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IRS1 (mouse)

Overview IRS1 an adaptor protein that is one of the major substrates of the insulin receptor kinase. Contains multiple tyrosine phosphorylation motifs that serve as docking sites for SH2-domain-containing proteins including phosphatidylinositol 3-kinase p85 subunit and GRB-2. Phosphorylated on ser/thr residues by kinases including JNK and IKK. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold Cellular Component: intracellular membrane-bound organelle; cytoplasm; plasma membrane; caveola; nucleus; cytosol Molecular Function: protein domain specific binding; insulin-like growth factor receptor binding; signal transducer activity; protein binding; protein kinase C binding; phospholipid binding; phosphoinositide 3-kinase binding; SH2 domain binding; transmembrane receptor protein tyrosine kinase adaptor protein activity; protein kinase binding; insulin receptor binding Biological Process: response to peptide hormone stimulus; phosphoinositide 3-kinase cascade; protein heterooligomerization; positive regulation of glycogen biosynthetic process; negative regulation of insulin receptor signaling pathway; positive regulation of phosphoinositide 3-kinase activity; signal transduction; response to insulin stimulus; negative regulation of insulin secretion; response to caffeine; positive regulation of fatty acid beta-oxidation; positive regulation of glucose import; mammary gland development; insulin-like growth factor receptor signaling pathway; cellular response to insulin stimulus; insulin secretion; regulation of gene expression; positive regulation of mesenchymal cell proliferation; protein kinase B signaling cascade; insulin receptor signaling pathway; positive regulation of insulin receptor signaling pathway; positive regulation of phosphorylation; lipid catabolic process; positive regulation of cell migration Reference #:  P35569 (UniProtKB) Alt. Names/Synonyms: G972R; Insulin receptor substrate 1; IRS-1; Irs1; OTTMUSP00000017705 Gene Symbols: Irs1 Molecular weight: 130,723 Da Basal Isoelectric point: 8.97  Predict pI for various phosphorylation states CST Pathways:  Insulin Receptor Signaling  |  MAPK/Erk in Growth and Differentiation  |  mTOR Signaling  |  PI3K/Akt Signaling  |  SAPK/JNK Signaling Cascades  |  Translation: eIF4E and p70S6K Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below IRS1 1AYB - P=887-898 (mouse) 1IRS - A=157-267 (human) 1K3A - B=891-902 (human) 1QQG - A/B=4-267 (human) 2Z8C - B=731-736 (human)

