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Protein Page:
DOCK8 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
DOCK8 Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Defects in DOCK8 are the cause of hyperimmunoglobulin E recurrent infection syndrome autosomal recessive (AR-HIES). It is a rare disorder of immunity characterized by immunodeficiency, recurrent infections, eczema, increased serum IgE, eosinophilia and lack of connective tissue and skeletal involvement. Defects in DOCK8 are the cause of mental retardation autosomal dominant type 2 (MRD2). Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. A chromosomal aberration disrupting DOCK8 has been found in a patient with mental retardation and ectodermal dysplasia. DOCK8 is disrupted in patients with mental retardation. A balanced translocation, t(X;9) (q13.1;p24). Belongs to the DOCK family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: GEFs, misc.; GEFs; Motility/polarity/chemotaxis
Cellular Component: cytosol
Molecular Function: protein binding; guanyl-nucleotide exchange factor activity
Biological Process: small GTPase mediated signal transduction; blood coagulation
Reference #:  Q8NF50 (UniProtKB)
Alt. Names/Synonyms: 1200017A24Rik; dedicator of cytokinesis 8; Dedicator of cytokinesis protein 8; DOCK8; FLJ00026; FLJ00152; FLJ00346; MRD2; ZIR8
Gene Symbols: DOCK8
Molecular weight: 238,529 Da
Basal Isoelectric point: 6.43  Predict pI for various phosphorylation states
Select Structure to View Below

DOCK8

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 4 T3 _____MATLPSAERR
0 2 Y19-p FALKINRysSAEIRK
0 2 S20-p ALKINRysSAEIRKQ
0 2 S139-p VNRKNQGsPEICGFK
0 2 A196 SGKGPVTACDFDLRS
0 2 S432 DSVVGRSSVGERRTL
0 5 S446-p LAQSRRLsERALsLE
0 11 S451-p RLsERALsLEENGVG
0 1 S494 FLADYKRSSSLQRRV
0 1 S496 ADYKRSSSLQRRVKS
0 1 L507 RVKSIPGLLRLEIST
0 1 K713-u PLQNPPIkWAEGHKG
0 1 K894-u SAAAVSSkLLQARVM
0 1 S902 LLQARVMSSsNPDLA
0 4 S904-p QARVMSSsNPDLAGT
0 2 S936-p DRNCSRMsyYCSGSS
0 3 Y937-p RNCSRMsyYCSGSSD
0 2 S1145-p FQDQKIAsMFDLTSE
0 1 S1243 DTRRYRTSGSDEEQE
0 1 K1356 VSTQVLQKSRDVKAR
0 13 Y1895-p FNLRRFMyTTPFTLE
0 1 K1929-u MHAFPYIkTRISVIQ
0 1 Y2050-p QQELKKNyNKLKENL
0 2 Y2069-p ERKIPELyKPIFRVE
0 20 S2077-p KPIFRVEsQKRDsFH
0 9 S2082-p VEsQKRDsFHRSsFR
0 8 S2087-p RDsFHRSsFRKCETQ
0 1 S2096-p RKCETQLsQGS____
  mouse

 
T3-p _____MAtLPSAERR
Y19 FALKINRYsSSEIRK
S20-p ALKINRYsSSEIRKQ
S139 VNRKNQGSSEFCSFK
S197-p SGKGPLTsCDFDLRS
S433-p EPGVGRNsVGEKRSL
S447-p LSQSRRPsERTLsLE
S452-p RPsERTLsLEENGVG
S495-p FLADYKRsSsLQRRV
S497-p ADYKRsSsLQRRVKS
S508-p RVKSIPGsLRLEISP
K714 PLQNPPIKWAEGHKG
K895 SAAAVSSKLMQARVM
S903-p LMQARVMsSsNPDLT
S905-p QARVMsSsNPDLTGS
S937-p DRNCSRMsYYCSGNS
Y938 RNCSRMsYYCSGNSD
S1146-p FQDQKIAsMFDLTPE
S1244-p RSGRSRAsGSYEEQD
K1357-u VSNQVLQkSRDVKAK
Y1896 FNLRRFMYTTPFTLE
K1930 MHAFPYIKTRIRVSQ
Y2051 QQELKKNYNKLRDSL
Y2070 ERKIPELYKPIFRVD
S2078-p KPIFRVDsQKRDsFH
S2083-p VDsQKRDsFHRSsFR
S2088-p RDsFHRSsFRKCETQ
S2097-p RKCETQLsQGS____
  rat

 
T3 _____MATLPSAERR
Y19 FALKINRYSSSEIRK
S20 ALKINRYSSSEIRKQ
S139 VNRKNQGSPEFCSFR
S197 SGKGPITSCDFDLRS
S432 EPGAGRNSVGERRSL
S446 LSQSRRPSERTLsFE
S451-p RPSERTLsFEENGVG
S494 FLADYKRSSSLQRRV
S496 ADYKRSSSLQRRVKS
S507 RVKSIPGSLRLEIAP
K713 PLQNPPIKWAEGHKG
K894 SAAAVSSKLMQARVM
S902 LMQARVMSSSNPDLA
S904 QARVMSSSNPDLAGT
S936 DRNCSRMSYYCSGNS
Y937 RNCSRMSYYCSGNSD
S1145 FQDQKIASMFDLTPE
S1243 RSGRSRASGSYEEQD
K1356 VSNQVLQKSRDVKAK
Y1895 FNLRRFMYTTPFTLE
K1929 MHAFPYIKTRIRVSQ
Y2050 QQELKKNYNRLKDSL
Y2069 ERKIPELYKPIFRVD
S2077 KPIFRVDSQKRDSFH
S2082 VDSQKRDSFHRSSFR
S2087 RDSFHRSSFRKCETQ
S2096 RKCETQLSQGS____
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