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Protein Page:
KCNE1 (human)

Overview
KCNE1 Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Associates with KCNQ1/KVLQT1 and KCNH2/HERG. Expressed in heart, lung, kidney, testis, ovaries, small intestine, peripheral blood leukocytes. Not detected in pancreas, spleen, prostate and colon. Restrictively localized in the apical membrane portion of epithelial cells. Belongs to the potassium channel KCNE family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Channel, potassium
Chromosomal Location of Human Ortholog: 21q22.12
Cellular Component: voltage-gated potassium channel complex; cell surface; endoplasmic reticulum; lysosome; apical plasma membrane; plasma membrane; Z disc
Molecular Function: voltage-gated potassium channel activity; protein binding; potassium channel regulator activity; telethonin binding; protein heterodimerization activity; delayed rectifier potassium channel activity
Biological Process: protein amino acid O-linked glycosylation; sensory perception of sound; epithelial cell maturation; heart contraction; male gonad development; protein amino acid N-linked glycosylation
Reference #:  P15382 (UniProtKB)
Alt. Names/Synonyms: cardiac delayed rectifier potassium channel protein; Delayed rectifier potassium channel subunit IsK; FLJ18426; FLJ38123; FLJ94103; IKs producing slow voltage-gated potassium channel subunit beta Mink; ISK; JLNS; JLNS2; KCNE1; LQT2/5; LQT5; MGC33114; Minimal potassium channel; MinK; Potassium voltage-gated channel subfamily E member 1; potassium voltage-gated channel, Isk-related family, member 1; potassium voltage-gated channel, Isk-related subfamily, member 1; voltage gated potassiun channel accessory subunit
Gene Symbols: KCNE1
Molecular weight: 14,675 Da
Basal Isoelectric point: 6.83  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

KCNE1

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T7-p _MILSNTtAVTPFLT
0 1 S28-p VQQGGNMsGLARRSP
2 0 S102-p VQARVLEsYRSCYVV
  mouse

 
T7 _MSLPNSTTVLPFLA
S28 AEQGGNVSGLARKSQ
S102 FQARVLESFRACYVI
  rat

 
T7 _MALSNSTTVLPFLA
S28 DEPGGNMSADLARRS
S103-p FQARVLEsFRACYVI
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