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	Sites Implicated In
cell growth, altered: S302‑p inhibition: S408‑p, S1097‑p molecular association, regulation: S612‑p, S632‑p, S662‑p, S731‑p phosphorylation: S302‑p, S307‑p, S318‑p protein degradation: S612‑p, S635‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			mouse
0	5		S3-p	_____MAsPPDTDGF
2	1		S24	GYLRKPKSMHKRFFV
0	27		Y46-p	GGPARLEyyENEKKW
0	4		Y47-p	GPARLEyyENEKKWR
0	1		K52	EyyENEKKWRHKSSA
0	1		K61	RHKSSAPKRSIPLES
0	7		Y87	NKHLVALYTRDEHFA
1	0		S99	HFAIAADSEAEQDSW
0	1		Y147-p	EAGEDLSyDTGPGPA
0	3		K164	EVWQVILKPKGLGQT
0	1		Y178	TKNLIGIYRLCLTSK
0	2		S263	SDEFRPRSKsQsSSS
3	29		S265-p	EFRPRSKsQsSSSCS
1	0		S267-p	RPRSKsQsSSSCSNP
0	1		S268	PRSKsQsSSSCSNPI
0	1		S269	RSKsQsSSSCSNPIS
2	2		S298	QVGLTRRSRTEsITA
0	2		T300	GLTRRSRTEsITATs
31	3		S302-p	TRRSRTEsITATsPA
0	2		T304	RSRTEsITATsPASM
0	1		T306	RTEsITATsPASMVG
62	5		S307-p	TEsITATsPASMVGG
0	1		S310	ITATsPASMVGGKPG
10	6		S318-p	MVGGKPGsFRVRAss
0	1		S324-p	GsFRVRAssDGEGTM
3	8		S325-p	sFRVRAssDGEGTMS
1	0		S332	sDGEGTMSRPASVDG
2	7		S336	GTMSRPASVDGSPVs
2	21		S343-p	SVDGSPVsPStNRTH
0	1		S345	DGSPVsPStNRTHAH
0	2		T346-p	GSPVsPStNRTHAHR
2	0		S357	HAHRHRGSSRLHPPL
3	0		S358	AHRHRGSSRLHPPLN
0	1		S367	LHPPLNHSRsIPMPS
1	3		S369-p	PPLNHSRsIPMPSSR
1	0		S407	DCLFPRRSsASVsGs
2	0		S408-p	CLFPRRSsASVsGsP
0	1		S412-p	RRSsASVsGsPSDGG
0	1		S414-p	SsASVsGsPSDGGFI
0	1		S423-p	SDGGFISsDEYGSSP
1	0		S436	SPCDFRSSFRsVtPD
0	1		S439-p	DFRSSFRsVtPDsLG
1	7		T441-p	RSSFRsVtPDsLGHt
0	2		S444-p	FRsVtPDsLGHtPPA
0	8		T448-p	tPDsLGHtPPARGEE
0	1		S458	ARGEEELSNyICMGG
1	8		Y460-p	GEEELSNyICMGGKG
0	2		Y478	LAAPNGHYILSRGGN
0	2		S481	PNGHYILSRGGNGHR
1	2		I490	GGNGHRYIPGANLGT
1	0		S498	PGANLGTSPALPGDE
1	0		P502	LGTSPALPGDEAAGA
0	1		T520-p	DNRFRKRtHsAGTSP
4	6		S522-p	RFRKRtHsAGTSPTI
0	1		T525	KRtHsAGTSPTIsHQ
2	5		S526	RtHsAGTSPTIsHQK
0	1		S530-p	AGTSPTIsHQKTPSQ
4	3		S570	RLPGYRHSAFVPTHS
