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Protein Page:
DOCK8 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
DOCK8 Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Defects in DOCK8 are the cause of hyperimmunoglobulin E recurrent infection syndrome autosomal recessive (AR-HIES). It is a rare disorder of immunity characterized by immunodeficiency, recurrent infections, eczema, increased serum IgE, eosinophilia and lack of connective tissue and skeletal involvement. Defects in DOCK8 are the cause of mental retardation autosomal dominant type 2 (MRD2). Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. A chromosomal aberration disrupting DOCK8 has been found in a patient with mental retardation and ectodermal dysplasia. DOCK8 is disrupted in patients with mental retardation. A balanced translocation, t(X;9) (q13.1;p24). Belongs to the DOCK family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Guanine nucleotide exchange factor, misc.
Cellular Component: cytosol
Molecular Function: guanyl-nucleotide exchange factor activity
Biological Process: small GTPase mediated signal transduction; blood coagulation
Reference #:  Q8NF50 (UniProtKB)
Alt. Names/Synonyms: 1200017A24Rik; dedicator of cytokinesis 8; Dedicator of cytokinesis protein 8; DOCK8; FLJ00026; FLJ00152; FLJ00346; MRD2; ZIR8
Gene Symbols: DOCK8
Molecular weight: 238,529 Da
Basal Isoelectric point: 6.43  Predict pI for various phosphorylation states
Select Structure to View Below

DOCK8
Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
0 4 T3 _____MATLPSAERR
0 1 Y19-p FALKINRySSAEIRK
0 1 S20 ALKINRySSAEIRKQ
0 1 T29-p AEIRKQFtLPPNLGQ
0 1 S139-p VNRKNQGsPEICGFk
0 1 K146-u sPEICGFkKTGSRKD
0 1 A196 SGKGPVTACDFDLRS
0 1 Y365-p IGDCAEPytVIKESD
0 1 T366-p GDCAEPytVIKESDG
0 1 S432 DSVVGRSSVGERRTL
0 1 S442-p ERRTLAQsRRLsERA
0 5 S446-p LAQsRRLsERALsLE
0 7 S451-p RLsERALsLEENGVG
0 1 Y491 LFKFLADYKRSSSLQ
0 1 L507 RVKSIPGLLRLEIST
0 1 Y615-p PEFLQEVyTAVTYHN
0 1 K713-u PLQNPPIkWAEGHKG
0 1 T882-p LDPRSYHtYGRTSAA
0 1 K894-u SAAAVSSkLLQARVM
0 1 S902 LLQARVMSSsNPDLA
0 3 S904-p QARVMSSsNPDLAGT
0 1 S933-p KIADRNCsRMSyYCS
0 1 S936 DRNCsRMSyYCSGSS
0 3 Y937-p RNCsRMSyYCSGSSD
0 1 S956-p PAAPRPAskKHFHEE
0 1 K957-a AAPRPAskKHFHEEL
0 1 S993-p FFELLVKsMAQHVHN
0 1 S1080-p RHYCSQLsAKLSNLP
0 1 S1145 FQDQKIASMFDLTSE
0 1 C1230 LDALPQLCDFTVADT
0 1 S1243 DTRRYRTSGSDEEQE
0 1 S1350-p KQSSDKVstQVLQKS
0 1 T1351-p QSSDKVstQVLQKSR
0 1 K1356 VstQVLQKSRDVKAR
0 1 S1524-p SSMDVTRsQACATLY
0 1 T1882-p YEMKDRVtyFEKNFN
0 1 Y1883-p EMKDRVtyFEKNFNL
0 13 Y1895-p FNLRRFMyTTPFTLE
0 1 K1929-u MHAFPYIkTRISVIQ
0 1 T1956-p IEDMKKKtLQLAVAI
0 1 Y2050-p QQELKKNyNKLKENL
0 2 Y2069-p ERKIPELyKPIFRVE
0 20 S2077-p KPIFRVEsQKRDsFH
0 9 S2082-p VEsQKRDsFHRSsFR
0 7 S2087-p RDsFHRSsFRKCETQ
0 1 S2096-p RKCETQLsQGS____
  mouse

 
T3-p _____MAtLPSAERR
Y19 FALKINRYsSSEIRK
S20-p ALKINRYsSSEIRKQ
T29 SEIRKQFTLPPNLGQ
S139 VNRKNQGSSEFCSFK
K146 SSEFCSFKKTGSRRD
S197-p SGKGPLTsCDFDLRS
Y366 IADCAEPYMIIKESD
M367 ADCAEPYMIIKESDG
S433-p EPGVGRNsVGEKRSL
S443-p EKRSLSQsRRPsERT
S447-p LSQsRRPsERTLsLE
S452-p RPsERTLsLEENGVG
Y492-p LFKFLADyKRSSSLQ
S508-p RVKSIPGsLRLEISP
Y616 PEFLQEVYTAITYHN
K714 PLQNPPIKWAEGHKG
T883 VPDPRYHTYGRTSAA
K895 SAAAVSSKLMQARVM
S903-p LMQARVMsSsNPDLT
S905-p QARVMsSsNPDLTGS
S934 KIADRNCSRMsYYCS
S937-p DRNCSRMsYYCSGNS
Y938 RNCSRMsYYCSGNSD
S957 TAAPRPVSKKHFHEE
K958 AAPRPVSKKHFHEEL
S994 FFELLVKSMAQYVHN
S1081 KHYCSQLSAKLNILP
S1146-p FQDQKIAsMFDLTPE
Y1231-p LDALPQLyDFTDARS
S1244-p RSGRSRAsGSYEEQD
S1351 KQSSDKVSNQVLQkS
N1352 QSSDKVSNQVLQkSR
K1357-u VSNQVLQkSRDVKAK
S1525 SSMDVTRSQACATLY
T1883 YEMKDRVTYFEKNFN
Y1884 EMKDRVTYFEKNFNL
Y1896 FNLRRFMYTTPFTLE
K1930 MHAFPYIKTRIRVSQ
T1957 IEDMKKKTLQLAVAT
Y2051 QQELKKNYNKLRDSL
Y2070 ERKIPELYKPIFRVD
S2078-p KPIFRVDsQKRDsFH
S2083-p VDsQKRDsFHRSsFR
S2088-p RDsFHRSsFRKCETQ
S2097 RKCETQLSQGS____
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