDT
1 4 S115-p DDLDVVLsPQRRsFG
0 6 S120-p VLsPQRRsFGGGCHV
0 3 S136-p AAVSSRRsGsPLEKD
0 5 S138-p VSSRRsGsPLEKDSD
0 1 S173-p FEKDHRLsDKDLRDL
0 6 K202-ac RREFGDSkRVFGERR
0 133 S213-p GERRRNDsytEEEPE
0 18 Y214-p ERRRNDsytEEEPEW
0 21 T215-p RRRNDsytEEEPEWF
0 1 S223-p EEEPEWFsAGPtSQS
0 1 T227-p EWFsAGPtSQSETIE
0 1 T253-p DHKGRKRtRRRtAsV
0 98 T257-p RKRtRRRtAsVKEGI
0 111 S259-p RtRRRtAsVKEGIVE
1 14 S301-p DAVLPEQsPGDFDFN
0 1 S321-p DKVPCLAsMIEDVLG
0 10 S342-p SRFSRWFsNPsRSGS
0 16 S345-p SRWFsNPsRSGSRss
0 1 S351-p PsRSGSRsssLGstP
0 1 S352-p sRSGSRsssLGstPH
0 4 S353-p RSGSRsssLGstPHE
0 2 S356-p SRsssLGstPHEELE
0 3 T357-p RsssLGstPHEELER
1 29 S374-p GLEQAILsPGQNsGN
0 9 S379-p ILsPGQNsGNyFAPI
0 22 Y382-p PGQNsGNyFAPIPLE
0 3 S417-p KPLLSSLsANKEKLK
0 1 S454-p VDQQVKNstPFMAEH
0 3 T455-p DQQVKNstPFMAEHL
0 2 T465-p MAEHLEEtLsAVTNN
0 1 S467-p EHLEEtLsAVTNNRQ
0 1 K486-ac GDMTAFNkLVSTMKA
0 1 S509-p KVSRNLEsHLMsPAE
1 7 S513-p NLEsHLMsPAEIPGQ
0 2 S541-p PVQRPASsNLLSGLM
0 138 S564-p LLGQRAPsPPLsQVF
0 4 S568-p RAPsPPLsQVFQTRA
0 45 S577-p VFQTRAAsADyLRPR
0 100 Y580-p TRAAsADyLRPRIPs
1 118 S587-p yLRPRIPsPIGFtPG
0 3 T592-p IPsPIGFtPGPQQLL
0 13 S611-p QGMRKPMsPItAQMs
0 2 T614-p RKPMsPItAQMsQLE
0 1 S618-p sPItAQMsQLELQQA
0 16 S670-p RQQRVTKsPAPVHRG
0 1 S680-p PVHRGNSssPAPAAS
0 4 S681-p VHRGNSssPAPAASI
1 4 S693-p ASITSMLsPSFTPTS
0 2 S746-p LSSSSVPsADRDSsP
1 1 S752-p PsADRDSsPTtNSKL
0 1 T755-p DRDSsPTtNSKLSAL
0 2 S768-p ALQRSSCstPLsQAN
0 29 T769-p LQRSSCstPLsQANR
0 1 S772-p SSCstPLsQANRYTK
0 1 R776 tPLsQANRYTKEQDY
0 1 S912-p SVLHPPGsGsHAAAV
0 1 S914-p LHPPGsGsHAAAVsV
0 1 S920-p GsHAAAVsVQTtPQN
0 2 T924-p AAVsVQTtPQNVPSR
0 2 S946-p SQLEHRPsQRSSsPV
0 22 S951-p RPsQRSSsPVGLAKW
0 19 Y983-p ISVDELEyRQ_____
  4E-T iso2  
S5 ___MDRRSMGETESG
K32 KCPHRYTKEELLDIK
K39 KEELLDIKELPHSKQ
Y71 EKWHASLYPASGRSS
S74 HASLYPASGRSSPVE
S77 LYPASGRSSPVESLK
S78 YPASGRSSPVESLKK
S82 GRSSPVESLKKELDT
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S138 DAVLPEQSPGDFDFN
S158 DKVPCLASMIEDVLG
S179 SRFSRWFSNPSRSGS
S182 SRWFSNPSRSGSRSS
