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NT-3 (human)

Overview NT-3 Seems to promote the survival of visceral and proprioceptive sensory neurons. Belongs to the NGF-beta family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Secreted, signal peptide; Secreted; Cytokine Cellular Component: cytoplasmic membrane-bound vesicle; extracellular region; plasma membrane Molecular Function: neurotrophin receptor binding; growth factor activity; nerve growth factor binding; receptor binding Biological Process: myelination; regulation of synaptic transmission; axon guidance; nervous system development; epidermis development; mechanoreceptor differentiation; glial cell fate determination; positive regulation of glial cell differentiation; signal transduction; enteric nervous system development; peripheral nervous system development; cell-cell signaling; neuromuscular synaptic transmission; smooth muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; nerve development; brain development; negative regulation of neuron apoptosis Reference #:  P20783 (UniProtKB) Alt. Names/Synonyms: HDNF; MGC129711; Nerve growth factor 2; Neurotrophic factor; neurotrophin 3; Neurotrophin-3; NGF-2; NGF2; NT-3; NT3; NTF3 Gene Symbols: NTF3 Molecular weight: 29,355 Da Basal Isoelectric point: 9.46  Predict pI for various phosphorylation states

Select Structure to View Below NT-3 1B8K - A=139-257 (human) 1BND - B=139-257 (human) 1NT3 - A=139-257 (human) 3BUK - A/B=139-257 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1B8K 1BND 1NT3 3BUK  |  Phospho3D  |  DISEASE  |  Source  |  InnateDB  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		S2	______MSILFYVIF
0	1		Y99-p	LLRQQRRyNSPRVLL
0	2		Y123-p	PLYLMEDyVGSPVVA
0	1		Y139-p	RTSRRKRyAEHKSHR
0	1		S156	YSVCDSESLWVTDKS

	NT-3 iso2
S15-p	LQVNKVMsILFYVIF
Y112	LLRQQRRYNSPRVLL
Y136	PLYLMEDYVGSPVVA
Y152	RTSRRKRYAEHKSHR
S169	YSVCDSESLWVTDKS

	mouse
S2	______MSILFYVIF
Y99	LLRQQRRYNSPRVLL
Y123	PLYLMEDYVGNPVVA
Y140	TSPRRKRYAEHKSHR
S157-p	YSVCDSEsLWVTDKS

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