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Protein Page:
DVL2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
DVL2 a protein in the WNT/planar cell polarity (PCP) signaling pathway. Dvl2-deficient mice indicate that Dvl2 is essential for normal cardiac morphogenesis, somite segmentation and neural tube closure. Transduces the Wnt signal by interacting with the cytoplasmic Axin complex. Dvl and Axin each contain a DIX domains, which mediate their dynamic polymerization. The Dvl-Axin interaction is essential for Wnt signaling. Interacts through its PDZ domain with the C-terminal regions of VANGL1 and VANGL2. Interacts with Dixin and Rac. There is functional redundancy between Dvl1 and Dvl2 in some phenotypes. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component: clathrin-coated vesicle; apical part of cell; cytoplasm; plasma membrane; clathrin-coated endocytic vesicle; cell cortex; cytoplasmic vesicle; cytosol; nucleus
Molecular Function: identical protein binding; protein domain specific binding; protein binding; signal transducer activity; protein self-association; frizzled binding
Biological Process: transcription from RNA polymerase II promoter; heart morphogenesis; positive regulation of JNK activity; Wnt receptor signaling pathway; Wnt receptor signaling pathway, planar cell polarity pathway; convergent extension involved in neural plate elongation; positive regulation of transcription, DNA-dependent; heart development; Wnt receptor signaling pathway through beta-catenin; cell migration in hindbrain; segment specification; convergent extension; neural tube closure; positive regulation of transcription factor activity; positive regulation of protein amino acid phosphorylation
Reference #:  O14641 (UniProtKB)
Alt. Names/Synonyms: dishevelled 2 (homologous to Drosophila dsh); dishevelled, dsh homolog 2 (Drosophila); Dishevelled-2; DSH homolog 2; DVL2; Segment polarity protein dishevelled homolog DVL-2
Gene Symbols: DVL2
Molecular weight: 78,948 Da
Basal Isoelectric point: 5.67  Predict pI for various phosphorylation states
CST Pathways:  Hippo Signaling  |  Microtubule Dynamics  |  mTOR Signaling  |  Translation: eIF4E and p70S6K  |  Wnt/├č-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DVL2

Protein Structure Not Found.


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Sites Implicated In
cell cycle regulation: T206‑p
cytoskeletal reorganization: S143‑p, T224‑p, S594‑p, T595‑p, S597‑p
transcription, induced: Y18‑p, Y27‑p, Y275‑p
transcription, inhibited: S594‑p, T595‑p, S597‑p
intracellular localization: S143‑p, T224‑p
molecular association, regulation: S143‑p, T224‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T14-p GGGGVGEtKVIyHLD
1 0 Y18-p VGEtKVIyHLDEEET
1 2 Y27-p LDEEETPyLVKIPVP
0 1 T39-p PVPAERItLGDFKSV
0 1 S135-p IGDSRPPsFHPNVSs
0 1 S142-p sFHPNVSssHENLEP
1 3 S143-p FHPNVSssHENLEPE
0 13 T151-p HENLEPEtEtEsVVs
0 8 T153-p NLEPEtEtEsVVsLR
0 9 S155-p EPEtEtEsVVsLRRE
0 28 S158-p tEtEsVVsLRRERPR
0 23 S169-p ERPRRRDssEHGAGG
0 19 S170-p RPRRRDssEHGAGGH
0 1 S195-p HLAGYESssTLMTSE
0 2 S196-p LAGYESssTLMTSEL
1 0 T206-p MTSELEStSLGDsDE
0 6 S211-p EStSLGDsDEEDTMS
0 2 S222-p DTMSRFSsStEQSSA
1 1 T224-p MSRFSsStEQSSASR
0 2 T250-p RPPRLERtSsFssVt
0 1 S252-p PRLERtSsFssVtDS
0 1 S254-p LERtSsFssVtDSTM
0 3 S255-p ERtSsFssVtDSTMS
0 1 T257-p tSsFssVtDSTMSLN
1 2 Y275-p VTLNMEKyNFLGISI
1 0 Y295-p ERGDGGIyIGSIMkG
0 3 K301-ub IyIGSIMkGGAVAAD
0 3 K343-ub VLRDIVHkPGPIVLT
0 93 Y362-p WDPSPQAyFtLPRNE
0 17 T364-p PSPQAyFtLPRNEPI
1 0 Y463-p SDVVDWLyHHVEGFP
0 6 Y478-p ERREARKyASGLLkA
0 2 K484-ub KyASGLLkAGLIRHT
1 0 S591-p QHSEGSRssGstRsD
1 0 S592-p HSEGSRssGstRsDG
1 0 S594-p EGSRssGstRsDGGA
1 0 T595-p GSRssGstRsDGGAG
1 0 S597-p RssGstRsDGGAGRT
0 2 S614-p PEERAPEsKSGsGsE
0 1 K615 EERAPEsKSGsGsES
0 2 S616 ERAPEsKSGsGsESE
0 2 S618-p APEsKSGsGsESEPS
0 1 S620-p EsKSGsGsESEPSsR
0 1 S626-p GsESEPSsRGGsLRR
0 2 S630-p EPSsRGGsLRRGGEA
0 1 T715-p GSVPPELtASRQsFH
0 1 S720-p ELtASRQsFHMAMGN
0 1 S729-p HMAMGNPsEFFVDVM
  mouse