0	21		T599-p	GGHHRPDtsNLHTDD
0	10		S600-p	GHHRPDtsNLHTDDG
0	20		N601	HHRPDtsNLHTDDGy
0	21		T604	PDtsNLHTDDGyMPM
17	301		Y608-p	NLHTDDGyMPMsPGV
30	7		S612-p	DDGyMPMsPGVAPVP
3	39		N625	VPSNRKGNGDyMPMs
6	286		Y628-p	NRKGNGDyMPMsPKs
31	11		S632-p	NGDyMPMsPKsVSAP
26	3		S635-p	yMPMsPKsVSAPQQI
0	92		Y658	QRVDPNGYMMMsPSG
1	6		S662-p	PNGYMMMsPSGSCSP
0	7		S664	GYMMMsPSGSCSPDI
0	3		S668	MsPSGSCSPDIGGGS
0	1		S675	SPDIGGGSSSSSSIS
0	1		S689	SAAPSGSSYGKPWTN
0	2		Y690	AAPSGSSYGKPWTNG
0	1		Y727	LLPCTGDYMNMsPVG
1	0		S731-p	TGDYMNMsPVGDSNT
0	3		S761	KPVLSYYSLPRSFKH
7	0		S789-p	QHLRLSSsSGRLRYT
0	1		T842	HLPRKVDTAAQTNSR
0	1		T854	NSRLARPTRLSLGDP
4	7		S887-p	LHPPEPKsPGEyVNI
8	1		Y891-p	EPKsPGEyVNIEFGS
1	0		S910	YLAGPATSRSSPSVR
0	1		T930	HPAPREETGSEEyMN
0	2		S932	APREETGSEEyMNMD
2	48		Y935-p	EETGSEEyMNMDLGP
1	0		N978	RPTRSVPNSRGDyMT
1	0		S979	PTRSVPNSRGDyMTM
2	18		Y983-p	VPNSRGDyMTMQIGC
3	4		S999-p	RQSYVDTsPVAPVSY
1	0		S1005	TsPVAPVSYADMRTG
0	1		Y1006	sPVAPVSYADMRTGI
2	1		S1032	GAAPPPSSTASSSAS
1	0		S1035	PPPSSTASSSASVTP
1	0		S1037	PSSTASSSASVTPQG
1	0		S1037	PSSTASSSASVTPQG
1	1		T1041	ASSSASVTPQGATAE
2	10		S1074-p	AFTRVNLsPNHNQSA
2	86		S1096-p	QGCRRRHssEtFSAP
7	110		S1097-p	GCRRRHssEtFSAPt
0	7		T1099-p	RRRHssEtFSAPtRA
0	2		-	gap
0	1		-	gap
0	4		T1104-p	sEtFSAPtRAGNTVP
2	3		S1136-p	SEDVKRHssASFENV
1	1		S1137-p	EDVKRHssASFENVW
2	4		S1139	VKRHssASFENVWLR
0	1		S1170-p	AAGGLEKsLNyIDLD
3	25		Y1173-p	GLEKsLNyIDLDLAK
2	3		S1213-p	EGNSPRRssEDLsNy
3	10		S1214-p	GNSPRRssEDLsNyA
0	1		S1218-p	RRssEDLsNyASISF
2	1		Y1220-p	ssEDLsNyASISFQK

	human
S3	_____MASPPESDGF
S24-p	GYLRKPKsMHKRFFV
Y46-p	GGPARLEyyENEKkW
Y47-p	GPARLEyyENEKkWR
K52-a	EyyENEKkWRHKSSA
K61-a	RHKSSAPkRSIPLES
Y87-p	NKHLVALyTRDEHFA
S99	HFAIAADSEAEQDSW
Y151	EAGEDLSYGDVPPGP
K169-u	EVWQVILkPKGLGQT
Y183-p	TKNLIGIyRLCLTSK
S268-p	SDEFRPRsKsQSssN
S270-p	EFRPRsKsQSssNCS
S272	RPRsKsQSssNCSNP
S273-p	PRsKsQSssNCSNPI
S274-p	RsKsQSssNCSNPIS
S303-p	QVGLTRRsRtEsItA
T305-p	GLTRRsRtEsItAts
S307-p	TRRsRtEsItAtsPA
T309-p	RsRtEsItAtsPAsM
T311-p	RtEsItAtsPAsMVG
S312-p	tEsItAtsPAsMVGG
S315-p	ItAtsPAsMVGGKPG
S323-p	MVGGKPGsFRVRAss
S329-p	GsFRVRAssDGEGTM
S330-p	sFRVRAssDGEGTMS
S337	sDGEGTMSRPAsVDG
S341-p	GTMSRPAsVDGSPVs
S348-p	sVDGSPVsPstNRTH
S350-p	DGSPVsPstNRTHAH
T351-p	GSPVsPstNRTHAHR
