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ITGB5 (human)

Overview ITGB5 Integrin alpha-V/beta-5 is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand. Heterodimer of an alpha and a beta subunit. Beta-5 associates with alpha-V. Interacts with MYO10. Belongs to the integrin beta chain family. Note: This description may include information from UniProtKB. Protein type: Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, integral Cellular Component: focal adhesion; leading edge; plasma membrane; phagocytic vesicle; integrin complex Molecular Function: integrin binding; protein binding; receptor activity Biological Process: integrin-mediated signaling pathway; antigen processing and presentation of peptide antigen via MHC class I; muscle contraction; cell-matrix adhesion; antigen processing and presentation of exogenous peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Reference #:  P18084 (UniProtKB) Alt. Names/Synonyms: FLJ26658; Integrin beta-5; integrin, beta 5; ITB5; ITGB5 Gene Symbols: ITGB5 Molecular weight: 88,054 Da Basal Isoelectric point: 5.72  Predict pI for various phosphorylation states CST Pathways:  GPCRs Signaling to MAPK/Erk  |  MAPK/Erk in Growth and Differentiation  |  PI3K/Akt Signaling  |  Regulation of Actin Dynamics Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ITGB5

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	Sites Implicated In
cell motility, altered: S759‑p, S762‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		T61-p	FGSPRSItSRCDLRA
0	2		S188-p	SFVDKDIsPFSYTAP
0	1		K206-a	TNPCIGYkLFPNCVP
0	1		T656-p	SGKPDNQtCHsLCRD
0	1		S659-p	PDNQtCHsLCRDEVI
1	0		S759-p	REFAKFQsERsRARy
1	0		S762-p	AKFQsERsRARyEMA
0	22		Y766-p	sERsRARyEMASNPL
0	55		Y774-p	EMASNPLyRKPIsTH
0	1		S779-p	PLyRKPIsTHTVDFt
0	1		T786-p	sTHTVDFtFNKFNkS
0	3		K792-u	FtFNKFNkSYNGTVD

	mouse
T61	FGNPRSITSRCDLKA
S188	SFVDKDISPFSYTAP
K206	TNPCIGYKLFPNCVP
T656	QGKPDNQTCHHQCKD
H659	PDNQTCHHQCKDEVI
S759	REFAKFQSERSRARY
S762	AKFQSERSRARYEMA
Y766	SERSRARYEMASNPL
Y774-p	EMASNPLyRKPISTH
S779	PLyRKPISTHTVDFA
A786	STHTVDFAFNKFNKS
K792	FAFNKFNKSYNGSV_

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