S188 PSRSGSRSSSLGSTP
S189 SRSGSRSSSLGSTPH
S190 RSGSRSSSLGSTPHE
S193 SRSSSLGSTPHEELE
T194 RSSSLGSTPHEELER
S211 GLEQAILSPGQNSGN
S216 ILSPGQNSGNYFAPI
Y219 PGQNSGNYFAPIPLE
S254 KPLLSSLSANKEKLK
S291 VDQQVKNSTPFMAEH
T292 DQQVKNSTPFMAEHL
T302 MAEHLEETLSAVTNN
S304 EHLEETLSAVTNNRQ
K323 GDMTAFNKLVSTMKR
S334 TMKRNLESHLMSPAE
S338 NLESHLMSPAEIPGQ
S366 PVQRPASSNLLSGLM
S389 LLGQRAPSPPLSQVF
S393 RAPSPPLSQVFQTRA
S402 VFQTRAASADYLRPR
Y405 TRAASADYLRPRIPS
S412 YLRPRIPSPIGFTPG
T417 IPSPIGFTPGPQQLL
S436-p QGMRKPMsPITAQQM
T439 RKPMsPITAQQMSQL
S444 PITAQQMSQLELQQA
S496 RQQRVTKSPAPVHRG
S506 PVHRGNSSSPAPAAS
S507 VHRGNSSSPAPAASI
S519 ASITSMLSPSFTPTS
S572 LSSSSVPSADRDSSP
S578 PSADRDSSPTTNSKL
T581 DRDSSPTTNSKLSAL
S594 ALQRSSCSTPLSQAN
T595 LQRSSCSTPLSQANR
S598 SSCSTPLSQANRYTK
R602 TPLSQANRYTKEQDY
S738 SVLHPPGSGSHAAAV
S740 LHPPGSGSHAAAVSV
S746 GSHAAAVSVQTTPQN
T750 AAVSVQTTPQNVPSR
S772 SQLEHRPSQRSSSPV
S777 RPSQRSSSPVGLAKW
Y809 ISVDELEYRQ_____
  mouse

 
S4 ____MEKSVAETENG
K31 KSPHRYTKEELLDIK
K38 KEELLDIKERPYSKQ
Y70-p EKWHASLyPAsGRss
S73-p HASLyPAsGRssPVE
S76-p LyPAsGRssPVEsLK
S77-p yPAsGRssPVEsLKK
S81-p GRssPVEsLKKESES
S114-p DDLDVVLsPQRRSFG
S119 VLsPQRRSFGGGCHV
S135 AAVSSRRSGsPLEKD
S137-p VSSRRSGsPLEKDSD
S172 FEKDHRLSDKDLRDL
K201 RREFGDSKRVFGERR
S212-p GERRRNDsytEEEPE
Y213-p ERRRNDsytEEEPEW
T214-p RRRNDsytEEEPEWF
S222 EEEPEWFSAGPTSQS
T226 EWFSAGPTSQSETIE
T252 DHKGRKRTRRRtAsV
T256-p RKRTRRRtAsVKEGI
S258-p RTRRRtAsVKEGIVE
S300-p DVILPEQsPGEFDFN
S320 DKVPCLASMIEDVLG
S341-p SRFSRWFsNPsRSGS
S344-p SRWFsNPsRSGSRSS
S350 PsRSGSRSSsLGstP
S351 sRSGSRSSsLGstPH
S352-p RSGSRSSsLGstPHE
S355-p SRSSsLGstPHEELE
T356-p RSSsLGstPHEELER
S373-p GLEQAVLsPGQNsGN
S378-p VLsPGQNsGNYFAPI
Y381 PGQNsGNYFAPIPSE
S416 KPLLSSLSANKEKLK
S453 VDQQMKNSTPFMAEH
T454 DQQMKNSTPFMAEHL
T464 MAEHLEETLSAASSN
S466 EHLEETLSAASSNRQ
K485 GDMTAFNKLVNTMKA
S508 KVSRNVESHLLAPAE
A512 NVESHLLAPAEIPGQ
S540 PVQRPASSNLLSGLM
S563-p LLSQRAPsPPMSQVF
S567 RAPsPPMSQVFRTQA
S576 VFRTQAASADyLHPR
Y579-p TQAASADyLHPRIPs
S586-p yLHPRIPsPIGFPSG
P591 IPsPIGFPSGPQQLL