S362-p	HAHRHRGsARLHPPL
A363	AHRHRGsARLHPPLN
S372-p	LHPPLNHsRsIPMPA
S374-p	PPLNHsRsIPMPASR
S412	DCLFPRRSSASVSGS
S413	CLFPRRSSASVSGSP
S417	RRSSASVSGSPSDGG
S419	SSASVSGSPSDGGFI
S428	SDGGFISSDEYGSSP
S441-p	SPCDFRSsFRSVtPD
S444	DFRSsFRSVtPDsLG
T446-p	RSsFRSVtPDsLGHt
S449-p	FRSVtPDsLGHtPPA
T453-p	tPDsLGHtPPARGEE
S463-p	ARGEEELsNyICMGG
Y465-p	GEEELsNyICMGGKG
Y483-p	LTAPNGHyILsRGGN
S486-p	PNGHyILsRGGNGHR
T495-p	GGNGHRCtPGTGLGT
S503	PGTGLGTSPALAGDE
A507	LGTSPALAGDEAASA
T525	DNRFRKRTHsAGtsP
S527-p	RFRKRTHsAGtsPTI
T530-p	KRTHsAGtsPTITHQ
S531-p	RTHsAGtsPTITHQK
T535	AGtsPTITHQKTPSQ
S574-p	RLPGHRHsAFVPTRS
S603-p	GGHHRPDsstLHtDD
S604-p	GHHRPDsstLHtDDG
T605-p	HHRPDsstLHtDDGy
T608-p	PDsstLHtDDGyMPM
Y612-p	tLHtDDGyMPMsPGV
S616-p	DDGyMPMsPGVAPVP
S629-p	VPSGRKGsGDyMPMs
Y632-p	GRKGsGDyMPMsPKs
S636-p	sGDyMPMsPKsVSAP
S639-p	yMPMsPKsVSAPQQI
Y662-p	QRVDPNGyMMMsPsG
S666-p	PNGyMMMsPsGGCsP
S668-p	GyMMMsPsGGCsPDI
S672-p	MsPsGGCsPDIGGGP
S680-p	PDIGGGPsSSSSSSN
S694-p	NAVPSGTsyGKLWTN
Y695-p	AVPSGTsyGKLWTNG
Y732-p	LLPCTGDyMNMSPVG
S736	TGDyMNMSPVGDSNT
S766-p	KPVLSYYsLPRSFKH
S794-p	QHLRLSTsSGRLLYA
T847-p	HLPRKVDtAAQTNSR
T859-p	NSRLARPtRLSLGDP
S892-p	LHPPEPKsPGEyVNI
Y896-p	EPKsPGEyVNIEFGS
F915	YLSGPVAFHSSPSVR
T936-p	PAPREEEtGtEEyMK
T938-p	PREEEtGtEEyMKMD
Y941-p	EEtGtEEyMKMDLGP
S984-g	RPTRAVPssRGDyMT
S985-g	PTRAVPssRGDyMTM
Y989-p	VPssRGDyMTMQMSC
S1005-p	RQSYVDTsPAAPVsy
S1011-g	TsPAAPVsyADMRTG
Y1012-p	sPAAPVsyADMRTGI
S1038	MAAASSSSAAsAsPT
S1041-p	ASSSSAAsAsPTGPQ
S1043-p	SSSAAsAsPTGPQGA
S1043	SSSAAsASPTGPQGA
G1046	AAsAsPTGPQGAAEL
S1078-p	AFTRVNLsPNRNQSA
S1100-p	QGCRRRHssEtFSSt
S1101-p	GCRRRHssEtFSStP
T1103-p	RRRHssEtFSStPsA
T1107-p	ssEtFSStPsAtRVG
S1109-p	EtFSStPsAtRVGNT
T1111-p	FSStPsAtRVGNTVP
S1142-p	SEDVKRHssAsFENV
S1143-p	EDVKRHssAsFENVW
S1145-p	VKRHssAsFENVWLR
G1176	AAGGLENGLNyIDLD
Y1179-p	GLENGLNyIDLDLVK
S1222-p	ESSSTRRssEDLSAY
S1223-p	SSSTRRssEDLSAYA
S1227	RRssEDLSAYASISF
Y1229	ssEDLSAYASISFQK

	rat
S3	_____MASPPDTDGF
S24-p	GYLRKPKsMHKRFFV
Y46	GGPARLEYYENEKKW
Y47	GPARLEYYENEKKWR
K52	EYYENEKKWRHKSSA
K61	RHKSSAPKRSIPLES
Y87	NKHLVALYTRDEHFA
S99-p	HFAIAADsEAEQDSW
Y147	EAGEDLSYDTGPGPA
K164	EVWQVILKPKGLGQT
Y178	TKNLIGIYRLCLTSK
T263	SDEFRPRTKsQSSSS
S265-p	EFRPRTKsQSSSSCS
S267	RPRTKsQSSSSCSNP
S268	PRTKsQSSSSCSNPI