 
T14 GGGGVGETKVIYHLD
Y18 VGETKVIYHLDEEET
Y27 LDEEETPYLVKIPVP
T39 PVPAERITLGDFKSV
S135 IGDSRPPSFHPNVSS
S142 SFHPNVSSSHENLEP
S143 FHPNVSSSHENLEPE
T151 HENLEPETETESVVS
T153 NLEPETETESVVSLR
S155 EPETETESVVSLRRD
S158 TETESVVSLRRDRPR
S169-p DRPRRRDssEHGAGG
S170-p RPRRRDssEHGAGGH
S195 HLAGYESSSTLMTSE
S196 LAGYESSSTLMTSEL
T206 MTSELESTSLGDsDE
S211-p ESTSLGDsDEDDTMS
S222-p DTMSRFSsSTEQSSA
T224 MSRFSsSTEQSSASR
T250 RPPRMERTSSFSSVT
S252 PRMERTSSFSSVTDS
S254 MERTSSFSSVTDSTM
S255 ERTSSFSSVTDSTMS
T257 TSSFSSVTDSTMSLN
Y275 VTLNMEKYNFLGISI
Y295 ERGDGGIYIGSIMKG
K301 IYIGSIMKGGAVAAD
K343 VLRDIVHKPGPIVLT
Y362 WDPSPQAYFTLPRNE
T364 PSPQAYFTLPRNEPI
Y463 SDVVDWLYHHVEGFP
Y478 ERREARKYASGLLKA
K484 KYASGLLKAGLIRHT
S591-p QHSEGSRssGstRsD
S592-p HSEGSRssGstRsDG
S594-p EGSRssGstRsDGGA
T595-p GSRssGstRsDGGAG
S597-p RssGstRsDGGAGRT
S614-p PEERAPEsksGsGsE
K615-ub EERAPEsksGsGsES
S616-p ERAPEsksGsGsESE
S618-p APEsksGsGsESELS
S620-p EsksGsGsESELSSR
S626 GsESELSSRGGSLRR
S630 ELSSRGGSLRRGGEP
T715 GSVPPELTASRQSFH
S720 ELTASRQSFHMAMGN
S729 HMAMGNPSEFFVDVM
  rat

 
T14 GGGGVGETKVIYHLD
Y18 VGETKVIYHLDEEET
Y27 LDEEETPYLVKIPVP
T39 PVPAERITLGDFKSV
S135 IGDSRPPSFHPNVSS
S142 SFHPNVSSSHENLEP
S143 FHPNVSSSHENLEPE
T151 HENLEPETETESVVS
T153 NLEPETETESVVSLR
S155 EPETETESVVSLRRD
S158 TETESVVSLRRDRPR
S169 DRPRRRDSSEHGAGG
S170 RPRRRDSSEHGAGGH
S195 HLAGYESSSTLMTSE
S196 LAGYESSSTLMTSEL
T206 MTSELESTSLGDSDE
S211 ESTSLGDSDEDDSMS
S222 DSMSRFSSSTEQSSA
T224 MSRFSSSTEQSSASR
T250 RPPRMERTSSFSSVT
S252 PRMERTSSFSSVTDS
S254 MERTSSFSSVTDSTM
S255 ERTSSFSSVTDSTMS
T257 TSSFSSVTDSTMSLN
Y275 VTLNMEKYNFLGISI
Y295 ERGDGGIYIGSIMKG
K301 IYIGSIMKGGAVAAD
K343 VLRDIVHKPGPIVLT
Y362 WDPSPQAYFTLPRNE
T364 PSPQAYFTLPRNEPI
Y463 SDVVDWLYHHVEGFP
Y478 ERREARKYASGLLKA
K484 KYASGLLKAGLIRHT
S591 QHSEGSRSSGSTRSD
S592 HSEGSRSSGSTRSDG
S594 EGSRSSGSTRSDGGA
T595 GSRSSGSTRSDGGAG
S597 RSSGSTRSDGGAGRT
S614 PEERAPESKSGSGSE
K615 EERAPESKSGSGSES
S616 ERAPESKSGSGSESE
S618 APESKSGSGSESELS
S620 ESKSGSGSESELSSR
S626 GSESELSSRGGSLRR
S630 ELSSRGGSLRRGGEP
T715 GSVPPELTASRQSFH
S720 ELTASRQSFHMAMGN
S729 HMAMGNPSEFFVDVM
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