S610 QGMRKPMSPVSAQMS
S613 RKPMSPVSAQMSQLE
S617 SPVSAQMSQLELQQA
S669 RQQRMSKSPAPMHGG
S679 PMHGGNSSsPAPAAS
S680-p MHGGNSSsPAPAASI
S692 ASITSMLSPSFTPTS
N745 LSSNPIPNTDQDSST
S751 PNTDQDSSTTNPKLS
T753 TDQDSSTTNPKLSTL
S766 TLQRSSCSTPLSQTS
T767 LQRSSCSTPLSQTSr
S770 SSCSTPLSQTSrYTK
R774-m2 TPLSQTSrYTKEQDY
S911 SVLHPPGSSSQAAAI
S913 LHPPGSSSQAAAISV
S919 SSQAAAISVQTPQNV
T922 AAAISVQTPQNVPSR
S944 SQLEHRTSQRSSsPV
S949-p RTSQRSSsPVGLAKW
Y981 ISVDELEYRQ_____
  rat

 
S5 ___MEKRSVDETENG
K32-ub KSPHRYTkEELLDIk
K39-ub kEELLDIkERPYSKQ
Y71 EKWHASLYPASGRSs
S74 HASLYPASGRSsPVE
S77 LYPASGRSsPVESLK
S78-p YPASGRSsPVESLKK
S82 GRSsPVESLKKEPES
S115 DDLDVVLSPQRRSFG
S120 VLSPQRRSFGGGCHV
S136 AAVSSRRSGSPLEKD
S138 VSSRRSGSPLEKDSD
S173 FEKDHRLSDKDLRDL
K202 RREFGDSKRVFGERR
S213 GERRRNDSYTEEEPE
Y214 ERRRNDSYTEEEPEW
T215 RRRNDSYTEEEPEWF
S223 EEEPEWFSAGPTSQS
T227 EWFSAGPTSQSETIE
T253 DHKGRKRTRRRTASV
T257 RKRTRRRTASVREGI
S259 RTRRRTASVREGIVE
S301-p DVILPEQsPGEFDFN
S321 DKVPCLASMIEDVLG
S342-p SRFSRWFsNPsRSGS
S345-p SRWFsNPsRSGSRSS
S351 PsRSGSRSSsLGstP
S352 sRSGSRSSsLGstPH
S353-p RSGSRSSsLGstPHE
S356-p SRSSsLGstPHEELE
T357-p RSSsLGstPHEELER
S374 GLEQAVLSPGQNSGN
S379 VLSPGQNSGNYFAPI
Y382 PGQNSGNYFAPIPSE
S417 KPLLSSLSANKEKLK
S454 VDQQIKNSTPFMAEH
T455 DQQIKNSTPFMAEHL
T465 MAEHLEETLSAVTSN
S467 EHLEETLSAVTSNRQ
K486 GDMTAFNKLVNTMKA
S509 KVSRNLESHLLAPAE
A513 NLESHLLAPAEIPGQ
S541 PVQRPASSNLLSGLM
S564-p LLSQRAPsPPMSQVF
S568 RAPsPPMSQVFRTQA
S577 VFRTQAASADYLHPR
Y580 TQAASADYLHPRIPs
S587-p YLHPRIPsPIGFPSG
P592 IPsPIGFPSGPQQLL
S611 QGMRKPMSPVTAQMS
T614 RKPMSPVTAQMSQLE
S618 SPVTAQMSQLELQQA
S670 RQQRMTKSPAPMHRG
S680 PMHRGNSSSPAPAAS
S681 MHRGNSSSPAPAASI
S693 ASITSMLSPSFTPTS
N746 LSSNSISNSDQDSSP
S752 SNSDQDSSPTANPKL
A755 DQDSSPTANPKLSTL
S768 TLQRSSCSTPLSQTN
T769 LQRSSCSTPLSQTNR
S772 SSCSTPLSQTNRYTK
R776 TPLSQTNRYTKEQDY
S913 SVLHPPGSSSQAAAI
S915 LHPPGSSSQAAAINV
N921 SSQAAAINVQTPPNV
T924 AAAINVQTPPNVPSR
S946 SQLEHRTSQRSSsPV
S951-p RTSQRSSsPVGLAKW
Y983 ISVDELEYRQ_____
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