S269	RTKsQSSSSCSNPIS
S298	QVGLTRRSRTEsITA
T300	GLTRRSRTEsITATs
S302-p	TRRSRTEsITATsPA
T304	RSRTEsITATsPASM
T306	RTEsITATsPASMVG
S307-p	TEsITATsPASMVGG
S310	ITATsPASMVGGKPG
S318-p	MVGGKPGsFRVRAss
S324-p	GsFRVRAssDGEGTM
S325-p	sFRVRAssDGEGTMs
S332-p	sDGEGTMsRPAsVDG
S336-p	GTMsRPAsVDGSPVs
S343-p	sVDGSPVsPSTNRTH
S345	DGSPVsPSTNRTHAH
T346	GSPVsPSTNRTHAHR
S357-p	HAHRHRGssRLHPPL
S358-p	AHRHRGssRLHPPLN
S367	LHPPLNHSRsIPMPS
S369-p	PPLNHSRsIPMPSSR
S407-p	DCLFPRRssASVSGS
S408-p	CLFPRRssASVSGSP
S412	RRssASVSGSPSDGG
S414	ssASVSGSPSDGGFI
S423	SDGGFISSDEYGSSP
S436	SPCDFRSSFRSVTPD
S439	DFRSSFRSVTPDSLG
T441	RSSFRSVTPDSLGHT
S444	FRSVTPDSLGHTPPA
T448	TPDSLGHTPPARGEE
S458	ARGEEELSNyICMGG
Y460-p	GEEELSNyICMGGKG
Y478	LTAPNGHYILSRGGN
S481	PNGHYILSRGGNGHR
I490	GGNGHRYIPGATMGT
S498-p	PGATMGTsPALtGDE
T502-p	MGTsPALtGDEAAGA
T520	DNRFRKRTHsAGTsP
S522-p	RFRKRTHsAGTsPTI
T525	KRTHsAGTsPTISHQ
S526-p	RTHsAGTsPTISHQK
S530	AGTsPTISHQKTPSQ
S570-p	RLPGYRHsAFVPTHS
S599	GGHHRPDSSNLHTDD
S600	GHHRPDSSNLHTDDG
N601	HHRPDSSNLHTDDGy
T604	PDSSNLHTDDGyMPM
Y608-p	NLHTDDGyMPMsPGV
S612-p	DDGyMPMsPGVAPVP
N625	VPSNRKGNGDyMPMs
Y628-p	NRKGNGDyMPMsPKs
S632-p	NGDyMPMsPKsVSAP
S635-p	yMPMsPKsVSAPQQI
Y658	QRVDPNGYMMMSPSG
S662	PNGYMMMSPSGSCSP
S664	GYMMMSPSGSCSPDI
S668	MSPSGSCSPDIGGGS
S675	SPDIGGGSCSSSSIS
S689	SAAPSGSSYGKPWTN
Y690	AAPSGSSYGKPWTNG
Y727	LLPCTGDYMNMSPVG
S731	TGDYMNMSPVGDSNT
S761	KPVLSYYSLPRSFKH
S789-p	QHLRLSSsSGRLRYT
T842	HLPRKVDTAAQTNSR
T854	NSRLARPTRLSLGDP
S891-p	LHPPEPKsPGEyVNI
Y895-p	EPKsPGEyVNIEFGS
S914-g	YLAGPATsRSSPSVR
T934	HPAPREETGSEEyMN
S936	APREETGSEEyMNMD
Y939-p	EETGSEEyMNMDLGP
N982	RPTRSVPNSRGDyMT
S983	PTRSVPNSRGDyMTM
Y987-p	VPNSRGDyMTMQIGC
S1003-p	RQSYVDTsPVAPVsY
S1009-g	TsPVAPVsYADMRTG
Y1010	sPVAPVsYADMRTGI
S1036-g	GAAPPPSsTASAsAS
S1039	PPPSsTASAsASVtP
S1041	PSsTASASASVtPQG
S1041-g	PSsTASAsASVtPQG
T1045-p	ASAsASVtPQGAAEQ
S1077-p	AFTRVNLsPNHNQSA
S1099-p	QGCRRRHssETFSAP
S1100-p	GCRRRHssETFSAPT
T1102	RRRHssETFSAPTRA
-	gap
-	gap
T1107	sETFSAPTRAANTVS
S1135	SEDVKRHSSASFENV
S1136	EDVKRHSSASFENVW
S1138	VKRHSSASFENVWLR
S1169	AAGGLEKSLNyIDLD
Y1172-p	GLEKSLNyIDLDLVK
S1215-p	EGSSPRRssEDLSTy
S1216-p	GSSPRRssEDLSTyA
S1220	RRssEDLSTyASINF
Y1222-p	ssEDLSTyASINFQK

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