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Protein Page:
ITGB5 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ITGB5 Integrin alpha-V/beta-5 is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand. Heterodimer of an alpha and a beta subunit. Beta-5 associates with alpha-V. Interacts with MYO10. Belongs to the integrin beta chain family. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Cell adhesion; Membrane protein, integral
Cellular Component: focal adhesion; leading edge; plasma membrane; phagocytic vesicle; integrin complex; receptor complex
Molecular Function: integrin binding; protein binding; receptor activity
Biological Process: integrin-mediated signaling pathway; extracellular matrix organization and biogenesis; antigen processing and presentation of peptide antigen via MHC class I; muscle contraction; multicellular organismal development; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of exogenous peptide antigen via MHC class I; cell adhesion
Reference #:  P18084 (UniProtKB)
Alt. Names/Synonyms: FLJ26658; Integrin beta-5; integrin, beta 5; ITB5; ITGB5
Gene Symbols: ITGB5
Molecular weight: 88,054 Da
Basal Isoelectric point: 5.72  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ITGB5

Protein Structure Not Found.


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Sites Implicated In
cell motility, altered: S759‑p, S762‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 T61-p FGSPRSItSRCDLRA
0 2 S188-p SFVDKDIsPFSYTAP
0 1 T199-ga YTAPRYQtNPCIGYk
0 1 K206-ac tNPCIGYkLFPNCVP
0 1 T656-p SGKPDNQtCHsLCRD
0 1 S659-p PDNQtCHsLCRDEVI
1 0 S759-p REFAKFQsERsRARy
1 0 S762-p AKFQsERsRARyEMA
0 23 Y766-p sERsRARyEMAsNPL
0 3 S770-p RARyEMAsNPLyRKP
0 56 Y774-p EMAsNPLyRKPIstH
0 1 S779-p PLyRKPIstHtVDFt
0 1 T780-p LyRKPIstHtVDFtF
0 1 T782-p RKPIstHtVDFtFNK
0 1 T786-p stHtVDFtFNKFNkS
0 3 K792-ub FtFNKFNkSYNGtVD
0 1 T797-p FNkSYNGtVD_____
  mouse

 
T61 FGNPRSITSRCDLKA
S188 SFVDKDISPFSYTAP
T199 YTAPRYQTNPCIGYK
K206 TNPCIGYKLFPNCVP
T656 QGKPDNQTCHHQCKD
H659 PDNQTCHHQCKDEVI
S759 REFAKFQSERSRARY
S762 AKFQSERSRARYEMA
Y766 SERSRARYEMAsNPL
S770-p RARYEMAsNPLyRKP
Y774-p EMAsNPLyRKPISTH
S779 PLyRKPISTHTVDFA
T780 LyRKPISTHTVDFAF
T782 RKPISTHTVDFAFNK
A786 STHTVDFAFNKFNKS
K792 FAFNKFNKSYNGSV_
S797 FNKSYNGSV______
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