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G-alpha3(i)
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(k) is the stimulatory G protein of receptor- regulated K(+) channels. The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division. Defects in GNAI3 are the cause of auriculocondylar syndrome 1 (ARCND1). ARCND1 is an autosomal dominant craniofacial malformation syndrome characterized by variable mandibular anomalies, including mild to severe micrognathia, temporomandibular joint ankylosis, cleft palate, and a characteristic ear malformation that consists of separation of the lobule from the external ear, giving the appearance of a question mark (question-mark ear). Other frequently described features include prominent cheeks, cupped and posteriorly rotated ears, preauricular tags, and microstomia. Belongs to the G-alpha family. G(i/o/t/z) subfamily. Note: This description may include information from UniProtKB.
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| Protein type: G protein, heterotrimeric; G protein; G protein, heterotrimeric alpha G((i/o/t/z)) |
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Cellular Component: Golgi apparatus; centrosome; extrinsic to internal side of plasma membrane; cytoplasm; plasma membrane; heterotrimeric G-protein complex; midbody; lipid raft
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Molecular Function: GTPase activity; signal transducer activity; GTP binding; metal ion binding; G-protein beta/gamma-subunit binding; metabotropic serotonin receptor binding
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Biological Process: vesicle fusion; platelet activation; synaptic transmission; cell division; GTP catabolic process; transport; negative regulation of adenylate cyclase activity; G-protein signaling, adenylate cyclase inhibiting pathway; cell cycle; blood coagulation; negative regulation of synaptic transmission
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Reference #:
P08754 (UniProtKB)
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| Alt. Names/Synonyms: 87U6; FLJ26559; G(i) alpha-3; GNAI3; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3; Guanine nucleotide-binding protein G(k) subunit alpha |
| Gene Symbols: GNAI3 |
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Molecular weight: 40,532 Da
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Basal Isoelectric point: 5.5
Predict pI for various phosphorylation states
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CST Pathways:
Hedgehog Signaling
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Parkinson's Disease
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Phospholipase Signaling
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PI3K/Akt Signaling
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Regulation of Actin Dynamics
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Regulation of Microtubule Dynamics
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